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4-aminophenyl sulfone
4,4'-diaminodiphenyl sulphone

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Name:4-(4-aminophenyl)sulfonylaniline
CAS Number: 80-08-0Picture of molecule3D/inchi
Other(deleted CASRN):1246638-15-2
ECHA EINECS - REACH Pre-Reg:201-248-4
FDA UNII: 8W5C518302
Nikkaji Web:J4.247A
Beilstein Number:0788055
MDL:MFCD00007887
XlogP3-AA:1.00 (est)
Molecular Weight:248.30504000
Formula:C12 H12 N2 O2 S
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:indirect food additives: adhesives and components of coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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NCBI:Search
DG SANTE Food Contact Materials:4,4'-diaminodiphenyl sulphone
 
Physical Properties:
Appearance:white crystalline powder crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 380mg/L @ 37 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Dapsone >98%
Odor: characteristic
Use: Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae, which has anti-inflammatory and immunomodulatory effects.
Glentham Life Sciences
Dapsone
Sigma-Aldrich: Aldrich
For experimental / research use only.
4-Aminophenyl Sulfone 97%
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-cat LDLo 357 mg/kg
Archives of Neurology and Psychiatry. Vol. 54, Pg. 319, 1945.

oral-child TDLo 5 mg/kg
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Journal of Toxicology, Clinical Toxicology. Vol. 19, Pg. 1061, 1982/1983.

oral-child TDLo 37500 ug/kg
GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Pediatric Emergency Care. Vol. 13, Pg. 127, 1997.

oral-guinea pig LD50 300 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

oral-human TDLo 18000 mg/kg/15Y
KIDNEY, URETER, AND BLADDER: OTHER CHANGES MUSCULOSKELETAL: JOINTS
British Medical Journal. Vol. 1, Pg. 78, 1978.

unreported-mammal (species unspecified) LD50 1400 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(9), Pg. 23, 1978.

oral-man TDLo 36 mg/kg
BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
Human Toxicology. Vol. 2, Pg. 507, 1983.

intraperitoneal-mouse LD50 313 mg/kg
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 48, Pg. 336, 1952.

intravenous-mouse LD50 225 mg/kg
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 48, Pg. 336, 1952.

oral-mouse LD50 250 mg/kg
American Review of Tuberculosis. Vol. 60, Pg. 62, 1949.

intraperitoneal-rat LD50 196 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 183, Pg. 36, 1970.

oral-rat LD50 1000 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955.

Dermal Toxicity:
subcutaneous-mouse LD50 250 mg/kg
American Review of Tuberculosis. Vol. 60, Pg. 62, 1949.

skin-rabbit LD50 > 4000 mg/kg
Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
indirect food additives: adhesives and components of coatings
Recommendation for 4-aminophenyl sulfone usage levels up to:
 not for fragrance use.
 
Recommendation for 4-aminophenyl sulfone flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to a 9th list of substances for food contact materials
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):80-08-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :2955
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
4-(4-aminophenyl)sulfonylaniline
Chemidplus:0000080080
EPA/NOAA CAMEO:hazardous materials
RTECS:BY8925000 for cas# 80-08-0
 
References:
 4-(4-aminophenyl)sulfonylaniline
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:80-08-0
Pubchem (cid):2955
Pubchem (sid):134971843
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C07666
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2921.42.7500
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
4-(4-aminophenyl)sulfonylaniline
 avlosulfone
 benzenamine, 4,4'-sulfonylbis-
 dapsone
4,4'-diaminodiphenyl sulphone
4,4'-sulfonylbisbenzenamine
 sumicure S
 
 
Notes:
None found
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