| Name: | (8R,9S,10R,13R,14S,17S)-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| CAS Number: | 379-68-0 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 206-834-3 |
| FDA UNII: | Search |
| Nikkaji Web: | J117.990J |
| Beilstein Number: | 3165102 |
| MDL: | MFCD00010486 |
| XlogP3: | 1.50 (est) |
| Molecular Weight: | 346.46690000 |
| Formula: | C21 H30 O4 |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 535.45 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 557.00 °F. TCC ( 291.70 °C. ) (est)
|
| logP (o/w): | 1.571 (est) |
| Soluble in: |
| | water, 113 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
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| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | information only not used for fragrances or flavors |
| Recommendation for 18-hydroxydesoxycorticosterone usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for 18-hydroxydesoxycorticosterone flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :64970 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| (8R,9S,10R,13R,14S,17S)-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| Chemidplus:0000379680 |
References:
| | (8R,9S,10R,13R,14S,17S)-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 64970 |
| Pubchem (sid): | 135021921 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 18,21- | dihydroxypregn-4-ene-3,20-dione | | (8R,9S,10R,13R,14S,17S)-17-(2- | hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | | | pregn-4-ene-3,20-dione, 18,21-dihydroxy- |
Articles:
| PubMed:Effect of uni-adrenalectomy on blood pressure in a patient with excessive adrenal 18-hydroxy-11-deoxycorticosterone production bilaterally. |
| PubMed:Chromatographic system for the simultaneous measurement of plasma 18-hydroxy-11-deoxycorticosterone and 18-hydroxycorticosterone by radioimmunoassay: reference data for neonates and infants and its application in aldosterone-synthase deficiency. |
| PubMed:Preclinical Cushing's syndrome due to ACTH-independent bilateral macronodular adrenocortical hyperplasia with excessive secretion of 18-hydroxydeoxycorticosterone and corticosterone. |
| PubMed:Candidate genes in the regulation of Na+ transport by inner medullary collecting duct cells from Dahl rats. |
| PubMed:Acute stress effects on the adrenal cortex in the rat. A biochemical and immunohistochemical study. |
| PubMed:Adrenal tumor producing 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone and aldosterone. |
| PubMed:A two cell type theory for aldosterone biosynthesis: the roles of 11 beta-hydroxylase and aldosterone synthase, and a high capacity tightly binding steroid carrier for 18-hydroxydeoxycorticosterone in rat adrenals. |
| PubMed:Cortisol: a tool to study aldosterone biosynthesis in rats. |
| PubMed:Thyrotropin-releasing hormone inhibits glucocorticoid secretion of rat adrenal cortex: in vivo and in vitro studies. |
| PubMed:In vitro glucocorticosteroid and mineralocorticosteroid biosynthesis in Conn's adenoma tissues. |
| PubMed:A case of weak mineralocorticoid-producing benign adrenal tumor. |
| PubMed:Origin of aldosterone in trypsin-stimulated rat adrenal zona glomerulosa incubations. |
| PubMed:Effects of prolonged sodium restriction on the morphology and function of rat adrenocortical autotransplants. |
| PubMed:Inappropriate elevation of the aldosterone/plasma renin activity ratio in hypertensive patients with increases of 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone: a subtype of essential hypertension? |
| PubMed:[18-Hydroxycorticosterone, 18-hydroxydesoxycorticosterone. Why, when, how to determine plasma levels in some adrenal pathologies]. |
| PubMed:Regulation of mineralocorticoid secretion by the superfused fetal monkey adrenal gland: lack of stimulation of aldosterone by ACTH. |
| PubMed:Plasma levels of aldosterone precursors (including the 18-hydroxylated compounds in this synthesis pathway)--a tool for the analysis of adrenal disorders? |
| PubMed:Trend analysis of serum progesterone, deoxycorticosterone, deoxycorticosterone sulfate, cortisol, corticosterone, 18-hydroxydeoxycorticosterone and estradiol in early neonates. |
| PubMed:[Hypertensinogenic steroid]. |
| PubMed:Studies on the mechanisms of ACTH-induced inhibition of aldosterone biosynthesis in the rat adrenal cortex. |
| PubMed:Influence of an enriched dietary sodium chloride regime during gestation and suckling and post-natally on the ontogeny of hypertension in the rat. |
| PubMed:[A case of bilateral adrenocortical nodular hyperplasia with hypertension, hypokalemia, and elevated serum 18-OH-DOC levels]. |
| PubMed:Diagnostic performance of basal free cortisol/18-hydroxy-11-deoxycorticosterone (18-OH-DOC) ratio in endogenous depression: comparison with the dexamethasone suppression test. |
| PubMed:Rats with regenerating adrenals are more hypertensive in the morning than afternoon. |
| PubMed:Suppression of adrenal renin in Dahl salt-sensitive rats. |
| PubMed:Effects of 18-hydroxydeoxycorticosterone on central nervous system excitability. |
| PubMed:Synthesis of 18,19-dihydroxycorticosterone. |
| PubMed:Regulation of 11 beta/18-steroid hydroxylation in newborn rat adrenal cells in primary culture. |
| PubMed:Male pseudohermaphroditism due to multiple defects in steroid-biosynthetic microsomal mixed-function oxidases. A new variant of congenital adrenal hyperplasia. |
| PubMed:Adrenocortical factors in hypertension. |
| PubMed:Multiple-sites of inhibition by intravenous metyrapone of human adrenal steroidogenesis. |
| PubMed:[The effect of ketoconazole and some other inhibitors of steroidogenesis on P-450 11 beta-catalyzed reactions]. |
| PubMed:19-Hydroxylation of 18-hydroxy-11-deoxycorticosterone by adrenal mitochondria prepared from various animal species. |
| PubMed:Mineralocorticoid properties of potential metabolites of 18-hydroxydeoxycorticosterone and 18-hydroxyprogesterone. |
| PubMed:[Physiological regulation and clinical significance of 18-hydroxy-11-deoxycorticosterone]. |
| PubMed:The role of ACTH in determining the metabolic pathways of deoxycorticosterone by newborn rat adrenal cells in primary culture. |
| PubMed:Evidence for endogenous dopaminergic control of mineralocorticoids secretion in normal subjects and in patients with hyperaldosteronism. |
| PubMed:alpha-MSH analogues and adrenal zona glomerulosa function. |
| PubMed:18,19-Dihydroxydeoxycorticosterone, a new metabolite produced from 18-hydroxydeoxycorticosterone by cytochrome P-450(11) beta. Chemical synthesis and structural analysis by 1H NMR. |
| PubMed:[Etiological studies of essential hypertension. B. Steroid hormones other than aldosterone]. |
| PubMed:Effect of metoprolol on 24-hour urinary excretion of adrenal steroids and kallikrein in patients with essential hypertension. |
| PubMed:[The role of endogenous dopamine on mineralocorticoids secretion in normal subjects, patients with primary aldosteronism, and idiopathic hyperaldosteronism]. |
| PubMed:Aldosterone effects on water and electrolyte metabolism. |
| PubMed:Acquired primary hypoaldosteronism due to an isolated zona glomerulosa defect. |
| PubMed:Affinity of 18,19-dihydroxydeoxycorticosterone and 18-hydroxy-19-nor-deoxycorticosterone to aldosterone receptor and their mineralocorticoid activity. |
| PubMed:Stimulation of sodium transport by toad skin incubated with natural derivatives of corticosterone and deoxycorticosterone. |
| PubMed:Impaired mineralocorticoid hormone responses to adrenocorticotropin stimulation: additional characterization of heterozygosity for the 21-hydroxylase deficiency type of congenital adrenal hyperplasia. |
| PubMed:Corticosteroid regulation of electrolytes. |
| PubMed:19-Hydroxylation of 18-hydroxy-11-deoxycorticosterone catalyzed by cytochrome P-45011 beta of bovine adrenocortex. |
| PubMed:Distinctive plasma aldosterone, 18-hydroxycorticosterone, and 18-hydroxydeoxycorticosterone profile in the 21-, 17 alpha-, and 11 beta-hydroxylase deficiency types of congenital adrenal hyperplasia. |
| PubMed:Relationship of 19-nor-deoxycorticosterone to other mineralocorticoids in low-renin hypertension. |
| PubMed:17 alpha-hydroxylase deficiency: mineralocorticoid hormone profiles in an affected family. |
| PubMed:Origins of the differences in function of rat adrenal zona glomerulosa cells incubated as intact tissue and as collagenase-prepared cell suspensions. |
| PubMed:A paradigm for identification of primary genetic causes of hypertension in rats. |
| PubMed:[Role of gonadotropins in the biosynthesis of corticosteroids measured in the blood of the adrenal vein in castrated rats]. |
| PubMed:Clinical and biochemical features of patients with aldosterone-producing adenoma and idiopathic hyperaldosteronism. |
| PubMed:Adrenocortical hormones, ageing and mental condition: seasonal and circadian rhythms of plasma 18-hydroxy-11-deoxycorticosterone, total and free cortisol and urinary corticosteroids. |
| PubMed:18,19-dihydroxydeoxycorticosterone; a novel product of cytochrome P-45011 beta-catalyzed reaction. |
| PubMed:Gonadectomy-induced reduction of blood pressure in adult spontaneously hypertensive rats. |
| PubMed:Rapid increase of mineralocorticoids after furosemide in low-renin essential hypertension: evidence for 18-hydroxycorticosterone to be a better marker than aldosterone. |
| PubMed:The unique patterns of plasma aldosterone and 18-hydroxycorticosterone concentrations in the 17 alpha-hydroxylase deficiency syndrome. |
| PubMed:Role of adrenal steroidogenesis in etiology of hypertension in the spontaneously hypertensive rat. |
| PubMed:Adrenal circadian system in young and elderly human subjects: a comparative study. |
| PubMed:The effect of ACTH stimulation on plasma steroids in two patients with congenital hypoaldosteronism and in their relatives. |
| PubMed:The mineralocorticoid hormone pathways in hypertension with hyperaldosteronism. |
| PubMed:Regulation of the mineralocorticoid hormones in adrenocortical disorders with adrenocorticotropin excess. |
| PubMed:Steroidogenic and glycolytic responses to nucleotides, nucleosides and steroids in rodent adrenal glands: opposing, species-dependent effects of cyclic GMP. |
| PubMed:Metoclopramide, a dopamine antagonist, stimulates aldosterone secretion in rhesus monkeys but not in dogs or rabbits. |
| PubMed:Synthesis and mass spectrometric analysis of hexahydrogenated products of aldosterone, 18-hydroxycorticosterone and 18-hydroxy-11-deoxycorticosterone. |
| PubMed:Studies on the mechanism of secretion of corticosteroids by the isolated perfused adrenal of the rat. |
| PubMed:The zonal origins of the mineralocorticoid hormones in the 21-hydroxylation deficiency of congenital adrenal hyperplasia. |
| PubMed:The relationship between plasma 18-hydroxy-11-deoxycorticosterone levels and production of hypertension in the rat. |
| PubMed:Effects of prolonged ACTH treatment on adrenal steroidogenesis and blood pressure in rats. |
| PubMed:Adrenal glomerulosa function in patients with dexamethasone-suppressible hyperaldosteronism. |
| PubMed:A simultaneous radioimmunoassay for aldosterone and its precursors: human plasma levels following the inhibition of converting enzyme, before and after blockade of prostaglandin biosynthesis. |
| PubMed:Mineralocorticoid response to low dose adrenocorticotropin infusion. |
| PubMed:Uptake and binding of [3H]aldosterone by the anterior pituitary and brain regions in adrenalectomized rats. |
| PubMed:Endocrine mechanisms in the pathogenesis of essential hypertension. III. Special reference on the interrelations between the prostaglandin and kallikrein-kinin systems. |
| PubMed:18-hydroxy-11-deoxycorticosterone response to ACTH, insulin and furosemide administration in essential hypertensive patients. |
| PubMed:Isolated aldosterone deficiency in man: acquired and inborn errors in the biosynthesis or action of aldosterone. |
| PubMed:[Current study possibilities of the hypothalamo-hypophyseal-adrenal axis and clinical applications]. |
| PubMed:Effect of prolonged infusions of angiotensin II on eight serum corticosteroids in man on different sodium diets. |
| PubMed:Peripheral plasma steroid concentrations in rats sacrificed by anoxia. |
| PubMed:Studies on the mechanism of secretion of rat adrenal steroids in vitro. |
| PubMed:Subcellular distribution of steroids in the rat adrenal cortex after incubation in vitro. |
| PubMed:Paper chromatographic systems for the separation of aldosterone, 18-hydroxycorticosterone, 18-hydroxydeoxycorticosterone, corticosterone and deoxycorticosterone. |
| PubMed:Long term spironolactone and the adrenal cortex in essential hypertension. |
| PubMed:Plasma concentrations of 18-hydroxy-11-deoxycorticosterone and 18-hydroxycorticosterone simultaneously measured in normal subjects and adrenocortical disorders. |
| PubMed:Parallelism of 11 beta- and 18-hydroxylation demonstrated by urinary free hormones in man. |
| PubMed:[Role of the anterior pituitary gland in the regulation of 18-hydroxydesoxycorticosterone by the adrenal cortex]. |
| PubMed:Characterisation of an adrenal zona glomerulosa-stimulating component of posterior pituitary extracts as alpha-MSH. |
| PubMed:Development and characterization of antisera to 18-hydroxycorticosterone and 18-hydroxy-11-deoxycorticosterone and radioimmunoassay for serum 18-hydroxycorticosterone. |
| PubMed:The conversion of 18-hydroxycorticosterone and 18-hydroxy-11-deoxycorticosterone to aldosterone by rat adrenal tissue: evidence for an alternative biosynthetic pathway. |
| PubMed:11 beta-hydroxylation of 18-hydroxy-11-deoxycorticosterone by rat adrenal tissue: zone specificity and effect of sodium and potassium restriction. |
| PubMed:Hypertension of childhood with suppressed renin. |
| PubMed:Adrenocorticotropin inhibition of mineralocorticoid hormone production. |
| PubMed:The effect of angiotensin II and saralasin on 18-hydroxy-11-deoxycorticosterone production by isolated human adrenal glomerulosa cells. |
| PubMed:Secretion of corticosteroids by the perfused rat adrenal cortex [proceedings]. |
| PubMed:Radioimmunoassay of plasma 18-hydroxy-11-deoxycorticosterone and its response to ACTH. |
| PubMed:[Mineralocorticoid excess in essential hypertension]. |
| PubMed:Urinary metabolites of 18-hydroxylated corticosteroids: microbial preparation of reference compounds. |
| PubMed:In vitro biosynthesis of 18-hydroxy-11-deoxycorticosterone from deoxycorticosterone by human adrenal glands removed from patients with hypercorticism. |
| PubMed:Steroid profiles formed by rat adrenocortical whole tissue and cell suspensions under different conditions of stimulation. |
| PubMed:[Hormonal changes in shock]. |
| PubMed:[Deviation in steroid hormone secretion in essential hypertension]. |
| PubMed:Different biological action of corticosteroids, corticosterone and cortisol, as a base of zonal function of adrenal cortex. |
| PubMed:Adrenocorticosteroids in experimental and human hypertension. |
| PubMed:Evidence of adrenal 18-hydroxylase inhibition by metyrapone in man. |
| PubMed:Serum corticosteroids at the high and low points of the circadian rhythm in rats with regenerating adrenals. |
| PubMed:Serum levels of corticosterone and 18-hydroxy-11-deoxycorticosterone in the female rat at the high and low points of the circadian rhythm. |
| PubMed:Corticosteroid transfer from rat fetuses injected with 4-14C progesterone to acutely and chronically adrenalectomized mothers. |
| PubMed:18-substituted steroids. Part 4. A chemical synthesis of 3 alpha,18,21-trihydroxy-5 beta-pregnan-20-one 18--20-hemiacetal (18-hydroxy-tetrahydro-DOC). |
| PubMed:Arterial levels and mineralocorticoid activity of 18-hydroxy-11-deoxycorticosterone in the rat. |
| PubMed:Fetal rat adrenal growth and steroidogenesis in vitro after maternal dexamethasone treatment. |
| PubMed:18-Hydroxy-11-deoxycorticosterone in hypertensive uremic patients during hemodialysis. |
| PubMed:[A review on hypertension with hypokalemia (continued) (author's transl)]. |
| PubMed:18-Hydroxy-11-deoxycorticosterone response to insulin in normal man. |
| PubMed:Studies on the distribution of steroid between medium and tissue after incubation of rat adrenal glands in vitro [proceedings]. |
| PubMed:Diurnal 18-hydroxy-11-deoxycorticosterone pattern in human stable hypertension. |
| PubMed:Urinary free 18-hydroxy-11-desoxycorticosterone excretion in normal and hypertensive patients. |
| PubMed:The use of high-pressure liquid chromatography in the simultaneous assay of 11beta-hydroxylase and 18-hydroxylase in zona fasciculata-reticularis tissue of the rat adrenal cortex. |
| PubMed:Radioimmunoassay of free urinary 18-hydroxydeoxycorticosterone (18-OH-DOC) in patients with essential hypertension. |
| PubMed:Stimulation of 18-hydroxy-11-deoxycorticosterone secretion by angiotensin II and potassium. |
| PubMed:Experimental hypertension and other responses to 18-hydroxy-deoxycorticosterone treatment in the rat. |
| PubMed:Adrenal steroidogenesis in methylandrostenediol-induced hypertension. |
| PubMed:Effect of aminoglutethimide on blood pressure and steroid secretion in patients with low renin essential hypertension. |
| PubMed:The effect of sex and strain of rats on the in vitro response of adrenocortical tissue of ACTH stimulation. |
| PubMed:Plasma levels of 18-hydroxy-11-deoxycorticosterone in essential hypertension. |
| PubMed:[Effect of acid polysaccharides on the corticosteroid biosynthesis]. |
| PubMed:24 hour profile of 18-hydroxy-11-deoxycorticosterone in normal supine man: relationship with cortisol and aldosterone. |
| PubMed:Effects of dibutyryl cyclic AMP, cyclic GMP, and calcium and magnesium ions on the steroid profile formed by rat adrenal tissue incubated in vitro [proceedings]. |
| PubMed:A radioimmunoassay of plasma 18-hydroxy-11-deoxycorticosterone. |
| PubMed:Simultaneous determination of plasma 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone, and aldosterone in man. |
| PubMed:Regulation of 18-hydroxydeoxycorticosterone in the rat. |
| PubMed:Estimation of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) in human plasma and urine including a comparison of various techniques. |
| PubMed:Plasma 18 hydroxy--II--deoxycorticosterone in dialysis patients with headache. |
| PubMed:Clinical, biochemical and pathological features of low-renin ("primary") hyperaldosteronism. |
| PubMed:A non-chromatographic radioimmunoassay of 18-hydroxy-11-deoxycorticosterone in human plasma. |
| PubMed:18-hydroxycorticosterone: a review. |
| PubMed:Relationship of basal plasma norepinephrine to blood pressure, plasma renin activity, mineralocorticoids, and plasma volume in essential hypertension. |
| PubMed:Aldosterone diagnosis in hypertension: comparative evaluation of radioimmunoassays for urinary aldosterone and 18-OH-corticosterone. |
| PubMed:Plasma mineralocorticoids, plasma renin, and urinary kallikrein in salt-sensitive and salt-resistant rats. |
| PubMed:Gas chromatographic determination of 18-hydroxy-11-deoxycorticosterone. |
| PubMed:The effect of chronic ACTH treatment on blood pressure and urinary excretion of steroids in the rat. |
| PubMed:Biosynthesis of aldosterone from 18-hydroxylated precursors by rat adrenal tissue in vitro. |
| PubMed:Urine electrolyte response to 18-hydroxy-11-deoxycorticosterone in normal man. |
| PubMed:Sex differences in corticosteroids in man. |
| PubMed:Plasma concentration of aldosterone, 18-hydroxy-deoxycorticosterone and cortisol in adrenal veins of patients with low-renin hypertension. |
| PubMed:[The measurement of plasma 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) levels by radioimmunoassay (author's transl)]. |
| PubMed:Role of 18-hydroxy-11-deoxycorticosterone and 16 alpha, 18-dihydroxy-11-deoxycorticosterone in hypertension. |
| PubMed:Mineralocorticoid hypertension in childhood. |
| PubMed:The role of the adrenal cortex in human essential hypertension: keynote address. |
| PubMed:Quantitative determination of 18-hydroxydeoxycorticosterone and corticosterone by high pressure liquid chromatography. |
| PubMed:Pathogenic significance of adrenocortical hormones in essential hypertension. |
| PubMed:[Importance of the simultaneous estimation of aldosterone, 18-hydroxy-11-deoxycorticosterone and cortisol in the adrenal veins in arterial hypertension with suppressed renin (author's transl)]. |
| PubMed:Evidence for an unidentified ACTH-induced steroid hormone causing hypertension. |
| PubMed:Corticosterone, 18-OH-deoxycorticosterone, deoxycorticosterone and aldosterone secretion in tissue culture of foetal rat adrenals in the presence and the absence of ACTH. |
| PubMed:Adrenocortical factors in hypertension. I. Significance of 18-hydroxy-11-deoxycorticosterone. |
| PubMed:New mineralocorticoids and adrenocorticosteroids in hypertension. |
| PubMed:Antihypertensive action of 18,20-cyclo-20,21-dihydroxy-4-pregnen-3-one, a structural analogue of 18-hydroxydeoxycorticosterone. |
| PubMed:Functionalization of a steroidal C-18 angular methyl group using a 21,20-chlorohydrin. |
| PubMed:Radioimmunoassay of 18-hydroxy-11-deoxycorticosterone in plasma. |
| PubMed:Tritiated 18-hydroxydeoxycorticosterone: binding in renal, cardiac and hepatic cytoplasm, and in plasma from adrenalectomized rats. |
| PubMed:Differential binding to renal receptor subpopulations as an explanation of mineralocorticoid agonist action. |
| PubMed:Simultaneous determination of plasma aldosterone, corticosterone, 11-deoxycorticosterone, 18-hydroxydeoxycorticosterone, cortisol, and 11-deoxycortisol. Methods and applications. |
| PubMed:Comparison of the ultrastructural and steroidogenic properties of mitochondria of fetal rat adrenals in tissue culture. A morphometric and a gas chromatographic analysis. |
| PubMed:Effects of corticosterone on adrenocorticotrophin-induced mitochondrial differentiation with special reference to 11 beta- and 18-hydroxylation. |
| PubMed:Unusual low plasma renin hypertension in a child. |
| PubMed:18-Hydroxy-11-deoxycorticosterone. Chemical synthesis, structure, and circular dichroism. |
| PubMed:The regulation of plasma 18-hydroxy 11-deoxycorticosterone in man. |
| PubMed:Proceedings: Effects of 18-hydroxydeoxycorticosterone on stress-induced release of corticotrophin. |
| PubMed:16alpha, 18-Dihydroxydeoxycorticosterone and the binding of aldosterone to mineralocorticoid receptors in kidney of adrenalectomized rats. |
| PubMed:Mineralocorticoid like effect of new 18-hydroxy-steroid isolated from urine of hypertensive patients. |
| PubMed:18-hydroxylated steroids in human hypertension - clinical study. |
| PubMed:Structure and mechanism of formation of the two forms of 18-hydroxy-11-deoxycorticosterone. |
| PubMed:The measurement of 18-hyroxy-11-deoxycorticosterone in human plasma by radioimmunoassay. |
| PubMed:Microbiological synthesis of 16alpha, 18-dihydroxydeoxycorticosterone. |
| PubMed:[Radioimmunoassay of 18-hydroxy-11-desoxycorticosterone (18-OH-DOC). Preliminary studies]. |
| PubMed:Separation and characterization of the reduced metabolites of the 18-hydroxydeoxycorticosterone hormone by gas-liquid chromatography-mass spectrometry. Occurrence of stereoisomeric forms in rat adrenals and liver. |
| PubMed:[Determination of 18-hydroxy-11-desoxycorticosterone in adrenal venous blood by gas chromatography (author's transl)]. |
| PubMed:Production and characterisation of antisera to 18-hydroxy-11-deoxycorticosterone. |
| PubMed:Aldosterone and renin in essential hypertension. |
| PubMed:Proceedings: Synthesis of 18-oxygenated steroids in the rat adrenal cortex. |
| PubMed:Effect of intravenous infusion of corticosteroids on blood pressure, electrolytes, and water metabolism in sheep. |
| PubMed:Adrenal steroidogenesis in "low renin" or hyporeninemic hypertension. |
| PubMed:Dynamic aldosterone and 18-hydroxydeoxycorticosterone studies in labile and stable benign essential hypertension. |
| PubMed:[Mode of action of mineralocorticoides: their binding with transcortin and cytoselic renal receptors]. |
| PubMed:Use of corticosteroid antibodies for the study of corticosteroid biosynthesis in vitro. |
| PubMed:Molecular configuration and conformation of aldosterone, 18-hydroxy-11-deoxycorticosterone and a new urinary 18-hydroxy-steroid--an N.M.R. study. |
| PubMed:Synthesis of 11-deoxy-hydroxycorticosterone and 18-hydroxycorticosterone 21-acetates. |
| PubMed:Synthesis of 18-substituted steroids. Part I. 18,21-Dihydroxypregn-4-ene-3,20-dione (18-hydroxydeoxycorticosterone). |
| PubMed:Improved synthesis of 18-hydroxydeoxycorticosterone. |
| PubMed:The role of adrenocortical hormones in ACTH-induced hypertension. |
| PubMed:[Cortisol metabolism in simians]. |
| PubMed:A sensitive assay of 18-hydroxydesoxycorticosterone and aldosterone by gas chromatography with electron capture detection. |
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