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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 61.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 241.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.023000 mmHg @ 20.00 °C. |
| Flash Point: | 213.00 °F. TCC ( 100.40 °C. ) (est)
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| logP (o/w): | 4.110 |
| Soluble in: |
| | water, 10 mg/L @ 20 °C (exp) | | | water, 11.8 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for 2,4,6-trichloroanisole usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for 2,4,6-trichloroanisole flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | anisole, 2,4,6-trichloro- (8CI) | | | benzene, 1,3,5-trichloro-2-methoxy- | | | benzene, 1,3,5-trichloro-2-methoxy- (9CI) | | | methyl 2,4,6-trichlorophenyl ether | | 2,4,6- | trichloranisole | | 2,4,6- | trichloro-1-methoxybenzene | | 1,3,5- | trichloro-2-methoxybenzene | | | tyrene |
Articles:
| PubMed:A rapid space-resolved solid-phase microextraction method as a powerful tool to determine contaminants in wine based on their volatility. |
| PubMed:The Problem of 2,4,6-Trichloroanisole in Cork Planks Studied by Attenuated Total Reflection Infrared Spectroscopy: Proof of Concept. |
| PubMed:A simple and sensitive vortex assisted liquid-liquid microextraction method for the simultaneous determination of haloanisoles and halophenols in wines. |
| PubMed:Using corona discharge-ion mobility spectrometry for detection of 2,4,6-Trichloroanisole. |
| PubMed:Extraction-less, rapid assay for the direct detection of 2,4,6-trichloroanisole (TCA) in cork samples. |
| PubMed:Simultaneous determination of ten taste and odor compounds in drinking water by solid-phase microextraction combined with gas chromatography-mass spectrometry. |
| PubMed:Gas chromatography-mass spectrometry determination of earthy-musty odorous compounds in waters by two phase hollow-fiber liquid-phase microextraction using polyvinylidene fluoride fibers. |
| PubMed:Occurrence of earthy and musty odor compounds (geosmin, 2-methylisoborneol and 2,4,6-trichloroanisole) in biologically treated wastewater. |
| PubMed:Cyclic voltammetry: a tool to quantify 2,4,6-trichloroanisole in aqueous samples from cork planks boiling industrial process. |
| PubMed:2,4,6-trichloroanisole is a potent suppressor of olfactory signal transduction. |
| PubMed:Different headspace solid phase microextraction--gas chromatography/mass spectrometry approaches to haloanisoles analysis in wine. |
| PubMed:Experimental design for the optimization of the derivatization reaction in determining chlorophenols and chloroanisoles by headspace-solid-phase microextraction-gas chromatography/mass spectrometry. |
| PubMed:Analysis of corky off-flavour compounds at ultra trace level with multidimensional gas chromatography-electron capture detection. |
| PubMed:Ionic liquids as novel stationary phases in gas liquid chromatography: inverse or normal isotope effect? |
| PubMed:[Determination of two mouldy compounds in cork by gas chromatography-mass spectrometry]. |
| PubMed:Headspace-multicapillary column-ion mobility spectrometry for the direct analysis of 2,4,6-trichloroanisole in wine and cork samples. |
| PubMed:[Determination of 2,4,6-trichloroanisole in wine by head-space solid phase micro-extraction and gas chromatography-mass spectrometry]. |
| PubMed:Headspace-single drop microextraction with a commercial capillary electrophoresis instrument. |
| PubMed:Method development and validation for the determination of 2,4,6-tribromoanisole, 2,4,6-tribromophenol, 2,4,6-trichloroanisole, and 2,4,6-trichlorophenol in various drug products using stir bar sorptive extraction and gas chromatography-tandem mass spectrometry detection. |
| PubMed:A framework for identifying characteristic odor compounds in municipal wastewater effluent. |
| PubMed:Accurate analysis of trace earthy-musty odorants in water by headspace solid phase microextraction gas chromatography-mass spectrometry. |
| PubMed:Optimisation of a sensitive method based on ultrasound-assisted emulsification-microextraction for the simultaneous determination of haloanisoles and volatile phenols in wine. |
| PubMed:The potential of ion mobility spectrometry (IMS) for detection of 2,4,6-trichloroanisole (2,4,6-TCA) in wine. |
| PubMed:Concentrations of organochlorine pesticides and 2,4,6-trichloroanisole in cork bark. |
| PubMed:Destruction of chloroanisoles by using a hydrogen peroxide activated method and its application to remove chloroanisoles from cork stoppers. |
| PubMed:Trace level analysis of corky off-flavor compounds: development of a new analytical method based on solid phase extraction and analysis by multidimensional gas chromatography with mass spectrometric detection. |
| PubMed:Odorous compounds in municipal wastewater effluent and potable water reuse systems. |
| PubMed:Direct determination of 2,4,6-tricholoroanisole in wines by single-drop ionic liquid microextraction coupled with multicapillary column separation and ion mobility spectrometry detection. |
| PubMed:Multivariate analysis of volatile compounds detected by headspace solid-phase microextraction/gas chromatography: A tool for sensory classification of cork stoppers. |
| PubMed:Volatile compounds in samples of cork and also produced by selected fungi. |
| PubMed:Development of a cellular biosensor for the detection of 2,4,6-trichloroanisole (TCA). |
| PubMed:Selectable one-dimensional or two-dimensional gas chromatography-olfactometry/mass spectrometry with preparative fraction collection for analysis of ultra-trace amounts of odor compounds. |
| PubMed:Origin and incidence of 2-methoxy-3,5-dimethylpyrazine, a compound with a "fungal" and "corky" aroma found in cork stoppers and oak chips in contact with wines. |
| PubMed:Concentrations of viable airborne fungal spores and trichloroanisole in wine cellars. |
| PubMed:Identification of a new source of contamination of Quercus sp. oak wood by 2,4,6-trichloroanisole and its impact on the contamination of barrel-aged wines. |
| PubMed:Sensitive determination of 2,4,6-trichloroanisole in water samples by ultrasound assisted emulsification microextraction prior to gas chromatography-tandem mass spectrometry analysis. |
| PubMed:Ultrasound-assisted emulsification microextraction for determination of 2,4,6-trichloroanisole in wine samples by gas chromatography tandem mass spectrometry. |
| PubMed:Development of a microwave assisted extraction method for the analysis of 2,4,6-trichloroanisole in cork stoppers by SIDA-SBSE-GC-MS. |
| PubMed:Sensory screening for large-format natural corks by "dry soak" testing and its correlation to headspace solid-phase microextraction (SPME) gas chromatography/mass spectrometry (GC/MS) releasable trichloroanisole (TCA) analysis. |
| PubMed:Off-odor compounds produced in cork by isolated bacteria and fungi: a gas chromatography-mass spectrometry and gas chromatography-olfactometry study. |
| PubMed:Modeling quality of premium spanish red wines from gas chromatography-olfactometry data. |
| PubMed:Catalytic ozonation for degradation of 2, 4, 6-trichloroanisole in drinking water in the presence of gamma-AlOOH. |
| PubMed:Ozonation catalyzed by the raw bauxite for the degradation of 2,4,6-trichloroanisole in drinking water. |
| PubMed:Multi-residue off-flavour profiling in wine using stir bar sorptive extraction-thermal desorption-gas chromatography-mass spectrometry. |
| PubMed:Molecular fingerprinting by PCR-denaturing gradient gel electrophoresis reveals differences in the levels of microbial diversity for musty-earthy tainted corks. |
| PubMed:Comparison of two SPME fibers for the extraction of some off-flavor cork-taint compounds in bottled wines investigated by GC-HRMS. |
| PubMed:Copper UPD as non-specific adsorption barrier in electrochemical displacement immunosensors. |
| PubMed:Analysis of earthy and musty odors in water samples by solid-phase microextraction coupled with gas chromatography/ion trap mass spectrometry. |
| PubMed:Application of robust NiTi-ZrO2-PEG SPME fiber in the determination of haloanisoles in cork stopper samples. |
| PubMed:Biodegradation of 2,4,6-TCA by the white-rot fungus Phlebia radiata is initiated by a phase I (O-demethylation)-phase II (O-conjugation) reactions system: implications for the chlorine cycle. |
| PubMed:Comparison of stir bar sorptive extraction and solid-phase microextraction to determine halophenols and haloanisoles by gas chromatography-ion trap tandem mass spectrometry. |
| PubMed:Determination of 2,4,6-trichloroanisole and 2,4,6-tribromoanisole in wine using microextraction in packed syringe and gas chromatography-mass spectrometry. |
| PubMed:Transformation ability of fungi isolated from cork and grape to produce 2,4,6-trichloroanisole from 2,4,6-trichlorophenol. |
| PubMed:Environmental significance of O-demethylation of chloroanisoles by soil bacterial isolates as a mechanism that improves the overall biodegradation of chlorophenols. |
| PubMed:Multiple headspace solid-phase microextraction for eliminating matrix effect in the simultaneous determination of haloanisoles and volatile phenols in wines. |
| PubMed:Assessment of the matrix effect on the headspace solid-phase microextraction (HS-SPME) analysis of chlorophenols in wines. |
| PubMed:Application of fractional factorial experimental and Box-Behnken designs for optimization of single-drop microextraction of 2,4,6-trichloroanisole and 2,4,6-tribromoanisole from wine samples. |
| PubMed:Analysis for chloroanisoles and chlorophenols in cork by stir bar sorptive extraction and gas chromatography-mass spectrometry. |
| PubMed:Optimisation of a microwave-assisted extraction method for the simultaneous determination of haloanisoles and halophenols in cork stoppers. |
| PubMed:Analysis of off-flavor compounds in water at sub part per trillion level by GC/MS with programmable temperature vaporizer inlet. |
| PubMed:Optimisation of a headspace solid-phase microextraction with on-fiber derivatisation method for the direct determination of haloanisoles and halophenols in wine. |
| PubMed:Rapid headspace solid-phase microextraction/gas chromatographic/mass spectrometric assay for the quantitative determination of some of the main odorants causing off-flavours in wine. |
| PubMed:Fungal strains isolated from cork stoppers and the formation of 2,4,6-trichloroanisole involved in the cork taint of wine. |
| PubMed:Fast and sensitive method to determine chloroanisoles in cork using an internally cooled solid-phase microextraction fiber. |
| PubMed:Determination of haloanisols in white wine by immunosorbent solid-phase extraction followed by enzyme-linked immunosorbent assay. |
| PubMed:Comparative study of two chromatographic methods for quantifying 2,4,6-trichloranisole in wines. |
| PubMed:Automated trace determination of earthy-musty odorous compounds in water samples by on-line purge-and-trap-gas chromatography-mass spectrometry. |
| PubMed:Multiple response optimisation based on desirability functions of a microwave-assisted extraction method for the simultaneous determination of chloroanisoles and chlorophenols in oak barrel sawdust. |
| PubMed:Assays on the simultaneous determination and elimination of chloroanisoles and chlorophenols from contaminated cork samples. |
| PubMed:Non-destructive method to determine halophenols and haloanisoles in cork stoppers by headspace sorptive extraction. |
| PubMed:Determination of 2,4,6-trichloroanisole and 2,4,6-tribromoanisole on ng L-1 to pgL-1 levels in wine by solid-phase microextraction and gas chromatography-high-resolution mass spectrometry. |
| PubMed:Routine analysis of off-flavor compounds in water at sub-part-per-trillion level by large-volume injection GC/MS with programmable temperature vaporizing inlet. |
| PubMed:Ethanol/Water extraction combined with solid-phase extraction and solid-phase microextraction concentration for the determination of chlorophenols in cork stoppers. |
| PubMed:Use of multiple headspace solid-phase microextraction and pervaporation for the determination of off-flavours in wine. |
| PubMed:Quantification of chloroanisoles in cork using headspace solid-phase microextraction and gas chromatography with electron capture detection. |
| PubMed:Simultaneous picogram determination of "earthy-musty" odorous compounds in water using solid-phase microextraction and gas chromatography-mass spectrometry coupled with initial cool programmable temperature vaporizer inlet. |
| PubMed:Determination of 2,4,6-trichloroanisole and guaiacol in cork stoppers by pressurised fluid extraction and gas chromatography-mass spectrometry. |
| PubMed:Identification of 2,4,6-trichloroanisole (TCA) causing a musty/muddy off-flavor in sake and its production in rice koji and moromi mash. |
| PubMed:Migration of contaminants by gas phase transfer from carton board and corrugated board box secondary packaging into foods. |
| PubMed:Highly selective solid-phase extraction and large volume injection for the robust gas chromatography-mass spectrometric analysis of TCA and TBA in wines. |
| PubMed:Detection of 2,4,6-trichloroanisole in chlorinated water at nanogram per litre levels by SPME-GC-ECD. |
| PubMed:Determination of odour-causing volatile organic compounds in cork stoppers by multiple headspace solid-phase microextraction. |
| PubMed:Removal of earthy-musty odorants in drinking water by powdered activated carbon. |
| PubMed:Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro-extraction and gas chromatography-mass detection. |
| PubMed:Purge-and-trap preconcentration system coupled to capillary gas chromatography with atomic emission detection for 2,4,6-trichloroanisole determination in cork stoppers and wines. |
| PubMed:Dynamic headspace coupled to perevaporation for the analysis of anisoles in wine by gas chromatography-ion-trap tandem mass spectrometry. |
| PubMed:Optimisation of a headspace solid-phase microextraction method for the direct determination of chloroanisoles related to cork taint in red wine. |
| PubMed:Determination of chloroanisole compounds in red wine by headspace solid-phase microextraction and gas chromatography-mass spectrometry. |
| PubMed:Analysis of anisoles in wines using pervaporation coupled to gas chromatography-mass spectrometry. |
| PubMed:Isolation and identification of 2-methoxy-3,5-dimethylpyrazine, a potent musty compound from wine corks. |
| PubMed:Formation and emission of chloroanisoles as indoor pollutants. |
| PubMed:Optimization of stir bar sorptive extraction applied to the determination of odorous compounds in drinking water. |
| PubMed:Stir bar sorptive extraction for the analysis of wine cork taint. |
| PubMed:Immunochemical determination of 2,4,6-trichloroanisole as the responsible agent for the musty odor in foods. 2. Immunoassay evaluation. |
| PubMed:Immunochemical determination of 2,4,6-trichloroanisole as the responsible agent for the musty odor in foods. 1. Molecular modeling studies for antibody production. |
| PubMed:Accurate determination of 2,4,6-trichloroanisole in wines at low parts per trillion by solid-phase microextraction followed by GC-ECD. |
| PubMed:Fast screening method for determining 2,4,6-trichloroanisole in wines using a headspace-mass spectrometry (HS-MS) system and multivariate calibration. |
| PubMed:Analysis of off-flavors in the aquatic environment by stir bar sorptive extraction-thermal desorption-capillary GC/MS/olfactometry. |
| PubMed:Application of stir bar sorptive extraction for wine analysis. |
| PubMed:Determination of 2,4,6-trichloroanisole in wines by headspace solid-phase microextraction and gas chromatography-electron-capture detection. |
| PubMed:Cork taint of wines: role of the filamentous fungi isolated from cork in the formation of 2,4,6-trichloroanisole by o methylation of 2,4,6-trichlorophenol. |
| PubMed:Evaluation of an extraction method in the determination of the 2,4,6-trichloroanisole content of tainted cork. |
| PubMed:Application of low-temperature glassy carbon films in solid-phase microextraction. |
| PubMed:Determination of trace amounts of off-flavor compounds in drinking water by stir bar sorptive extraction and thermal desorption GC-MS. |
| PubMed:The determination of six taste and odour compounds in water using Ambersorb 572 and high resolution mass spectrometry. |
| PubMed:Trends of organochlorine compounds in Finnish inland waters. Results of mussel incubation monitoring 1984-1998. |
| PubMed:Cork taint in wine: scientific knowledge and public perception: a critical review. |
| PubMed:Supercritical fluid extraction of 2,4,6-trichloroanisole from cork stoppers. |
| PubMed:Analysis of 2,4,6-trichloroanisole in wines using solid-phase microextraction coupled to gas chromatography-mass spectrometry. |
| PubMed:Identification of 2,4,6-trichloroanisole in several essential oils. |
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3D/inchi