EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

2-hydroxyisobutyric acid

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Name:2-hydroxy-2-methylpropanoic acid
CAS Number: 594-61-6Picture of molecule3D/inchi
Other(deleted CASRN):27909-95-1
ECHA EINECS - REACH Pre-Reg:209-848-8
Beilstein Number:1744739
XlogP3:-0.40 (est)
Molecular Weight:104.10536000
Formula:C4 H8 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 82.50 °C. @ 760.00 mm Hg
Boiling Point: 212.00 °C. @ 760.00 mm Hg
logP (o/w): -0.360
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: fragrance
BOC Sciences
For experimental / research use only.
a-Hydroxyisobutyric acid 98%
For experimental / research use only.
Hydroxyisobutyric acid
EMD Millipore
For experimental / research use only.
2-Hydroxyisobutyric Acid
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
2-Hydroxyisobutyric Acid
Sigma-Aldrich: Aldrich
For experimental / research use only.
a-Hydroxyisobutyric acid 99%
For experimental / research use only.
2-Hydroxyisobutyric Acid >98.0%(T)
Universal Preserv-A-Chem Inc.
Odor: characteristic
Use: Used as a paint and ink additive. For cosmetics it is used as a base, a thickening agent, a pigment wetting agent, a dispersant, a solvent and an emollient in skin and eye make-up and in lipstick. Thickening agent, skin conditioning agent and emollient in skin care products. Used as a lubricant for plastics. Procesing agent for rubber and it is also used as an oiling agent for textiles.
Universal Preserv-A-Chem Inc.
Odor: characteristic
Use: Used as a paint and ink additive. For Cosmetics it is used as a Base, a Thickening Agent, a Pigment Wetting Agent, a Dispersant, a Solvent and an Emollient in Skin and Eye Make-Up and in Lipstick. Thickening Agent, Skin Conditioning Agent and Emollient in Skin Care Products. Used as a Lubricant for Plastics. Procesing agent for rubber. Oiling agent for textiles.
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for 2-hydroxyisobutyric acid flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):594-61-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :11671
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-hydroxy-2-methylpropanoic acid
 2-hydroxy-2-methylpropanoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:594-61-6
Pubchem (cid):11671
Pubchem (sid):134978460
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
UM BBD:Search
HMDB (The Human Metabolome Database):HMDB00729
Export Tariff Code:2918.19.9000
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 acetonic acid
2-hydroxy-2-methyl-propanoic acid
2-hydroxy-2-methyl-propionic acid
2-hydroxy-2-methylpropanoic acid
2-hydroxy-2-methylpropionic acid
a-hydroxy-a-methylpropanoic acid
alpha-hydroxy-alpha-methylpropanoic acid
alpha-hydroxy-alpha-methylpropionic acid
alpha-hydroxy-isobutyric acid
.alpha.-hydroxyisobutanoic acid
a-hydroxyisobutanoic acid
alpha-hydroxyisobutanoic acid
.alpha.-hydroxyisobutyric acid
alpha-hydroxyisobutyric acid
 lactic acid, 2-methyl-
2-methyl lactic acid
2-methyl-2-hydroxypropanoic acid
2-methyllactic acid
 propanoic acid, 2-hydroxy-2-methyl-
Alpha-Hydroxyisobutyric acid is a metabolite of methyl tert-butyl ether (MTBE). MTBE may be obtained through environmental exposure. MTBE is rapidly eliminated from the body, mainly through expired air as the unchanged compound. MTBE is to some extent metabolised to t-butyl alcohol (TBA) and formaldehyde and oxidised to 2-methyl-1,2-propanediol and a-hydroxy isobuturic acid. Alpha-Hydroxyisobutyric acid has been used as an arial bactericide. [HMDB]
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