EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

1,4-benzenediamine, 2-nitro-

Supplier Sponsors

CAS Number: 5307-14-2Picture of molecule3D/inchi
Other(deleted CASRN):29467-01-4
ECHA EINECS - REACH Pre-Reg:226-164-5
Nikkaji Web:J3.720F
Beilstein Number:2210195
XlogP3:0.50 (est)
Molecular Weight:153.14119000
Formula:C6 H7 N3 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:hair dyeing agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Appearance:almost black needles (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 137.00 °C. @ 760.00 mm Hg
Boiling Point: 385.40 °C. @ 760.00 mm Hg (est)
Vapor Pressure:5.600000 mmHg @ 25.00 °C. (est)
Flash Point: 368.00 °F. TCC ( 186.90 °C. ) (est)
logP (o/w): 0.530
Soluble in:
 water, 2.592e+004 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair dyeing agents
not used anymore
BOC Sciences
For experimental / research use only.
2-Nitro-1,4-phenylenediamine 97%
Sigma-Aldrich: Aldrich
For experimental / research use only.
2-Nitro-1,4-phenylenediamine 95%
For experimental / research use only.
2-Nitro-1,4-phenylenediamine >94.0%(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 214 mg/kg
Genetica Polonica. Vol. 26, Pg. 109, 1985.

intraperitoneal-rat LD50 348 mg/kg
Journal of Toxicology and Environmental Health. Vol. 2, Pg. 657, 1977.

oral-rat LD50 2100 mg/kg
Journal of the Society of Cosmetic Chemists. Vol. 23, Pg. 259, 1972.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
hair dyeing agents
Recommendation for 2-nitro-p-phenylenediamine usage levels up to:
 not for fragrance use.
Recommendation for 2-nitro-p-phenylenediamine flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):5307-14-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :4338370
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
EPA/NOAA CAMEO:hazardous materials
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:5307-14-2
Pubchem (cid):4338370
Pubchem (sid):134985290
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C19385
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2921.51.5000
•...avail in us as commercial grade with following typical specifications: assay, 97% min; melting range, 135-138 deg c; loss on drying, 1.0% max; iron content, 100 mgkg max; residue on ignition, 0.3%. •2-nitro-p-phenylenediamine is available commercially in purities ranging from 95 to 100%, with 4-amino-3-nitroacetanilide as a possible impurity. •2-nitro-p-phenylenediamine has the following specifications: ash, 0.1% (max); iron, 40 ppm (max); lead, 5 ppm (max); and arsenic, 2ppm(max). •it has been used in hair dyes dark-brown (@ levels of 0.1%), medium-brown (0.15%), medium-red (2.5%) & ash-blond (0.065%) dye formulations. it can also be used in bleach-toner formulations for golden-blond (0.008%) & red-blond (0.02%) shades.
Potential Blenders and core components note
None Found
Potential Uses:
 hair dyeing agents
Occurrence (nature, food, other):note
 not found in nature
1,4-benzenediamine, 2-nitro-
 c.i. 76070
 C.I. oxidation base 22
 ci 76070
 du rafur brown
 durafur brown
 durafur brown 2R
 fouramine 2R
 fourrine 36
 fourrine brown 2R
 glycidyl-4-nitrophenyl ether
2-nitro-1,4-phenylene diamine
2-nitro-para-phenylene diamine
p-phenylenediamine, 2-nitro-
 ursol brown RR
 zoba brown RR


PubMed:Single strand dna breaks in human lymphocytes exposed to para-phenylenediamine and its derivatives.
PubMed:Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rats in a 28-day repeat-dose toxicity study.
PubMed:Percutaneous penetration and metabolism of 2-nitro-p-phenylenediamine in human and fuzzy rat skin.
PubMed:Comparison of the mutagenic specificity induced by four nitro-group-containing aromatic amines in Salmonella typhimurium his genes.
PubMed:Mutagenicity and antimutagenicity studies of tannic acid and its related compounds.
PubMed:Base-pair mutation caused by four nitro-group containing aromatic amines in Salmonella typhimurium TA100, TA104, TA4001 and TA4006.
PubMed:Evaluation of the in vivo genotoxic potential of three carcinogenic aromatic amines using the Big Blue transgenic mouse mutation assay.
PubMed:Effects of the nitro-group on the mutagenicity and toxicity of some benzamines.
PubMed:Mutagenicity and toxicity studies of p-phenylenediamine and its derivatives.
PubMed:Mutagenicity of selected aniline derivatives to Salmonella following plant activation and mammalian hepatic activation.
PubMed:Percutaneous absorption of hair dyes: correlation with partition coefficients.
PubMed:Assessment of sister chromatid exchange in spermatogonia and intestinal epithelium in Chinese hamsters.
PubMed:Percutaneous absorption of 2-nitro-p-phenylenediamine.
PubMed:Chemically-induced sister-chromatid exchange in vivo in bone marrow of Chinese hamsters. An evaluation of 24 compounds.
PubMed:Distribution, excretion, and metabolism of nitro-p-phenylenediamine in rats.
PubMed:Teratogenic evaluation of 2-nitro-p-phenylenediamine, 4-nitro-o-phenylenediamine, and 2,5-toluenediamine sulfate in the mouse.
PubMed:In vivo skin penetration studies of 2,4-toluenediamine, 2,4-diaminoanisole, 2-nitro-p-phenylenediamine, p-dioxane and N-nitrosodiethanolamine in cosmetics.
PubMed:Induction of mitotic recombination by certain hair-dye chemicals in Saccharomyces cerevisiae.
PubMed:Carcinogenicity of the hair-dye component 2-nitro-p-phenylenediamine: induction of eosinophilic hepatocellular neoplasms in female B6C3F1 mice.
PubMed:Dominant lethal assay of some hair-dye components in random-bred male rats.
PubMed:Bioassay of 2-nitro-p-phenylenediamine for possible carcinogenicity.
PubMed:The mutagenic assay of some hair dye components, using the thymidine kinase locus of L5178Y mouse lymphoma cells.
PubMed:Testing of known carcinogens and noncarcinogens for their ability to induce unscheduled DNA synthesis in HeLa cells.
PubMed:Dominant lethal mutagenicity study on hair dyes.
PubMed:Hair dyes are mutagenic: identification of a variety of mutagenic ingredients.
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