EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2,4-dihydroxyquinoline
2,4-quinolinediol

Supplier Sponsors

Name:4-hydroxy-1H-quinolin-2-one
CAS Number: 86-95-3Picture of molecule3D/inchi
Other(deleted CASRN):1677-28-7
ECHA EINECS - REACH Pre-Reg:201-711-0
FDA UNII: N58HX8G9CN
Nikkaji Web:J3.897K
Beilstein Number:0124854
MDL:MFCD00006744
XlogP3-AA:0.70 (est)
Molecular Weight:161.16019000
Formula:C9 H7 N O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 408.70 °C. @ 760.00 mm Hg (est)
Flash Point: 394.00 °F. TCC ( 201.00 °C. ) (est)
logP (o/w): 1.020 (est)
Soluble in:
 water, 26 mg/L @ 20 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
2,4-Quinolinediol 98%
Kingchem Laboratories
2,4 Dihydroxyquinoline
Santa Cruz Biotechnology
For experimental / research use only.
2,4-Quinolinediol
Sigma-Aldrich: Aldrich
For experimental / research use only.
2,4-Quinolinediol 97%
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for 2,4-dihydroxyquinoline usage levels up to:
 not for fragrance use.
 
Recommendation for 2,4-dihydroxyquinoline flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):86-95-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :54680871
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
4-hydroxy-1H-quinolin-2-one
Chemidplus:0000086953
RTECS:FG7300000 for cas# 86-95-3
 
References:
 4-hydroxy-1H-quinolin-2-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):54680871
Pubchem (sid):134971275
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C16716
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.40.4500
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 carbostyril, 4-hydroxy-
4-hydroxy-1H-quinolin-2-one
4-hydroxy-2-quinolinone
4-hydroxy-2-quinolone
4-hydroxycarbostyril
4-hydroxyquinolin-2(1H)-one
2,4-quinoline diol
 quinoline-2,4-diol
2,4-quinolinediol
2(1H)-quinolinone, 4-hydroxy-
 

Articles:

PubMed:A Pseudomonas putida bioreporter for the detection of enzymes active on 2-alkyl-4(1H)-quinolone signalling molecules.
PubMed:Synthesis and biotransformation of 2-alkyl-4(1H)-quinolones by recombinant Pseudomonas putida KT2440.
PubMed:Structure of PqsD, a Pseudomonas quinolone signal biosynthetic enzyme, in complex with anthranilate.
PubMed:PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa.
PubMed:A liquid chromatography-quadrupole time-of-flight (LC-QTOF)-based metabolomic approach reveals new metabolic effects of catechin in rats fed high-fat diets.
PubMed:PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by Pseudomonas aeruginosa and Burkholderia thailandensis.
PubMed:Synthesis of 4-hydroxycoumarin and 2,4-quinolinediol derivatives and evaluation of their effects on the viability of HepG2 cells and human hepatocytes culture.
PubMed:A new synthesis of 2,4-dihydroxyquinoline.
 
Notes:
None found
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