(1R,2S)-(-)-ephedrine hydrochloride
(1R,2S)-2-(methylamino)-1-phenyl-1-propanol hydrochloride (1:1)

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  BOC Sciences

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  CODE113756 CODE113756
  Product(s):
  50-98-6 (-)-Ephedrine hydrochloride 97 % (TLC).
  alpha and beta Adrenoreceptors subtypes agonist; MAO inhibitor. Alkaloid derivative of l-Ephedrine from plants of the Ephedra genus, Ephedraceae. ADCs Cytotoxin

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  Penta International Corporation

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  CODE113756 CODE113756
  Product(s):
  05-04290 EPHEDRINE HYDROCHLORIDE

Name: (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride CAS Number: 50-98-6 3D/inchi Other(deleted CASRN): 14992-57-5 ECHA EINECS - REACH Pre-Reg: 200-074-6 FDA UNII: NLJ6390P1Z Beilstein Number: 3630391 MDL: MFCD00066127 Molecular Weight: 201.69572000 Formula: C10 H16 Cl N O BioActivity Summary: listing NMR Predictor: Predict (works with chrome, Edge or firefox) Category:pharmaceuticals / chemical synthisis   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Melting Point: 218.00 °C. @ 760.00 mm Hg Boiling Point: 255.00 °C. @ 760.00 mm Hg (est) Vapor Pressure: 0.008650 mmHg @ 25.00 °C. (est) Flash Point: 186.00 °F. TCC ( 85.60 °C. ) (est) logP (o/w): 1.054 (est) Soluble in:   water, 2.50E+05 mg/L @ 25 °C (exp)   water, 1e+006 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: BOC Sciences For experimental / research use only. (-)-Ephedrine hydrochloride 97 % (TLC). Odor: characteristic Use: alpha and beta Adrenoreceptors subtypes agonist; MAO inhibitor. Alkaloid derivative of l-Ephedrine from plants of the Ephedra genus, Ephedraceae. ADCs Cytotoxin Penta International EPHEDRINE HYDROCHLORIDE Sigma-Aldrich: Aldrich For experimental / research use only. (1R,2S)-(-)-Ephedrine hydrochloride 99% sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: intravenous-cat LDLo 60 mg/kg CARDIAC: OTHER CHANGES Medecine Vol. 9, Pg. 59, 1930. intravenous-dog LDLo 70 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Medecine Vol. 9, Pg. 59, 1930. parenteral-frog LDLo 440 mg/kg Manshu Igaku Zasshi. Manchuria Medical Journal. Vol. 3, Pg. 1, 1925. intravenous-guinea pig LD50 98 mg/kg PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: EXCITEMENT Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963. intraperitoneal-hamster LDLo 350 mg/kg CARDIAC: OTHER CHANGES Medecine Vol. 9, Pg. 59, 1930. intraperitoneal-mouse LD50 242 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 158, Pg. 135, 1967. intravenous-mouse LD50 95 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949. oral-mouse LD50 400 mg/kg Journal of Medicinal Chemistry. Vol. 9, Pg. 966, 1966. parenteral-mouse LDLo 500 mg/kg Manshu Igaku Zasshi. Manchuria Medical Journal. Vol. 3, Pg. 1, 1925. intramuscular-rabbit LD50 175 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946. intravenous-rabbit LD50 65 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949. intraperitoneal-rat LD50 165 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946. intravenous-rat LD50 69 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 33, Pg. 80, 1944. Dermal Toxicity: subcutaneous-dog LDLo 220 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Medecine Vol. 9, Pg. 59, 1930. subcutaneous-frog LDLo 400 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE Medecine Vol. 9, Pg. 59, 1930. subcutaneous-guinea pig LD50 192 mg/kg PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: EXCITEMENT Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963. subcutaneous-mouse LD50 40870 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 214, 1946. subcutaneous-rabbit LD50 165 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946. subcutaneous-rat LD50 1150 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949. Inhalation Toxicity: Not determined   Safety in Use Information: Category: pharmaceuticals / chemical synthisis Recommendation for (1R,2S)-(-)-ephedrine hydrochloride usage levels up to:   not for fragrance use.   Recommendation for (1R,2S)-(-)-ephedrine hydrochloride flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View ClinicalTrials.gov:search Daily Med:search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA Substance Registry Services (TSCA):50-98-6 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :65326 National Institute of Allergy and Infectious Diseases:Data WGK Germany:1 (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride Chemidplus:0000050986 RTECS:KB1750000 for cas# 50-98-6   References:   (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride NIST Chemistry WebBook: Search Inchi Canada Domestic Sub. List: 50-98-6 Pubchem (cid): 65326 Pubchem (sid): 135022311   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEMBL: View KEGG (GenomeNet): D01386 HMDB (The Human Metabolome Database): Search Export Tariff Code: 2939.40.5000 ChemSpider: View Wikipedia: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms:   altusin   benzenemethanol, a-[(1S)-1-(methylamino)ethyl]-, (aR)-, hydrochloride (1:1)   bronkotabs (-)- ephedrine hydrochloride (1R,2S)- ephedrine hydrochloride L-erythro- ephedrine hydrochloride   ephedroguent   ephedronguent L- erythro-2-(Methylamino)-1-phenylpropan-1-ol hydrochloride (1R,2S)-(-)-2- methylamino-1-phenyl-1-propanol hydrochloride (1R,2S)-2-( methylamino)-1-phenyl-1-propanol hydrochloride (1:1) (1R,2S)-2-( methylamino)-1-phenylpropan-1-ol hydrochloride (1:1) (1R,2S)-2-( methylamino)-1-phenylpropan-1-ol;hydrochloride [R-(R*,S*)]-a-[1-( methylamino)ethyl]benzenemethanol hydrochloride (1R,2S)-a-[1-( methylamino)ethyl]benzyl alcohol hydrochloride   primatene tablets   quadrinal   sanedrine   tedral   Articles:   None found yet. 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Notes: a phenethylamine found in ephedra sinica. pseudoephedrine is an isomer. it is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. it has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. it has become less extensively used with the advent of more selective agonists. a phenethylamine found in ephedra sinica. pseudoephedrine is an isomer. it is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. it has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. it has become less extensively used with the advent of more selective agonists.