EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

p-phenylenediamine
4-phenylenediamine

Supplier Sponsors

Name:benzene-1,4-diamine
CAS Number: 106-50-3Picture of molecule3D/inchi
Other(deleted CASRN):56481-76-6
ECHA EINECS - REACH Pre-Reg:203-404-7
FDA UNII: U770QIT64J
Nikkaji Web:J4.035E
Beilstein Number:749029
MDL:MFCD00007901
XlogP3:-0.30 (est)
Molecular Weight:108.14376000
Formula:C6 H8 N2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:hair dyeing agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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NCBI:Search
FDA Mainterm (IAUFC):106-50-3 ; P-PHENYLENEDIAMINE
 
Physical Properties:
Appearance:white to purple crystalline solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 146.00 °C. @ 760.00 mm Hg
Boiling Point: 267.00 °C. @ 760.00 mm Hg
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): -0.300
Soluble in:
 water, 3.70E+04 mg/L @ 23C (exp)
 water, 1.99e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair dyeing agents
 
Suppliers:
ECSA Chemicals
P-PHENYLENEDIAMINE
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
EMD Millipore
For experimental / research use only.
1,4-Phenylenediamine
sds
Santa Cruz Biotechnology
For experimental / research use only.
1,4-Phenylenediamine
Sigma-Aldrich: Aldrich
For experimental / research use only.
p-Phenylenediamine sublimed, ≥99%
sds
TCI AMERICA
For experimental / research use only.
p-Phenylenediamine >98.0%(GC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-bird - wild LD50 100 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.

oral-cat LDLo 100 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.

intravenous-dog LDLo 17 mg/kg
Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.

oral-guinea pig LD50 145 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(7), Pg. 62, 1988.

unreported-guinea pig LD50 145 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 46, 1987.

oral-man TDLo 71 mg/kg
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE WEAKNESS
Human Toxicology. Vol. 8, Pg. 345, 1989.

intraperitoneal-mouse LD50 50 mg/kg
National Technical Information Service. Vol. AD277-689

unreported-mouse LD50 331 mg/kg
BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(6), Pg. 78, 1985.

oral-mouse LDLo 100 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 23(5), Pg. 14, 1958.

oral-quail LD50 100 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.

intraperitoneal-rabbit LDLo 150 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Infectious Diseases. Vol. 42, Pg. 473, 1928.

intravenous-rabbit LDLo 300 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Archives of Internal Medicine. Vol. 36, Pg. 724, 1925.

oral-rabbit LDLo 250 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.

intraperitoneal-rat LD50 37 mg/kg
Journal of Toxicology and Environmental Health. Vol. 2, Pg. 657, 1977.

oral-rat LD50 80 mg/kg
Journal of Toxicology and Environmental Health. Vol. 2, Pg. 657, 1977.

unreported-rat LD50 133 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 46, 1987.

intravenous-rat LDLo 50 mg/kg
Bulletin de la Societe Royale des Sciences de Liege. Vol. 41, Pg. 302, 1972.

Dermal Toxicity:
subcutaneous-dog LDLo 100 mg/kg
BEHAVIORAL: COMA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING
U.S. Public Health Service, Public Health Bulletin. Vol. 271, Pg. 40, 1941.

subcutaneous-mouse LDLo 140 mg/kg
Journal of the Society of Cosmetic Chemists. Vol. 12, Pg. 500, 1961.

skin-rabbit LDLo 5000 mg/kg
Journal of Toxicology and Environmental Health. Vol. 2, Pg. 657, 1977.

subcutaneous-rabbit LDLo 200 mg/kg
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.

subcutaneous-rat LDLo 170 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.

Inhalation Toxicity:
inhalation-rat LC50 920 mg/m3/4H
KIDNEY, URETER, AND BLADDER: HEMATURIA BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: NAUSEA OR VOMITING
National Technical Information Service. Vol. OTS0530403
 
Safety in Use Information:
Category:
hair dyeing agents
Recommendation for p-phenylenediamine usage levels up to:
 not for fragrance use.
 
Recommendation for p-phenylenediamine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Daily Med:search
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):106-50-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7814
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:3
benzene-1,4-diamine
Chemidplus:0000106503
EPA/NOAA CAMEO:hazardous materials
RTECS:106-50-3
 
References:
 benzene-1,4-diamine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:106-50-3
Pubchem (cid):7814
Pubchem (sid):134971774
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C19499
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2921.51.5000
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
one technical grade of para-phenylenediamine available in the usa has the following specifications: purity, 99.2% minimum; moisture content, 0.1% maximum; ortho-phenylenediamine (1,2-diaminobenzene) content, 0.1% maximum; and iron content, 50 mgkg maximum.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 hair dyeing agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
p-aminoaniline
 aminogen II
(4-aminophenyl)amine
4-aminophenylamine
 benzene-1,4-diamine
1,4-benzenediamine
p-benzenediamine
1,4-benzenediamine (9CI)
 benzofur D
 c.i. 76060
 C.I. developer 13
 C.I. oxidation base 10
 ci 76060
 developer 13
 developer PF
1,4-diaminobenzene
p-diaminobenzene
para-diaminobenzene
 durafur black R
p-fenylendiamin
 fouramine D
 fourrine 1
 fourrine D
 fur black 41867
 fur black R
 fur brown 41866
 fur yellow
 furro D
 futramine D
 nako H
 oxidation base 10
 pelagol D
 pelagol DR
 pelagol grey D
 peltol D
1,4-phenyldiamine
1,4-phenylene diamine
4-phenylene diamine
p-phenylene diamine
para-phenylene diamine (c.i. 76060)
 phenylenediamine
1,4-phenylenediamine
4-phenylenediamine
para-phenylenediamine
 phenylenediamine, para
 renal PF
 rodol D
 santoflex IC
 santoflex LC
 tertral D
 ursol D
 ursol-D
 vulkanox 4020
 zoba black D
 

Articles:

PubMed:Oligomeric complexes of some heteroaromatic ligands and aromatic diamines with rhodium and molybdenum tetracarboxylates: (13) C and (15) N CPMAS NMR and density functional theory studies.
PubMed:Batchwise dyeing of bamboo cellulose fabric with reactive dye using ultrasonic energy.
PubMed:Application of mechanosynthesized azine-decorated zinc(II) metal-organic frameworks for highly efficient removal and extraction of some heavy-metal ions from aqueous samples: a comparative study.
PubMed:Photocatalytic applications with CdS • block copolymer/exfoliated graphene nanoensembles: hydrogen generation and degradation of Rhodamine B.
PubMed:Enhanced lifetime of organic light-emitting diodes using an anthracene derivative with high glass transition temperature.
PubMed:meso-Tetraphenylbenzoporphyrin-2(2),2(3)-dicarboxylic anhydride: a platform to benzoporphyrin derivatives.
PubMed:Conformational landscape, photochemistry, and infrared spectra of sulfanilamide.
PubMed:Synthesis and characterization of new donor-acceptor type copolymers based on fluorene derivatives for photovoltaic solar cells.
PubMed:N,N'-Bis[1-(pyridin-2-yl)-ethyl-idene]benzene-1,4-diamine.
PubMed:Poly[di-μ(3)-chlorido-di-μ(2)-chlorido-{μ(4)-N,N,N',N'-tetra-kis-[(diphenyl-phosphan-yl)meth-yl]benzene-1,4-diamine-κ(4)P:P':P'':P'''}tetra-copper(II)].
PubMed:Effect of the environment on the electrical conductance of the single benzene-1,4-diamine molecule junction.
PubMed:A third polymorph of N,N'-bis-(pyridin-2-yl)benzene-1,4-diamine.
PubMed:N,N'-Bis(4-methyl-benzyl-idene)benzene-1,4-diamine.
PubMed:(E,E)-N-(2,3,4,5,6-Penta-fluoro-benzyl-idene)-N-(3,4,5-trimeth-oxy-benzyl-idene)benzene-1,4-diamine.
PubMed:N,N'-Bis(pyridin-2-yl)benzene-1,4-diamine-naphthalene (2/1).
PubMed:N,N'-Bis(pyridin-2-yl)benzene-1,4-diamine-quinoxaline (2/1).
PubMed:N,N-Diethynyl-N,N-diphenyl-benzene-1,4-diamine.
PubMed:Tetra-aqua-bis-[N,N'-bis-(pyridin-3-yl-methyl-idene)benzene-1,4-diamine]-zinc dinitrate 1.49-hydrate.
PubMed:{μ-N,N,N',N'-Tetra-kis[(diphenyl-phosphan-yl)meth-yl]benzene-1,4-diamine}-bis-[(2,2'-bipyrid-yl)copper(I)] bis-(tetra-fluoridoborate).
PubMed:A centrosymmetric monoclinic polymorph of N,N-bis-(pyridin-3-yl-methyl-idene)benzene-1,4-diamine.
PubMed:2,5-Bis{2,2-bis-[4-(dimethyl-amino)-phen-yl]ethen-yl}-N,N'-diphenyl-N,N'-dipropyl-benzene-1,4-diamine.
PubMed:Synthesis, structural characterization and luminescent properties of a series of Cu(I) complexes based on polyphosphine ligands.
PubMed:Conformational polymorphism of (E,E)-N,N'-bis(4-nitrobenzylidene)benzene-1,4-diamine.
PubMed:DNA binding, oxidative DNA cleavage, cytotoxicity, and apoptosis-inducing activity of copper(II) complexes with 1,4-tpbd (N,N,N',N'-tetrakis(2-yridylmethyl)benzene-1,4-diamine) ligand.
PubMed:4-Salicylideneamino-3-methyl-1,2,4-triazole-5-thione as a sensor for aniline recognition.
PubMed:Novel on-site sample preparation approach with a portable agitator using functional polymer-coated multi-fibers for the microextraction of organophosphorus pesticides in seawater.
PubMed:Electrochemical degradation of aromatic amines on BDD electrodes.
PubMed:Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.
PubMed:N-[(E)-4-Chloro-benzyl-idene]-N'-phenyl-benzene-1,4-diamine.
PubMed:catena-Poly[[(nitrato-κO,O')silver(I)]-μ-N,N'-bis-(3-pyridyl-methyl-idene)benzene-1,4-diamine].
PubMed:Dichlorido[N-(2-pyridylmethyl-idene)benzene-1,4-diamine]zinc(II).
PubMed:Small molecule modulators of copper-induced Abeta aggregation.
PubMed:N,N-Diethyl-N'-[(E)-4-pyridylmethylene]benzene-1,4-diamine: a combined X-ray and density functional theory study.
PubMed:Synthesis, X-ray crystal structures, magnetism, and DNA cleavage properties of copper(II) complexes with 1,4-tpbd ligand.
PubMed:Self-assembly of 2D Borromean networks through hydrogen-bonding recognition.
PubMed:N,N'-Bis(2-thienylmethyl-ene)benzene-1,4-diamine.
PubMed:{μ-trans-N,N'-Bis[(diphenyl-phosphan-yl)meth-yl]benzene-1,4-diamine-κP:P'}bis-{(acetonitrile-κN)[dipyrido[3,2-a:2',3'-c]phenazine-κN,N]copper(I)} bis-(tetra-fluoridoborate).
PubMed:Self-assembly of triple helical and meso-helical cylindrical arrays tunable by bis-tripodal coordination converters.
PubMed:Final report on the safety assessment of HC Red No. 7.
PubMed:Self-assembly of a one-dimensional iron(II) coordination polymer with p-phenylenebis(picolinaldimine).
PubMed:[The expanding role of occupational and non-occupational allergy to paraphenylenediamine].
PubMed:N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors.
PubMed:Self-assembly, reorganization, and photophysical properties of silver(I)-Schiff-base molecular rectangle and polymeric array species.
PubMed:N,N-dimethyl-N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-enylidene]benzene-1,4-diamine and N,N-dimethyl-4-[(1E,3E)-4-(4-nitrophenyl)buta-1,3-dienyl]-1-naphthylamine.
PubMed:Degradation of aniline by newly isolated, extremely aniline-tolerant Delftia sp. AN3.
 
Notes:
agent hair dye responsible for contact dermatitis.
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