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Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.98400 @ 25.00 °C.
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| Melting Point: | 11.20 °C. @ 760.00 mm Hg
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| Boiling Point: | 215.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.130000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 196.00 °F. TCC ( 91.11 °C. )
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| logP (o/w): | 1.840 |
| Soluble in: |
| | water, 2666 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 707 mg/kg
National Technical Information Service. Vol. PB214-270
oral-rat LD50 840 mg/kg
BLOOD: CHANGES IN SPLEEN
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Toxicology and Applied Pharmacology. Vol. 22, Pg. 153, 1972.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for 2,6-xylidine usage levels up to: | | | not for fragrance use.
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| Recommendation for 2,6-xylidine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | amino-1,3-dimethylbenzene | | 2- | amino-1,3-xylene | | 1- | amino-2,6-dimethylbenzene | | 2- | amino-m-xylene | | | aniline, 2,6-dimethyl- | | | benzenamine, 2,6-dimethyl- | | | benzene, 2-amino-1,3-dimethyl- | | 2,6- | dimethyl aniline | | 2,6- | dimethylanilin | | 2,6- | dimethylaniline | | 2,6- | dimethylphenylamine | | o- | xylidine | | 2,6- | xylylamine |
Articles:
| PubMed:Formation of N-nitrosamines by chloramination or ozonation of amines listed in Pollutant Release and Transfer Registers (PRTRs). |
| PubMed:Determination of xylazine and 2,6-xylidine in animal tissues by liquid chromatography-tandem mass spectrometry. |
| PubMed:Elevated 4-aminobiphenyl and 2,6-dimethylaniline hemoglobin adducts and increased risk of bladder cancer among lifelong nonsmokers--The Shanghai Bladder Cancer Study. |
| PubMed:Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation. |
| PubMed:Genotoxicity of 2,6- and 3,5-dimethylaniline in cultured mammalian cells: the role of reactive oxygen species. |
| PubMed:Effect of carrier composition on 2,6-dimethylaniline degradation in aqueous solution by fluidized-bed Fenton process. |
| PubMed:Further investigations into the genotoxicity of 2,6-xylidine and one of its key metabolites. |
| PubMed:Occurrence and removal of lidocaine, tramadol, venlafaxine, and their metabolites in German wastewater treatment plants. |
| PubMed:Oxidation of 2,6-dimethylaniline by the Fenton, electro-Fenton and photoelectro-Fenton processes. |
| PubMed:Kinetics of 2,6-dimethylaniline oxidation by various Fenton processes. |
| PubMed:Third-order nonlinear optical properties and structures of (E)-N-(4-nitrobenzylidene)-2,6-dimethylaniline and (E)-N-(4-nitrobenzylidene)-2,3-dimethylaniline. |
| PubMed:Chemical oxidation of 2,6-dimethylaniline in the fenton process. |
| PubMed:Chemical oxidation of 2,6-dimethylaniline by electrochemically generated Fenton's reagent. |
| PubMed:Iron-catalyzed dehydrogenative phosphonation of N,N-dimethylanilines. |
| PubMed:Separation and analysis of dimethylaniline isomers by supercritical fluid chromatography--electrospray ionization tandem mass spectrometry. |
| PubMed:Kinetics and mechanism of 2,6-dimethyl-aniline degradation by hydroxyl radicals. |
| PubMed:Retention time prediction of compounds in Grob standard mixture for apolar capillary columns in temperature-programmed gas chromatography. |
| PubMed:Kinetics of 2,6-dimethylaniline degradation by electro-Fenton process. |
| PubMed:Assessment of the medicines lidocaine, prilocaine, and their metabolites, 2,6-dimethylaniline and 2-methylaniline, for DNA adduct formation in rat tissues. |
| PubMed:Temperature investigations of E/Z isomers in ketimines based of p-dibenzoylobenzene with aniline and 2,6-dimethylaniline by infrared spectroscopy. |
| PubMed:DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice. |
| PubMed:Amine mediated proton transfer reaction and C-Cl bond activation of solvent chloroform by a trinuclear copper(II) complex of a glucopyranosylamine derived ligand. |
| PubMed:Changes in production of lignin degrading enzymes during interactions between mycelia of the tropical decomposer basidiomycetes Marasmiellus troyanus and Marasmius pallescens. |
| PubMed:Mechanisms of cytotoxicity of selected organogold(III) compounds. |
| PubMed:Solution chemistry and cytotoxic properties of novel organogold(III) compounds. |
| PubMed:Synthesis, structure and pharmacology of acyl-2,6-xylidines. |
| PubMed:Gold complexes inhibit mitochondrial thioredoxin reductase: consequences on mitochondrial functions. |
| PubMed:Metabolic activation of 2,6-xylidine in the nasal olfactory mucosa and the mucosa of the upper alimentary and respiratory tracts in rats. |
| PubMed:Liquid phase overtone spectral investigations of 2,6-dimethylaniline and 2,4-dimethylaniline-evidence for steric nature of the ortho effect and the consequent base weakening. |
| PubMed:Pharmacokinetics of xylazine, 2,6-dimethylaniline, and tolazoline in tissues from yearling cattle and milk from mature dairy cows after sedation with xylazine hydrochloride and reversal with tolazoline hydrochloride. |
| PubMed:Determination of 2,6-dimethylaniline and o-toluidine impurities in preparations for local anaesthesia by the HPLC method with amperometric detection. |
| PubMed:The effect of deuterium and fluorine substitution upon the mutagenicity of N-hydroxy-2,6-dimethylaniline. |
| PubMed:Involvement of liver carboxylesterases in the in vitro metabolism of lidocaine. |
| PubMed:Lack of DNA binding in the rat nasal mucosa and other tissues of the nasal toxicants roflumilast, a phosphodiesterase 4 inhibitor, and a metabolite, 4-amino-3,5-dichloropyridine, in contrast to the nasal carcinogen 2,6-dimethylaniline. |
| PubMed:Analysis of the lidocaine metabolite 2,6-dimethylaniline in bovine and human milk. |
| PubMed:Immunohistochemical and ultrastructural studies of 2,6-dimethylaniline-induced nasal proliferative lesions in a rat two-stage nasal carcinogenesis model initiated with N-bis(2-hydroxypropyl)nitrosamine. |
| PubMed:Oxidation of 2,6-dimethylaniline by recombinant human cytochrome P450s and human liver microsomes. |
| PubMed:Plasma levels of lidocaine and prilocaine after application of Oraqix, a new intrapocket anesthetic, in patients with advanced periodontitis. |
| PubMed:Synthesis, characterization, and comparative 32P-postlabeling efficiencies of 2,6-dimethylaniline-DNA adducts. |
| PubMed:Identification of impurities in technical metalaxyl. |
| PubMed:Sequential observation of 2,6-dimethylaniline-induced nasal lesions in a rat two-stage nasal carcinogenesis model after initiation with N-bis(2-hydroxypropyl) nitrosamine. |
| PubMed:High-performance liquid chromatography-tandem electrospray mass spectrometry for the determination of lidocaine and its metabolites in human plasma and urine. |
| PubMed:Toxicity and blood concentrations of xylazine and its metabolite, 2,6-dimethylaniline, in rats after single or continuous oral administrations. |
| PubMed:Tumor-promoting activity of 2,6-dimethylaniline in a two-stage nasal carcinogenesis model in N-bis(2-hydroxypropyl)nitrosamine-treated rats. |
| PubMed:Studies on sulfation of synthesized metabolites from the local anesthetics ropivacaine and lidocaine using human cloned sulfotransferases. |
| PubMed:The regulatory status of xylazine for use in food-producing animals in the United States. |
| PubMed:An update of the National Toxicology Program database on nasal carcinogens. |
| PubMed:Pharmacokinetics and metabolism of the novel anticonvulsant agent N-(2,6-dimethylphenyl)-5-methyl-3-isoxazolecarboxamide (D2624) in rats and humans. |
| PubMed:Identification of 2,6-xylidine as a major lidocaine metabolite in human liver slices. |
| PubMed:Metabolism and excretion of ropivacaine in humans. |
| PubMed:Validation of high-performance liquid chromatographic methods on two silica base-deactivated reversed phases for the determination of chloroprocaine and bupivacaine. |
| PubMed:Determination of combined residues of metalaxyl and 2,6-dimethylaniline metabolites in urine by gas chromatography/mass spectrometry. |
| PubMed:2,6-Dimethylaniline--hemoglobin adducts from lidocaine in humans. |
| PubMed:Take the pain? Lidocaine comes under suspicion as a carcinogen. |
| PubMed:Simultaneous determination of xylazine and its major metabolite, 2,6-dimethylaniline, in bovine and swine kidney by liquid chromatography. |
| PubMed:Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure. |
| PubMed:2,6-Dimethylaniline (2,6-xylidine). |
| PubMed:Fluorescence polarization immunoassay and HPLC assays compared for measuring monoethylglycinexylidide in liver-transplant patients. |
| PubMed:Effects of parenteral nutrition on hepatic elimination of lidocaine: a study using the isolated perfused rat liver. |
| PubMed:The evaluation of a multiple dosing protocol for the mouse bone-marrow micronucleus assay using benzidine and 2,6-xylidine. |
| PubMed:Quantification of three lidocaine metabolites and their conjugates. |
| PubMed:NTP Toxicology and Carcinogenesis Studies of 2,6-Xylidine (2,6-Dimethylaniline) (CAS No. 87-62-7) in Charles River CD Rats (Feed Studies). |
| PubMed:The in vivo oxidative metabolism of 2,4- and 2,6-dimethylaniline in the dog and rat. |
| PubMed:Measurement of unscheduled DNA synthesis and S-phase synthesis in rodent hepatocytes following in vivo treatment: testing of 24 compounds. |
| PubMed:Covalent binding of [14C]-2,6-dimethylaniline to DNA of rat liver and ethmoid turbinate. |
| PubMed:[Amino acid derivatives of 2,6-xylidine and p-aminobenzoic acid. II. Synthesis of derivatives of N-(p-aminobenzoylaminoalkylacyl)-2,6-xylidines and study of their resistance to proteolytic factors]. |
| PubMed:[Amino acid derivatives of 2,6 and p-aminobenzoic acid. I. Synthesis of derivatives of 2,6-xylidine and various derivatives of PAB]. |
| PubMed:The in vivo effect of 2,6-xylidine on induction of micronuclei in mouse bone marrow cells. |
| PubMed:In vivo metabolism of lidocaine in the rat. Isolation of urinary metabolites as pentafluorobenzoyl derivatives and their identification by combined gas chromatography-mass spectrometry. |
| PubMed:New antiarrhythmic agents. 6. Quantitative structure-activity relationships of aminoxylidides. |
| PubMed:Determination and temperature effects of lidocaine (lignocaine) hydrochloride, epinephrine, methylparaben, 2,6-dimethylaniline, and p-hydroxybenzoic acid in USP lidocaine injection by ion-pair reversed-phase high pressure liquid chromatography. |
| PubMed:New antiarrhythmic agents. 5. alpha-Aminoaceto-2,6-xylidides with functionalized amide alkyl substituents. |
| PubMed:New antiarrhythmic agents. 2. Amide alkyl alpha-amino xylidides. |
| PubMed:Hepatic effects of xylidine isomers in rats. |
| PubMed:Micromethod for determination of meperidine in plasma. |
| PubMed:[Studies on Xipamide (4-chloro-5-sulfamoyl-2',6'-salicyloxylidide). Part 1: Physico-chemical and chemical properties (author's transl)]. |
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3D/inchi