• Lansdowne Chemicals
    • Lansdowne Chemicals
      With a focus on providing the highest level of service
      Lansdowne Chemicals has established itself at the forefront of the global chemical industry.
      Headquarters are in Carterton, Oxfordshire encompassing all of Lansdowne's Business Units. Our Regulatory Team and Quality Control Departments are based out of Carterton. Lansdowne Aromatic's state of the art warehouse facilities are located in Cricklade, covering 12,000 square ft. We are able to offer just-in-time deliveries for our full range of products, in a variety of pack sizes. Bonded facilities are available for goods going outside of the EU.
      Email:Contact Us:
      US Email:Dean Matienzo - Sales Manager
      Voice:+44 1993 843081
      Fax:+44 1993 841261
      US Voice:+1 973 886 3778
      US Fax:+1 973 346 1106
      Product(s):
      2-Methyl-1,4 Napthoquinone
       
 
menadione
Notes :
a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin k2, menaquinone, after alkylation in vivo.
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  • Organoleptics
      • Organoleptic Properties
  • Properties
      • Physical Properties
        Assay : 95.00 to 100.00 % 
        Food Chemicals Codex Listed :No
        Melting Point : 107.00 °C. @ 760.00 mm Hg
        Boiling Point : 304.50 °C. @ 760.00 mm Hg (est)
        Vapor Pressure :0.001000 mm/Hg @ 25.00 °C. (est)
        Flash Point : 237.00 °F. TCC ( 113.80 °C. ) (est)
        logP (o/w) : 2.200
  • Safety
      • Safety Information
        Oral/Parenteral Toxicity : 
          intraperitoneal-chicken LDLo  100 mg/kg
        Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 125, 1940.

        intraperitoneal-mouse LD50  50 mg/kg
        National Technical Information Service. Vol. AD691-490

        oral-mouse LD50  500 mg/kg
        Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 125, 1940.

        oral-rabbit LDLo  230 mg/kg
        VASCULAR: OTHER CHANGES
        Journal of Pharmacology and Experimental Therapeutics. Vol. 75, Pg. 111, 1942.

        intraperitoneal-rat LD50  75 mg/kg
        Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

        Dermal Toxicity : 
          subcutaneous-mouse LD50 138 mg/kg
        Journal of Pharmacology and Experimental Therapeutics. Vol. 75, Pg. 111, 1942.

        Inhalation Toxicity : 
          Not determined
  • Safety in Use
      • Safety in Use Information
        Category :cosmetic agents
        Recommendation for menadione fragrance usage levels up to :
         not for fragrance use.
        Recommendation for menadione flavor usage levels up to :
         not for flavor use.
  • Safety References
      • Safety References
        European Food Safety Authority (EFSA) reference(s) :
        Scientific Opinion on the safety and efficacy of vitamin K3 (menadione sodium bisulphite and menadione nicotinamide bisulphite) as a feed additive for all animal species:page or pdf
        EPI System :View
        Chemicalize.org :Calculate predicted properties
        ClinicalTrials.gov :search
        Daily Med :search
        NLM Hazardous Substances Data Bank :Search
        Chemical Carcinogenesis Research Information System :Search
        Cancer Citations :Search
        Toxicology Citations :Search
        Env. Mutagen Info. Center :Search
        EPA Substance Registry Services (TSCA) :58-27-5
         2-methylnaphthalene-1,4-dione
        Chemidplus :0000058275
        RTECS :QL9100000 for cas# 58-27-5
  • References
      • References
         2- methylnaphthalene-1,4-dione
        Canada Domestic Sub. List :58-27-5
        Pubchem (cid):4055
        Pubchem (sid):134971654
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  • Other
      • Other Information
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        (IUPAC) :Atomic Weights of the Elements 2009
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        Dietary Supplements Labels Database : Search
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        Export Tariff Code :2914.69.5000
        ChemSpider : View
        Wikipedia : View
        RSC Learn Chemistry : View
        Formulations/Preparations :
        •menadione, nf (vit k3)...avail in oral admin in tablets containing 2, 5, or 10 mg, & as sterile soln of menadione in oil (usually 2, 10, or 25 mgml) designed for im admin. •menadione sodium bisulfite, nf (hykinone)...white crystalline, hygroscopic powder. ...sol in water...marketed in 5-mg tablets & in ampuls5-10 mgml. menadiol sodium diphosphate injection, nf (kappadione, synkavite)...ampuls...5, 10, or 37.5 mgml. menadiol sodium diphosphate tablets, nf...5 mg... •menadiol sodium diphosphate injection, nf (kappadione, synkavite), is marketed in ampuls containing 5, 10, or 37.5 mgml. menadiol sodium diphosphate tablets, nf, contain 5 mg of salt for oral use. •commercially significant forms are menadione sodium bisulfite and menadione dimethyl pyrimidinol. •menadione is available as a 2, 5, and 10 mg tablet and as a 2 and 10 mgml injection (in oil). •trade names for menadione include: aquakay, aquinone, austrovit-k depot, hemodal, k-thrombyl, k-vitan, kaergona, kanone, kaom belgarum, kappaxan, kappaxin, karanum, karcon, kareon, kativ-g, kavitamin, kayklot, kaykot, kayquinone, kipca, kipca-oil soluble, klottone, koaxin, kolklot, menadion, menaphthon, menaphthone, menaquinone 0, mitenon, mitenone, mnq, neo-zimema-k, panosine, prokayvit, synkay, thyloquinone, vikaman, vita-noxi k, and vitavel-k.
  • Blenders
      • Potential Blenders and core components note
        None Found
  • Uses
      • Potential Uses
        None Found
  • Occurrence
      • Natural Occurrence in : note
         not found in nature
  • Search
      • Search for Name, Cas,
        Enics, Fema, Flavis
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        Odor
2-methylnaphthalene-1,4-dione (Click)
CAS Number : 58-27-5
ESIS EC# (EINECS) :200-372-6
XlogP3 :2.20 (est)
Molecular Weight :172.18316000
Formula :C11 H8 O2
BioActivity Summary :listing
NMR Predictor :Predict
Category :cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information :
Google Scholar : Search Google Books : Search
Google Scholar : with word "volatile"Search Google Scholar : with word "flavor"Search
Google Scholar : with word "odor"Search 
Google Patents : Search US Patents : Search
EU Patents : Search
Pubchem Patents:Search
PubMed : SearchNCBI : Search
click on the picture(s) below to
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Picture of molecule
2-methylnaphthalene-1,4-dione
Synonyms :
 aquakay
 aquinone
1,4-dhydro-1,4-dioxo-2-methylnaphthalene
1,4-dihydro-1,4-dioxo-2-methylnaphthalene
1,4-dihydro-2-methylnaphthalene-1,4-dione
 hykinone
 juva-K
 K-vitan
 kaergona
 kanone
 kappaxan
 kappaxin
 karcon
 kareon
 kativ-G
 kayklot
 kaykot
 kaynone
 kayquinone
 koaxin
 kolklot
 menadion
 menaphthene
 menaphtone
 menaquinone O
2-methyl-1,4-naphthalendione
2-methyl-1,4-naphthochinone
2-methyl-1,4-naphthodione
2-methyl-1,4-naphthoquinone
2-methylnaphthalene-1,4-dione
1,4-naphthalenedione, 2-methyl-
1,4-naphthoquinone, 2-methyl-
 panosine
 synkay
 vitamin K3
 vitamin-K3
Soluble in :
 water, 160 mg/L @ 30 °C (exp)
 water, 793.8 mg/L @ 25 °C (est)
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