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2,3-dihydroxybenzoic acid
3-hydroxysalicylic acid

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Name:2,3-dihydroxybenzoic acid
CAS Number: 303-38-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:206-139-5
Nikkaji Web:J79.590I
Beilstein Number:2209117
XlogP3:1.20 (est)
Molecular Weight:153.11365000
Formula:C7 H5 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Appearance:cream to pale brown powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 204.00 to 208.00 °C. @ 760.00 mm Hg
Boiling Point: 362.00 to 363.00 °C. @ 760.00 mm Hg (est)
Flash Point: 369.00 °F. TCC ( 187.20 °C. ) (est)
logP (o/w): 1.200
Soluble in:
 water, 2.612e+004 mg/L @ 25 °C (est)
Insoluble in:
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
None found
BOC Sciences
For experimental / research use only.
2,3-Dihydroxybenzoic acid
For experimental / research use only.
2,3-Dihydroxybenzoic Acid (HPLC) ≥90%
Matrix Scientific
For experimental / research use only.
2,3-Dihydroxybenzoic acid, 97%
Santa Cruz Biotechnology
For experimental / research use only.
2,3-Dihydroxybenzoic Acid
Sigma-Aldrich: Aldrich
For experimental / research use only.
2,3-Dihydroxybenzoic Acid 99%
For experimental / research use only.
2,3-Dihydroxybenzoic Acid >98.0%(HPLC)(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rabbit LD50 > 3000 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 196, Pg. 478, 1976.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
natural substances and extractives
Recommendation for 2,3-dihydroxybenzoic acid usage levels up to:
 not for fragrance use.
Recommendation for 2,3-dihydroxybenzoic acid flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :19
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
2,3-dihydroxybenzoic acid
RTECS:DG8576490 for cas# 303-38-8
 2,3-dihydroxybenzoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):19
Pubchem (sid):134973442
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Golm Metabolome Database:Search
UM BBD:Search
KEGG (GenomeNet):C00196
HMDB (The Human Metabolome Database):HMDB00397
Export Tariff Code:2918.29.7500
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 evening-primrose plant
Search Trop Picture
 gentian yellow gentian
Search Trop Picture
 benzoic acid, 2,3-dihydroxy-
 catechol-3-carboxylic acid
 catecholcarboxylic acid
2,3-dihdroxybenzoic acid
3-hydroxysalicylic acid
2-pyrocatechuic acid
Occurs in Gentiana lutea (yellow gentian) 2-Pyrocatechuic acid is a normal human benzoic acid metabolite found in plasma (PMID 16351159), and is normally found with increased levels after consumption of many nutrients and drugs, i.e.: cranberry juice (PMID 14733499), aspirin ingestion. (PMID 3342084) It has been found associated with idiopathic oro-facial pain due to stress (oxidative stress might enhance the production of free radicals); it has been suggested that OH radicals are responsible for the production of many systemic and local tissue injury diseases which may initially manifest as pain syndrome, and 2-Pyrocatechuic acid is a biological marker for the detection and quantification of OH radicals, and patients had significantly increased circulating levels of 2-Pyrocatechuic acid after aspirin ingestion than control subjects. (PMID 7748148)
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