EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

luminol
1,4-phthalazinedione, 5-amino-2,3-dihydro-

Supplier Sponsors

CAS Number: 521-31-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:208-309-4
FDA UNII: 5EXP385Q4F
Nikkaji Web:J9.432C
Beilstein Number:383929
MDL:MFCD00006890
Molecular Weight:177.16319000
Formula:C8 H7 N3 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:yellow to light beige crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 330.50 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -0.245 (est)
Soluble in:
 water, 1.329e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
3-Aminophthalhydrazide
Glentham Life Sciences
Luminol
Penta International
LUMINOL
Santa Cruz Biotechnology
For experimental / research use only.
Luminol 98%
Sarchem Laboratories
For experimental / research use only.
Luminol
Sigma-Aldrich: Aldrich
For experimental / research use only.
Luminol 97%
sds
TCI AMERICA
For experimental / research use only.
Luminol [Chemiluminescence Reagent] >98.0%(HPLC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD > 500 mg/kg
National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 11, 1953.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for luminol usage levels up to:
 not for fragrance use.
 
Recommendation for luminol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):521-31-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10638
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
5-amino-2,3-dihydrophthalazine-1,4-dione
Chemidplus:0000521313
EPA/NOAA CAMEO:hazardous materials
RTECS:TH8890060 for cas# 521-31-3
 
References:
 5-amino-2,3-dihydrophthalazine-1,4-dione
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:521-31-3
Pubchem (cid):10638
Pubchem (sid):134977204
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.99.8290
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
5-amino-1,2,3,4-tetrahydrophthalazine-1,4-dione
5-amino-2,3-dihydro-1,4-phthalazine dione
5-amino-2,3-dihydro-1,4-phthalazinedione
5-amino-2,3-dihydro-1,4-phthalazinedone
5-amino-2,3-dihydro-phthalazine-1,4-dione
5-amino-2,3-dihydrophthalazine-1,4-dione
5-amino-4-hydroxyphthalazin-1(2H)-one
3-aminophthalhydrazide
3-aminophthalic acid hydrazide
3-aminophthalic hydrazide
o-aminophthaloyl hydrazide
o-aminophthalyl hydrazide
3-aminophthalylhydrazide
o-aminophthalylhydrazide
1,4-phthalazinedione, 5-amino-2,3-dihydro-
 

Articles:

PubMed:Sensitive assay of hexythiazox residue in citrus fruits using gold nanoparticles-catalysed luminol-H2O2 chemiluminescence.
PubMed:[Antioxidative and membranotropic activities of rosmarinic acid].
PubMed:Photoluminescence, chemiluminescence and anodic electrochemiluminescence of hydrazide-modified graphene quantum dots.
PubMed:A novel biosensor array with a wheel-like pattern for glucose, lactate and choline based on electrochemiluminescence imaging.
PubMed:A magnetic particles-based chemiluminescence enzyme immunoassay for rapid detection of ovalbumin.
PubMed:A competitive immunoassay for sensitive detection of small molecules chloramphenicol based on luminol functionalized silver nanoprobe.
PubMed:Multiplex chemiluminescent immunoassay for screening of mycotoxins using photonic crystal microsphere suspension array.
PubMed:Determination of residual enrofloxacin in food samples by a sensitive method of chemiluminescence enzyme immunoassay.
PubMed:Comparison of uric Acid quantity with different food in human urine by flow injection chemiluminescence analysis.
PubMed:Hydrogen peroxide generation from hydrated protein drink mixes.
PubMed:Sensitive determination of positional isomers of benzenediols in human urine by boronate affinity capillary electrophoresis with chemiluminescence detection.
PubMed:Paper-based chromatographic chemiluminescence chip for the detection of dichlorvos in vegetables.
PubMed:A highly sensitive chemiluminescent metalloimmunoassay for H1N1 influenza virus detection based on a silver nanoparticle label.
PubMed:An investigation into the enhancement of fingermarks in blood on fruit and vegetables.
PubMed:4-methylcoumarin derivatives inhibit human neutrophil oxidative metabolism and elastase activity.
PubMed:Molecularly imprinted polymer grafted paper-based multi-disk micro-disk plate for chemiluminescence detection of pesticide.
PubMed:Aptamer--nanoparticle-based chemiluminescence for p53 protein.
PubMed:A novel chemiluminescent ELISA for detecting furaltadone metabolite, 3-amino-5-morpholinomethyl-2-oxazolidone (AMOZ) in fish, egg, honey and shrimp samples.
PubMed:Quantification of 2,4-dichlorophenoxyacetic acid in oranges and mandarins by chemiluminescent ELISA.
PubMed:Comparative study of β-glucan induced respiratory burst measured by nitroblue tetrazolium assay and real-time luminol-enhanced chemiluminescence assay in common carp (Cyprinus carpio L.).
PubMed:Highly sensitive analysis of four hemeproteins by dynamically-coated capillary electrophoresis with chemiluminescence detector using an off-column coaxial flow interface.
PubMed:Development of a generic assay for the determination of total trihydroxybenzoate derivatives based on gold-luminol chemiluminescence.
PubMed:Electrogenerated chemiluminescence immunosensor for Bacillus thuringiensis Cry1Ac based on Fe3O4@Au nanoparticles.
PubMed:Reusable light-emitting-diode induced chemiluminescence aptasensor for highly sensitive and selective detection of riboflavin.
PubMed:CoFe2O4 nanoparticles as oxidase mimic-mediated chemiluminescence of aqueous luminol for sulfite in white wines.
PubMed:Identification of antioxidants in Fructus aurantii and its quality evaluation using a new on-line combination of analytical techniques.
PubMed:Enzymeless determination of total sugar by luminol-tetrachloroaurate chemiluminescence on chip to analyze food samples.
PubMed:Assay of picogram level isocarbophos residue on tangerines and oranges with luminol-albumin chemiluminescence system.
PubMed:Kinetics of luminol sonochemiluminescence quenched by purines.
PubMed:In vitro modulation of oxidative burst via release of reactive oxygen species from immune cells by extracts of selected tropical medicinal herbs and food plants.
PubMed:Enhanced competitive chemiluminescent enzyme immunoassay for the trace detection of insecticide triazophos.
PubMed:Enhanced electrochemiluminescence employed for the selective detection of methyl parathion based on a zirconia nanoparticle film modified electrode.
PubMed:Fast simultaneous determination of traces of Cu(II) and Co(II) in soils and sediments with the luminol/perborate chemiluminescent system.
PubMed:Development of dipstick-based immuno-chemiluminescence techniques for the rapid detection of dichlorodiphenyltrichloroethane.
PubMed:Application of optimized chemiluminescence assay for determination of the antioxidant capacity of herbal extracts.
PubMed:A new potassium tetrabromoaurate (III)-luminol chemiluminescence system for the determination of folic acid in milk powder.
PubMed:Cathodic electrochemiluminescent behavior of luminol at nafion-nano-TiO2 modified glassy carbon electrode.
PubMed:A highly sensitive method for simultaneous determination of ultra trace levels of copper and cadmium in food and water samples with luminol as a chelating agent by adsorptive stripping voltammetry.
PubMed:"Turn-on" chemiluminescence sensor for the highly selective and ultrasensitive detection of Hg2+ ions based on interstrand cooperative coordination and catalytic formation of gold nanoparticles.
PubMed:Carbon dioxide gas sensor based on ionic liquid-induced electrochemiluminescence.
PubMed:Determination of melamine by flow injection analysis based on chemiluminescence system.
PubMed:Extraction of brown pigment from Rosa laevigata and its antioxidant activities.
PubMed:Determination of malachite green residues in fish using a highly sensitive electrochemiluminescence method combined with molecularly imprinted solid phase extraction.
PubMed:Ultrasensitive chemiluminescent immunoassay of Salmonella with silver enhancement of nanogold labels.
PubMed:Sensitive quantification of Escherichia coli O157:H7, Salmonella enterica , and Campylobacter jejuni by combining stopped polymerase chain reaction with chemiluminescence flow-through DNA microarray analysis.
PubMed:In vitro effects of very low levels of aflatoxin B₁ on free radicals production and bactericidal activity of bovine blood neutrophils.
PubMed:An aqueous pomegranate peel extract inhibits neutrophil myeloperoxidase in vitro and attenuates lung inflammation in mice.
PubMed:Miniaturised hybrid immunoassay for high sensitivity analysis of aflatoxin M1 in milk.
PubMed:Total low-molecular-weight antioxidants as a summary parameter, quantified in biological samples by a chemiluminescence inhibition assay.
PubMed:Electrochemiluminescent aptamer biosensor for the determination of ochratoxin A at a gold-nanoparticles-modified gold electrode using N-(aminobutyl)-N-ethylisoluminol as a luminescent label.
PubMed:A novel chemiluminescence assay of organophosphorous pesticide quinalphos residue in vegetable with luminol detection.
PubMed:Advances and analytical applications in chemiluminescence coupled to capillary electrophoresis.
PubMed:Determination of Sudan IV in hot chilli powder with luminol/dissolved oxygen chemiluminescence system.
PubMed:Trace-level detection of atrazine using immuno-chemiluminescence: dipstick and automated flow injection analyses formats.
PubMed:Semi-micro flow injection analysis method for evaluation of quenching effect of health foods or food additive antioxidants on peroxynitrite.
PubMed:Antioxidative activity of the buckwheat polyphenol rutin in combination with ovalbumin.
PubMed:Chelating Langmuir-Blodgett film: a new versatile chemiluminescent sensing layer for biosensor applications.
PubMed:Biocompatible electrochemiluminescent biosensor for choline based on enzyme/titanate nanotubes/chitosan composite modified electrode.
PubMed:Light emitting diode induced chemiluminescence and its application as a detector for high performance liquid chromatography.
PubMed:Antioxidant potential of peels and fleshes of peaches from different cultivars.
PubMed:A cobalt-based tetrazolium salts reduction test to assay polyphenols.
PubMed:In vitro inhibitory effect of apple peel extract on the growth of Helicobacter pylori and respiratory burst induced on human neutrophils.
PubMed:Determination of organophosphorous pesticide phosphamidon in environmental water with luminol chemiluminescence detection.
PubMed:Chemiluminescence determination of surfactant Triton X-100 in environmental water with luminol-hydrogen peroxide system.
PubMed:A flow-injection chemiluminescent method for the evaluation of the antioxidant activity of 5'-nucleotides.
PubMed:Simultaneous determination of thiamine and its phosphate esters by a liquid chromatographic method based on post-column photolysis and chemiluminescence detection.
PubMed:Chemiluminescence detection in liquid chromatography: applications to clinical, pharmaceutical, environmental and food analysis--a review.
PubMed:Subpicogram determination of melamine in milk products using a luminol-myoglobin chemiluminescence system.
PubMed:Enhancement of chemiluminescence for vitamin B12 analysis.
PubMed:Locally applied TCP inhibits tumor growth via possible activation of macrophages.
PubMed:Heated indium tin oxide cell for studying ionic liquid-mediated electrochemiluminescence.
PubMed:An electrochemiluminescent biosensor for glucose based on the electrochemiluminescence of luminol on the nafion/glucose oxidase/poly(nickel(II)tetrasulfophthalocyanine)/multi-walled carbon nanotubes modified electrode.
PubMed:Modulation of human neutrophil oxidative metabolism and degranulation by extract of Tamarindus indica L. fruit pulp.
PubMed:Automated and manual luminescent assay of antioxidant capacity: analytical features by comparison.
PubMed:On-line screening methods for antioxidants scavenging superoxide anion radical and hydrogen peroxide by liquid chromatography with indirect chemiluminescence detection.
PubMed:Comparison of anti-oxidant activities of seventy herbs that have been used in Korean traditional medicine.
PubMed:In vitro effects of beetroot juice and chips on oxidative metabolism and apoptosis in neutrophils from obese individuals.
PubMed:Cadmium toxicity in cultured tomato cells--role of ethylene, proteases and oxidative stress in cell death signaling.
PubMed:[Sensitive determination of reactive oxygen species by chemiluminescence methods and their application to biological samples and health foods].
PubMed:LC-DAD-MS (ESI+) analysis and antioxidant capacity of crocus sativus petal extracts.
PubMed:Electrochemiluminescent biosensor for hypoxanthine based on the electrically heated carbon paste electrode modified with xanthine oxidase.
PubMed:Development of a chemiluminescent immunosensor for chloramphenicol.
PubMed:Study on the electrochemiluminescent behavior of menadione sodium bisulfite in presence of luminol.
PubMed:Development of an analytical method for the determination of beta2-agonist residues in animal tissues by high-performance liquid chromatography with on-line electrogenerated [Cu(HIO6)2]5- -luminol chemiluminescence detection.
PubMed:A rapid multiplexed chemiluminescent immunoassay for the detection of Escherichia coli O157:H7, Yersinia enterocolitica, Salmonella typhimurium, and Listeria monocytogenes pathogen bacteria.
PubMed:Simultaneous determination of glucose, fructose and lactose in food samples using a continuous-flow chemiluminescence method with the aid of artificial neural networks.
PubMed:Study on the antioxidant activity of tea flowers (Camellia sinensis).
PubMed:Evaluation of antioxidant activity and preventing DNA damage effect of pomegranate extracts by chemiluminescence method.
PubMed:An electrochemiluminescent sensor for glucose employing a modified carbon nanotube paste electrode.
PubMed:Flow injection chemiluminescence determination of sudan I in hot chilli sauce.
PubMed:Real-time detection of dopamine released from a nerve model cell by an enzyme-catalyzed luminescence method and its application to drug assessment.
PubMed:Development and optimization of an analytical method for the determination of Sudan dyes in hot chilli pepper by high-performance liquid chromatography with on-line electrogenerated BrO- -luminol chemiluminescence detection.
PubMed:Development of a chemiluminescent ELISA for determining chloramphenicol in chicken muscle.
PubMed:On-column coaxial flow chemiluminescence detection for underivatized amino acids by pressurized capillary electrochromatography using a monolithic column.
PubMed:[Menadione-catalyzed luminol chemiluminescence assay for the rapid detection of viable bacteria].
PubMed:Use of soybean peroxidase in chemiluminescent enzyme-linked immunosorbent assay.
PubMed:Respiratory burst activity of Atlantic cod (Gadus morhua L.) blood phagocytes differs markedly from that of rainbow trout.
PubMed:Mother's milk and hydrogen peroxide.
PubMed:Establishment of signal-recovery functions for calculation of recovery factor. Application to monitoring of contaminant residues in vegetables by chemiluminescence detection.
PubMed:Antioxidant potential of thymol determined by chemiluminescence inhibition in human neutrophils and cell-free systems.
PubMed:Determination of tannin in green tea infusion by flow-injection analysis based on quenching the fluorescence of 3-aminophthalate.
PubMed:Detection of methyl parathion using immuno-chemiluminescence based image analysis using charge coupled device.
PubMed:Soybean peroxidase-catalyzed oxidation of luminol by hydrogen peroxide.
PubMed:Chemiluminescence immunoassay for chloramphenicol.
PubMed:Detection of synthetic corticosteroids in bovine urine by chemiluminescence high-performance liquid chromatography.
PubMed:Development and validation of an ultrasensitive chemiluminescent enzyme immunoassay for aflatoxin M1 in milk.
PubMed:Biological effect of vaccination can be assessed directly from diluted whole blood of rainbow trout using homologous blood phagocytes as immunosensors.
PubMed:Adhesion and ingestion activities of fish phagocytes induced by bacterium Aeromonas salmonicida can be distinguished and directly measured from highly diluted whole blood of fish.
PubMed:Menadione-catalyzed luminol chemiluminescence assay for the rapid detection of viable bacteria in foods under aerobic conditions.
PubMed:Antioxidant properties of phenolic compounds from Pelargonium reniforme.
PubMed:In utero infection with PRRS virus modulates cellular functions of blood monocytes and alveolar lung macrophages in piglets.
PubMed:Bioguided isolation and identification of the nonvolatile antioxidant compounds from fennel (Foeniculum vulgare Mill.) waste.
PubMed:High-performance liquid chromatographic separation and quantification of citric, lactic, malic, oxalic and tartaric acids using a post-column photochemical reaction and chemiluminescence detection.
PubMed:Evaluation of antiradical capacity by H2O2-hemin-induced luminol chemiluminescence.
PubMed:Relationship between peroxyl radical scavenging capability measured by the chemiluminescence method and an aminocarbonyl reaction product in soy sauce.
PubMed:Microfluidic enzyme immunosensors with immobilised protein A and G using chemiluminescence detection.
PubMed:Peroxyl radical scavenging capability of fish sauces measured by the chemiluminescence method.
PubMed:A comprehensive experimental study of industrial, domestic and environmental interferences with the forensic luminol test for blood.
PubMed:Suppressive effect of carotenoids on the luminol dependent chemiluminescence of the stimulated rat macrophages.
PubMed:Rapid detection of Escherichia coli O157:H7 inoculated in ground beef, chicken carcass, and lettuce samples with an immunomagnetic chemiluminescence fiber-optic biosensor.
PubMed:Comparison between the radical scavenging activity and antioxidant activity of six distilled and nondistilled mediterranean herbs and aromatic plants.
PubMed:A new green analytical procedure for monitoring sub-nanogram amounts of chlorpyrifos on fruits using flow injection chemiluminescence with immobilized reagents.
PubMed:Chemiluminescence investigation of detection of rutin in medicine and human urine using controlled-reagent-release technology.
PubMed:A simple chemiluminescence-based method for rapid enumeration of Listeria spp. microcolonies.
PubMed:Cytochrome P450 (P450) isoforms expression, P450 concentration, monooxygenase activities, reactive oxygen species formation, lipid peroxidation, and glutathione content in wild catch carp and tench liver--influence of a two weeks exposure to phenobarbital.
PubMed:Chemiluminescence detection of nine corticosteroids in liver.
PubMed:Rapid detection of enterotoxigenic Escherichia coli O6 in water by using monoclonal antibody and a photon-counting television camera.
PubMed:Antioxidative activity of flavonoids in stimulated human neutrophils.
PubMed:Antimicrobial and antioxidant activities of Feijoa sellowiana fruit.
PubMed:Attenuation of luminol-amplified chemiluminescent intensity and lipid peroxidation in the livers of quercetin-fed mice.
PubMed:Effect of decaglycerol mono-oleate on chemiluminescence of human neutrophils.
PubMed:Shaken, not stirred: bioanalytical study of the antioxidant activities of martinis.
PubMed:Analysis of terbuthylazine in soil samples by two test strip immunoassay formats using reflectance and luminescence detection.
PubMed:Quantitative HPLC determination of the antioxidant activity of capsaicin on the formation of lipid hydroperoxides of linoleic acid: a comparative study against BHT and melatonin.
PubMed:Determination of dexamethasone in bovine liver by chemiluminescence high-performance liquid chromatography.
PubMed:Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: implications for the anti-tumor-promoter effect of vegetables.
PubMed:Ethanol-related gastric mucosal damage: evidence of a free radical-mediated mechanism and beneficial effect of oral supplementation with bionormalizer, a novel natural antioxidant.
PubMed:Additional information to the in vitro antioxidant activity of Ginkgo biloba L.
PubMed:Effect of carotenoids on the respiratory burst of rat peritoneal macrophages.
PubMed:Influence of SNN-6010, an elemental diet, on the generation of cytokines, NO, and chemiluminescence from leukocytes and umbilical vein endothelial cells in man.
PubMed:Evaluation of antioxidant activity by chemiluminescence.
PubMed:Radiolyo-chemiluminescence of bones and seafood shells - a new, promising method for the detection of food irradiation?
PubMed:Effects of bio-normalizer (a food supplementation) on free radical production by human blood neutrophils, erythrocytes, and rat peritoneal macrophages.
PubMed:Effect of in vivo corticosterone and acute food deprivation on rat resident peritoneal cell chemiluminescence after activation ex vivo.
PubMed:Enhanced chemiluminescent sandwich enzyme immunoassay for hen egg lysozyme.
PubMed:Generation of reactive oxygen species from the reaction of selenium compounds with thiols and mammary tumor cells.
PubMed:Identification and enumeration of Listeria monocytogenes by nonradioactive DNA probe colony hybridization.
PubMed:Chemiluminescent simultaneous determination of phosphatidylcholine hydroperoxide and phosphatidylethanolamine hydroperoxide in the liver and brain of the rat.
PubMed:[Functional activity of leukocytes and enzyme indicators in acute intestinal infections].
PubMed:Rapid detection and counting of single bacteria in a wide field using a photon-counting TV camera.
PubMed:Determination of lipid hydroperoxides in low density lipoprotein from human plasma using high performance liquid chromatography with chemiluminescence detection.
PubMed:[The chemiluminescence of the polymorphonuclear leukocytes in food poisoning].
PubMed:Chemiluminescence response and arachidonic acid metabolism of macrophages induced by gamma-hexachlorocyclohexane (lindane).
PubMed:Spontaneous and luminol-dependent chemiluminescences from tissue preparations of benzo[a]pyrene-injected mice.
PubMed:Detection of chemiluminescence in lipid peroxidation of biological systems and its application to HPLC.
PubMed:Determination of phospholipid hydroperoxides in human blood plasma by a chemiluminescence-HPLC assay.
PubMed:Presence of phosphatidylcholine hydroperoxide in human plasma.
PubMed:Optical and electrochemical detection of DNA.
PubMed:Detection of oxygen activation and determination of the activity of antioxidants towards reactive oxygen species by use of the chemiluminigenic probes luminol and lucigenin.
PubMed:[Effect of pro- and antioxidant food factors on macrophage oxidative metabolism].
PubMed:Different efficiency of various synthetic antioxidants towards NADPH induced chemiluminescence in rat liver microsomes.
 
Notes:
substance that emits light on oxidation. it is used in chemical determinations.
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