EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2,4-diamino-6-hydroxypyrimidine
2,4-diaminohypoxanthine

Supplier Sponsors

CAS Number: 56-06-4Picture of molecule3D/inchi
Other(deleted CASRN):40306-60-3
ECHA EINECS - REACH Pre-Reg:200-254-4
FDA UNII: EDH7CNS75I
Nikkaji Web:J41.153A
Beilstein Number:125006
MDL:MFCD00006098
XlogP3-AA:-1.80 (est)
Molecular Weight:126.11902000
Formula:C4 H6 N4 O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:indirect food additives: adhesives and components of coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Google Patents:Search
US Patents:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
DG SANTE Food Contact Materials:2,4-diamino-6-hydroxypyrimidine
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 8.585e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Beijing Lys Chemicals
2,4-Diamino-6-hydroxypyrimidine
BOC Sciences
For experimental / research use only.
2,4-Diamino-6-hydroxypyrimidine ≥99%
Odor: characteristic
Use: 2,4-Diamino-6-hydroxypyrimidine has been found to be a GCH1 inhibitor and coul
EMD Millipore
For experimental / research use only.
2,4-Diamino-6-hydroxypyrimidine
Matrix Scientific
For experimental / research use only.
2,4-Diamino-6-hydroxypyrimidine, 95+%
Santa Cruz Biotechnology
For experimental / research use only.
2,4-Diamino-6-hydroxypyrimidine ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
2,4-Diamino-6-hydroxypyrimidine 96%
TCI AMERICA
For experimental / research use only.
2,4-Diamino-6-hydroxypyrimidine >98.0%(HPLC)(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
indirect food additives: adhesives and components of coatings
Recommendation for 2,4-diamino-6-hydroxypyrimidine usage levels up to:
 not for fragrance use.
 
Recommendation for 2,4-diamino-6-hydroxypyrimidine flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the safety evaluation of the substance, 2,4-diamino-6-hydroxypyrimidine, CAS No. 56-06-4, for use in food contact materials
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):56-06-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :2944
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2,6-diamino-1H-pyrimidin-4-one
Chemidplus:0000056064
 
References:
 2,6-diamino-1H-pyrimidin-4-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:56-06-4
Pubchem (cid):2944
Pubchem (sid):135021950
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB02128
FooDB:FDB022857
Export Tariff Code:2933.59.9500
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
2-aminoisocytosine
2,6-diamino-1H-pyrimidin-4-one
2,6-diamino-4(1H)-pyrimidinone
2,4-diaminohypoxanthine
4(3H)-pyrimidinone, 2,6-diamino-
 
 
Notes:
2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective inhibitor of GTP cyclohydrolase I (GTPCH) that restricts the de novo synthesis of tetrahydrobiopterin (BH4) or the BH4 precursor in vascular smooth muscle cells (VSMC). (PMID 12883322) 2,4-Diamino-6-hydroxypyrimidine also inhibits nitric oxide (NO) in both Interferon-gamma (IFN-gamma) and antigen (Ag)/IgE (Ag/IgE) systems, increasing Mast cells (MC) degranulation. (PMID 14514683) Sepiapterin, a precursor to tetrahydrobiopterin in the salvage pathway, completely reverses the effect of 2,4-diamino-6-hydroxypyrimidine on neuronal NO-synthase (nNOS) ubiquitylation. (PMID 16216381) [HMDB]
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