a bioflavonoid that strengthens vascular walls. Isol. from parsley
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CAS Number: 520-27-4Picture of molecule
ECHA EINECS - REACH Pre-Reg: 208-289-7
Nikkaji Web: J6.600A
MDL: MFCD00009772
XlogP3-AA: -0.80 (est)
Molecular Weight: 608.55104000
Formula: C28 H32 O15
BioActivity Summary: listing
Category: antioxidants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Google Scholar: with word "odor"Search
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PubMed: Search
NCBI: Search
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Physical Properties:
Appearance: white crystalline powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 274.00 °C. @ 760.00 mm Hg
Boiling Point: 926.78 °C. @ 760.00 mm Hg (est)
Flash Point: 581.00 °F. TCC ( 305.20 °C. ) (est)
logP (o/w): 0.140
Soluble in:
 water, 407.8 mg/L @ 25 °C (est)
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Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
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BOC Sciences
For experimental / research use only.
For experimental / research use only.
Diosmin (HPLC) ≥99%
Santa Cruz Biotechnology
For experimental / research use only.
Diosmin ≥95%
For experimental / research use only.
Sinoway Industrial
For experimental / research use only.
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Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antioxidants
Recommendation for diosmin usage levels up to:
 not for fragrance use.
Recommendation for diosmin flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous tone pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous-capillary permeability pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
EPI System: View
ClinicalTrials.gov: search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 5281613
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0000520274
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NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 5281613
Pubchem (sid): 134976843
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
KEGG (GenomeNet): C10039
HMDB (The Human Metabolome Database): HMDB29548
FooDB: FDB000693
Export Tariff Code: 2938.10.0000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 horsemint plant
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 hyssop leaf
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 hyssop plant
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 hyssop shoot
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 lemon leaf
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 mandarin leaf
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 orange flower
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 petitgrain lemon
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 petitgrain mandarin
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 rosemary leaf
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 spearmint leaf
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 spearmint shoot
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 diosmetin 7-b-rutinoside
3',5,7-trihydroxy-4'-methoxyflavone 7-rutinoside
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PubMed: Hydrolysis of flavanone glycosides by β-glucosidase from Pyrococcus furiosus and its application to the production of flavanone aglycones from citrus extracts.
PubMed: A review on pharmacological and analytical aspects of diosmetin: a concise report.
PubMed: Confirmation of diosmetin 3-O-glucuronide as major metabolite of diosmin in humans, using micro-liquid-chromatography-mass spectrometry and ion mobility mass spectrometry.
PubMed: PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppression.
PubMed: Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application.
PubMed: Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity.
PubMed: Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells.
PubMed: Determination of flavonoids in citrus juices by micro-HPLC-ESI/MS.
PubMed: Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin.
PubMed: Monograph. Diosmin.
PubMed: Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway.
PubMed: Effect of the rootstock and interstock grafted in lemon tree (Citrus limon (L.) Burm.) on the flavonoid content of lemon juice.
PubMed: Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.
PubMed: Flavonoids detection by HPLC-DAD-MS-MS in lemon juices from Sicilian cultivars.
PubMed: Radioprotective effects in vivo of phenolics extracted from Olea europaea L. leaves against X-ray-induced chromosomal damage: comparative study versus several flavonoids and sulfur-containing compounds.
PubMed: Selection of hybrids and edible citrus species with a high content in the diosmin functional compound. Modulating effect of plant growth regulators on contents.
PubMed: In vitro inhibitory effect of some flavonoids on rotavirus infectivity.
PubMed: Antioxidant activity and radioprotective effects against chromosomal damage induced in vivo by X-rays of flavan-3-ols (Procyanidins) from grape seeds (Vitis vinifera): comparative study versus other phenolic and organic compounds.
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