lactide
p-dioxane-2,5-dione, 3,6-dimethyl- (8CI)
 
Notes:
None found
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3,6-dimethyl-1,4-dioxane-2,5-dione (Click)
CAS Number: 95-96-5Picture of molecule
Other: 116559-43-4
ECHA EINECS - REACH Pre-Reg: 202-468-3
FDA UNII: 7EH08MWO6M
Nikkaji Web: J4.715E
MDL: MFCD00011685
XlogP3-AA: 0.60 (est)
Molecular Weight: 144.12656000
Formula: C6 H8 O4
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: abrasives, skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 285.50 °C. @ 760.00 mm Hg (est)
Flash Point: 303.00 °F. TCC ( 150.60 °C. ) (est)
logP (o/w): -1.450 (est)
Soluble in:
 water, 3165 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: abrasives
skin conditioning
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Suppliers:
Sigma-Aldrich: Aldrich
For experimental / research use only.
3,6-Dimethyl-1,4-dioxane-2,5-dione
TCI AMERICA
For experimental / research use only.
DL-Lactide >98.0%(T)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  > 5000 mg/kg
Food and Chemical Toxicology. Vol. 37, Pg. 335, 1999.

Dermal Toxicity:
skin-rabbit LD50 > 2000 mg/kg
Food and Chemical Toxicology. Vol. 37, Pg. 335, 1999.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: abrasives, skin conditioning
Recommendation for lactide usage levels up to:
 not for fragrance use.
 
Recommendation for lactide flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
EPA Substance Registry Services (TSCA): 95-96-5
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 7272
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 3,6-dimethyl-1,4-dioxane-2,5-dione
Chemidplus: 0000095965
RTECS: JH1100000 for cas# 95-96-5
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References:
 3,6-dimethyl-1,4-dioxane-2,5-dione
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 7272
Pubchem (sid): 134972205
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2932.20.5050
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 dilactide
3,6-dimethyl-1,4-dioxane-2,5-dione
3,6-dimethyl-2,5-dioxo-1,4-dioxane
1,4-dioxane-2,5-dione, 3,6-dimethyl-
p-dioxane-2,5-dione, 3,6-dimethyl- (8CI)
 lactic acid, bimol. cyclic ester
 propanoic acid, 2-hydroxy-, bimol. cyclic ester
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Articles:
PubMed: Biodegradable polylactide microspheres enhance specific immune response induced by Hepatitis B surface antigen.
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PubMed: Creep loading during degradation attenuates mechanical property loss in PLGA.
PubMed: Delivery of phytochemicals of tropical fruit by-products using poly (DL-lactide-co-glycolide) (PLGA) nanoparticles: synthesis, characterization, and antimicrobial activity.
PubMed: Biodegradable polylactide microspheres enhance specific immune response induced by Hepatitis B surface antigen.
PubMed: Detection of PLGA-based nanoparticles at a single-cell level by synchrotron radiation FTIR spectromicroscopy and correlation with X-ray fluorescence microscopy.
PubMed: Properties of poly(lactide)-whey protein isolate laminated films.
PubMed: Physicochemical features and transfection properties of chitosan/poloxamer 188/poly(D,L-lactide-co-glycolide) nanoplexes.
PubMed: Effects of N-octyl lactate as plasticizer on the thermal and functional properties of extruded PLA-based films.
PubMed: Development of Yersinia pestis F1 antigen-loaded microspheres vaccine against plague.
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PubMed: Effect of chain-extenders on the properties and hydrolytic degradation behavior of the poly(lactide)/poly(butylene adipate-co-terephthalate) blends.
PubMed: Preparation and characterization of poly(L-lactide)-co-poly(trimethylene carbonate)/talc film.
PubMed: In vitro and in vivo study of sustained nitric oxide release coating using diazeniumdiolate-oped poly(vinyl chloride) matrix with poly(lactide-co-glycolide) additive.
PubMed: Curcumin protects neuronal-like cells against acrolein by restoring Akt and redox signaling pathways.
PubMed: Biodegradable poly([D,L]-lactide-co-glycolide) nanofibers for the sustainable delivery of lidocaine into the epidural space after laminectomy.
PubMed: PLGA nanoparticle entrapped killed porcine reproductive and respiratory syndrome virus vaccine helps in viral clearance in pigs.
PubMed: Local demixion in plasticized polylactide probed by electron spin resonance.
PubMed: Effect of composition ratio on the thermal and physical properties of semicrystalline PLA/PHB-HHx composites.
PubMed: Antimicrobial efficacy of poly (DL-lactide-co-glycolide) (PLGA) nanoparticles with entrapped cinnamon bark extract against Listeria monocytogenes and Salmonella typhimurium.
PubMed: Three-month subchronic intramuscular toxicity study of rotigotine-loaded microspheres in SD rats.
PubMed: Evaluation of silver-infused polylactide films for inactivation of Salmonella and feline calicivirus in vitro and on fresh-cut vegetables.
PubMed: Local and systemic immune responses in mice to intranasal delivery of peptides representing bovine respiratory syncytial virus epitopes encapsulated in poly (DL-lactide-co-glycolide) microparticles.
PubMed: Biodegradable nanoparticle-entrapped vaccine induces cross-protective immune response against a virulent heterologous respiratory viral infection in pigs.
PubMed: Three-month subchronic intramuscular toxicity study of rotigotine-loaded microspheres in Cynomolgus monkeys.
PubMed: A biocompatible tissue scaffold produced by supercritical fluid processing for cartilage tissue engineering.
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PubMed: Self-assembly and paclitaxel loading capacity of cellulose-graft-poly(lactide) nanomicelles.
PubMed: Use of mid- and near-infrared spectroscopy to track degradation of bio-based eating utensils during composting.
PubMed: Transparent films based on PLA and montmorillonite with tunable oxygen barrier properties.
PubMed: The use of poly-L-lactic acid filler in facial aesthetics.
PubMed: Can leptin-derived sequence-modified nanoparticles be suitable tools for brain delivery?
PubMed: Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA.
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PubMed: Effects of poly-(lactide-co-glycolide) nanoparticles on electrophysiological properties of enteroendocrine cells.
PubMed: Poly (DL-lactide-co-glycolide) (PLGA) nanoparticles with entrapped trans-cinnamaldehyde and eugenol for antimicrobial delivery applications.
PubMed: Thermal and rheological properties of L-polylactide/polyethylene glycol/silicate nanocomposites films.
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PubMed: Endostar-loaded PEG-PLGA nanoparticles: in vitro and in vivo evaluation.
PubMed: Adipose-derived stem cells and BMP2: part 1. BMP2-treated adipose-derived stem cells do not improve repair of segmental femoral defects.
PubMed: Preparation of fish gelatin and fish gelatin/poly(L-lactide) nanofibers by electrospinning.
PubMed: Migration of antimicrobial silver from composites of polylactide with silver zeolites.
PubMed: Rheological and thermal properties of polylactide/silicate nanocomposites films.
PubMed: Equivalence randomized controlled trial of bioresorbable versus titanium miniplates in treatment of mandibular fracture: a pilot study.
PubMed: Spectral and spatial characterization of protein loaded PLGA nanoparticles.
PubMed: Pharmacokinetics and efficacy of a biweekly dosage formulation of exenatide in Zucker diabetic fatty (ZDF) rats.
PubMed: Ammonolysis-based microencapsulation technique using isopropyl formate as dispersed solvent.
PubMed: Preparation of antimicrobial membranes: coextrusion of poly(lactic acid) and Nisaplin in the presence of Plasticizers.
PubMed: Properties of poly(lactide)-coated paperboard for the use of 1-way paper cup.
PubMed: Activation of lactoperoxidase system in milk by glucose oxidase immobilized in electrospun polylactide microfibers.
PubMed: Migration of lactic acid, lactide and oligomers from polylactide food-contact materials.
PubMed: Effect of filler content and size on transport properties of water vapor in PLA/calcium sulfate composites.
PubMed: [Preparation of biodegradable and sustained release gel of tinidazole].
PubMed: PLGA 90/10 and caprolactone biodegradable nerve guides for the reconstruction of the rat sciatic nerve.
PubMed: Microencapsulation of insulin into biodegradable microcapsules by the high voltage field method.
PubMed: Poly(D,L-lactide-co-glycolide acid) nanoparticles for DNA delivery: waiving preparation complexity and increasing efficiency.
PubMed: Electrospray encapsulation of water-soluble protein with polylactide. I. Effects of formulations and process on morphology and particle size.
PubMed: Electrospray encapsulation of water-soluble protein with polylactide. Effects of formulations on morphology, encapsulation efficiency and release profile of particles.
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PubMed: An overview of polylactides as packaging materials.
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PubMed: Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery.
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PubMed: Adjuvanticity and protective immunity elicited by Bordetella pertussis antigens encapsulated in poly(DL-lactide-co-glycolide) microspheres.
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PubMed: Medical devices; reclassification and codification of absorbable poly(glycolide/L-lactide) surgical suture--FDA. Final rule.
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