EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2-methoxyethanol
ethanol, 2-methoxy-

Supplier Sponsors

Name:2-methoxyethanol
CAS Number: 109-86-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-713-7
FDA UNII: EK1L6XWI56
Nikkaji Web:J2.442B
Beilstein Number:1731074
MDL:MFCD00002867
XlogP3:-0.80 (est)
Molecular Weight:76.09516000
Formula:C3 H8 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (IAUFC):109-86-4 ; ETHYLENE GLYCOL MONOMETHYL ETHER
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.96500 @ 25.00 °C.
Melting Point: -85.10 °C. @ 760.00 mm Hg (est)
Boiling Point: 124.10 °C. @ 760.00 mm Hg
Vapor Pressure:5.975000 mmHg @ 25.00 °C. (est)
Vapor Density:2.62 ( Air = 1 )
Flash Point: 115.00 °F. TCC ( 46.11 °C. )
logP (o/w): -0.770
Soluble in:
 water, 1.00E+06 mg/L @ 25 °C (exp)
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Penta International
2-METHOXYETHANOL
Santa Cruz Biotechnology
For experimental / research use only.
2-Methoxyethanol ≥99%
Sigma-Aldrich
For experimental / research use only.
2-Methoxyethanol anhydrous, 99.8%
Wedor Corporation
ETHYLENE GLYCOL MONOMETHYL ETHER
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-guinea pig LD50 950 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.

oral-human LDLo 3380 mg/kg
KIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: GASTRITIS LIVER: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 28, Pg. 267, 1946.

intraperitoneal-mouse LD50 2147 mg/kg
BLOOD: CHANGES IN SPLEEN BLOOD: OTHER CHANGES KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.

oral-mouse LD50 2560 mg/kg
CARDIAC: OTHER CHANGES BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(3), Pg. 48, 1988.

oral-rabbit LD50 890 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA
AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.

intraperitoneal-rat LD50 2500 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 57, 1974.

intravenous-rat LD50 2068 mg/kg
BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA
AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.

oral-rat LD50 2370 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Veterinary and Human Toxicology. Vol. 29, Pg. 361, 1987.

Dermal Toxicity:
skin-rabbit LD50 1280 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 57, 1974.

Inhalation Toxicity:
inhalation-human TCLo 25 ppm
BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Industrial Hygiene and Toxicology. Vol. 20, Pg. 134, 1938.

inhalation-mouse LC50 1480 ppm/7H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA KIDNEY, URETER, AND BLADDER: HEMATURIA BEHAVIORAL: ANALGESIA
Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 157, 1943.

inhalation-rat LC50 1500 ppm/7H
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 57, 1974.

 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
IFRA Critical Effect:
Reproductive toxicity
 View the IFRA Standard
Recommendation for 2-methoxyethanol usage levels up to:
 PROHIBITED: Should not be used as a fragrance ingredient.
 
Recommendation for 2-methoxyethanol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):109-86-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8019
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
2-methoxyethanol
Chemidplus:0000109864
EPA/NOAA CAMEO:hazardous materials
RTECS:109-86-4
 
References:
 2-methoxyethanol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:109-86-4
Pubchem (cid):8019
Pubchem (sid):134974006
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D05554
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2909.42.0000
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•grade or purity: commercial •ektasolve em •glycol ether em •jeffersol em •poly-solv em •prist •dowanol em
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 solvents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 amsco-solv EE
 anesthenyl
3-oxa-1-butanol
 dowanol 7
 dowanol EM
 EGME
 ektasolve EM
 ethanol, 2-methoxy-
 ethylene glycol methyl ether
 ethylene glycol monomethyl ether
 glycol ether EM
 glycol methyl ether
 glycol monomethyl ether
 glycolmethyl ether
1-hydroxy-2-methoxyethane
2-hydroxyethyl methyl ether
 jeffersol EM
2-methoxy ethanol
2-methoxy-1-ethanol
2-methoxyethan-1-ol
.beta.-methoxyethanol
b-methoxyethanol
2-methoxyethyl alcohol
 methyl cellosolve
monomethyl ether of ethylene glycol
 methyl ethoxol
monomethyl ethylene glycol ether
 methyl glycol
monomethyl glycol
 methyl oxitol
2-metossietanolo
 prist
 

Articles:

PubMed:Base-catalyzed derivatization methodology for FA analysis. application to milk fat and celery seed lipid TAG.
PubMed:Toxicity review of ethylene glycol monomethyl ether and its acetate ester.
PubMed:Subchronic inhalation toxicity of diglyme.
PubMed:Cutaneous toxicity studies with methoxy polyethylene glycol-350 (MPEG-350) in rats and rabbits.
PubMed:Mouse placenta: hemodynamics in the main maternal vessel and histopathologic changes induced by 2-methoxyethanol and 2-methoxyacetic acid following maternal dosing.
PubMed:The developmental toxicity of 2-ethylhexanol applied dermally to pregnant Fischer 344 rats.
PubMed:Effects of subchronic exposure of rats to 2-methoxyethanol or 2-butoxyethanol: thymic atrophy and immunotoxicity.
 
Notes:
widely used industrial solvent for resins, lacquers, dyes & inks; may cause anemia macrocytosis, appearance of young granulocytes in blood.
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