EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

meta-guaiacol
resorcinol methyl ether

Supplier Sponsors

CAS Number: 150-19-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:205-754-6
FDA UNII:HXB7441U87
Nikkaji Web:J2.030C
Beilstein Number:1209898
MDL:MFCD00002267
XlogP3:1.60 (est)
Molecular Weight:124.13916000
Formula:C7 H8 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:cosmetic and flavor agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FLAVIS Number:04.076 (Old)
DG SANTE Food Flavourings:04.076 3-methoxyphenol
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.06300 to 1.06900 @ 25.00 °C.
Pounds per Gallon - (est).: 8.845 to 8.895
Refractive Index:1.54700 to 1.55300 @ 20.00 °C.
Boiling Point: 243.00 to 244.00 °C. @ 760.00 mm Hg
Boiling Point: 113.00 to 115.00 °C. @ 5.00 mm Hg
Vapor Pressure:0.020000 mmHg @ 25.00 °C. (est)
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 1.340
Soluble in:
 alcohol
 water, 497 mg/L @ 37 °C (exp)
 
Organoleptic Properties:
Odor Strength:high ,
recommend smelling in a 1.00 % solution or less
Odor Description:at 1.00 % in dipropylene glycol. phenolic
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
m-Methoxyphenol
Carbosynth
For experimental / research use only.
3-Methoxyphenol
Coompo
For experimental / research use only.
m-Methoxyphenol from Plants ≥96%
EMD Millipore
For experimental / research use only.
3-Methoxyphenol
Penta International
3-METHOXYPHENOL
Santa Cruz Biotechnology
For experimental / research use only.
meta-Guaiacol
Sigma-Aldrich: Aldrich
For experimental / research use only.
3-methoxyphenol 96%
TCI AMERICA
For experimental / research use only.
3-Methoxyphenol >98.0%(GC)
Zanos
3-methoxyphenol
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 320 mg/kg

oral-mouse LD50 312 mg/kg

oral-rat LD50 597 mg/kg

oral-mammal (species unspecified) LD50 597 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.

intraperitoneal-mouse LD50 320 mg/kg
BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 46, Pg. 185, 1957.

oral-mouse LD50 312 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 37(3), Pg. 108, 1972.

oral-rat LD50 597 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 37(3), Pg. 108, 1972.

Dermal Toxicity:
skin-rat LD50 682 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 37(3), Pg. 108, 1972.

skin-mammal (species unspecified) LD50 682 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.

skin-rat LD50 682 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 37(3), Pg. 108, 1972.

Inhalation Toxicity:
inhalation-rat LC50 11500 gm/m3/4hours
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 37(3), Pg. 108, 1972.

inhalation-human TCLo 230 ug/m3/22W
BEHAVIORAL: IRRITABILITY BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: HEADACHE
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 37(3), Pg. 108, 1972.

inhalation-mouse LC50 11500 mg/m3/4H
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 105, 1982.

inhalation-rat LC50 11500 mg/m3/4H
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 105, 1982.

 
Safety in Use Information:
Category: cosmetic and flavor agents
Recommendation for meta-guaiacol usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.011 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 420 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.500002.50000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.200001.00000
Edible ices, including sherbet and sorbet (03.0): 0.500002.50000
Processed fruit (04.1): 0.400002.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 1.000005.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 2.0000010.00000
Meat and meat products, including poultry and game (08.0): 0.200001.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.200001.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.300001.50000
Foodstuffs intended for particular nutritional uses (13.0): 0.500002.50000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 0.200001.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 1.000005.00000
Ready-to-eat savouries (15.0): 2.0000010.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.400002.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 22 (FGE.22): Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 58 (FGE.58) Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 60 (FGE.60): Consideration of eugenol and related hydroxyallylbenzene derivatives evaluated by JECFA (65th meeting) structurally related to ring- substituted phenolic substances evaluated by EFSA in FGE.22 (2006)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25
View page or View pdf

EPI System: View
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):150-19-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :9007
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2810
WGK Germany:3
3-methoxyphenol
Chemidplus:0000150196
RTECS:SL7524000 for cas# 150-19-6
 
References:
 3-methoxyphenol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):9007
Pubchem (sid):134973071
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2909.50.5000
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
m-guaiacol
1-hydroxy-3-methoxybenzene
3-hydroxyanisol
m-hydroxyanisol
3-hydroxyanisole
m-hydroxyanisole
meta-hydroxyanisole
3-methoxy phenol
3-methoxyphenol
m-methoxyphenol
meta-methoxyphenol
3-(methyloxy)phenol
 phenol, 3-methoxy-
 phenol, m-methoxy-
 resorcinol methyl ether
 resorcinol monomethyl ether
 

Articles:

PubMed:Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol.
PubMed:Encecalol angelate, an unstable chromene from Ageratum conyzoides L.: total synthesis and investigation of its antiprotozoal activity.
PubMed:Cannabidiol-2',6'-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor.
PubMed:A meta effect in nonphotochemical processes: the homolytic chemistry of m-methoxyphenol.
PubMed:A functional genomics investigation of allelochemical biosynthesis in Sorghum bicolor root hairs.
PubMed:Total synthesis of 10-norparvulenone and of O-methylasparvenone using a xanthate-mediated free radical addition-cyclization sequence.
PubMed:Metabolic activation of 3-hydroxyanisole by isolated rat hepatocytes.
PubMed:Deoxygenation of polyhydroxybenzenes: an alternative strategy for the benzene-free synthesis of aromatic chemicals.
PubMed:Isolation and characterization of a veratrol:corrinoid protein methyl transferase from Acetobacterium dehalogenans.
PubMed:Action mechanism of tyrosinase on meta- and para-hydroxylated monophenols.
PubMed:Kinetic study of the oxidation of 3-hydroxyanisole catalysed by tyrosinase.
PubMed:Oxidative and non-oxidative metabolism of 4-iodoanisole by rat liver microsomes.
PubMed:New isoflavonoids as inhibitors of porcine 5-lipoxygenase.
PubMed:Allergic contact dermatitis to two antioxidants in latex gloves: 4,4'-thiobis(6-tert-butyl-meta-cresol) (Lowinox 44S36) and butylhydroxyanisole. Allergen alternatives for glove-allergic patients.
PubMed:Association of chemically induced forestomach cell proliferation and carcinogenesis.
PubMed:CHANGES OF APPARENT IONIC MOBILITIES IN PROTOPLASM : II. THE ACTION OF GUAIACOL AS AFFECTED BY pH.
PubMed:CHANGES OF APPARENT IONIC MOBILITIES IN PROTOPLASM : I. EFFECTS OF GUAIACOL ON VALONIA.
 
Notes:
None found
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