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Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 333.22 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 337.00 °F. TCC ( 169.50 °C. ) (est)
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| logP (o/w): | 1.472 (est) |
| Soluble in: |
| | water, 7103 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for 2,4,6-trihydroxyacetophenone usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for 2,4,6-trihydroxyacetophenone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acetophenone, 2',4',6'-trihydroxy- | | | acetophloroglucine | | 1- | acetyl-2,4,6-trihydroxybenzene | | | acetylphloroglucinol | | | ethanone, 1-(2,4,6-trihydroxyphenyl)- | | | phloroacetophenone | | 2,4,6- | trihydroxy acetophenone | | 1-(2,4,6- | trihydroxy-phenyl)-ethanone | | 2',4',6'- | trihydroxyacetophenone | | 1-(2,4,6- | trihydroxyphenyl)-ethanone | | 1-(2,4,6- | trihydroxyphenyl)ethan-1-one | | 1-(2,4,6- | trihydroxyphenyl)ethanone |
Articles:
| PubMed:Diastereomeric Ellagitannin Isomers from Penthorum chinense. |
| PubMed:Analyte-Size-Dependent Ionization and Quantification of Monosaccharides in Human Plasma Using Cation-Exchanged Smectite Layers. |
| PubMed:Excited state dynamics in the matrix-assisted laser desorption/ionization matrix 2,4,6-trihydroxyacetophenone: evidence for triplet pooling charge separation reactions. |
| PubMed:Purification, molecular cloning and functional characterization of flavonoid C-glucosyltransferases from Fagopyrum esculentum M. (buckwheat) cotyledon. |
| PubMed:Contribution of thermal energy to initial ion production in matrix-assisted laser desorption/ionization observed with 2,4,6-trihydroxyacetophenone. |
| PubMed:Ion intensity and thermal proton transfer in ultraviolet matrix-assisted laser desorption/ionization. |
| PubMed:Thotneosides A, B and C: potent antioxidants from nepalese crude drug, leaves of Aconogonon molle. |
| PubMed:Is energy pooling necessary in ultraviolet matrix-assisted laser desorption/ionization? |
| PubMed:Rapid estimation of the energy charge from cell lysates using matrix-assisted laser desorption/ionization mass spectrometry: role of in-source fragmentation. |
| PubMed:Laser desorption ionization mass spectrometry of bioactive substances by using 2,4,6-trihydroxyacetophenone on cation-substituted zeolite. |
| PubMed:Enhanced visualization of small peptides absorbed in rat small intestine by phytic-acid-aided matrix-assisted laser desorption/ionization-imaging mass spectrometry. |
| PubMed:Alkylated trihydroxyacetophenone as a MALDI matrix for hydrophobic peptides. |
| PubMed:Surface analysis of lipids by mass spectrometry: more than just imaging. |
| PubMed:MALDI-MS/MS with traveling wave ion mobility for the structural analysis of N-linked glycans. |
| PubMed:Matrix-assisted laser desorption ionization mass spectrometry of maltohexaose and acetylsalicylic acid using alkali metal cation-substituted zeolites. |
| PubMed:Analysis of initial reactions of MALDI based on chemical properties of matrixes and excitation condition. |
| PubMed:Synthesis and antimicrobial activity of geranyloxy- and farnesyloxy-acetophenone derivatives against oral pathogens. |
| PubMed:MALDI imaging and structural analysis of rat brain lipid negative ions with 9-aminoacridine matrix. |
| PubMed:Production and fragmentation of negative ions from neutral N-linked carbohydrates ionized by matrix-assisted laser desorption/ionization. |
| PubMed:Sublimation of new matrix candidates for high spatial resolution imaging mass spectrometry of lipids: enhanced information in both positive and negative polarities after 1,5-diaminonapthalene deposition. |
| PubMed:Geranyl derivative of phloroacetophenone induces cancer cell-specific apoptosis through Bax-mediated mitochondrial pathway in MCF-7 human breast cancer cells. |
| PubMed:EJMS protocol: systematic studies on TiO2-based phosphopeptide enrichment procedures upon in-solution and in-gel digestions of proteins. Are there readily applicable protocols suitable for matrix-assisted laser desorption/ionization mass spectrometry-based phosphopeptide stability estimations? |
| PubMed:Plume expansion dynamics of matrix-assisted laser desorption ionization. |
| PubMed:Matrix-assisted laser desorption/ionization time-of-flight mass spectrometric behavior of succinoglycan monomers, dimers, and trimers isolated from Sinorhizobium meliloti 1021. |
| PubMed:Isoliquiritigenin (4,2',4'-trihydroxychalcone): a new matrix-assisted laser desorption/ionization matrix with outstanding properties for the analysis of neutral oligosaccharides. |
| PubMed:The 2',4',6'-trihydroxyacetophenone isolated from Myrcia multiflora has antiobesity and mixed hypolipidemic effects with the reduction of lipid intestinal absorption. |
| PubMed:Structure of dihydrochalcones and related derivatives and their scavenging and antioxidant activity against oxygen and nitrogen radical species. |
| PubMed:Solid-phase thermodynamic interpretation of ion desorption in matrix-assisted laser desorption/ionization. |
| PubMed:Synthesis of kaempferol 3-O-(3'',6''-di-O-E-p-coumaroyl)-β-D-glucopyranoside, efficient glycosylation of flavonol 3-OH with glycosyl o-alkynylbenzoates as donors. |
| PubMed:MALDI mass spectrometry using 2,4,6-trihydroxyacetophenone and 2,4-dihydroxyacetophenone with cyclodextrins: suppression of matrix-related ions in low-molecular-weight region. |
| PubMed:Synthesis of vicenin-1 and 3, 6,8- and 8,6-di-C-beta-D-(glucopyranosyl-xylopyranosyl)-4',5,7-trihydroxyflavones using two direct C-glycosylations of naringenin and phloroacetophenone with unprotected D-glucose and D-xylose in aqueous solution as the key reactions. |
| PubMed:Potent hepatoprotective effect in CCl(4)-induced hepatic injury in mice of phloroacetophenone from Myrcia multiflora. |
| PubMed:Use of a novel ionic liquid matrix for MALDI-MS analysis of glycopeptides and glycans out of total tryptic digests. |
| PubMed:Synthesis and cytotoxic activities of C-benzylated flavonoids. |
| PubMed:The effect of temperature on the stability of compounds used as UV-MALDI-MS matrix: 2,5-dihydroxybenzoic acid, 2,4,6-trihydroxyacetophenone, alpha-cyano-4-hydroxycinnamic acid, 3,5-dimethoxy-4-hydroxycinnamic acid, nor-harmane and harmane. |
| PubMed:Suppression of matrix-related ions using cyclodextrin in MALDI mass spectrometry. |
| PubMed:Using solvent-free sample preparation to promote protonation of poly(ethylene oxide)s with labile end-groups in matrix-assisted laser desorption/ionisation. |
| PubMed:Alkali-hydroxide-doped matrices for structural characterization of neutral underivatized oligosaccharides by MALDI time-of-flight mass spectrometry. |
| PubMed:Application of pressure probe and UV-MALDI-TOF MS for direct analysis of plant underivatized carbohydrates in subpicoliter single-cell cytoplasm extract. |
| PubMed:Profiles of structural heterogeneity in native lipooligosaccharides of Neisseria and cytokine induction. |
| PubMed:Characterization of the molecular mass distribution of pullulans by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using 2,5-dihydroxybenzoic acid butylamine (DHBB) as liquid matrix. |
| PubMed:Simultaneous analysis of vitamins and caffeine in energy drinks by surfactant-mediated matrix-assisted laser desorption/ionization. |
| PubMed:Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of oligonucleotides. |
| PubMed:Rapid screening of anthocyanins in berry samples by surfactant-mediated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. |
| PubMed:Ion-induced nucleation in solution: promotion of solute nucleation in charged levitated droplets. |
| PubMed:Suppression and enhancement of secondary ion formation due to the chemical environment in static-secondary ion mass spectrometry. |
| PubMed:Strategies for the analysis of poly(methacrylic acid) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. |
| PubMed:Matrix-assisted laser desorption/ionization mass spectrometry of polysaccharides with 2',4',6'-trihydroxyacetophenone as matrix. |
| PubMed:Determining enediol compounds in tea using surface-assisted laser desorption/ionization mass spectrometry with titanium dioxide nanoparticle matrices. |
| PubMed:Polyketide folding in higher plants: biosynthesis of the phenylanthraquinone knipholone. |
| PubMed:Analysis of lipids using 2,4,6-trihydroxyacetophenone as a matrix for MALDI mass spectrometry. |
| PubMed:Phloracetophenone-induced choleresis in rats is mediated through Mrp2. |
| PubMed:Combined use of 2,4,6-trihydroxyacetophenone as matrix and enzymatic deglycosylation in organic-aqueous solvent systems for the simultaneous characterization of complex glycoproteins and N-glycans by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. |
| PubMed:Differential effects of hydroxyacetophenone analogues on the transcytotic vesicular pathway in rat liver. |
| PubMed:Detection of hypoxia-related proteins in medaka (Oryzias latipes) brain tissue by difference gel electrophoresis and de novo sequencing of 4-sulfophenyl isothiocyanate-derivatized peptides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. |
| PubMed:Simple and fast method for recognition of reducing and nonreducing neutral carbohydrates by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. |
| PubMed:MALDI analysis of oligonucleotides directly from montmorillonite. |
| PubMed:Detection of phosphopeptides using Fe(III)-nitrilotriacetate complexes immobilized on a MALDI plate. |
| PubMed:Characterization of various analytes using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 2-[(2E)-3-(4-tert-butylphenyl)-2-methylprop-2-enylidene]malononitrile matrix. |
| PubMed:Effective detection of peptides containing cysteine sulfonic acid using matrix-assisted laser desorption/ionization and laser desorption/ionization on porous silicon mass spectrometry. |
| PubMed:Complete MALDI-ToF MS analysis of cross-linked peptide-RNA oligonucleotides derived from nonlabeled UV-irradiated ribonucleoprotein particles. |
| PubMed:Inhibitory effects of choleretic hydroxyacetophenones on ileal bile acid transport in rats. |
| PubMed:Analysis of acidic carbohydrates as their quaternary ammonium or phosphonium salts by matrix-assisted laser desorption/ionization mass spectrometry. |
| PubMed:Glycoproteomics of N-glycosylation by in-gel deglycosylation and matrix-assisted laser desorption/ionisation-time of flight mass spectrometry mapping: application to congenital disorders of glycosylation. |
| PubMed:Induction of human cholesterol 7alpha-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone. |
| PubMed:[Determination of oligonucleotide molecular masses by MS-MALDI]. |
| PubMed:Proline-based modulation of 2,4-diacetylphloroglucinol and viable cell yields in cultures of Pseudomonas fluorescens wild-type and over-producing strains. |
| PubMed:Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of 4-sulfophenyl isothiocyanate-derivatized peptides on AnchorChip sample supports using the sodium-tolerant matrix 2,4,6-trihydroxyacetophenone and diammonium citrate. |
| PubMed:Detection and quantification of lanthanide complexes in cell lysates by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. |
| PubMed:Mass spectrometry of N-linked oligosaccharides using atmospheric pressure infrared laser ionization from solution. |
| PubMed:Acetophenone C-glucosides and stilbene O-glucosides in Upuna borneensis. |
| PubMed:Enhanced ionization of phosphorylated peptides during MALDI TOF mass spectrometry. |
| PubMed:Chromone studies. Part 13. Synthesis and electron-impact mass spectrometric studies of 5-hydroxy-2-isopropyl-7-methoxychromone, a constituent of the medicinal plant Baeckea frutescens, and side-chain analogues. |
| PubMed:Investigation of sample preparation and instrumental parameters in the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of noncovalent peptide/peptide complexes. |
| PubMed:Synthesis and PGE2 inhibitory activity of 5,7-dihydroxyflavones and their O-methylated flavone analogs. |
| PubMed:Characterization of poly(butylene terephthalate) by size-exclusion chromatography and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. |
| PubMed:Sodium-tolerant matrix for matrix-assisted laser desorption/ionization mass spectrometry and post-source decay of oligonucleotides. |
| PubMed:Cholesterol lowering effects of a choleretic phloracetophenone in hypercholesterolemic hamsters. |
| PubMed:Evaluation of the acute and subacute toxicity of a choleretic phloracetophenone in experimental animals. |
| PubMed:Identification and structural analysis of synthetic oligosaccharides of Shigella sonnei using MALDI-TOF MS. |
| PubMed:Investigating the molecular heterogeneity of polysorbate emulsifiers by MALDI-TOF MS. |
| PubMed:A facile synthetic approach to prenylated flavanones: first total syntheses of (+/-)-bonannione A and (+/-)-sophoraflavanone A. |
| PubMed:Artifact-free matrix-assisted laser desorption ionization time-of-flight mass spectra of tert.-butyldimethylsilyl ether derivatives of cyclodextrins used for the synthesis of single-isomer, chiral resolving agents for capillary electrophoresis. |
| PubMed:MALDI-TOF MS analysis of isoflavones in soy products. |
| PubMed:Improvement of resolution, mass accuracy, and reproducibility in reflected mode DE-MALDI-TOF analysis of DNA using fast evaporation--overlayer sample preparations. |
| PubMed:MALDI-TOF MS analysis of food flavonol glycosides. |
| PubMed:Choleretic activity of phloracetophenone in rats: structure-function studies using acetophenone analogues. |
| PubMed:Analysis of anthocyanins in red wine and fruit juice using MALDI-MS. |
| PubMed:Polyamine co-matrices for matrix-assisted laser desorption/ionization mass spectrometry of oligonucleotides. |
| PubMed:Glycoalkaloid concentration in Alberta potatoes determined by matrix-assisted laser desorption/ionization mass spectrometry. |
| PubMed:Enhanced detection of oligonucleotides in UV MALDI MS using the tetraamine spermine as a matrix additive. |
| PubMed:Noncovalent RNA-peptide complexes detected by matrix-assisted laser desorption/ionization mass spectrometry. |
| PubMed:Total synthesis of (R,S)-sophoraflavanone C |
| PubMed:Characterization of enzymatic pectin digests by matrix-assisted laser desorption/ionization mass spectrometry. |
| PubMed:Polyacrylamide gel electrophoresis coupled with matrix-assisted laser desorption/ionization mass spectrometry for tRNA mutant analysis. |
| PubMed:Matrix performance in matrix-assisted laser desorption/ionization for molecular weight determination in sialyl and non-sialyl oligosaccharide proteins. |
| PubMed:Does matrix-assisted laser desorption/ionization mass spectrometry allow analysis of carbohydrate heterogeneity in glycoproteins? A study of natural human interferon-gamma. |
| PubMed:Analysis of acidic oligosaccharides and glycopeptides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. |
| PubMed:Studies on the selection of new matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. |
| PubMed:The study of 2,3,4-trihydroxyacetophenone and 2,4,6-trihydroxyacetophenone as matrices for DNA detection in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. |
| PubMed:Characterization of phloretin-sensitive urea export from the perfused rat liver. |
| PubMed:Instability of side-chain protecting groups during MALDI-TOF mass spectrometry of peptide fragments. |
| PubMed:In vitro inhibition of prostaglandin H synthase by compounds from the exocrine secretions of lace bugs. |
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3D/inchi