Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Assay: | 95.00 to 100.00
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Food Chemicals Codex Listed: | No |
Soluble in: |
| water, 400 mg/L @ 20 °C (exp) |
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | natural substances and extractives |
Recommendation for 2H-1,4-benzoxazin-3(4H)-one usage levels up to: | | not for fragrance use.
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Recommendation for 2H-1,4-benzoxazin-3(4H)-one flavor usage levels up to: |
| not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
4.3-oxo-4H- | benzo[1,4]oxazine | 2H-1,4- | benzoxazin-3-one | 4H-1,4- | benzoxazin-3-one |
Articles:
PubMed:Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction. |
PubMed:Melanogenesis inhibitors from Coix lacryma-jobi seeds in B16-F10 melanoma cells. |
PubMed:Plant defense and herbivore counter-defense: benzoxazinoids and insect herbivores. |
PubMed:Benzoxazinone-Mediated Triazine Degradation: A Proposed Reaction Mechanism. |
PubMed:A New Neolignan from Coix lachryma-jobi var. mayuen. |
PubMed:Synthesis and antifungal activity of 2H-1,4-benzoxazin-3(4H)-one derivatives. |
PubMed:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA) inhibits trichothecene production by Fusarium graminearum through suppression of Tri6 expression. |
PubMed:In vitro evaluation of the antioxidant and antimicrobial activity of DIMBOA [2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one]. |
PubMed:Plant-plant-microbe mechanisms involved in soil-borne disease suppression on a maize and pepper intercropping system. |
PubMed:Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists. |
PubMed:A new phenolic component from Triticum aestivum sprouts and its effects on LPS-stimulated production of nitric oxide and TNF-α in RAW 264.7 cells. |
PubMed:In silico characterization of three two-component systems of Ehrlichia canis and evaluation of a natural plant-derived inhibitor. |
PubMed:Benzoxazinoids from Scoparia dulcis (sweet broomweed) with antiproliferative activity against the DU-145 human prostate cancer cell line. |
PubMed:Benzoxazinoids in root exudates of maize attract Pseudomonas putida to the rhizosphere. |
PubMed:Study of the role played by NfsA, NfsB nitroreductase and NemA flavin reductase from Escherichia coli in the conversion of ethyl 2-(2'-nitrophenoxy)acetate to 4-hydroxy-(2H)-1,4-benzoxazin-3(4H)-one (D-DIBOA), a benzohydroxamic acid with interesting biological properties. |
PubMed:Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists. |
PubMed:Is the basal area of maize internodes involved in borer resistance? |
PubMed:Benzoxazinoid metabolites regulate innate immunity against aphids and fungi in maize. |
PubMed:Acanmontanoside, a new phenylethanoid diglycoside from Acanthus montanus. |
PubMed:Structure-activity relationship of benzoxazinones and related compounds with respect to the growth inhibition and alpha-amylase activity in cress seedlings. |
PubMed:A novel glycoside from Acanthus hirsutus (Acanthaceae). |
PubMed:Pharmacological characterization of olodaterol, a novel inhaled beta2-adrenoceptor agonist exerting a 24-hour-long duration of action in preclinical models. |
PubMed:Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents. |
PubMed:Rediscovering the bioactivity and ecological role of 1,4-benzoxazinones. |
PubMed:Aromatic-ring-functionalised benzoxazinones in the system Oryza sativa-Echinochloa crus-galli as biorational herbicide models. |
PubMed:Species-specific glucosylation of DIMBOA in larvae of the rice Armyworm. |
PubMed:Hydroxamic acids derived from 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one: key defense chemicals of cereals. |
PubMed:8-Chloro-4-cyclo-hexyl-2H-1,4-benzoxazin-3(4H)-one. |
PubMed:7-Chloro-4-phenethyl-2H-1,4-benzoxazin-3(4H)-one. |
PubMed:Activity of Hydroxamic Acids from Secale cereale Against the Plant-Parasitic Nematodes Meloidogyne incognita and Xiphinema americanum. |
PubMed:Benzoxazinoid biosynthesis in dicot plants. |
PubMed:Modified benzoxazinones in the system Oryza sativa-Echinochloa crus-galli: an approach to the development of biorational herbicide models. |
PubMed:Novel 5-HT(1A/1B/1D) receptors antagonists with potent 5-HT reuptake inhibitory activity. |
PubMed:Preparative isolation and purification of two benzoxazinoid glucosides from Acanthus ilicifolius L. by high-speed counter-current chromatography. |
PubMed:Effects of four benzoxazinoids on gibberellin-induced alpha-amylase activity in barley seeds. |
PubMed:Elucidation of the final reactions of DIMBOA-glucoside biosynthesis in maize: characterization of Bx6 and Bx7. |
PubMed:6-Chloro-2H-1,4-benzoxazin-3(4H)-one. |
PubMed:Synthesis of novel 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones as anticonvulsant agents. |
PubMed:cis-Jasmone induces accumulation of defence compounds in wheat, Triticum aestivum. |
PubMed:Characterization of the potent 5-HT(1A/B) receptor antagonist and serotonin reuptake inhibitor SB-649915: preclinical evidence for hastened onset of antidepressant/anxiolytic efficacy. |
PubMed:Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B. |
PubMed:New herbicide models from benzoxazinones: aromatic ring functionalization effects. |
PubMed:Optimization of benzoxazinones as natural herbicide models by lipophilicity enhancement. |
PubMed:SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue. |
PubMed:Structure-activity relationship (SAR) studies of benzoxazinones, their degradation products, and analogues. Phytotoxicity on problematic weeds Avena fatua L. and Lolium rigidum Gaud. |
PubMed:Isolation and synthesis of allelochemicals from gramineae: benzoxazinones and related compounds. |
PubMed:Effects of the benzoxazoid DIMBOA, selected degradation products, and structure-related pesticides on soil organisms. |
PubMed:Hydroxamic acid content and toxicity of rye at selected growth stages. |
PubMed:On the structural basis of the catalytic mechanism and the regulation of the alpha subunit of tryptophan synthase from Salmonella typhimurium and BX1 from maize, two evolutionarily related enzymes. |
PubMed:The possible role of hydroxylation in the detoxification of atrazine in mature vetiver (Chrysopogon zizanioides Nash) grown in hydroponics. |
PubMed:Structure-activity relationship studies of benzoxazinones and related compounds. Phytotoxicity on Echinochloa crus-galli (L.) P. Beauv. |
PubMed:Evolution of the indole alkaloid biosynthesis in the genus Hordeum: distribution of gramine and DIBOA and isolation of the benzoxazinoid biosynthesis genes from Hordeum lechleri. |
PubMed:Enantioseparation of 2-O-beta-D-glucopyranosyl-2H-1,4-benzoxazin-3(4H)-one and its 7-chloro-derivative by capillary zone electrophoresis using native and substituted beta-cyclodextrins as chiral additives. |
PubMed:Detoxification and transcriptome response in Arabidopsis seedlings exposed to the allelochemical benzoxazolin-2(3H)-one. |
PubMed:Degradation studies on benzoxazinoids. Soil degradation dynamics of (2R)-2-O-beta-D-glucopyranosyl-4-hydroxy-(2H)- 1,4-benzoxazin-3(4H)-one (DIBOA-Glc) and its degradation products, phytotoxic allelochemicals from Gramineae. |
PubMed:Structure-Activity Relationships (SAR) studies of benzoxazinones, their degradation products and analogues. phytotoxicity on standard target species (STS). |
PubMed:Chemical composition of corn leaf essential oils and their role in the oviposition behavior of Sesamia nonagrioides females. |
PubMed:Differential exudation of two benzoxazinoids--one of the determining factors for seedling allelopathy of Triticeae species. |
PubMed:Development of a liquid chromatography-electrospray mass spectrometric method for the simultaneous analysis of benzoxazolinones and their degradation products. |
PubMed:Degradation studies on benzoxazinoids. Soil degradation dynamics of 2,4-dihydroxy-7-methoxy-(2H)-1,4-benzoxazin-3(4H)-one (DIMBOA) and its degradation products, phytotoxic allelochemicals from gramineae. |
PubMed:Benzoxazinoids and iridoid glucosides from four Lamium species. |
PubMed:Utilisation of electrospray time-of-flight mass spectrometry for solving complex fragmentation patterns: application to benzoxazinone derivatives. |
PubMed:Antitumor agents. Part 218: Cappamensin A, a new In vitro anticancer principle, from Capparis sikkimensis. |
PubMed:A mechanistic dehydration study with [2-(13)C]-DIMBOA. |
PubMed:Megastigmane, aliphatic alcohol and benzoxazinoid glycosides from Acanthus ebracteatus. |
PubMed:Benzoxazinoid glucosides from Acanthus ilicifolius. |
PubMed:Simple method for large scale isolation of the cyclic arylhydroxamic acid DIMBOA from maize (Zea mays L.). |
PubMed:Metabolism of 7-fluoro-6-(3,4,5,6-tetrahydrophthalimido)-4- (2-propynyl)-2H-1,4-benzoxazin-3(4H)-one (S-53482, flumioxazin) in the rat: II. Identification of reduced metabolites. |
PubMed:Metabolism of 7-fluoro-6-(3,4,5,6-tetrahydrophthalimido)-4- (2-propynyl)-2H-1,4-benzoxazin-3(4H)-one (S-53482) in rat. 1. Identification of a sulfonic acid type conjugate. |
PubMed:Chemistry of biologically active benzoxazinoids. |
PubMed:[Chemistry of benzoxazinoids produced by plants as phytoalexin]. |
PubMed:Isolation and characterization of a cyclic hydroxamic acid from a pollen extract, which inhibits cancerous cell growth in vitro. |
PubMed:Corn metabolites affect growth and virulence of Agrobacterium tumefaciens. |
PubMed:Hydroxamic Acid glucosyltransferases from maize seedlings. |
PubMed:Lipid lowering actions of 7-(2-methylene butyryl)-(2H)-1,4-benzoxazin-3-(4H)-one derivatives in mice, rats and Syrian hamsters. |
PubMed:Identification of 1,4-Benzoxazin-3-ones in Maize Extracts by Gas-Liquid Chromatography and Mass Spectrometry. |
PubMed:Factors That Influence the Activity of 2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one on Erwinia Species in Growth Assays. |
PubMed:Decomposition of 2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one in Aqueous Solutions. |
PubMed:2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one, an Inhibitor from Zea mays with Differential Activity against Soft Rotting Erwinia Species. |
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