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1,4-dioxane
1,4-diethyleneoxide

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Name:1,4-dioxane
CAS Number: 123-91-1Picture of molecule3D/inchi
Other(deleted CASRN):28347-88-8
ECHA EINECS - REACH Pre-Reg:204-661-8
FDA UNII: J8A3S10O7S
Nikkaji Web:J2.502J
Beilstein Number:0102551
MDL:MFCD00006571
XlogP3:-0.30 (est)
Molecular Weight:88.10616000
Formula:C4 H8 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (IAUFC):123-91-1 ; 1,4-DIOXANE
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.03400 @ 25.00 °C.
Melting Point: 11.80 °C. @ 760.00 mm Hg
Boiling Point: 101.50 °C. @ 760.00 mm Hg
Vapor Pressure:38.233002 mmHg @ 25.00 °C. (est)
Flash Point: 54.00 °F. TCC ( 12.22 °C. )
logP (o/w): -0.270
Soluble in:
 water, 2.139e+005 mg/L @ 25 °C (est)
 water, 1.00E+06 mg/L @ 20 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BASF
1,4-Dioxane
Charkit Chemical
DIOXANE, 1,4- (0.003% WATER)
ECSA Chemicals
1,4-DIOXANE RE-PURE, ML 2500
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
1,4-DIOXANE RPE-ACS-FOR ANALYSIS-REAG. PH.EU
EMD Millipore
For experimental / research use only.
1,4-Dioxane
Glentham Life Sciences
1,4-Dioxane
Santa Cruz Biotechnology
For experimental / research use only.
1,4-Dioxane ≥99%
Sigma-Aldrich
For experimental / research use only.
1,4-Dioxane anhydrous, 99.8%
TCI AMERICA
For experimental / research use only.
1,4-Dioxane >99.0%(GC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-cat LD50 2000 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.

intravenous-cat LDLo 1500 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: IRRITABILITY
Journal of Hygiene. Vol. 35, Pg. 540, 1935.

oral-guinea pig LD50 3150 mg/kg
KIDNEY, URETER, AND BLADDER: OTHER CHANGES BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.

intraperitoneal-mouse LD50 790 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.

oral-mouse LD50 5300 mg/kg
Indian Journal of Experimental Biology. Vol. 16, Pg. 54, 1978.

oral-rabbit LD50 2000 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.

intravenous-rabbit LDLo 1500 mg/kg
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Journal of Hygiene. Vol. 35, Pg. 540, 1935.

intraperitoneal-rat LD50 799 mg/kg
Environmental Research. Vol. 40, Pg. 411, 1986.

oral-rat LD50 4200 mg/kg
Industrial Health. Vol. 32, Pg. 145, 1994.

Dermal Toxicity:
skin-rabbit LD50 7600 uL/kg
Union Carbide Data Sheet. Vol. 12/17/1971

Inhalation Toxicity:
inhalation-cat LCLo 44000 mg/m3/7H
BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA
"Beitrag zur Toxikologischen Wirkung Technischer Losungsmittel, Dissertation," Klimmer, O., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1937Vol. -, Pg. -, 1937.

inhalation-human LCLo 470 ppm/3D
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES LIVER: OTHER CHANGES
Pollution Engineering. Vol. 7(9), Pg. 22, 1975.

inhalation-human TCLo 470 ppm
GASTROINTESTINAL: OTHER CHANGES VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
AMA Archives of Industrial Health. Vol. 20, Pg. 445, 1959.

inhalation-human TCLo 5500 ppm/1M
SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Public Health Reports. Vol. 45, Pg. 2023, 1930.

inhalation-mammal (species unspecified) LC50 20500 mg/m3
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(5), Pg. 61, 1986.

inhalation-mouse LC50 37000 mg/m3/2H
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 63, 1982.

inhalation-rat LC50 46000 mg/m3/2H
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Kosmicheskaya Biologiya I Aviakosmicheskaya Meditsina. Space Biology and Aerospace Medicine. Vol. 11(6), Pg. 53, 1977.

 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for 1,4-dioxane usage levels up to:
 not for fragrance use.
 
Recommendation for 1,4-dioxane flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):123-91-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :31275
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
1,4-dioxane
Chemidplus:0000123911
EPA/NOAA CAMEO:hazardous materials
RTECS:123-91-1
 
References:
 1,4-dioxane
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:123-91-1
Pubchem (cid):31275
Pubchem (sid):134974749
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
UM BBD:Search
KEGG (GenomeNet):C14440
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.99.9090
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•commercial 1,4-dioxane: purity, 99.90 wt% min; acidity (as acetic acid), 100 ppm max; water, 150 ppm max; peroxide, 5 ppm max; non-volatile matter 0.0025 gm100 ml max; suspended matter, nil •grade: reagent, technical, spectrophotometric, scintillation.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 di (ethylene oxide)
 di(ethylene oxide)
 diethylene dioxide
1,4-diethylene dioxide
 diethylene ether
 diethylene oxide
1,4-diethylenedioxide
1,4-diethyleneoxide
 diokan
 dioksan
1,4-dioxacyclohexane
p-dioxane
 dioxane, 1,4-
 dioxanne
 ethylene glycol ethylene ether
 glycol ethylene ether
 glycolethylenether
 
 
Notes:
dehydrating agent; polar solvent miscible both with water & most organic solvents.
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