EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

12-hydroxystearic acid
octadecanoic acid, 12-hydroxy-


Name:12-hydroxyoctadecanoic acid
CAS Number: 106-14-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-366-1
Nikkaji Web:J48.641H
Beilstein Number:1726730
XlogP3:6.50 (est)
Molecular Weight:300.48252000
Formula:C18 H36 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
DG SANTE Food Contact Materials:12-hydroxystearic acid
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 82.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 436.28 °C. @ 760.00 mm Hg (est)
Vapor Pressure:1.940000 mm/Hg @ 25.00 °C. (est)
Flash Point: 449.00 °F. TCC ( 231.80 °C. ) (est)
logP (o/w): 5.767 (est)
Soluble in:
 water, 0.3315 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: cleansing agents
emulsifying agents
12-Hydroxy Stearic Acid
Odor: characteristic
Use: Intermediate, Activator / Accelerator. Ingredient in Lithium Grease and Lithium Complex Grease. Also used in Personal Care Products as an Emollient and in Underarm Deodorants.
BOC Sciences
For experimental / research use only.
12-Hydroxystearic acid technical
CFC Scientific
12-Hydroxystearic acid, 98+ %
12-Hydroxystearic Acid
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
12-Hydroxystearic Acid 95%
Sigma-Aldrich: Aldrich
For experimental / research use only.
12-Hydroxystearic Acid 99%
For experimental / research use only.
12-Hydroxystearic Acid >80.0%(GC)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
Category: cosmetic agents
Recommendation for 12-hydroxystearic acid usage levels up to:
 not for fragrance use.
Recommendation for 12-hydroxystearic acid flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
NLM Hazardous Substances Data Bank:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):106-14-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7789
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
12-hydroxyoctadecanoic acid
RTECS:WI3850000 for cas# 106-14-9
 12-hydroxyoctadecanoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:106-14-9
Pubchem (cid):7789
Pubchem (sid):134971492
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2918.19.9000
Household Products:Search
RSC Learn Chemistry:View
Potential Blenders and core components note
None Found
Potential Uses:
 emulsifying agents
Occurrence (nature, food, other):note
 not found in nature
 harwax A
 hydrofol acid 200
12-hydroxy stearic acid
DL-12-hydroxy stearic acid
12-hydroxy-octadecanoic acid
12-hydroxyoctadecanoic acid
 hydroxystearic acid
DL-12-hydroxystearic acid
 loxiol G 21
 octadecanoic acid, 12-hydroxy-
 stearic acid, 12-hydroxy-


PubMed:Allergic contact dermatitis from 12-hydroxystearic Acid and hydrogenated castor oil.
PubMed:Synthesis of new sugar-based surfactants and evaluation of their hemolytic activities.
PubMed:Long chain oxoaldehydes and oxoalcohols from esters as major constituents of the surface lipids of Manduca sexta pupae in diapause.
PubMed:Occurrence of fatty acid chlorohydrins in jellyfish lipids.
PubMed:Aqueous dispersions of organogel nanoparticles - potential systems for cosmetic and dermo-cosmetic applications.
PubMed:Yielding and flow of solutions of thermoresponsive surfactant tubes: tuning macroscopic rheology by supramolecular assemblies.
PubMed:Interaction between surfactants and colloidal latexes in nonpolar solvents studied using contrast-variation small-angle neutron scattering.
PubMed:Poly(dimethylsiloxane)-stabilized polymer particles from radical dispersion polymerization in nonpolar solvent:influence of stabilizer properties and monomer type [corrected].
PubMed:Increased production of γ-lactones from hydroxy fatty acids by whole Waltomyces lipofer cells induced with oleic acid.
PubMed:Cooling rate effects on the microstructure, solid content, and rheological properties of organogels of amides derived from stearic and (R)-12-hydroxystearic acid in vegetable oil.
PubMed:Gelled oil particles: a new approach to encapsulate a hydrophobic metallophthalocyanine.
PubMed:Phase-selective sorbent xerogels as reclamation agents for oil spills.
PubMed:Lipid-based microtubes for topical delivery of amphotericin B.
PubMed:Thermoreversible luminescent organogels doped with Eu(TTA)3phen complex.
PubMed:Nanoincorporation of layered double hydroxides into a miscible blend system of cellulose acetate with poly(acryloyl morpholine).
PubMed:Solvation effects with a photoresponsive two-component 12-hydroxystearic acid-azobenzene additive organogel.
PubMed:CriticalSorb: a novel efficient nasal delivery system for human growth hormone based on Solutol HS15.
PubMed:A structural study of an organogel investigated by small-angle neutron scattering and synchrotron small-angle X-ray scattering.
PubMed:Allergic contact dermatitis caused by bis-diglycerylpolyacyladipate-2 (Softisan® 649) owing to its 12-hydroxystearic acid content.
PubMed:Multiscale structural characterizations of fatty acid multilayered tubes with a temperature-tunable diameter.
PubMed:Revisiting the synthesis of a well-known comb-graft copolymer stabilizer and its application to the dispersion polymerization of poly(methyl methacrylate) in organic media.
PubMed:Pair interaction potentials of colloids by extrapolation of confocal microscopy measurements of collective suspension structure.
PubMed:Structural relationships in 2,3-bis-n-decyloxyanthracene and 12-hydroxystearic acid molecular gels and aerogels processed in supercritical CO(2).
PubMed:Preparation and evaluation of microporous organogel scaffolds for cell viability and proliferation.
PubMed:Characterization of organogel as a novel oral controlled release formulation for lipophilic compounds.
PubMed:Allergic contact dermatitis from 12-hydroxystearic Acid and hydrogenated castor oil.
PubMed:12-Hydroxystearic acid lipid tubes under various experimental conditions.
PubMed:Rheological characterization of a new type of colloidal dispersion based on nanoparticles of gelled oil.
PubMed:Solvent-modulated nucleation and crystallization kinetics of 12-hydroxystearic acid: a nonisothermal approach.
PubMed:Nanoengineering of a biocompatible organogel by thermal processing.
PubMed:Robust organogels from nitrogen-containing derivatives of (R)-12-hydroxystearic acid as gelators: comparisons with gels from stearic acid derivatives.
PubMed:Low molecular mass organogelator based gel electrolyte with effective charge transport property for long-term stable quasi-solid-state dye-sensitized solar cells.
PubMed:Detailed structural elucidation of polyesters and acrylates using Fourier transform mass spectrometry.
PubMed:Electrostatic charging of nonpolar colloids by reverse micelles.
PubMed:Synthesis of new sugar-based surfactants and evaluation of their hemolytic activities.
PubMed:Preparation of monodisperse, fluorescent PMMA-latex colloids by dispersion polymerization.
PubMed:Production of gamma-lactones by the brown-rot basidiomycete Piptoporus soloniensis.
PubMed:Effect of fatty acids on the membrane potential of an alkaliphilic bacillus.
PubMed:How hard is a colloidal "hard-sphere" interaction?
PubMed:Ricinoleic acid-based biopolymers.
PubMed:The phosphatidyl-myo-inositol anchor of the lipoarabinomannans from Mycobacterium bovis bacillus Calmette Guérin. Heterogeneity, structure, and role in the regulation of cytokine secretion.
PubMed:Selective inhibition of cyclic AMP-dependent protein kinase by amphiphilic triterpenoids and related compounds.
PubMed:Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance.
PubMed:Isolation of mast cells from rabbit lung and liver: comparison of histamine release induced by the hypnotics Althesin and propanidid.
PubMed:Comparison of the histamine-releasing activity of cremophor E1 and some of its derivatives in two experimental models: the in vivo anaesthetized dog and in vitro rat peritoneal mast cells.
PubMed:Long chain oxoaldehydes and oxoalcohols from esters as major constituents of the surface lipids of Manduca sexta pupae in diapause.
PubMed:The active part of the [6]-gingerol molecule in mutagenesis.
PubMed:Histamine release and hypotensive reactions in dogs by solubilizing agents and fatty acids: analysis of various components in cremophor El and development of a compound with reduced toxicity.
PubMed:Occurrence of fatty acid chlorohydrins in jellyfish lipids.
None found
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