EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

para-chlorophenol
phenol, 4-chloro-

Sponsors

Name:4-chlorophenol
CAS Number: 106-48-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-402-6
FDA UNII:3DLC36A01X
Nikkaji Web:J3.611K
Beilstein Number:507004
MDL:MFCD00002318
XlogP3:2.40 (est)
Molecular Weight:128.55705000
Formula:C6 H5 Cl O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:antimicrobial agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.30600 @ 25.00 °C.
Melting Point: 42.70 °C. @ 760.00 mm Hg
Boiling Point: 220.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.078000 mm/Hg @ 25.00 °C. (est)
Vapor Density:4.43 ( Air = 1 )
Flash Point: 240.00 °F. TCC ( 115.56 °C. )
logP (o/w): 2.390
Soluble in:
 water, 3222 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
 
Suppliers:
EMD Millipore
For experimental / research use only.
4-Chlorophenol
Penta International
p-CHLOROPHENOL
Santa Cruz Biotechnology
For experimental / research use only.
4-Chlorophenol
Sigma-Aldrich: Aldrich
For experimental / research use only.
4-Chlorophenol ≥99%
TCI AMERICA
For experimental / research use only.
4-Chlorophenol >98.0%(GC)(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mammal (species unspecified) LD50 500 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.

intraperitoneal-mouse LD50 332 mg/kg
Journal of Medicinal Chemistry. Vol. 18, Pg. 868, 1975.

oral-mouse LD50 367 mg/kg
BEHAVIORAL: COMA BEHAVIORAL: EXCITEMENT
Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny. Journal of Experimental and Clinical Medicine. Vol. 25, Pg. 339, 1985.

unreported-mouse LD50 605 mg/kg
AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 54(1), Pg. 68, 1989.

intraperitoneal-rat LD50 281 mg/kg
BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
British Journal of Pharmacology and Chemotherapy. Vol. 13, Pg. 20, 1958.

oral-rat LD50 670 mg/kg
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 2, Pg. 76, 1943.

unreported-rat LD50 625 mg/kg
AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 54(1), Pg. 68, 1989.

Dermal Toxicity:
skin-mammal (species unspecified) LD50 1000 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.

skin-rat LD50 1500 mg/kg
SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(10), Pg. 37, 1964.

subcutaneous-rat LD50 1030 mg/kg
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 2, Pg. 76, 1943.

Inhalation Toxicity:
inhalation-human TCLo 10000 mg/m3/8H
BEHAVIORAL: EXCITEMENT BEHAVIORAL: IRRITABILITY
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(10), Pg. 37, 1964.

inhalation-mouse LCLo 3200 mg/m3/2H
BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 9, 1992.

inhalation-rat LC50 11 mg/m3
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(10), Pg. 37, 1964.

 
Safety in Use Information:
Category: antimicrobial agents
Recommendation for para-chlorophenol usage levels up to:
 not for fragrance use.
 
Recommendation for para-chlorophenol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):106-48-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :4684
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
4-chlorophenol
Chemidplus:0000106489
EPA/NOAA CAMEO:hazardous materials
RTECS:106-48-9
 
References:
 4-chlorophenol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:106-48-9
Pubchem (cid):4684
Pubchem (sid):134971772
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C02124
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2908.19.6000
Haz-Map:View
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
grade: nf, technical
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 antimicrobial agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
4-chlorbenzolol
4-chloro-1-hydroxybenzene
1-chloro-4-hydroxybenzene
4-chloro-phenol
p-chlorophenic acid
4-chlorophenol
p-chlorophenol
4-chlorphenol
4-hydroxychlorobenzene
p-hydroxychlorobenzene
 parachlorophenol
 phenol, 4-chloro-
 phenol, p-chloro-
 

Articles:

PubMed:Evaluation of the utility of the lifetime mouse bioassay in the identification of cancer hazards for humans.
PubMed:Photocatalytic pre-treatment with food-grade TiO(2) increases the bioavailability and bioremediation potential of weathered oil from the Deepwater Horizon oil spill in the Gulf of Mexico.
PubMed:Waste-derived bioorganic substances for light-induced generation of reactive oxygenated species.
PubMed:Purification and characterization of a peroxidase isozyme from Indian turnip roots.
PubMed:[Analysis of chlorophenol compounds contaminating food by LC/MS].
PubMed:Metabolic fate of [14C] chlorophenols in radish (Raphanus sativus), lettuce (Lactuca sativa), and spinach (Spinacia oleracea).
PubMed:4-monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats.
PubMed:Effects of high temperature and disinfectants on the viability of Sarcocystis neurona sporocysts.
PubMed:Determination of phenolic disinfectant agents in commercial formulations by liquid chromatography.
PubMed:Toxicological profile for o-benzyl-p-chlorophenol.
PubMed:Thietanium ion formation from the food mutagen 2-chloro-4-(methylthio)butanoic acid.
PubMed:Investigating the potential impacts of chlorophenols on the lake baikal (Siberia, russia) food web by employing daphnia grazing bioassays and a chlorella growth bioassay
PubMed:Effects of the naturally occurring alkenylbenzenes eugenol and trans-anethole on drug-metabolizing enzymes in the rat liver.
 
Notes:
used as a root canal irrigant.
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