2,4-diamino-6-hydroxypyrimidine
2,4-diaminohypoxanthine

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  Beijing Lys Chemicals Co, LTD.

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  30091 2,4-Diamino-6-hydroxypyrimidine

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  56-06-4 2,4-Diamino-6-hydroxypyrimidine ≥99%
  2,4-Diamino-6-hydroxypyrimidine has been found to be a GCH1 inhibitor and coul

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  TCI AMERICA

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  Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis.
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  Product(s):
  D1321 2,4-Diamino-6-hydroxypyrimidine >98.0%(HPLC)(T)
  SDS

CAS Number: 56-06-4 3D/inchi Other(deleted CASRN): 40306-60-3 ECHA EINECS - REACH Pre-Reg: 200-254-4 FDA UNII: EDH7CNS75I Nikkaji Web: J41.153A Beilstein Number: 125006 MDL: MFCD00006098 XlogP3-AA: -1.80 (est) Molecular Weight: 126.11902000 Formula: C4 H6 N4 O NMR Predictor: Predict (works with chrome, Edge or firefox) Category:indirect food additives: adhesives and components of coatings   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search DG SANTE Food Contact Materials: 2,4-diamino-6-hydroxypyrimidine   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Soluble in:   water, 8.585e+005 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: Beijing Lys Chemicals 2,4-Diamino-6-hydroxypyrimidine BOC Sciences For experimental / research use only. 2,4-Diamino-6-hydroxypyrimidine ≥99% Odor: characteristic Use: 2,4-Diamino-6-hydroxypyrimidine has been found to be a GCH1 inhibitor and coul EMD Millipore For experimental / research use only. 2,4-Diamino-6-hydroxypyrimidine sds Matrix Scientific For experimental / research use only. 2,4-Diamino-6-hydroxypyrimidine, 95+% sds Santa Cruz Biotechnology For experimental / research use only. 2,4-Diamino-6-hydroxypyrimidine ≥98% Sigma-Aldrich: Aldrich For experimental / research use only. 2,4-Diamino-6-hydroxypyrimidine 96% sds TCI AMERICA For experimental / research use only. 2,4-Diamino-6-hydroxypyrimidine >98.0%(HPLC)(T) sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: Not determined Dermal Toxicity: Not determined Inhalation Toxicity: Not determined   Safety in Use Information: Category: indirect food additives: adhesives and components of coatings Recommendation for 2,4-diamino-6-hydroxypyrimidine usage levels up to:   not for fragrance use.   Recommendation for 2,4-diamino-6-hydroxypyrimidine flavor usage levels up to:   not for flavor use.   Safety References: European Food Safety Authority (EFSA) reference(s): Scientific Opinion on the safety evaluation of the substance, 2,4-diamino-6-hydroxypyrimidine, CAS No. 56-06-4, for use in food contact materials View page or View pdf EPI System: View AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA Substance Registry Services (TSCA):56-06-4 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :2944 National Institute of Allergy and Infectious Diseases:Data WGK Germany:3 2,6-diamino-1H-pyrimidin-4-one Chemidplus:0000056064   References:   2,6-diamino-1H-pyrimidin-4-one NIST Chemistry WebBook: Search Inchi Canada Domestic Sub. List: 56-06-4 Pubchem (cid): 2944 Pubchem (sid): 135021950   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements FDA Indirect Additives used in Food Contact Substances: View CHEMBL: View HMDB (The Human Metabolome Database): HMDB02128 FooDB: FDB022857 Export Tariff Code: 2933.59.9500 ChemSpider: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms: 2- aminoisocytosine 2,6- diamino-1H-pyrimidin-4-one 2,6- diamino-4(1H)-pyrimidinone 2,4- diaminohypoxanthine 4(3H)- pyrimidinone, 2,6-diamino-   Articles:   None found yet. Try the PubMed Search.

Notes: 2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective inhibitor of GTP cyclohydrolase I (GTPCH) that restricts the de novo synthesis of tetrahydrobiopterin (BH4) or the BH4 precursor in vascular smooth muscle cells (VSMC). (PMID 12883322) 2,4-Diamino-6-hydroxypyrimidine also inhibits nitric oxide (NO) in both Interferon-gamma (IFN-gamma) and antigen (Ag)/IgE (Ag/IgE) systems, increasing Mast cells (MC) degranulation. (PMID 14514683) Sepiapterin, a precursor to tetrahydrobiopterin in the salvage pathway, completely reverses the effect of 2,4-diamino-6-hydroxypyrimidine on neuronal NO-synthase (nNOS) ubiquitylation. (PMID 16216381) [HMDB]