EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

mercaptopropyltrimethoxysilane
1-propanethiol, 3-(trimethoxysilyl)-

Supplier Sponsors

Name:3-trimethoxysilylpropane-1-thiol
CAS Number: 4420-74-0Picture of molecule3D/inchi
Other(deleted CASRN):161756-15-6
ECHA EINECS - REACH Pre-Reg:224-588-5
FDA UNII: 8CB1M08OIW
Nikkaji Web:J8.721A
Beilstein Number:2038119
MDL:MFCD00004901
Molecular Weight:196.34142000
Formula:C6 H16 O3 S Si
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:nail conditioning agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.03900 @ 25.00 °C.
Boiling Point: 198.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.500000 mmHg @ 25.00 °C. (est)
Flash Point: 120.00 °F. TCC ( 48.89 °C. )
logP (o/w): 1.090 (est)
Soluble in:
 water, 2.77e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: nail conditioning
 
Suppliers:
Achiewell
For experimental / research use only.
3-Mercaptopropyl
Santa Cruz Biotechnology
For experimental / research use only.
(3-Mercaptopropyl)trimethoxysilane 95%
Sigma-Aldrich: Aldrich
For experimental / research use only.
(3-Mercaptopropyl)trimethoxysilane 95%
TCI AMERICA
For experimental / research use only.
(3-Mercaptopropyl)trimethoxysilane >96.0%(GC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 633 mg/kg
Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. Vol. 229, Pg. 1011, 1976.

oral-rat LD50 730 uL/kg
Journal of Toxicology, Cutaneous and Ocular Toxicology. Vol. 15, Pg. 261, 1996.

Dermal Toxicity:
skin-rabbit LD50 2140 uL/kg
Journal of Toxicology, Cutaneous and Ocular Toxicology. Vol. 15, Pg. 261, 1996.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
nail conditioning agents
Recommendation for mercaptopropyltrimethoxysilane usage levels up to:
 not for fragrance use.
 
Recommendation for mercaptopropyltrimethoxysilane flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):4420-74-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :20473
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
3-trimethoxysilylpropane-1-thiol
Chemidplus:0004420740
RTECS:TZ7800000 for cas# 4420-74-0
 
References:
 3-trimethoxysilylpropane-1-thiol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:4420-74-0
Pubchem (cid):20473
Pubchem (sid):134984788
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2931.90.9010
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 GF 70
 KBE 803
 KBM 803
 M 8500
(3-mercaptopropyl) trimethoxysilane
(3-mercaptopropyl)trimethoxysilane
(gamma-mercaptopropyl)trimethoxysilane
3-mercaptopropyltrimethoxysilane
gamma-mercaptopropyltrimethoxysilane
 MPS-M
 NUCA 189
1-propanethiol, 3-(trimethoxysilyl)-
 prosil 196
 SH 6062
 sila-ace S 810
 silane A 189
 silane, 3-mercaptopropyltrimethoxy-
 silquest A 189
3-(sulfanylpropyl)trimethoxysilane
(3-thiopropyl)trimethoxysilane
3-(trimethoxysilyl)propanethiol
3-(trimethoxysilyl)propyl mercaptan
3-trimethoxysilylpropane-1-thiol
 union carbide A-189
 

Articles:

PubMed:Facile preparation of an immobilized surfactant-free palladium nanocatalyst for metal hydride trapping: a novel sensing platform for TXRF analysis.
PubMed:A novel hierarchical nanobiocomposite of graphene oxide-magnetic chitosan grafted with mercapto as a solid phase extraction sorbent for the determination of mercury ions in environmental water samples.
PubMed:Coating of magnetite with mercapto modified rice hull ash silica in a one-pot process.
PubMed:β-Cyclodextrin/thermosensitive containing polymer brushes grafted onto magnetite nano-particles for extraction and determination of venlafaxine in biological and pharmaceutical samples.
PubMed:Polymer brushes containing thermosensitive and functional groups grafted onto magnetic nano-particles for interaction and extraction of famotidine in biological samples.
PubMed:Effect of surface charge and electrode material on the size-dependent oxidation of surface-attached metal nanoparticles.
PubMed:Synthesis of nanospheres-on-microsphere silica with tunable shell morphology and mesoporosity for improved HPLC.
PubMed:Shaped platinum nanoparticles directly synthesized inside mesoporous silica supports.
PubMed:Investigation of the interfacial effects of small chemical-modified TiO2 nanotubes on 3T3 fibroblast responses.
PubMed:Preparation of a sulfo-group-containing rod-like polysilsesquioxane with a hexagonally stacked structure and its proton conductivity.
PubMed:Synthesis and characterization of poly[N-isopropylacrylamide-co-1-(N,N-bis-carboxymethyl)amino-3-allylglycerol] grafted to magnetic nano-particles for the extraction and determination of fluvoxamine in biological and pharmaceutical samples.
PubMed:DNA hybridization detection with 100 zM sensitivity using piezoelectric plate sensors with an improved noise-reduction algorithm.
PubMed:Magnetic and noble metallic nanoparticles deposited on silica spheres via silanization.
PubMed:The regulation of sepiolite surface free energy and its impact on the thermal insulation property of coating.
PubMed:Nanostructured optical photonic crystal biosensor for HIV viral load measurement.
PubMed:Self-assembled monolayers of gold nanostars: a convenient tool for near-IR photothermal biofilm eradication.
PubMed:Adsorption of cadmium ions on thiol or sulfonic-functionalized poly(dimethylsiloxane) networks.
PubMed:Stir bar sorptive extraction combined with high performance liquid chromatography-ultraviolet/inductively coupled plasma mass spectrometry for analysis of thyroxine in urine samples.
PubMed:Preparation of saline-stable, silica-coated triangular silver nanoplates of use for optical sensing.
PubMed:Synthesis and characterization of poly[1-(N,N-bis-carboxymethyl)amino-3-allylglycerol-co-dimethylacrylamide] grafted to magnetic nano-particles for extraction and determination of letrozole in biological and pharmaceutical samples.
PubMed:Establishment of a derivatization method to quantify thiol function in sulfur-containing plasma polymer films.
PubMed:[Preparation of organic-inorganic hybrid boronate affinity monolith via thiol-ene click reaction for specific capture of glycoproteins].
PubMed:Magnetic materials as sorbents for metal/metalloid preconcentration and/or separation. A review.
PubMed:Fabrication of SiO2 beads with high concentrated hydrophobic CdSe/Cd(x)Zn(1-x)S quantum dots using functional alkoxides.
PubMed:Silanization effect on the photoluminescence characteristics of crystalline and amorphous silicon nanoparticles.
PubMed:Biofunctionalization of silica microspheres for protein separation.
PubMed:Cage-like silica nanoparticles-functionalized silica hybrid monolith for high performance capillary electrochromatography via "one-pot" process.
PubMed:Facile preparation of organic-silica hybrid monolith for capillary hydrophilic liquid chromatography based on "thiol-ene" click chemistry.
PubMed:Improvement of adhesive strength of segmented polyurethane on Ti-29Nb-13Ta-4.6Zr alloy through H₂O₂ treatment for biomedical applications.
PubMed:Real-time, in situ DNA hybridization detection with attomolar sensitivity without amplification using (pb(Mg1/3Nb2/3)O3)0.65-(PbTiO3)0.35 piezoelectric plate sensors.
PubMed:Polymeric ionic liquid modified stainless steel wire as a novel fiber for solid-phase microextraction.
PubMed:Grafting 3-mercaptopropyl trimethoxysilane on multi-walled carbon nanotubes surface for improving on-line cadmium(II) preconcentration from water samples.
PubMed:Growth kinetics of MPS-capped CdS quantum dots in self-assembled thin films.
PubMed:One-pot synthesis of spheres-on-sphere silica particles from a single precursor for fast HPLC with low back pressure.
PubMed:Label-free Growth Receptor-2 Detection and Dissociation Constant Assessment in Diluted Human Serum Using a Longitudinal Extension Mode of a Piezoelectric Microcantilever Sensor.
PubMed:A new imidazolium-embedded C18 stationary phase with enhanced performance in reversed-phase liquid chromatography.
PubMed:Nanowire transistor-based ultrasensitive virus detection with reversible surface functionalization.
PubMed:Selectivity enhancement for the separation of tocopherols and steroids by integration of highly ordered weak interaction sites along the polymer main chain.
PubMed:Influence of interface layers on Ag thin film growth.
PubMed:Screening and determinations of tissue polypeptide antigen by label-free optical immunosensing method.
PubMed:Cadmium (II) imprinted 3-mercaptopropyltrimethoxysilane coated stir bar for selective extraction of trace cadmium from environmental water samples followed by inductively coupled plasma mass spectrometry detection.
PubMed:Flower-like self-assembly of gold nanoparticles for highly sensitive electrochemical detection of chromium(VI).
PubMed:Facile fabrication of gold nanoparticles-poly(vinyl alcohol) electrospun water-stable nanofibrous mats: efficient substrate materials for biosensors.
PubMed:Chemical functionalization of diatom silica microparticles for adsorption of gold (III) ions.
PubMed:Probing quenched dye fluorescence of Cy3-DNA-Au-nanoparticle hybrid conjugates using solution and array platforms.
PubMed:Optical method for predicting the composition of self-assembled monolayers of mixed thiols on surfaces coated with silver nanoparticles.
PubMed:Molecular-shape selective high-performance liquid chromatography: stabilization effect of polymer main chain by alternating copolymerization.
PubMed:Polymeric ionic liquid modified organic-silica hybrid monolithic column for capillary electrochromatography.
PubMed:Synthesis, characterization and catalytic behavior of functionalized mesoporous SBA-15 with various organo-silanes.
PubMed:Photoluminescent properties of novel rare earth organic-inorganic nanocomposite with TiO2 modified silica via double crosslinking units.
PubMed:Investigation of folate-conjugated fluorescent silica nanoparticles for targeting delivery to folate receptor-positive tumors and their internalization mechanism.
PubMed:Nanostructures of functionalized gold nanoparticles prepared by particle lithography with organosilanes.
PubMed:Effect of surface chemical composition on the work function of silicon substrates modified by binary self-assembled monolayers.
PubMed:Adsorption characteristics of haloacetonitriles on functionalized silica-based porous materials in aqueous solution.
PubMed:Thiolated mucoadhesive and PEGylated nonmucoadhesive organosilica nanoparticles from 3-mercaptopropyltrimethoxysilane.
PubMed:New solid-phase-nanoscavenger for the analytical enrichment of mercury from water.
PubMed:Back-surface gold mirrors for vibrationally resonant sum-frequency (VR-SFG) spectroscopy using 3-mercaptopropyltrimethoxysilane as an adhesion promoter.
PubMed:Preparation and characterization of silica monolith modified with bovine serum albumin-gold nanoparticles conjugates and its use as chiral stationary phases for capillary electrochromatography.
PubMed:Synthesis and solid-state NMR characterization of cubic mesoporous silica SBA-1 functionalized with sulfonic acid groups.
PubMed:Preparation of nanoporous carbons via a grafting method for the application to electrochemical double layer capacitors.
PubMed:Novel photofunctional multicomponent rare earth (Eu3+, Tb3+, Sm3+ and Dy3+) hybrids with double cross-linking siloxane covalently bonding SiO2/ZnS nanocomposite.
PubMed:Formation mechanism and size control in one-pot synthesis of mercapto-silica colloidal spheres.
PubMed:Effect of surface chemical composition on the surface potential and iso-electric point of silicon substrates modified with self-assembled monolayers.
PubMed:Polyoxometalate (POM)-based, multi-functional, inorganic-organic, hybrid compounds: syntheses and molecular structures of silanol- and/or siloxane bond-containing species grafted on mono- and tri-lacunary Keggin POMs.
PubMed:Enzyme integrated silicate-Pt nanoparticle architecture: a versatile biosensing platform.
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PubMed:Capillary electrophoresis with immobilized quantum dot fluorescence detection for rapid determination of organophosphorus pesticides in vegetables.
PubMed:Label free detection of white spot syndrome virus using lead magnesium niobate-lead titanate piezoelectric microcantilever sensors.
PubMed:Comparison of adsorption of mercaptopropyltrimethoxysilane on amphiphilic TiO2 and hydroxylated SiO2.
PubMed:Elaborate control over the morphology and structure of mercapto-functionalized mesoporous silicas as multipurpose carriers.
PubMed:Potential-controlled electrochemical seed-mediated growth of gold nanorods directly on electrode surfaces.
PubMed:Grafting of poly[1-(N,N-bis-carboxymethyl)amino-3-allylglycerol-co-dimethylacrylamide] copolymer onto siliceous support for preconcentration and determination of lead (II) in human plasma and environmental samples.
PubMed:Photophysical properties of a novel organic-inorganic hybrid material: Eu(III)-β-diketone complex covalently bonded to SiO(2) /ZnO composite matrix.
PubMed:Rapid approach to biobased telechelics through two one-pot thiol-ene click reactions.
PubMed:Preparation and characterization of silica coated iron oxide magnetic nano-particles.
PubMed:Size-controlled synthesis, surface functionalization, and biological applications of thiol-organosilica particles.
PubMed:Preparation of organic-inorganic hybrid silica monolith with octyl and sulfonic acid groups for capillary electrochromatograhpy and application in determination of theophylline and caffeine in beverage.
PubMed:Copper pattern on self-assembled monolayer through microcontact printing.
PubMed:A reusable liposome array and its application to assay of growth-hormone-related peptides.
PubMed:Improvement of cytotoxicity of titanocene-functionalized mesoporous materials by the increase of the titanium content.
PubMed:Screening platelet-surface interactions using negative surface charge gradients.
PubMed:Size-tunable highly luminescent SiO2 particles impregnated with number-adjusted CdTe nanocrystals.
PubMed:Fabrication of micro- and nano-scale gold patterns on glass by transfer printing.
PubMed:Influence of organosiloxanes on the properties of mesoporous materials.
PubMed:Alumina nanofibers grafted with functional groups: a new design in efficient sorbents for removal of toxic contaminants from water.
PubMed:New synthesis strategies for effective functionalization of kaolinite and saponite with silylating agents.
PubMed:Hybrid organic-inorganic silica monolith with hydrophobic/strong cation-exchange functional groups as a sorbent for micro-solid phase extraction.
PubMed:Silver nanoparticles self assembly as SERS substrates with near single molecule detection limit.
PubMed:One-step synthesis of functional chiral porous silica nanorods using an achiral surfactant.
PubMed:Convective assembly and dry transfer of nanoparticles using hydrophobic/hydrophilic monolayer templates.
PubMed:Factors affecting the reactivity of thiol-functionalized mesoporous silica adsorbents toward mercury(II).
PubMed:Colorimetric sensing of pyrophosphate in aqueous media using bis-functionalised silica surfaces.
PubMed:Nitric oxide-releasing S-nitrosothiol-modified xerogels.
PubMed:Stepwise formation approach to improve ellipsometric biosensor response.
PubMed:Photochemical shape control of cadmium sulfide nanorods coated with an amorphous silica thin layer.
PubMed:Modifications induced by pretreatments on Au/SBA-15 and their influence on the catalytic activity for low temperature CO oxidation.
PubMed:Spectroscopic evaluation of surface functionalization efficiency in the preparation of mercaptopropyltrimethoxysilane self-assembled monolayers on glass.
PubMed:Transfection of aqueous CdS quantum dots using polyethylenimine.
PubMed:Preparation of poly(lactic acid)/siloxane/calcium carbonate composite membranes with antibacterial activity.
PubMed:Solution chemistry approach to fabricate vertically aligned carbon nanotubes on gold wires: towards vertically integrated electronics.
PubMed:A palm-sized surface plasmon resonance sensor with microchip flow cell.
PubMed:Bifunctionalized mesoporous silicas for Cr(VI) reduction and concomitant Cr(III) immobilization.
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PubMed:Label-free, all-electrical, in situ human epidermal growth receptor 2 detection.
PubMed:Preparation, telomerization, immobilization and application of N-alkyl L-phenylalanine-derived polymerizable organogelator for reversed-phase high-performance liquid chromatography.
PubMed:[Preparation and characterization of poly(N-isopropylacrylamide) bonded silica gel stationary phase].
PubMed:Enhancement of retentivity and selectivity for PAHs in NP-HPLC by high-density immobilization of poly(4-vinylpyridine) as an organic phase on silica.
PubMed:Design of novel hybrid organic-inorganic nanostructured biomaterials for immunoassay applications.
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PubMed:Speciation of inorganic tellurium from seawater by ICP-MS following magnetic SPE separation and preconcentration.
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PubMed:MPTS-silica coated capillary microextraction on line hyphenated with inductively coupled plasma atomic emission spectrometry for the determination of Cu, Hg and Pb in biological samples.
PubMed:Synthesis and alignment of silver nanorods and nanowires and the formation of Pt, Pd, and core/shell structures by galvanic exchange directly on surfaces.
PubMed:Fabrication and self-assembly of hydrophobic gold nanorods.
PubMed:Ultrasonic-assisted synthesis of highly dispersed MoO3 nanospheres using 3-mercaptopropyltrimethoxysilane.
PubMed:3-mercaptopropyltrimethoxysilane as insulating coating and surface for protein immobilization for piezoelectric microcantilever sensors.
PubMed:Pilot evaluation of resin composite cement adhesion to zirconia using a novel silane system.
PubMed:Adsorption of trimethoxysilane and of 3-mercaptopropyltrimethoxysilane on silica and on silicon wafers from vapor phase: an IR study.
PubMed:Manipulation of the growth of gold and silver nanomaterials on glass by seeding approach.
PubMed:A tunnel current in self-assembled monolayers of 3-mercaptopropyltrimethoxysilane.
PubMed:Studies of thiol additions of silane coupling agents by vibrational spectroscopy.
PubMed:The effect of five silane coupling agents on the bond strength of a luting cement to a silica-coated titanium.
PubMed:Physicochemically modified silicon as a substrate for protein microarrays.
PubMed:Factors affecting the preparation and properties of electrodeposited silica thin films functionalized with amine or thiol groups.
PubMed:A novel and simplified procedure for patterning hydrophobic and hydrophilic SAMs for microfluidic devices by using UV photolithography.
PubMed:Structural relation properties of hydrothermally stable functionalized mesoporous organosilicas and catalysis.
PubMed:Silver-nanoparticle-attached indium tin oxide surfaces fabricated by a seed-mediated growth approach.
PubMed:Immobilization of DNA onto poly(dimethylsiloxane) surfaces and application to a microelectrochemical enzyme-amplified DNA hybridization assay.
PubMed:Micropatterning of copper on a poly(ethylene terephthalate) substrate modified with a self-assembled monolayer.
PubMed:[Preparation of polymer modified stationary phases through surface radical chain transfer reaction].
PubMed:Negatively charged sol-gel column with stable electroosmotic flow for online preconcentration of zwitterionic biomolecules in capillary electromigration separations.
PubMed:Two independent routes to synthesize identical silicas by grafting ethylenimine or 2-aminoethanethiol, their cation adsorbing abilities, and thermodynamic data.
PubMed:Functionalized organosilica microspheres via a novel emulsion-based route.
PubMed:Vibrational spectroscopic studies of (3-mercaptopropyl)trimethoxylsilane sol-gel and its coating.
PubMed:Highly photoluminescent multilayer QD-glass films prepared by LbL self-assembly.
PubMed:Growth and reactions of SiOx/Si nanostructures on surface-templated molecule corrals.
PubMed:[Microchip capillary electrophoresis-electrochemical detection of nitrite using a modified carbon paste electrode].
PubMed:Microstructuring of phospholipid bilayers on gold surfaces by micromolding in capillaries.
PubMed:Preparation of monolithic silica column with strong cation-exchange stationary phase for capillary electrochromatography.
PubMed:Biomaterial with chemically engineered surface for protein immobilization.
PubMed:Electrochemical impedance behavior of DNA biosensor based on colloidal Ag and bilayer two-dimensional sol-gel as matrices.
PubMed:Novel potentiometric immunosensor for determination of diphtheria antigen based on compound nanoparticles and bilayer two-dimensional sol-gel as matrices.
PubMed:Preparation of a sulfonated fused-silica capillary and its application in capillary electrophoresis and electrochromatography.
PubMed:Novel polymeric chelating fibers for selective removal of mercury and cesium from water.
PubMed:High surface density immobilization of oligonucleotide on silicon.
PubMed:Ethyleneimine Anchored on Thiol-Modified Silica Gel Surface-Adsorption of Divalent Cations and Calorimetric Data.
PubMed:Effects of mixed silane coupling agent on porcelain tooth material and various dental alloys.
PubMed:[Effect of 3-mercaptopropyltrimethoxysilane coupling agent on stainless steel and silica surface].
PubMed:Affinity fibre--a new support for rapid enzyme purification by high-performance liquid affinity chromatography.
PubMed:[Properties of urease immobilized on silochrome by means of disulfide bonds].
 
Notes:
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