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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.88000 @ 25.00 °C.
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| Boiling Point: | 184.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 1.050000 mmHg @ 25.00 °C. |
| Flash Point: | 121.00 °F. TCC ( 49.44 °C. )
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| logP (o/w): | 3.720 |
| Soluble in: |
| | water, 71.1 mg/L @ 20 °C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LDLo 5000 mg/kg
"Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde, H., New York, Elsevier, 1960Vol. -, Pg. 57, 1960.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for 1,2-diethyl benzene usage levels up to: | | | not for fragrance use.
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| Recommendation for 1,2-diethyl benzene flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzene, 1,2-diethyl- | | | benzene, o-diethyl- | | ortho- | diethyl benzene | | 1,2- | diethylbenzene | | o- | diethylbenzene | | ortho- | diethylbenzene |
Articles:
| PubMed:Olfactory mucosal necrosis in rats following acute intraperitoneal administration of 1,2-diethylbenzene, 1,2-diacetylbenzene and 2,5-hexanedione. |
| PubMed:The low-melting compounds 1,4-diethyl-, 1,2-diethyl- and ethylbenzene. |
| PubMed:Organic solvent metabolite, 1,2-diacetylbenzene, impairs neural progenitor cells and hippocampal neurogenesis. |
| PubMed:Probing mechanisms of axonopathy. Part II: Protein targets of 2,5-hexanedione, the neurotoxic metabolite of the aliphatic solvent n-hexane. |
| PubMed:Probing mechanisms of axonopathy. Part I: Protein targets of 1,2-diacetylbenzene, the neurotoxic metabolite of aromatic solvent 1,2-diethylbenzene. |
| PubMed:Bio-distribution study of 1,2-diethylbenzene and its main metabolites by whole-body autoradiography and tissue homogenates. |
| PubMed:Using supercritical fluid chromatography to determine diffusion coefficients of 1,2-diethylbenzene, 1,4-diethylbenzene, 5-tert-butyl-m-xylene and phenylacetylene in supercritical carbon dioxide. |
| PubMed:Environmental metabolite, 1,2-diacetylbenzene, produces cytotoxicity through ROS generation in HUVEC cells. |
| PubMed:Axonopathy-inducing 1,2-diacetylbenzene forms adducts with motor and cytoskeletal proteins required for axonal transport. |
| PubMed:A liquid chromatographic-mass spectrometric method to evaluate the distribution kinetics of 1,2-diethylbenzene and its metabolite 1,2-diacetylbenzene in the F344 male rat. |
| PubMed:A new murine model of giant proximal axonopathy. |
| PubMed:Aromatic as well as aliphatic hydrocarbon solvent axonopathy. |
| PubMed:Theoretical determination of chromophores in the chromogenic effects of aromatic neurotoxicants. |
| PubMed:1,2-diacetylbenzene, the neurotoxic metabolite of a chromogenic aromatic solvent, induces proximal axonopathy. |
| PubMed:Toxicokinetics and metabolism of 1,2-diethylbenzene in male Sprague Dawley rats--part 2: evidence for in vitro and in vivo stereoselectivity of 1,2-diethylbenzene metabolism. |
| PubMed:Toxicokinetics of 1,2-diethylbenzene in male Sprague-Dawley rats-part 1: excretion and metabolism of [(14)C]1,2-diethylbenzene. |
| PubMed:Assessment of the developmental toxicity and placental transfer of 1,2-diethylbenzene in rats. |
| PubMed:Biotransformation of diethenylbenzenes, V. Identification of urinary metabolites of 1,2-diethenylbenzene in the rat. |
| PubMed:Alteration of brainstem auditory evoked potentials in diethylbenzene and diacetylbenzene-treated rats. |
| PubMed:Possible involvement of 1,2-diacetylbenzene in diethylbenzene-induced neuropathy in rats. |
| PubMed:Diethylbenzene-induced sensorimotor neuropathy in rats. |
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3D/inchi