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Category:extraction solvents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 99.80 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.57000 @ 25.00 °C.
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| Refractive Index: | 1.35800 @ 20.00 °C.
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| Melting Point: | -35.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 47.00 to 48.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 363.000000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 2.00 °F. TCC ( -16.80 °C. ) (est)
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| logP (o/w): | 3.160 |
| Soluble in: |
| | water, 170 mg/L @ 25 °C (exp) | | | alcohol | | | chloroform | | | ether |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | R 02 - Risk of explosion by shock, friction, fire or other sources of ignition. |
R 52/53 - Harmful to qauatic organisms, may cause long-term adverse effects in the aquatic environment.
R 59 - Dangerous for the ozone layer.
S 02 - Keep out of the reach of children.
S 59 - Refer to manufacturer for information on recovery/recycling.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 43000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: OTHER CHANGES
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Journal of Medicinal Chemistry. Vol. 7, Pg. 378, 1964.
oral-guinea pig LDLo > 10000 mg/kg
National Technical Information Service. Vol. OTS0520705
intravenous-mouse LD50 9000 mg/kg
AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
National Technical Information Service. Vol. OTS0520355
unreported-mouse LD50 40000 mg/kg
United States Patent Document. Vol. #4164653
oral-rabbit LDLo 17000 mg/kg
American Industrial Hygiene Association Journal. Vol. 29, Pg. 521, 1968.
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| Dermal Toxicity: |
skin-rabbit LD50 > 11000 mg/kg
American Industrial Hygiene Association Journal. Vol. 29, Pg. 521, 1968.
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| Inhalation Toxicity: |
inhalation-rat LC50 38500 ppm/4H
BEHAVIORAL: GENERAL ANESTHETIC
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: ATAXIA
National Technical Information Service. Vol. OTS0520341
inhalation-guinea pig LC50 > 12 pph/2H
Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. Vol. 29, Pg. 381, 1968.
inhalation-mouse LC50 260000 mg/m3/2H
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
BEHAVIORAL: ATAXIA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. Vol. 75, Pg. 241, 1963.
inhalation-rabbit LC50 59500 ppm/2H
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BEHAVIORAL: EXCITEMENT
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
National Technical Information Service. Vol. OTS0520343
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Safety in Use Information:
| Category: | | extraction solvents |
| Recommendation for 1,1,2-trichlorotrifluoroethane usage levels up to: | | | not for fragrance use.
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| Recommendation for 1,1,2-trichlorotrifluoroethane flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | arcton 113 | | | asahifron 113 | | | chlorofluorocarbon 113 | | | daiflon 113 | | | delifrene 113 | | | ethane, 1,1,2-trichloro-1,2,2-trifluoro- | | | flugene 113 | | | forane 113 | | | freon F113 | | | frigen 113 | | | fronsolve 113 | | | genetron 113 | | | halocarbon 113 | | | isceon 113 | | | khladon 113 | | | refrigerant 113 | | 1,1,2- | trichloro-1,2,2-trifluorethane | | | trichloro-1,2,2-trifluoroethane | | 1,1,2- | trichloro-1,2,2-trifluoroethane | | 1,2,2- | trichlorotrifluoroethane | | 1,1,2- | trifluoro-1,2,2-trichloroethane | | 1,1,2- | trifluorotrichloroethane |
Articles:
| PubMed:Cell adhesion response on femtosecond laser initiated liquid assisted silicon surface. |
| PubMed:Quantitative assessment of hydrocarbon contamination in soil using reflectance spectroscopy: a "multipath" approach. |
| PubMed:How to improve reliability in groundwater analysis: over a decade of experience with external quality control in field campaigns on volatile halogenated compounds. |
| PubMed:Chemical analysis and risk assessment of diethyl phthalate in alcoholic beverages with special regard to unrecorded alcohol. |
| PubMed:Effects of extracellular purines on cytotoxicity of methotrexate. |
| PubMed:Breath figure templated self-assembly of porous diblock copolymer films. |
| PubMed:Determination of furaneol (4-hydroxy-2,5-dimethyl-3(2H)-furanone) in some wines from Italian native grapes by Gas-Chromatography-SIM/MASS spectrometry. |
| PubMed:Aroma composition of red wines by different extraction methods and Gas Chromatography-SIM/MASS spectrometry analysis. |
| PubMed:C6, C7, and C8 perfluoroalkyl-substituted phosphinic acids. |
| PubMed:Isomerization and dissociation of C2X5+ and C2X4+* ions (X = Cl, F) from chlorofluoroethanes in an ion trap mass spectrometer. |
| PubMed:Positive and negative gas-phase ion chemistry of chlorofluorocarbons in air at atmospheric pressure. |
| PubMed:Quantitative determination of n-propane, iso-butane, and n-butane by headspace GC-MS in intoxications by inhalation of lighter fluid. |
| PubMed:Products, rate constants and mechanisms of gas-phase reactions of CX(3)(+), CX(2)(+), CX(+) (X = F and/or Cl) and Cl(+) with 1,1,1- and 1,1,2-trichlorotrifluoroethane. |
| PubMed:Assay method for the perfluorooctyl bromide (perflubron) in rat blood by gas chromatography-mass spectrometry. |
| PubMed:Different effects of volatile anesthetics and polyhalogenated alkanes on depolarization-evoked glutamate release in rat cortical brain slices. |
| PubMed:Highly sensitive detection of swine vesicular disease virus based on a single tube RT-PCR system and DIG-ELISA detection. |
| PubMed:Biological degradation of VCCs and CFCs under simulated anaerobic landfill conditions in laboratory test digesters. |
| PubMed:Bimolecular OH rate constants of organic compounds in solution. 2. Measurements in 1,2,2-trichlorotrifluoroethane using hydrogen peroxide as an OH source. |
| PubMed:Stereoselective determination of R(-)- and S(+)-MK-571, a leukotriene D4 antagonist, in human plasma by chiral high-performance liquid chromatography. |
| PubMed:Organic photochemistry. 20. A method for estimating gas-phase rate constants for reactions of hydroxyl radicals with organic compounds from their relative rates of reaction with hydrogen peroxide under photolysis in 1,1,2-trichlorotrifluoroethane solution. |
| PubMed:Effects of Freon-113 on the survival of bacteria. |
| PubMed:Purification of adenovirus hexon protein by high-performance liquid chromatography. |
| PubMed:Isolation of a foot-and-mouth disease polyuridylic acid polymerase and its inhibition by antibody. |
| PubMed:Use of 1,1,2-trichlorotrifluoroethane for the quantitative determination of mineral oil air sample concentrations by u.v. absorption. |
| PubMed:High-performance liquid-chromatographic analysis for tryptophan in serum. |
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Used in freezing of foods
CFC-113 is a very unreactive chlorofluorocarbon, that will stay in the atmosphere for a great deal of time if it is released. CFC-113 will stay in the atmosphere long enough that it will cycle out of the troposphere and into the stratosphere. In the stratosphere, CFC-113 can be broken up by ultraviolet radiation, creating chlorine radicals, which can in turn react with ozone molecules to form molecular oxygen (O2), leading to the overall depletion of stratospheric ozone. The amount of CFC-113 in the atmosphere has stayed relatively stable, at about 80 parts per trillion, since the early 1990s.; CFC-113 was one of the many forms of CFCs that were made to eliminate toxic and flammable substances in the areas that they were used. It has been used as a cooling agent in refrigerants and air conditioners, aerosol propellant, and a cleansing agent for electrical and electronic components. CFC-113 is one of the three most popular CFCs, along with CFC-11 and CFC-12 and saw much use in its time. CFC-113 has a unique property that makes it perfect for cooling systems. When it is in a gas form and compressed, it heats up, when it is expanded, it cools. This makes them ideal for the vapor compression cycle systems. They were also very desirable because of their low toxicity, non-flammability, thermophysical properties, and normal boiling point. CFC-113 also has a flexible form so it was used in the production of plastics, packaging material, insulation, foams for cushioning, and things like the soles of your shoes. CFC-113 has such a low flammability and low toxicity that it was also used as a cleaner for delicate electrical equipment, fabrics, and even metals. Because it would not warm the product it was cleaning, catch fire with a spark or react to and other chemicals it was ideal for this purpose. CFC-113 in laboratory analytics has been replaced by other solvents.; Trichlorotrifluoroethane, also called 1,1,2-Trichloro-1,2,2-trifluoroethane or CFC-113 is a chlorofluorocarbon. It has the formula Cl2FC-CClF2.
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3D/inchi