diosmin
3',5,7-trihydroxy-4'-methoxyflavone-7-rutinoside
 
Notes:
a bioflavonoid that strengthens vascular walls. Isol. from parsley
Synonyms   Articles   Notes   Search
CAS Number: 520-27-4Picture of molecule
ECHA EINECS - REACH Pre-Reg: 208-289-7
FDA UNII: 7QM776WJ5N
Nikkaji Web: J6.600A
MDL: MFCD00009772
XlogP3-AA: -0.80 (est)
Molecular Weight: 608.55104000
Formula: C28 H32 O15
BioActivity Summary: listing
Category: antioxidants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: white crystalline powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 274.00 °C. @ 760.00 mm Hg
Boiling Point: 926.78 °C. @ 760.00 mm Hg (est)
Flash Point: 581.00 °F. TCC ( 305.20 °C. ) (est)
logP (o/w): 0.140
Soluble in:
 water, 407.8 mg/L @ 25 °C (est)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
  
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
Synonyms   Articles   Notes   Search   Top
Suppliers:
BOC Sciences
For experimental / research use only.
Diosmin
ExtraSynthese
For experimental / research use only.
Diosmin (HPLC) ≥99%
Santa Cruz Biotechnology
For experimental / research use only.
Diosmin ≥95%
Sigma-Aldrich
For experimental / research use only.
Diosmin
Sinoway Industrial
For experimental / research use only.
Diosmin/Hesperidin
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: antioxidants
Recommendation for diosmin usage levels up to:
 not for fragrance use.
 
Recommendation for diosmin flavor usage levels up to:
 not for flavor use.
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous tone pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous-capillary permeability pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
EPI System: View
ClinicalTrials.gov: search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 5281613
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0000520274
Synonyms   Articles   Notes   Search   Top
References:
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 5281613
Pubchem (sid): 134976843
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C10039
HMDB (The Human Metabolome Database): HMDB29548
FooDB: FDB000693
Export Tariff Code: 2938.10.0000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
None Found
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
None Found
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 horsemint plant
Search Trop  Picture
 hyssop leaf
Search Trop  Picture
 hyssop plant
Search Trop  Picture
 hyssop shoot
Search Trop  Picture
 lemon leaf
Search Trop  Picture
 mandarin leaf
Search Trop  Picture
 orange flower
Search Trop  Picture
 parsley
Search Trop  Picture
 petitgrain lemon
Search Trop  Picture
 petitgrain mandarin
Search Trop  Picture
 rosemary leaf
Search Trop  Picture
 spearmint leaf
Search Trop  Picture
 spearmint shoot
Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
 barosmin
7-[[6-O-6-deoxy-a-L-mannopyranosyl-b-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
 diosmetin 7-b-rutinoside
 diosminum
5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(O6-a-L-rhamnopyranosyl-b-D-glucopyranosyloxy)chromen-4-one
5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-b-rutinosyloxy-4H-chromen-4-one
3,5,7-trihydroxy-4-methoxyflavone-7-rutinoside
3',5,7-trihydroxy-4'-methoxyflavone 7-rutinoside
3',5,7-trihydroxy-4'-methoxyflavone-7-rutinoside
 veno-V
 diosmine
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Hydrolysis of flavanone glycosides by β-glucosidase from Pyrococcus furiosus and its application to the production of flavanone aglycones from citrus extracts.
PubMed: A review on pharmacological and analytical aspects of diosmetin: a concise report.
PubMed: Confirmation of diosmetin 3-O-glucuronide as major metabolite of diosmin in humans, using micro-liquid-chromatography-mass spectrometry and ion mobility mass spectrometry.
PubMed: PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppression.
PubMed: Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application.
PubMed: Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity.
PubMed: Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells.
PubMed: Determination of flavonoids in citrus juices by micro-HPLC-ESI/MS.
PubMed: Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin.
PubMed: Monograph. Diosmin.
PubMed: Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway.
PubMed: Effect of the rootstock and interstock grafted in lemon tree (Citrus limon (L.) Burm.) on the flavonoid content of lemon juice.
PubMed: Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.
PubMed: Flavonoids detection by HPLC-DAD-MS-MS in lemon juices from Sicilian cultivars.
PubMed: Radioprotective effects in vivo of phenolics extracted from Olea europaea L. leaves against X-ray-induced chromosomal damage: comparative study versus several flavonoids and sulfur-containing compounds.
PubMed: Selection of hybrids and edible citrus species with a high content in the diosmin functional compound. Modulating effect of plant growth regulators on contents.
PubMed: In vitro inhibitory effect of some flavonoids on rotavirus infectivity.
PubMed: Antioxidant activity and radioprotective effects against chromosomal damage induced in vivo by X-rays of flavan-3-ols (Procyanidins) from grape seeds (Vitis vinifera): comparative study versus other phenolic and organic compounds.
Synonyms   Articles   Notes   Search   Top
Please share your Comments.
Email Address:
 
 
 
 
Top of Page Home
Copyright © 1980-2018 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy