2,4-dihydroxyquinoline, 86-95-3

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CODE116465 CODE116465
Product(s):
86-95-3 2,4-Quinolinediol 98%

Name:	4-hydroxy-1H-quinolin-2-one
CAS Number:	86-95-3	3D/inchi
Other(deleted CASRN):	1677-28-7
ECHA EINECS - REACH Pre-Reg:	201-711-0
FDA UNII:	N58HX8G9CN
Nikkaji Web:	J3.897K
Beilstein Number:	0124854
MDL:	MFCD00006744
XlogP3-AA:	0.70 (est)
Molecular Weight:	161.16019000
Formula:	C9 H7 N O2
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:pharmaceuticals / chemical synthisis

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Boiling Point:	408.70 °C. @ 760.00 mm Hg (est)
Flash Point:	394.00 °F. TCC ( 201.00 °C. ) (est)
logP (o/w):	1.020 (est)
Soluble in:
	water, 26 mg/L @ 20 °C (exp)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

BOC Sciences

For experimental / research use only.

2,4-Quinolinediol 98%

Kingchem Laboratories

2,4 Dihydroxyquinoline

Santa Cruz Biotechnology

For experimental / research use only.

2,4-Quinolinediol

Sigma-Aldrich: Aldrich

For experimental / research use only.

2,4-Quinolinediol 97%

sds

Safety Information:

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
pharmaceuticals / chemical synthisis
Recommendation for 2,4-dihydroxyquinoline usage levels up to:
	not for fragrance use.

Recommendation for 2,4-dihydroxyquinoline flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA GENetic TOXicology:Search

EPA Substance Registry Services (TSCA):86-95-3

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :54680871

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

4-hydroxy-1H-quinolin-2-one

Chemidplus:0000086953

RTECS:FG7300000 for cas# 86-95-3

References:

	4-hydroxy-1H-quinolin-2-one
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	54680871
Pubchem (sid):	134971275

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
CHEMBL:	View
KEGG (GenomeNet):	C16716
HMDB (The Human Metabolome Database):	Search
Export Tariff Code:	2933.40.4500
ChemSpider:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

not found in nature

Synonyms:

	carbostyril, 4-hydroxy-
4-	hydroxy-1H-quinolin-2-one
4-	hydroxy-2-quinolinone
4-	hydroxy-2-quinolone
4-	hydroxycarbostyril
4-	hydroxyquinolin-2(1H)-one
2,4-	quinoline diol
	quinoline-2,4-diol
2,4-	quinolinediol
2(1H)-	quinolinone, 4-hydroxy-

Articles:

PubMed:A Pseudomonas putida bioreporter for the detection of enzymes active on 2-alkyl-4(1H)-quinolone signalling molecules.

PubMed:Synthesis and biotransformation of 2-alkyl-4(1H)-quinolones by recombinant Pseudomonas putida KT2440.

PubMed:Structure of PqsD, a Pseudomonas quinolone signal biosynthetic enzyme, in complex with anthranilate.

PubMed:PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa.

PubMed:A liquid chromatography-quadrupole time-of-flight (LC-QTOF)-based metabolomic approach reveals new metabolic effects of catechin in rats fed high-fat diets.

PubMed:PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by Pseudomonas aeruginosa and Burkholderia thailandensis.

PubMed:Synthesis of 4-hydroxycoumarin and 2,4-quinolinediol derivatives and evaluation of their effects on the viability of HepG2 cells and human hepatocytes culture.

PubMed:A new synthesis of 2,4-dihydroxyquinoline.

Notes:

None found

2,4-dihydroxyquinoline 2,4-quinolinediol

Supplier Sponsors

Articles:

2,4-dihydroxyquinoline
2,4-quinolinediol