EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

3,4-lutidine
pyridine, 3,4-dimethyl-

Sponsors

Name:3,4-dimethylpyridine
CAS Number: 583-58-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:209-511-5
FDA UNII:FCU895KJ7H
Nikkaji Web:J7.443H
Beilstein Number:0106583
MDL:MFCD00006403
XlogP3-AA:1.60 (est)
Molecular Weight:107.15573000
Formula:C7 H9 N
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FLAVIS Number:14.105 (Old)
DG SANTE Food Flavourings:14.105 3,4-dimethylpyridine
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.95400 to 0.96000 @ 25.00 °C.
Pounds per Gallon - (est).: 7.938 to 7.988
Refractive Index:1.50700 to 1.51300 @ 20.00 °C.
Melting Point: -12.00 °C. @ 760.00 mm Hg
Boiling Point: 176.00 to 178.00 °C. @ 760.00 mm Hg
Vapor Pressure:2.694000 mm/Hg @ 25.00 °C. (est)
Flash Point: 129.00 °F. TCC ( 53.89 °C. )
logP (o/w): 1.749 (est)
Soluble in:
 alcohol
 water, 52000 mg/L @ 20 °C (exp)
 water, 5.298e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Flavor Type: green
">green
Taste Description: green
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Santa Cruz Biotechnology
For experimental / research use only.
3,4-Lutidine
Sigma-Aldrich: Aldrich
For experimental / research use only.
3,4-Lutidine 98%
TCI AMERICA
For experimental / research use only.
3,4-Lutidine >98.0%(GC)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
T - Toxic.
R 10 - Flammable.
R 23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 01/02 - Keep locked up and out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 710 uL/kg
American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.

Dermal Toxicity:
skin-rabbit LD50 140 uL/kg
American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.

Inhalation Toxicity:
inhalation-rat TCLo 500 ppm/4H
American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.

 
Safety in Use Information:
Category: flavoring agents
Recommendation for 3,4-lutidine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.13 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 400 (μg/person/day)
Threshold of Concern:540 (μg/person/day)
Structure Class: II
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.400002.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.100000.50000
Edible ices, including sherbet and sorbet (03.0): 0.400002.00000
Processed fruit (04.1): 0.400002.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 1.000005.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 2.0000010.00000
Meat and meat products, including poultry and game (08.0): 0.200001.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.200001.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.100000.50000
Foodstuffs intended for particular nutritional uses (13.0): 0.200001.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 0.200001.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): --
Ready-to-eat savouries (15.0): 1.000005.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.200001.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 24 (FGE.24): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 Flavouring Group Evaluation 24, Revision 1 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 77 (FGE77) [1] - Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev1 (2008)
View page or View pdf

Scientific opinion on Flavouring Group Evaluation 24, Revision 2 (FGE.24Rev2): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28
View page or View pdf

EPI System: View
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):583-58-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :11417
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2929
WGK Germany:3
3,4-dimethylpyridine
Chemidplus:0000583584
RTECS:OK9800000 for cas# 583-58-4
 
References:
 3,4-dimethylpyridine
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):11417
Pubchem (sid):134978232
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.39.1000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 whiskey - up to 0.0002 mg/kg
Search Picture
 
Synonyms:
3,4-dimethyl pyridine
3,4-dimethylpyridine
 pyridine, 3,4-dimethyl-
 

Articles:

US Patents:3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines
PubMed:New π-arene ruthenium(II) piano-stool complexes with nitrogen ligands.
US Patents:Flavoring agent
PubMed:Factors dictating the nuclearity/aggregation and acetate coordination modes of lutidine-coordinated zinc(II) acetate complexes.
PubMed:Theoretical studies on the molecular structure and vibrational spectra of some dimethyl substituted pyridine derivatives.
PubMed:Aerobic biodegradation of 4-methylpyridine and 4-ethylpyridine by newly isolated Pseudonocardia sp. strain M43.
PubMed:Topological ferrimagnetic behavior of two new [Mn(L)2(N3)2]n chains with the new AF/AF/F alternating sequence (L = 3-methylpyridine or 3,4-dimethylpyridine).
PubMed:Use of borinium ions as probes of steric effects in gas-phase ion-molecule complexes.
PubMed:[Effectiveness of new quarternary ammonium chloride compounds against selected bacteria and fungi. XXI. Synthesis of alkoxymethyl-3,4-dimethyl- pyridine and 1-ethyloxymethyl-3-alkylthiomethylimidazole chlorides].
PubMed:In vitro drug delivery mediated by ecto-NAD+-glycohydrolase ligand-targeted liposomes.
PubMed:Targeting of liposomes by covalent coupling with ecto-NAD+-glycohydrolase ligands.
 
Notes:
None found
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