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3-hydroxyanthranilic acid
3-oxyanthranilic acid

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CAS Number: 548-93-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:208-962-5
Nikkaji Web:J1.608J
Beilstein Number:0973356
XlogP3:0.90 (est)
Molecular Weight:153.13739000
Formula:C7 H7 N O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1.297e+004 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
None found
BOC Sciences
For experimental / research use only.
2-amino-3-hydroxybenzoic acid
Santa Cruz Biotechnology
For experimental / research use only.
3-Hydroxyanthranilic Acid ≥95%
Sigma-Aldrich: Aldrich
For experimental / research use only.
3-Hydroxyanthranilic Acid 97%
For experimental / research use only.
3-Hydroxyanthranilic Acid >98.0%(HPLC)(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
natural substances and extractives
Recommendation for 3-hydroxyanthranilic acid usage levels up to:
 not for fragrance use.
Recommendation for 3-hydroxyanthranilic acid flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :86
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-amino-3-hydroxybenzoic acid
RTECS:DG2625000 for cas# 548-93-6
 2-amino-3-hydroxybenzoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):86
Pubchem (cas):548-93-6
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Golm Metabolome Database:Search
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C00632
HMDB (The Human Metabolome Database):HMDB01476
YMDB (Yeast Metabolome Database):YMDB00254
Export Tariff Code:2922.50.4000
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
Search Trop Picture
2-amino-3-hydroxybenzoic acid
3-oxyanthranilic acid
 anthranilic acid, 3-hydroxy-
 benzoic acid, 2-amino-3-hydroxy-


PubMed:Inhibition of LPS-induced inflammatory mediators by 3-hydroxyanthranilic acid in macrophages through suppression of PI3K/NF-κB signaling pathways.
PubMed:Associations between intake of fish and n-3 long-chain polyunsaturated fatty acids and plasma metabolites related to the kynurenine pathway in patients with coronary artery disease.
PubMed:Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users.
PubMed:Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults.
PubMed:Evaluation of the bioactive properties of avenanthramide analogs produced in recombinant yeast.
PubMed:Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes.
PubMed:The urinary ratio of 3-hydroxykynurenine/3-hydroxyanthranilic acid is an index to predicting the adverse effects of D-tryptophan in rats.
PubMed:Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats.
PubMed:Pantothenic acid deficiency may increase the urinary excretion of 2-oxo acids and nicotinamide catabolites in rats.
PubMed:Metabonomic analysis of quercetin against the toxicity of chronic exposure to low-level dichlorvos in rats via ultra-performance liquid chromatography-mass spectrometry.
PubMed:The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.
PubMed:Supplementing healthy women with up to 5.0 g/d of L-tryptophan has no adverse effects.
PubMed:Increased conversion of tryptophan to nicotinamide in rats by dietary valproate.
PubMed:Fate of dietary tryptophan in young Japanese women.
PubMed:Urinary excretory ratio of anthranilic acid/kynurenic acid as an index of the tolerable amount of tryptophan.
PubMed:Effect of nicotinamide administration on the tryptophan-nicotinamide pathway in humans.
PubMed:The effects of phthalate esters on the tryptophan-niacin metabolism.
PubMed:Increase in conversion of tryptophan to niacin in pregnant rats.
PubMed:Influence of adenine-induced renal failure on tryptophan-niacin metabolism in rats.
PubMed:Characterization of a novel manganese peroxidase-lignin peroxidase hybrid isozyme produced by Bjerkandera species strain BOS55 in the absence of manganese.
PubMed:In vivo antioxidant activity of Okara Koji, a fermented okara, by Aspergillus oryzae.
PubMed:Antioxidative mechanism and apoptosis induction by 3-hydroxyanthranilic acid, an antioxidant in Indonesian food Tempeh, in the human hepatoma-derived cell line, HuH-7.
PubMed:Difference in Tryptophan-nicotinamide Conversion According to Dietary Nitrogen Sources; Casein, Casein Hydrolysate, and Mixtures of Amino Acids.
PubMed:The effects of high dietary concentrations of sodium saccharin on in vivo metabolism of xenobiotics in rats.
PubMed:Liver 3-hydroxyanthranilic acid oxygenase activity in rainbow trout (Oncorhynchus mykiss).
PubMed:Beef liver 3-hydroxyanthranilic acid oxidase.
Isol. from Brassica oleracea (cauliflower) 3-Hydroxyanthranilic acid is an intermediate in the metabolism of tryptophan.; An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen.
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