EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

veratric acid
benzoic acid, 3,4-dimethoxy-

Supplier Sponsors

CAS Number: 93-07-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:202-215-7
FDA UNII: 1YY04E7RR4
Nikkaji Web:J10.598H
Beilstein Number:0518285
MDL:MFCD00002500
XlogP3:1.60 (est)
Molecular Weight:182.17550000
Formula:C9 H10 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white to pale yellow powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 181.00 °C. @ 760.00 mm Hg
Boiling Point: 302.00 to 303.00 °C. @ 760.00 mm Hg (est)
Flash Point: 250.00 °F. TCC ( 120.90 °C. ) (est)
logP (o/w): 1.610
Soluble in:
 alcohol
 ether
 water, 1 part to 2100-2150 parts water
 water, 500 mg/L @ 14C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Veratric acid 98%
BOC Sciences
For experimental / research use only.
3,4-Dimethoxybenzoic acid >98%
Odor: characteristic
Use: 3,4-Dimethoxybenzoic acid is a natural phenol found in the fruits of Phyllanthus emblica L..
EMD Millipore
For experimental / research use only.
3,4-Dimethoxybenzoic acid
sds
ExtraSynthese
For experimental / research use only.
Veratric Acid
George Uhe Company
Veratric Acid
Penta International
VERATRIC ACID
Santa Cruz Biotechnology
For experimental / research use only.
3,4-Dimethoxybenzoic acid ≥99%
Sigma-Aldrich: Aldrich
For experimental / research use only.
3,4-Dimethoxybenzoic acid ≥99%
sds
TCI AMERICA
For experimental / research use only.
3,4-Dimethoxybenzoic Acid >98.0%(GC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 > 800 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 196, Pg. 478, 1976.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for veratric acid usage levels up to:
 not for fragrance use.
 
Recommendation for veratric acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):93-07-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7121
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
3,4-dimethoxybenzoic acid
Chemidplus:0000093072
RTECS:DG8598750 for cas# 93-07-2
 
References:
 3,4-dimethoxybenzoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:93-07-2
Pubchem (cid):7121
Pubchem (sid):134972681
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
HMDB (The Human Metabolome Database):HMDB59763
FooDB:FDB000222
Export Tariff Code:2909.30.6000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 capsicum
Search Trop Picture
 coriander plant
Search Trop Picture
 olive fruit
Search Trop Picture
 sabadill
Search PMC Picture
 trollius chinensis
Search Trop Picture
 
Synonyms:
 benzoic acid, 3,4-dimethoxy-
3,4-dimethoxy-benzoic acid
3,4-dimethoxybenzoic acid
3,4-dimethoxybenzoicacid
3,4-dimethyl protocatechuic acid
3,4-dimethylprotocatechuic acid
(±)-m-methoxymandelic acid
 

Articles:

PubMed:Veratric acid inhibits iNOS expression through the regulation of PI3K activation and histone acetylation in LPS-stimulated RAW264.7 cells.
PubMed:Studies on the Biotransformation of Veratric Acid, a Human Metabolite of Mebeverine, by Using the Incubated Hen's Egg.
PubMed:Absorption properties and mechanism of trolline and veratric acid and their implication to an evaluation of the effective components of the flowers of Trollius chinensis.
PubMed:Inhibitory effect of aqueous extracts from Miracle Fruit leaves on mutation and oxidative damage.
PubMed:Protective effect of veratric acid on lipopolysaccharide-induced acute lung injury in mice.
PubMed:Distribution of Two bioactive compounds in flowers of Trollius chinensis.
PubMed:Crabgrass (Digitaria sanguinalis) allelochemicals that interfere with crop growth and the soil microbial community.
PubMed:Antagonist effects of veratric acid against UVB-induced cell damages.
PubMed:The regulatory effect of veratric acid on NO production in LPS-stimulated RAW264.7 macrophage cells.
PubMed:Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli.
PubMed:Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering.
PubMed:The wood rot ascomycete Xylaria polymorpha produces a novel GH78 glycoside hydrolase that exhibits α-L-rhamnosidase and feruloyl esterase activities and releases hydroxycinnamic acids from lignocelluloses.
PubMed:Veratric acid ameliorates hyperlipidemia and oxidative stress in Wistar rats fed an atherogenic diet.
PubMed:Effect of veratric acid on the cardiovascular risk of L-NAME-induced hypertensive rats.
PubMed:Nonlinear changes in the activity of the oxygen-dependent demethylase system in Rhodococcus erythropolis cells in the presence of low and very low doses of formaldehyde.
PubMed:Veratric acid, a phenolic acid attenuates blood pressure and oxidative stress in L-NAME induced hypertensive rats.
PubMed:Synthesis of homoveratric acid-imprinted polymers and their evaluation as selective separation materials.
PubMed:Photoenhanced degradation of veratraldehyde upon the heterogeneous ozone reactions.
PubMed:Selective oxidative demethylation of veratric acid to vanillic acid by CYP199A4 from Rhodopseudomonas palustris HaA2.
PubMed:[Spectroscopic investigation on the interaction of protocatechuic acid and veratric acid with biomacromolecules].
PubMed:Influence of very low doses of mediators on fungal laccase activity - nonlinearity beyond imagination.
PubMed:Hansch analysis of veratric acid derivatives as antimicrobial agents.
PubMed:Assessment of the genotoxicity of olive mill waste water (OMWW) with the Vicia faba micronucleus test.
PubMed:Isolation and characterization of Streptomyces sp. NL15-2K capable of degrading lignin-related aromatic compounds.
PubMed:Molecular cloning of streptomyces genes encoding vanillate demethylase.
PubMed:Metabolism of isovanillate, vanillate, and veratrate by Comamonas testosteroni strain BR6020.
PubMed:Investigative implications of the instability and metabolism of mebeverine.
PubMed:Regulation of Laccase Gene Transcription in Trametes versicolor.
PubMed:Involvement of lipid peroxidation in the degradation of a non-phenolic lignin model compound by manganese peroxidase of the litter-decomposing fungus Stropharia coronilla.
PubMed:Production of laccase by immobilized cells of Agaricus sp.: induction effect of xylan and lignin derivatives.
PubMed:Biotransformation of lignin polymers derived from beech wood pulping by Sporobolomyces roseus isolated from leafy material.
PubMed:[Phenyl pyrazolones--novel oxidoreductase redox-mediators for degradation of xenobiotics].
PubMed:Acylated flavone C-glycosides from Trollius ledebouri.
PubMed:Trollioside, a new compound from the flowers of Trollius chinensis.
PubMed:Tyrosinase inhibitor from black rice bran.
PubMed:Enzyme production by Mycena galopus mycelium in artificial media and in Picea sitchensis F1 horizon needle litter.
PubMed:Mechanistic features of lignin peroxidase-catalyzed oxidation of substituted phenols and 1,2-dimethoxyarenes.
PubMed:Relationship of demethylation processes to veratric acid concentration and cell density in cultures of Rhodococcus erythropolis.
PubMed:[A study on chemical constituents in the herb of Mentha spicata].
PubMed:Lignin degradation in a compost environment by the deuteromycete Paecilomyces inflatus.
PubMed:Induction of laccase activity in the edible straw mushroom, Volvariella volvacea.
PubMed:Influence of aromatic compounds on biodegradation of [14C]-labeled xylan and mannan by the white-rot fungus Phlebia radiata.
PubMed:Identification of mebeverine acid as the main circulating metabolite of mebeverine in man.
PubMed:Kinetic model for phenolic compound oxidation by Fenton's reagent.
PubMed:The antispasmodic drug mebeverine leads to positive amphetamine results by fluorescence polarization immunoassay (FPIA)--studies on the toxicological analysis of urine by FPIA and GC-MS.
PubMed:Differential regulation of laccase gene expression in Pleurotus sajor-caju.
PubMed:Demethylation of [14C]-labelled veratric acid and oxidation of methanol and formaldehyde by the white-rot fungus Phlebia radiata.
PubMed:Multiple respiratory bursts as a response to veratrate stress in Rhodococcus erythropolis cells.
PubMed:On the metabolism of the amphetamine-derived antispasmodic drug mebeverine: gas chromatography-mass spectrometry studies on rat liver microsomes and on human urine.
PubMed:Relationships between demethylase activity, formaldehyde and oxygen during incubation of Rhodococcus erythropolis with veratrate.
PubMed:Genetics of ferulic acid bioconversion to protocatechuic acid in plant-growth-promoting Pseudomonas putida WCS358.
PubMed:Lack of bioavailability of mebeverine even after pretreatment with pyridostigmine.
PubMed:Comparison of the Efficacies of Chloromethane, Methionine, and S-Adenosylmethionine as Methyl Precursors in the Biosynthesis of Veratryl Alcohol and Related Compounds in Phanerochaete chrysosporium.
PubMed:Decoloration of azo dyes by three whiterot fungi: influence of carbon source.
PubMed:Anisaldehyde and Veratraldehyde Acting as Redox Cycling Agents for H(2)O(2) Production by Pleurotus eryngii.
PubMed:The metabolism of mebeverine in man: identification of urinary metabolites by gas chromatography/mass spectrometry.
PubMed:Degradation of non-phenolic beta-o-4 lignin substructure model compounds by Acinetobacter sp.
PubMed:Facile hydrolysis of mebeverine in vitro and in vivo: negligible circulating concentrations of the drug after oral administration.
PubMed:Formation and Action of Lignin-Modifying Enzymes in Cultures of Phlebia radiata Supplemented with Veratric Acid.
PubMed:Degradation of labelled lignins and veratrylglycerol-beta-guaiacyl ether by Acinetobacter sp.
PubMed:Regulation of the production of hemicellulolytic and cellulolytic enzymes by a Streptomyces sp. growing on lignocellulose.
PubMed:Metabolism of Lignin Model Compounds of the Arylglycerol-beta-Aryl Ether Type by Pseudomonas acidovorans D(3).
PubMed:The action of mebeverine and metabolites on mammalian non-myelinated nerve fibres.
PubMed:Antimicrobial properties of aromatic compounds of plant origin.
PubMed:Variation of melatonin and serotonin content in rat pineal gland with sex and oestrous phase difference determined by high-performance liquid chromatography with fluorimetric detection.
PubMed:Substrate-induction of veratric acid O-demethylase in Nocardia sp.
PubMed:Aerobic and Anaerobic Catabolism of Vanillic Acid and Some Other Methoxy-Aromatic Compounds by Pseudomonas sp. Strain PN-1.
PubMed:New compounds: Reissert compound studies XXXII: facile synthesis of 3-azapapaverine.
PubMed:[O-Demethylation of benzoic acids in wheat seedlings].
PubMed:Degradation of methoxylated benzoic acids by a Nocardia from a lignin-rich environment: significance to lignin degradation and effect of chloro substituents.
PubMed:A note on the synthesis of veratric acid.
PubMed:Studies in detoxication; the metabolism of veratraldehyde and veratric acid in the rabbit.
PubMed:Studies in detoxication: 14. The metabolism of veratraldehyde and veratric acid in the rabbit.
 
Notes:
None found
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