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1,2,4-triazole
pyrrodiazole

Supplier Sponsors

Name:1H-1,2,4-triazole
CAS Number: 288-88-0Picture of molecule3D/inchi
Other(deleted CASRN):116421-29-5
ECHA EINECS - REACH Pre-Reg:206-022-9
FDA UNII: 10MS0Y1RDI
Nikkaji Web:J5.455K
Beilstein Number:605619
MDL:MFCD00005228
XlogP3:-0.60 (est)
Molecular Weight:69.06691000
Formula:C2 H3 N3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 260.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.603000 mmHg (est)
Flash Point: 282.00 °F. TCC ( 139.10 °C. ) (est)
logP (o/w): -0.580
Soluble in:
 water, 4.244e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
1H-1, 2, 4Triazole
Odor: characteristic
Use: 1H-1, 2, 4 Triazole is a C14-demethylase-inhibitor that is commonly used in fungicides. It is also used as an ingredient in the preparation of Rizatriptan, Letrozole, Vorozolea and Posaconazole.
Charkit Chemical
TRIAZOLE, 1,2,4-
Glentham Life Sciences
1,2,4-Triazole
Penta International
1,2,4-TRIAZOLE
Shiva Chemicals and Pharmaceuticals
1-H,1,2,4 triazole
Sigma-Aldrich: Aldrich
For experimental / research use only.
1,2,4-Triazole 98%
sds
TCI AMERICA
For experimental / research use only.
1,2,4-Triazole >99.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 1350 mg/kg
BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: EXCITEMENT
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(11), Pg. 65, 1986.

oral-quail LD50 > 316 mg/kg
Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.

oral-rat LD50 1750 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: EXCITEMENT BEHAVIORAL: TREMOR
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(11), Pg. 65, 1986.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for 1,2,4-triazole usage levels up to:
 not for fragrance use.
 
Recommendation for 1,2,4-triazole flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Outcome of the consultation with Member States, the applicant and EFSA on the pesticide risk assessment for triazole derivative metabolites in light of confirmatory data
View page or View pdf

Peer review of the pesticide risk assessment for the triazole derivative metabolites in light of confirmatory data submitted
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):288-88-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :9257
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:2
1H-1,2,4-triazole
Chemidplus:0000288880
RTECS:288-88-0
 
References:
 1H-1,2,4-triazole
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:288-88-0
Pubchem (cid):9257
Pubchem (sid):134974463
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.99.9700
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 pyrrodiazole
1H-1,2,4-triazol
1H-1,2,4-triazole
 

Articles:

PubMed:Triazole GHS-R1a antagonists JMV4208 and JMV3002 attenuate food intake, body weight, and adipose tissue mass in mice.
PubMed:Access to a new class of biologically active quinoline based 1,2,4-triazoles.
PubMed:Combined repeated-dose and reproductive/developmental toxicity screening test of 3-amino-5-mercapto-1,2,4-triazole in rats.
PubMed:The involvement of several enzymes in methanol detoxification in Drosophila melanogaster adults.
PubMed:Ghrelin-induced orexigenic effect in rats depends on the metabolic status and is counteracted by peripheral CB1 receptor antagonism.
PubMed:Synthesis, fungicidal activity, and sterol 14α-demethylase binding interaction of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum.
PubMed:Synthesis, crystal structure, in vitro acetohydroxyacid synthase inhibition, in vivo herbicidal activity, and 3D-QSAR of new asymmetric aryl disulfides.
PubMed:The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist.
PubMed:Synthesis and fungicidal activity of novel 3-(substituted/unsubstituted phenylselenonyl)-1-ribosyl/deoxyribosyl-1H-1,2,4-triazole.
PubMed:The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae.
PubMed:Separation and preconcentration of Cd(II), Cu(II), Ni(II), and Pb(II) in water and food samples using Amberlite XAD-2 functionalized with 3-(2-nitrophenyl)-1H-1,2,4-triazole-5(4H)-thione and determination by inductively coupled plasma-atomic emission spectrometry.
PubMed:Efficient synthesis of novel 1,2,4-triazole fused acyclic and 21-28 membered macrocyclic and/or lariat macrocyclic oxaazathia crown compounds with potential antimicrobial activity.
PubMed:β-ODAP accumulation could be related to low levels of superoxide anion and hydrogen peroxide in Lathyrus sativus L.
PubMed:Synthesis and biological activity of some novel trifluoromethyl-substituted 1,2,4-triazole and bis(1,2,4-triazole) Mannich bases containing piperazine rings.
PubMed:Synthesis, crystal structure, and biological activity of 4-methyl-1,2,3-thiadiazole-containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.
PubMed:The effects of buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on propyl gallate-treated HeLa cells in relation to cell growth, reactive oxygen species and glutathione.
PubMed:Determination of stereoselective interaction between enantiomers of chiral gamma-aryl-1H-1,2,4-triazole derivatives and Penicillium digitatum.
PubMed:Resistance to cadmium as a function of Caco-2 cell differentiation: role of reactive oxygen species in cadmium- but not zinc-induced adaptation mechanisms.
PubMed:Synthesis and PET studies of [(11)C-cyano]letrozole (Femara), an aromatase inhibitor drug.
PubMed:Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities.
PubMed:Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats.
PubMed:Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor.
PubMed:New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations.
PubMed:Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations.
PubMed:Development of potential manufacturing routes for substituted thiophenes--preparation of halogenated 2-thiophenecarboxylic acid derivatives as building blocks for a new family of 2,6-dihaloaryl 1,2,4-triazole insecticides.
PubMed:First synthesis and antimicrobial activity Of N- and S-alpha-L-arabinopyranosyl-1,2,4-triazoles.
PubMed:Synthesis and pharmacological in vitro and in vivo evaluations of novel triazole derivatives as ligands of the ghrelin receptor. 1.
PubMed:Sterol demethylation inhibitor fungicides as disruptors of insect development and inducers of glutathione S-transferase activities in Mamestra brassicae.
PubMed:Contributions of pro-oxidant and anti-oxidant conditions to the actions of 24,25-dihydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on phosphate uptake in intestinal cells.
PubMed:Synthesis and herbicidal activity of N,N-diethyl-3-(arylselenonyl)-1H-1,2,4-triazole-1-carboxamide.
PubMed:Efficient synthesis, structure, and antimicrobial activity of some novel N- and S-beta-D-glucosides of 5-pyridin-3-yl-1,2,4-triazoles.
PubMed:Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21.
PubMed:Determination of 22 triazole compounds including parent fungicides and metabolites in apples, peaches, flour, and water by liquid chromatography/tandem mass spectrometry.
PubMed:Determination of Fe(II) and Zn(II) by spectrophotometry, atomic absorption spectrometry and ions chromatography methods in Vitrum.
PubMed:Kinetics and products of photo-Fenton degradation of triazophos.
PubMed:Spectrophotometric determination of Fe(II) and Zn(II) in the pharmaceutical multivitamin preparations with microelements.
PubMed:Comparison of three colorimetric reagents in the determination of methanol with alcohol oxidase. Application to the assay of pectin methylesterase.
PubMed:Sorption behavior of triazole fungicides in Indian soils and its correlation with soil properties.
PubMed:Liquid chromatographic determination of ampicillin residues in porcine muscle tissue by a multipenicillin analytical method: European Collaborative Study.
PubMed:Role of acetaldehyde in the discriminative stimulus effects of ethanol.
PubMed:A specific and potent inhibitor of brassinosteroid biosynthesis possessing a dioxolane ring.
PubMed:Acetylation of 5-amino-1H-[1,2,4]triazole revisited.
PubMed:Characterization of a catalase-peroxidase from the hyperthermophilic archaeon Archaeoglobus fulgidus.
PubMed:Metabolism of [(14)C]flusilazole in the goat.
PubMed:Purification and some properties of catalase from wheat germ (Triticum aestivum L.).
PubMed:Multi-residue analysis of penicillin residues in porcine tissue using matrix solid phase dispersion.
PubMed:Multiresidue liquid chromatographic method for determining residues of mono- and dibasic penicillins in bovine muscle tissues.
PubMed:The catalase-peroxidase of Synechococcus PCC 7942: purification, nucleotide sequence analysis and expression in Escherichia coli.
PubMed:Effects of 3-amino-1,2,4-triazole on brain catalase in the mediation of ethanol consumption in mice.
PubMed:Analysis of penicillin G in milk by liquid chromatography.
PubMed:Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum.
PubMed:Molecular mechanisms of action of ribavirin.
PubMed:Extraction of 3-amino-1,2,4-triazole (amitrole) and 2,6-dichloro-4-nitroaniline (DCNA) from soils.
 
Notes:
None found
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