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Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | dark brown liquid (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.98000 @ 25.00 °C.
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| Melting Point: | -14.30 °C. @ 760.00 mm Hg (est)
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| Boiling Point: | 214.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.154000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 195.00 °F. TCC ( 90.56 °C. )
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| logP (o/w): | 1.680 |
| Soluble in: |
| | water, 3652 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 250 mg/kg
National Technical Information Service. Vol. PB214-270
oral-rat LD50 467 mg/kg
National Technical Information Service. Vol. PB214-270
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
inhalation-mouse LC50 149 ppm/7H
"Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 6, Pg. 1743, 1991.
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for 2,4-xylidine usage levels up to: | | | not for fragrance use.
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| Recommendation for 2,4-xylidine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4- | amino-1,3-dimethylbenzene | | 4- | amino-1,3-xylene | | 1- | amino-2,4-dimethylbenzene | | | aniline, 2,4-dimethyl- | | | benzenamine, 2,4-dimethyl- | | 2,4- | dimethyl aniline | | 2,4- | dimethyl-benzenamine | | 2,4- | dimethyl-phenylamine | | 2,4- | dimethylanilin | | 2,4- | dimethylaniline | | 2,4- | dimethylbenzenamine | | 2,4- | dimethylbenzene-1-amine | | 2,4- | dimethylbenzeneamine | | 2,4- | dimethylphenylamine | | 2- | methyl-p-toluidine | | 2- | methyl-para-toluidine | | m- | xylidine | | 2,4- | xylylamine |
Articles:
| PubMed:Determination method for xylidines in workplace air. |
| PubMed:Simultaneous determination of amitraz and its metabolite residue in food animal tissues by gas chromatography-electron capture detector and gas chromatography-mass spectrometry with accelerated solvent extraction. |
| PubMed:Determination of amitraz and 2,4-dimethylaniline residues in honey by using LC with UV detection and MS/MS. |
| PubMed:Separation and analysis of dimethylaniline isomers by supercritical fluid chromatography--electrospray ionization tandem mass spectrometry. |
| PubMed:Determination of amitraz and its transformation products in pears by ethyl acetate extraction and liquid chromatography-tandem mass spectrometry. |
| PubMed:Directed evolution of aniline dioxygenase for enhanced bioremediation of aromatic amines. |
| PubMed:Anaerobic metabolism of 1-amino-2-naphthol-based azo dyes (Sudan dyes) by human intestinal microflora. |
| PubMed:Probing the molecular determinants of aniline dioxygenase substrate specificity by saturation mutagenesis. |
| PubMed:Identification of pesticide transformation products in food by liquid chromatography/time-of-flight mass spectrometry via "fragmentation-degradation" relationships. |
| PubMed:Electrochemical monitoring of the biodegradation of 2,4-dimethylaniline. |
| PubMed:Electrochemical investigation of the effect of pH and solvent on amitraz stability. |
| PubMed:[Cosmetic colorants. Toxicology and regulation]. |
| PubMed:Oxidative degradation of 2,4-xylidine by photosensitization with 2,4,6-triphenylpyrylium: homogeneous and heterogeneous catalysis. |
| PubMed:Liquid phase overtone spectral investigations of 2,6-dimethylaniline and 2,4-dimethylaniline-evidence for steric nature of the ortho effect and the consequent base weakening. |
| PubMed:New insights into the mechanisms of the thermal Fenton reactions occurring using different iron(II)-complexes. |
| PubMed:Ruthenium(II)-tris-bipyridine/titanium dioxide codoped zeolite Y photocatalysts: II. Photocatalyzed degradation of the model pollutant 2,4-xylidine, evidence for percolation behavior. |
| PubMed:[FeII(bpy)3]2+/TiO2-codoped zeolites: synthesis, characterization, and first application in photocatalysis. |
| PubMed:Teratogenic effects of amitraz, 2,4-dimethylaniline, and paraquat on developing frog (Xenopus) embryos. |
| PubMed:An N,N'-dialkyl-4,4'-bipyridinium-modified titanium-dioxide photocatalyst for water remediation--observation and application of supramolecular effects in photocatalytic degradation of pi-donor organic compounds. |
| PubMed:Optimal experimental design and artificial neural networks applied to the photochemically enhanced Fenton reaction. |
| PubMed:Assessment of aniline derivatives-induced DNA damage in the liver cells of B6C3F1 mice using the alkaline single cell gel electrophoresis ('comet') assay. |
| PubMed:Assessment of aniline derivatives-induced DNA damage in the liver cells of B6C3F1 mice using the alkaline single cell gel electrophoresis ("comet") assay. |
| PubMed:An evaluation of the DNA damaging effect of selected aniline derivatives using the alkaline single cell gel electrophoresis ("comet") assay. |
| PubMed:The genotoxicity of a variety of aniline derivatives in a DNA repair test with primary cultured rat hepatocytes. |
| PubMed:[Various characteristics of the combined effects of chemical substances on the body after their inhalation and skin absorption]. |
| PubMed:Metabolic activation of 2,4-xylidine and its mutagenic metabolite. |
| PubMed:Serum bile acid concentration in some experimental liver lesions of rat. |
| PubMed:Testing of twenty-one environmental aromatic amines or derivatives for long-term toxicity or carcinogenicity. |
| PubMed:2,4-xylidine (hydrochloride). |
| PubMed:Personal air sampling for vapors of aniline compounds. |
| PubMed:Proceedings: Early biochemical and morphological changes in the liver of mice after a single oral administration of 2,4-xylidine. |
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3D/inchi