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Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 93.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 216.38 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.243000 mmHg (est) |
| Flash Point: | 184.00 °F. TCC ( 84.70 °C. ) (est)
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| logP (o/w): | 0.380 |
| Soluble in: |
| | water, 5.534e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-cat LDLo 120 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: COMA
BEHAVIORAL: TREMOR
Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 71, 1948.
oral-guinea pig LDLo 120 mg/kg
BEHAVIORAL: COMA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: TREMOR
Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 71, 1948.
intraperitoneal-mouse LD50 200 mg/kg
National Technical Information Service. Vol. AD277-689
oral-rabbit LD50 370 mg/kg
BEHAVIORAL: TREMOR
BEHAVIORAL: COMA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 71, 1948.
intravenous-rat LD50 570 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 211, Pg. 367, 1950.
oral-rat LD50 480 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: COMA
BEHAVIORAL: TREMOR
Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 71, 1948.
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| Dermal Toxicity: |
|
Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for 2-aminothiazole usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for 2-aminothiazole flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | amino-1,3-thiazole | | | aminothiazole | | | thiazol-2-amine | | 1,3- | thiazol-2-amine | | | thiazol-2-ylamine | | 1,3- | thiazol-2-ylamine | | 2- | thiazolamine | | 1,3- | thiazole-2-ylamine | | | thiazole, 2-amino- | | 2- | thiazolylamine | | 2- | thiazylamine |
Articles:
| PubMed:Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice. |
| PubMed:2-Aminothiazole derivatives as antimycobacterial agents: Synthesis, characterization, in vitro and in silico studies. |
| PubMed:Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains. |
| PubMed:Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. |
| PubMed:Design, synthesis and investigation on the structure-activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents. |
| PubMed:Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition. |
| PubMed:A 4-(o-chlorophenyl)-2-aminothiazole: microwave assisted synthesis, spectral, thermal, XRD and biological studies. |
| PubMed:Molecular dynamic simulations give insight into the mechanism of binding between 2-aminothiazole inhibitors and CDK5. |
| PubMed:Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents. |
| PubMed:Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors. |
| PubMed:Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA. |
| PubMed:Correction to N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent. |
| PubMed:2-Aminothiazole based P2Y(1) antagonists as novel antiplatelet agents. |
| PubMed:Antimicrobial and anti-biofilm activity of thiourea derivatives incorporating a 2-aminothiazole scaffold. |
| PubMed:Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors. |
| PubMed:Synthesis, characterization and biological activity of some new VO(IV), Co(II), Ni(II), Cu(II) and Zn(II) complexes of chromone based NNO Schiff base derived from 2-aminothiazole. |
| PubMed:Parallel solution-phase synthesis of a 2-aminothiazole library including fully automated work-up. |
| PubMed:Determination of Cu2+ using poly(2-aminothiazole)/ multi-walled carbon nanotubes composite film modified glassy carbon electrodes. |
| PubMed:Identification of 2-aminothiazolobenzazepine metabolites in human, rat, dog, and monkey microsomes by ion-molecule reactions in linear quadrupole ion trap mass spectrometry. |
| PubMed:A derivative of 2-aminothiazole inhibits melanogenesis in B16 mouse melanoma cells via glycogen synthase kinase 3β phosphorylation. |
| PubMed:Screening of thiourea derivatives and carbonyl-2-aminothiazole derivatives for potential CCR4 antagonists using capillary zone electrophoresis. |
| PubMed:Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening. |
| PubMed:Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo. |
| PubMed:Identification of Aminoimidazole and Aminothiazole Derivatives as Src Family Kinase Inhibitors. |
| PubMed:Design, synthesis and pharmacological evaluation of 2-(thiazol-2-amino)-4-arylaminopyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors. |
| PubMed:Multicomponent assembly of proposed DNA precursors in water. |
| PubMed:Validated quantitative structure-activity relationship analysis of a series of 2-aminothiazole based p56(Lck) inhibitors. |
| PubMed:A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. |
| PubMed:Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. |
| PubMed:SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease. |
| PubMed:A solid paraffin-based carbon paste electrode modified with 2-aminothiazole organofunctionalized silica for differential pulse adsorptive stripping analysis of nickel in ethanol fuel. |
| PubMed:[The design and synthesis of 2-aminothiazole derivatives and their inhibitory activity on apoptosis]. |
| PubMed:[Antihypoxant activity in a series of 2-aminothiazole homologs]. |
| PubMed:2-aminothiazole and 2-aminothiazolinone derivatives. |
| PubMed:Introduction of novel substrate oxidation into cytochrome c peroxidase by cavity complementation: oxidation of 2-aminothiazole and covalent modification of the enzyme. |
| PubMed:Structure-activity relationships of 2-aminothiazole derivatives as inducible nitric oxide synthase inhibitor. |
| PubMed:Activation of peroxidase-catalyzed oxidation of aromatic amines with 2-aminothiazole and melamine. |
| PubMed:Molecular co-crystals of 2-aminothiazole derivatives. |
| PubMed:Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines. |
| PubMed:Palladium-catalyzed N-arylation of 2-aminothiazoles. |
| PubMed:Determination of Cu, Ni, and Zn in fuel ethanol by FAAS after enrichment in column packed with 2-aminothiazole-modified silica gel. |
| PubMed:Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH. |
| PubMed:Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease. |
| PubMed:Synthesis and antimicrobial evaluation of some novel 2-aminothiazole derivatives of 4-hydroxy-chromene-2-one. |
| PubMed:Recognition of 2-aminothiazole-4-acetic acid derivatives by the peptide transporters PEPT1 and PEPT2. |
| PubMed:Interaction of metronidazole with antibiotics containing the 2-aminothiazole moiety. |
| PubMed:Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt. |
| PubMed:Identification and optimisation of a 4',5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors. |
| PubMed:Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels. |
| PubMed:Copper determination in ethanol fuel by differential pulse anodic stripping voltammetry at a solid paraffin-based carbon paste electrode modified with 2-aminothiazole organofunctionalized silica. |
| PubMed:2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor. |
| PubMed:Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9. |
| PubMed:Ureas of 5-aminopyrazole and 2-aminothiazole inhibit growth of gram-positive bacteria. |
| PubMed:Determination of cadmium in river water samples by flame AAS after on-line preconcentration in mini-column packed with 2-aminothiazole-modified silica gel. |
| PubMed:Optimization of 2-aminothiazole derivatives as CCR4 antagonists. |
| PubMed:DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice. |
| PubMed:New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities. |
| PubMed:Farnesyltransferase inhibitors: CAAX mimetics based on different biaryl scaffolds. |
| PubMed:Synthesis, anti-inflammatory and anti-ulcer evaluations of thiazole, thiophene, pyridine and pyran derivatives derived from androstenedione. |
| PubMed:Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo. |
| PubMed:Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold. |
| PubMed:In silico studies and fluorescence binding assays of potential anti-prion compounds reveal an important binding site for prion inhibition from PrP(C) to PrP(Sc). |
| PubMed:Successes and challenges in phenotype-based lead discovery for prion diseases. |
| PubMed:Structure-function relationships within Keppler-type antitumor ruthenium(III) complexes: the case of 2-aminothiazolium[trans-tetrachlorobis(2-aminothiazole)ruthenate(III)]. |
| PubMed:Cephalosporins. VII. Synthesis and antibacterial activity of new cephalosporins bearing a 2-imino-3-hydroxythiazoline (2-aminothiazole N-oxide) in the C-7 acylamino side chain. |
| PubMed:[Electronic structure of 2-aminothiazole, its derivatives and analogs]. |
| PubMed:[3,4-Dihydroxy)-4-phenyl-2-aminothiazole (Ag310)]. |
| PubMed:[Studies on synthesis of the 2-aminothiazole derivatives. I]. |
| PubMed:[Studies on the synthesis of the 2-aminothiazole derivatives. IV. Reaction of the 1,1'-dithiodiformamidine hydrohalide with the ketones]. |
| PubMed:[Synthetic antitubercular agents. Note 3. Derivatives of phenylthiourea and of N-phenyl-2-aminothiazole]. |
| PubMed:Use of oxygen consumption method for measuring antithyroid activity of n-propylthiouracil, thiouracil and 2-aminothiazole in rats. |
| PubMed:The physiological response of experimental animals following absorption of 2-aminothiazole. |
| PubMed:Late-Stage C-H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues. |
| PubMed:Discovery of 4-aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 inhibitors. Part I: optimization of in vitro potencies and pharmacokinetic properties. |
| PubMed:Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials. |
| PubMed:Structure-based drug design to the discovery of new 2-aminothiazole CDK2 inhibitors. |
| PubMed:Complexes of ruthenium(III) with some 2-aminothiazole derivatives/synthesis, properties and pharmacological studies. |
| PubMed:N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent. |
| PubMed:[Studies on the synthesis of the 2-aminothiazole derivatives. II. On the bromination of the alkyl ethyl ketones]. |
| PubMed:[Studies on the synthesis of the 2-aminothiazole derivatives. III. King's reaction in the basic medium]. |
| PubMed:t-Aminoalkyl derivatives of 2-aminothiazole. |
| PubMed:A highly selective molecularly imprinted sorbent for extraction of 2-aminothiazoline-4-carboxylic acid - Synthesis, characterization and application in post-mortem whole blood analysis. |
| PubMed:Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects. |
| PubMed:Drug resistance confounding prion therapeutics. |
| PubMed:[Changes in chlorhydric and mucinous secretions induced by synthetic antithyroid agents (4-methyl-2-thiouracil=6n propyl-2-thiouracile=4-methyl-2-aminothiazole=5,5-diethyl-2-thiobarbituric acid)]. |
| PubMed:Biologically Active Transition Metal Chelates of Ni(II), Cu(II) and Zn(II) With 2-Aminothiazole-Derived Schiff-bases: Their Synthesis, Characterization and the Role of Anions (NO(3), SO(4), C(2)O(4)and CH(3)CO(2-)) on Their Antibacterial Properties. |
| PubMed:Discovery of 2-aminothiazole-4-carboxamides, a novel class of muscarinic M(3) selective antagonists, through solution-phase parallel synthesis. |
| PubMed:2-aminothiazole-derived opioids. Bioisosteric replacement of phenols. |
| PubMed:Synthesis and biological evaluation of some novel thiazole compounds as potential anti-inflammatory agents. |
| PubMed:Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. |
| PubMed:2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion disease. |
| PubMed:Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. |
| PubMed:Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca²⁺ overload. |
| PubMed:Characterization of 8-hydroxyquinoline derivatives containing aminobenzothiazole as inhibitors of dengue virus type 2 protease in vitro. |
| PubMed:Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. |
| PubMed:Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases. |
| PubMed:Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells. |
| PubMed:Synthesis and antioxidant evaluation of some new 3-substituted coumarins. |
| PubMed:Synthesis, Characterization and Biological Properties of Tridentate NNO, NNS and NNN Donor Thiazole-Derived Furanyl, Thiophenyl and Pyrrolyl Schiff Bases and Their Co(II), Cu(II), Ni(II) and Zn(II) Metal Chelates. |
| PubMed:Assessing the nitrogen and carbon nucleophilicities of 2-aminothiazoles through coupling with superelectrophilic 4,6-dinitrobenzofuroxan. |
| PubMed:Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer's disease. |
| PubMed:Thiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase. |
| PubMed:Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase. |
| PubMed:Organic microchemical performance of solvent resistant polycarbosilane based microreactor. |
| PubMed:Streamlined synthesis of substituted 2-aminothiazoles using tandem precipitative and polymer-assisted reactions. |
| PubMed:Z and E isomers of butenedioic acid with 2-amino-1,3-thiazole: 2-amino-1,3-thiazolium hydrogen maleate and 2-amino-1,3-thiazolium hydrogen fumarate. |
| PubMed:Selective inhibition of cytosolic epoxide hydrolase activity in vitro by compounds that inhibit catalase. |
| PubMed:Thiazoloindans and thiazolobenzopyrans: a novel class of orally active central dopamine (partial) agonists. |
| PubMed:2-Amino-4-benzyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridines: novel selective beta3-adrenoceptor agonists. |
| PubMed:Characterization of endothelial nitric-oxide synthase and its reaction with ligand by electron paramagnetic resonance spectroscopy. |
| PubMed:Synthesis of chiral polyaminothiazoles. |
| PubMed:2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics. |
| PubMed:Discovery of 2-aminothiazoles as potent antiprion compounds. |
| PubMed:Allosteric enhancers of A1 adenosine receptors: state of the art and new horizons for drug development. |
| PubMed:Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease. |
| PubMed:Diazald, a newly recognized antimicrobial agent and its spectrophotometric determination. |
| PubMed:Imidazo[2,1-b]thiazoles and their use as pharmaceuticals: Sanofi-Aventis EP 1 923 062 A1 (equivalent to WO2008058641). |
| PubMed:Nucleophilic capture of the imino-quinone methide type intermediates generated from 2-aminothiazol-5-yl carbinols. |
| PubMed:[Initiation and inhibition of free-radical processes in biochemical peroxidase systems: a review]. |
| PubMed:A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif. |
| PubMed:Evidence for the intermediacy of Wheland-Meisenheimer complexes in SEAr reactions of aminothiazoles with 4,6-dinitrobenzofuroxan. |
| PubMed:4,5-dialkylsubstituted 2-imino-1,3-thiazolidine derivatives as potent inducible nitric oxide synthase inhibitors. |
| PubMed:Structure-activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists. |
| PubMed:2-Aminothiazoles: a new class of agonist allosteric enhancers of A(1) adenosine receptors. |
| PubMed:Chemistry of stable iminopropadienones, RN=C=C=C=O. |
| PubMed:Preparation of N'-[2-(5,6-dimethylbenzothiazolyl)]-N-furfuryloxamide with plant growth regulatory activity. |
| PubMed:Mutation of Glu-361 in human endothelial nitric-oxide synthase selectively abolishes L-arginine binding without perturbing the behavior of heme and other redox centers. |
| PubMed:Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. |
| PubMed:4- or 5- (omega-aminoalkyl) thiazoles and derivatives; new selective H2-receptor agonists. |
| PubMed:Derivatization-liquid chromatographic assay of chloroacetaldehyde in biological samples. |
| PubMed:4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties. |
| PubMed:Metabolism of the renal carcinogen FNT by peroxidases. |
| PubMed:[Thiazolylalkylamines: synthesis of analogs of imidazolylethylamines and their effect on gastric secretion]. |
| PubMed:On the capacity of nitroheterocyclic compounds to elicit an unusual axial asymmetry in cultured rat embryos. |
| PubMed:Synthesis, cytostatic, and antitumor properties of new rh(i) thiazole complexes. |
| PubMed:The capacity of some nitro- and amino-heterocyclic sulfur compounds to induce base-pair substitutions. |
| PubMed:Inhibition of Clostridium botulinum by 5-nitrothiazoles. |
| PubMed:Preparation of leukotriene B(4) inhibitory active 2- and 3-(2-aminothiazol-4-yl)benzo[b]furan derivatives and their growth inhibitory activity on human pancreatic cancer cells. |
| PubMed:Antioxidant activity of an aminothiazole compound: possible mechanisms. |
| PubMed:New methods for the synthesis of 2-aminothiazolones. |
| PubMed:Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes. |
| PubMed:Synthesis and biological evaluation of 2-aminothiazoles and their amide derivatives on human adenosine receptors. Lack of effect of 2-aminothiazoles as allosteric enhancers. |
| PubMed:Isolation and characterization of herpes simplex virus type 1 resistant to aminothiazolylphenyl-based inhibitors of the viral helicase-primase. |
| PubMed:New highly potent and selective adenosine A(3) receptor antagonists. |
| PubMed:Traceless solid-phase synthesis of 2-aminothiazoles: receptor tyrosine kinase inhibitors with dual selectivity for Tie-2 and VEGFR-2. |
| PubMed:Synthesis of some novel quinoline-3-carboxylic acids and pyrimidoquinoline derivatives as potential antimicrobial agents. |
| PubMed:Designing focused libraries using MoSELECT. |
| PubMed:4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A): a potent and selective corticotrophin-releasing factor(1) receptor antagonist. I. Biochemical and pharmacological characterization. |
| PubMed:Antiproliferative activity of mixed-ligand dien-Cu(II) complexes with thiazole, thiazoline and imidazole derivatives. |
| PubMed:Synthesis and anti-HIV activity of some isatin derivatives. |
| PubMed:Tetrakis(2-amino-5-methyl-1,3,4-thiadiazole-N3)chlorocopper(II) chloride monohydrate and tetrakis(2-amino-5-ethyl-1,3,4-thiadiazole-N3)chlorocopper(II) chloride. |
| PubMed:[Unification of methods for determining the trace quantities of lead, zinc, sodium and potassium ions in the assessment of drinking water adn transfusion fluid quality]. |
| PubMed:Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors. |
| PubMed:seco-Cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties. |
| PubMed:Synthesis and antimicrobial activity of 4-carbethoxymethyl-2-[(alpha-haloacyl)amino] thiazoles and 5-nonsubstituted/substituted 2-[(4-carbethoxymethylthiazol-2-yl)imino]-4-thiazolidinones. |
| PubMed:Synthesis of (Z)-2-(2-formamido-4-thiazolyl)-2-(substituted alkoxyimino) acetic acids. |
| PubMed:Inhibition of herpes simplex virus replication by a 2-amino thiazole via interactions with the helicase component of the UL5-UL8-UL52 complex. |
| PubMed:Structure-activity relationships of cephalosporins having a (dimethylisoxazolidinio)vinyl moiety at their 3-position. |
| PubMed:Electrochemical oxidation of CBS-113 A, a new anti-inflammatory drug: applicability to liquid chromatography-electrochemical detection. |
| PubMed:Matrix isolation applied to the 252Cf plasma-desorption mass spectrometry of underivatized oligosaccharides. |
| PubMed:Aryl diazo compounds and diazonium salts as potential irreversible probes of the gamma-aminobutyric acid receptor. |
| PubMed:[Derivatives of 1,2-condensed pyrimidines. II. Synthesis and pharmacological study of N,N-disubstituted 5-amino-7H-thiazol [3,2-a]pyrimdine-7-ones]. |
| PubMed:Studies on the anti-inflammatory activity and ulcerogenic adverse effect of thiazole derivatives, especially 2-amino-thiazoleacetic acid derivatives. |
| PubMed:THE ACTION OF SULFONAMIDES ON THE RESPIRATION OF BACTERIA AND YEAST : INHIBITION OF BACTERIAL AND YEAST CARBOXYLASES BY SULFONAMIDE DRUGS STRUCTURALLY RELATED TO COCARBOXYLASE. |
| PubMed:Trityl isothiocyanate support for solid-phase synthesis. |
| PubMed:Mass spectrometry of 2-substituted-4-arylthiazoles. 3--Identification of microsomal nitroreduction products by mass spectrometry. |
| PubMed:In vitro activity of HR 810, a new broad-spectrum cephalosporin. |
| PubMed:The chemistry and structure-activity relationships of C3-quaternary ammonium cephem antibiotics. |
| PubMed:Formation of thioether conjugates of the bladder carcinogen ANFT catalyzed by prostaglandin H synthase. |
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3D/inchi