EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes


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CAS Number: 90-15-3Picture of molecule3D/inchi
Other(deleted CASRN):50356-21-3
ECHA EINECS - REACH Pre-Reg:201-969-4
Nikkaji Web:J3.911J
Beilstein Number:1817321
XlogP3:2.80 (est)
Molecular Weight:144.17296000
Formula:C10 H8 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 94.00 to 95.00 °C. @ 760.00 mm Hg
Boiling Point: 279.00 to 280.00 °C. @ 760.00 mm Hg
Boiling Point: 142.00 to 143.00 °C. @ 10.00 mm Hg
Vapor Pressure:0.001000 mmHg @ 25.00 °C. (est)
Flash Point: 291.00 °F. TCC ( 144.00 °C. ) (est)
logP (o/w): 2.850
Soluble in:
 water, 866 mg/L @ 24C (exp)
 water, 1126 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair dyeing agents
Alfa Biotechnology
For experimental / research use only.
1-Naphthalenol 98%
BOC Sciences
For experimental / research use only.
Duloxetine EP Impurity D (1-Naphthol) > 95%
Odor: characteristic
Use: Used in the manufacturing of dyes, intermediates, synthetic perfumes.
ECSA Chemicals
EMD Millipore
For experimental / research use only.
1-Naphthol for synthesis
Glentham Life Sciences
Santa Cruz Biotechnology
For experimental / research use only.
1-Naphthol ≥99%
For experimental / research use only.
1-Naphthol ReagentPlus®, ≥99%
For experimental / research use only.
1-Naphthol >99.0%(GC)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-cat LD50 134 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 30(9), Pg. 22, 1965.

oral-guinea pig LD50 2000 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 30(9), Pg. 22, 1965.

oral-mouse LD50 275 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 30(9), Pg. 22, 1965.

oral-rabbit LD50 9000 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 30(9), Pg. 22, 1965.

unreported-rabbit LDLo 9100 mg/kg
Yakkyoku. Pharmacy. Vol. 32, Pg. 605, 1981.

intraperitoneal-rat LD50 250 mg/kg
Office of Toxic Substances Report. Vol. FYI-OTS-0885-0443

oral-rat LD50 1870 mg/kg
Office of Toxic Substances Report. Vol. FYI-OTS-0885-0443

Dermal Toxicity:
skin-rabbit LD50 880 mg/kg
American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.

Inhalation Toxicity:
inhalation-rat LC50 > 420 mg/m3/1H
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 25-4/1973

Safety in Use Information:
cosmetic agents
Recommendation for 1-naphthol usage levels up to:
 not for fragrance use.
Recommendation for 1-naphthol flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):90-15-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7005
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
RTECS:QL2800000 for cas# 90-15-3
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:90-15-3
Pubchem (cid):7005
Pubchem (sid):134970785
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
UM BBD:Search
KEGG (GenomeNet):C11714
HMDB (The Human Metabolome Database):HMDB12138
Export Tariff Code:2907.15.1000
Potential Blenders and core components note
None Found
Potential Uses:
 hair dyeing agents
Occurrence (nature, food, other):note
 not found in nature
 walnut black walnut oil
Search Trop Picture
 C.I. oxidation base 33
 CI oxidation base 33
 durafur developer D
 fouramine ERN
 fourrine 99
 fourrine ERN
 furro ER
 molisch's reagent
 nako TRB
a-naphthyl alcohol
 tertral ERN
 ursol ERN
 zoba ERN


PubMed:HCR-stimulated formation of DNAzyme concatamers on gold nanoparticle for ultrasensitive impedimetric immunoassay.
PubMed:Tyramine-based enzymatic conjugate repeats for ultrasensitive immunoassay accompanying tyramine signal amplification with enzymatic biocatalytic precipitation.
PubMed:Metabolism of chamaechromone in vitro with human liver microsomes and recombinant human drug-metabolizing enzymes.
PubMed:DNAzyme-functionalized gold-palladium hybrid nanostructures for triple signal amplification of impedimetric immunosensor.
PubMed:Graphene oxide-labeled sandwich-type impedimetric immunoassay with sensitive enhancement based on enzymatic 4-chloro-1-naphthol oxidation.
PubMed:Characterization of modified high-amylose maize starch-α-naphthol complexes and their influence on rheological properties of wheat starch.
PubMed:Rapid determination of nitrites in food using a diffuse UV-visible reflectance method.
PubMed:Excretion profiles and half-lives of ten urinary polycyclic aromatic hydrocarbon metabolites after dietary exposure.
PubMed:Ionic liquid-based dispersive liquid-liquid microextraction with back-extraction coupled with capillary electrophoresis to determine phenolic compounds.
PubMed:Inhibitory effects of naphthols on the activity of mushroom tyrosinase.
PubMed:Assessment of polyaromatic hydrocarbon degradation by potentially pathogenic environmental Vibrio parahaemolyticus isolates from coastal Louisiana, USA.
PubMed:Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4.
PubMed:Multi-enzyme inhibition assay for the detection of insecticidal organophosphates and carbamates by high-performance thin-layer chromatography applied to determine enzyme inhibition factors and residues in juice and water samples.
PubMed:[Effect of naphthalene and its derivatives on Candida pseudotropicalis 44 PK sensitivity to trichothecene mycotoxins].
PubMed:Speciation and separation of Cr(VI) and Cr(III) using coprecipitation with Ni2+/2-Nitroso-1-naphthol-4-sulfonic acid and determination by FAAS in water and food samples.
PubMed:Surfactant effects on the affinity of plant cuticles with organic pollutants.
PubMed:Pomegranate juice inhibits sulfoconjugation in Caco-2 human colon carcinoma cells.
PubMed:[Determination of aniline in water by flow injection spectrophotometry].
PubMed:Effect of breed upon cytochromes P450 and phase II enzyme expression in cattle liver.
PubMed:SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens.
PubMed:Disposable electrochemical genosensor for the simultaneous analysis of different bacterial food contaminants.
PubMed:Liquid chromatographic determination of N-methyl carbamate pesticide residues at low parts-per-billion levels in eggs.
PubMed:Comparison of hydrolytic and conjugative biotransformation pathways in horse, cattle, pig, broiler chick, rabbit and rat liver subcellullar fractions.
PubMed:Hydrolysis of carbaryl by carbonate impurities in reference clay SWy-2.
PubMed:Application of micellar electrokinetic capillary chromatography to the analysis of uncharged pesticides of environmental impact.
PubMed:Oligonucleotide-modified screen-printed gold electrodes for enzyme-amplified sensing of nucleic acids.
PubMed:A colony blot immunoassay for the rapid identification of Bacillus cereus.
PubMed:An analytical device for on-site immunoassay. Demonstration of its applicability in semiquantitative detection of aflatoxin B1 in a batch of samples with ultrahigh sensitivity.
PubMed:A simple method for the determination of carbaryl and 1-naphthol in fruit juices by high-performance liquid chromatography-diode-array detection.
PubMed:Naphthalene--an environmental and occupational toxicant.
PubMed:Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile.
PubMed:Investigation of the relation between self-reported food consumption and household chemical exposures with urinary levels of selected nonpersistent pesticides.
PubMed:Oxidation of carbaryl in aqueous solution by membrane anodic fenton treatment.
PubMed:Purification and characterization of acetyl esterase from Candida guilliermondii.
PubMed:Kuwait's total diet study: dietary intake of organochlorine, carbamate, benzimidazole and phenylurea pesticide residues.
PubMed:A study for the proper application of urinary naphthols, new biomarkers for airborne polycyclic aromatic hydrocarbons.
PubMed:Spectrophotometric determination of carbaryl pesticide and its hydrolysis product in soil and strawberry samples.
PubMed:A simple colony-blot method for identification of Listeria in food samples.
PubMed:Detection of exo-beta-1,3-glucanase activity in polyacrylamide gels after electrophoresis under denaturing or nondenaturing conditions.
PubMed:Effects of 1-isothiocyanato-3-(methylsulfinyl)-propane on xenobiotic metabolizing enzymes in rats.
PubMed:Evidence for an NIH shift in oxidation of naphthalene by the marine cyanobacterium Oscillatoria sp. strain JCM.
PubMed:Degradation of carbaryl in natural waters: enhanced hydrolysis rate in micellar solution.
PubMed:Disposition of 1-naphthol in the channel catfish (Ictalurus punctatus).
PubMed:Identification of [14C]carmoisine metabolites in bacterial suspension of rat faeces.
PubMed:Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation.
PubMed:1-Naphthol--single and repeated dose (30-day) oral toxicity studies in the mouse.
PubMed:Effects of the fungicide prochloraz on xenobiotic metabolism in rainbow trout: in vivo induction.
PubMed:Multigeneration reproduction and carcinogenicity studies in Sprague-Dawley rats exposed topically to oxidative hair-colouring formulations containing p-phenylenediamine and other aromatic amines.
PubMed:Effects of dietary zinc deficiency on the activity of enzymes associated with phase I and II of drug metabolism in Fischer-344 rats: activities of drug metabolising enzymes in zinc deficiency.
PubMed:Metabolic disposition of 14C-labelled carmoisine in the rat, mouse and guinea-pig.
PubMed:Metabolism of zearalenone by sow intestinal mucosa in vitro.
PubMed:Glucuronidation of morphine and six beta 2-sympathomimetics in isolated rat intestinal epithelial cells.
PubMed:Effects of semisynthetic diets on xenobiotic metabolizing enzyme activity and morphology of small intestinal mucosa in humans.
PubMed:Glucuronidation in the reindeer: dietary modification in the UDP-glucuronosyltransferase activity with 4-nitrophenol, 1-naphthol and phenolphthalein as acceptors.
PubMed:Preparative separation of alpha- and beta-naphthols catalyzed by immobilized sulfatase.
PubMed:Bacterial metabolism of 1-naphthol.
PubMed:Automated steam distillation and fluorometry for screening for carbaryl as 1-naphthol in fruits and vegetables.
PubMed:Degradation of 1-naphthol in sea water.
PubMed:[Determination of residual amounts of sevin and 1-naphthol in the blood and milk of cows].
1-Naphthol, or ?-naphthol, is a colorless crystalline solid with the formula C10H7OH. It is an isomer of 2-naphthol differing by the location of the hydroxyl group on naphthalene. The naphthols are naphthalene homologues of phenol, with the hydroxyl group being more reactive than in the phenols. Both isomers are soluble in simple alcohols, ethers, and chloroform. They can be used in the production of dyes and in organic synthesis.; 1-naphthol (1N) is a metabolite of carbaryl and naphthalene that is an intermediate in Metabolism of xenobiotics by cytochrome P450. It is generated by spontaneous reaction from (1R,2S)-Naphthalene epoxide then is it converted to 1,4-Dihydroxynaphthalene. Although 1-Naphthol is not persistent in the body, a single urine sample may adequately predict exposure over several months to chlorpyrifos, which is a broad-spectrum organophosphate insecticide. In adult men, TCPY and 1N were associated with reduced testosterone levels (PMID: 16357596, 15579421)
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