EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

(R)-(-)-phenyl ephrine hydrochloride
benzenemethanol, 3-hydroxy-a-[(methylamino)methyl]-, (aR)-, hydrochloride (1:1)

Supplier Sponsors

CAS Number: 61-76-7Picture of molecule3D/inchi
Other(deleted CASRN):50741-76-9
ECHA EINECS - REACH Pre-Reg:200-517-3
FDA UNII: 04JA59TNSJ
Beilstein Number:4158948
MDL:MFCD00012605
Molecular Weight:203.66798000
Formula:C9 H14 Cl N O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white microcrystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 142.50 °C. @ 760.00 mm Hg
Boiling Point: 341.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000032 mmHg @ 25.00 °C. (est)
Flash Point: 326.00 °F. TCC ( 163.40 °C. ) (est)
logP (o/w): -0.310
Soluble in:
 water, 2.931e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American International Chemical, LLC.
Phenylephrine HCI
BOC Sciences
For experimental / research use only.
(R)-Phenylephrine Hydrochloride >98%
Odor: characteristic
Use: Phenylephrine HCl is a selective à1-adrenergic receptor agonist of the phenethylamine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure.
Glentham Life Sciences
(R)-(-)-Phenylephrine hydrochloride
Maypro Industries
Phenylephrine HCl
Santa Cruz Biotechnology
For experimental / research use only.
(R)-(-)-Phenylephrine Hydrochloride
Sigma-Aldrich: Sigma
For experimental / research use only.
(R)-(-)-Phenylephrine hydrochloride powder
TCI AMERICA
For experimental / research use only.
(R)-(-)-Phenylephrine Hydrochloride >98.0%(HPLC)(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-dog LDLo 16 mg/kg
International Journal of Neuropharmacology. Vol. 4, Pg. 219, 1965.

intraperitoneal-mouse LD50 89 mg/kg
Toxicology and Applied Pharmacology. Vol. 28, Pg. 227, 1974.

intravenous-mouse LD50 1120 ug/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
European Journal of Pharmacology. Vol. 9, Pg. 289, 1970.

oral-mouse LD50 120 mg/kg
International Journal of Neuropharmacology. Vol. 4, Pg. 219, 1965.

intramuscular-rabbit LD50 7200 ug/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.

intravenous-rabbit LD50 500 ug/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.

intraperitoneal-rat LD50 17 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.

intravenous-rat LD50 440 ug/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 341, 1955.

oral-rat LD50 350 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.

Dermal Toxicity:
subcutaneous-mouse LD50 22 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.

subcutaneous-rabbit LD50 22 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.

subcutaneous-rat LD50 27 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for (R)-(-)-phenyl ephrine hydrochloride usage levels up to:
 not for fragrance use.
 
Recommendation for (R)-(-)-phenyl ephrine hydrochloride flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):61-76-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5284443
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride
Chemidplus:0000061767
EPA/NOAA CAMEO:hazardous materials
RTECS:DO7525000 for cas# 61-76-7
 
References:
 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:61-76-7
Pubchem (cid):5284443
Pubchem (sid):134971205
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D00511
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2922.50.1300
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 benzenemethanol, 3-hydroxy-a-[(methylamino)methyl]-, (aR)-, hydrochloride
 benzenemethanol, 3-hydroxy-a-[(methylamino)methyl]-, (aR)-, hydrochloride (1:1)
3-[(1R)-1-hydroxy-2-(méthylamino)éthyl]phénol chlorhydrate
3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol hydrochloride
3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol hydrochloride (1:1)
3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride
(aR)-3-hydroxy-a-((methylamino)methyl)benzenemethanol hydrochloride
(R)-3-hydroxy-a-((methylamino)methyl)benzenemethanol hydrochloride
(R)-(-)-3-hydroxy-a-(methylaminomethyl)benzyl alcohol hydrochloride
(R)-3-hydroxy-a-[(methylamino)methyl]benzenemethanol hydrochloride
1-m-hydroxy-a-[(methylamino)methyl]benzyl Alcohol Hydrochloride
L-a-hydroxy-b-methylamino-3-hydroxy-1-ethylbenzene hydrochloride
(R)-(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol hydrochloride
L-1-(m-hydroxyphenyl)-2-methylaminoethanol hydrochloride
(-)-phenylephrine hydrochloride
(R)-phenylephrine hydrochloride
L-phenylephrine hydrochloride
 phenylephrine hydrochloride USP
 
 
Notes:
an alpha-adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy