EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

2,5-dihydroxybenzoic acid
gentisic acid

Supplier Sponsors

Name:2,5-dihydroxybenzoic acid
CAS Number: 490-79-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:207-718-5
Nikkaji Web:J6.046A
Beilstein Number:2209119
XlogP3:1.60 (est)
Molecular Weight:154.12162000
Formula:C7 H6 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 199.00 to 200.00 °C. @ 760.00 mm Hg
Boiling Point: 406.00 to 407.00 °C. @ 760.00 mm Hg (est)
Flash Point: 417.00 °F. TCC ( 214.00 °C. ) (est)
logP (o/w): 1.740
Soluble in:
 water, 5000 mg/L @ 5C (exp)
Insoluble in:
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
Alfa Biotechnology
For experimental / research use only.
Gentisic acid 98%
BOC Sciences
For experimental / research use only.
Mesalamine Impurity G >98%
Odor: characteristic
Use: 2,5-Dihydroxybenzoic Acid is an active metabolite of salicylic acid degradation. Evidence indicates that gentisic acid has anti-inflammatory, antirheumatic and antioxidant properties. It is also a byproduct of both tyrosine and benzoate metabolisms.
EMD Millipore
For experimental / research use only.
2,5-Dihydroxybenzoic Acid
For experimental / research use only.
Gentisic acid (HPLC) ≥90%
George Uhe Company
Gentisic Acid
Glentham Life Sciences
Gentisic acid
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
2,5-Dihydroxybenzoic Acid
Sigma-Aldrich: Aldrich
For experimental / research use only.
2,5-Dihydroxybenzoic Acid 98%
For experimental / research use only.
2,5-Dihydroxybenzoic Acid [Matrix for MALDI-TOF/MS] >99.0%(GC)(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 3000 mg/kg
Bollettino Chimico Farmaceutico. Vol. 112, Pg. 53, 1973.

oral-mouse LD50 4500 mg/kg
British Journal of Pharmacology and Chemotherapy. Vol. 8, Pg. 30, 1953.

intravenous-mouse LD50 374 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 254, 1953.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for 2,5-dihydroxybenzoic acid usage levels up to:
 not for fragrance use.
Recommendation for 2,5-dihydroxybenzoic acid flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):490-79-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3469
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2,5-dihydroxybenzoic acid
RTECS:LY3850000 for cas# 490-79-9
 2,5-dihydroxybenzoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:490-79-9
Pubchem (cid):3469
Pubchem (sid):134976464
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Golm Metabolome Database:Search
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C00628
HMDB (The Human Metabolome Database):HMDB00152
Export Tariff Code:2918.29.7500
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
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Search Picture
 benzoic acid, 2,5-dihydroxy-
2,5-dihydroxy benzoic acid
2,5-dihydroxy-benzoic acid
 gentisic acid
 hydroquinonecarboxylic acid


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PubMed:Modulation of hepatic phase II phenol sulfotransferase and antioxidant status by phenolic acids in rats.
PubMed:Selective extraction of derivates of p-hydroxy-benzoic acid from plant material by using a molecularly imprinted polymer.
PubMed:Induction of hepatic antioxidant enzymes by phenolic acids in rats is accompanied by increased levels of multidrug resistance-associated protein 3 mRNA expression.
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PubMed:[Breeding of a biotype of Myzus persicae sulzer on a synthetic medium. V- Influence of oxalic and gentisic acids on the nutritive value of a synthetic medium].
a oxidative product of saligenin. Gentisic acid is a dihydroxybenzoic acid. It is a crystalline powder that forms monoclinic prism in water solution. Gentisic acid is an active metabolite of salicylic acid degradation. There is an increasing amount of evidence indicating that gentisic acid has a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and antioxidant properties. Gentisic acid is also a byproduct of tyrosine and benzoate metabolism. [HMDB]
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