Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Assay: | 95.00 to 100.00
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Food Chemicals Codex Listed: | No |
Melting Point: | 218.00 °C. @ 760.00 mm Hg
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Boiling Point: | 255.00 °C. @ 760.00 mm Hg (est)
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Vapor Pressure: | 0.008650 mmHg @ 25.00 °C. (est) |
Flash Point: | 186.00 °F. TCC ( 85.60 °C. ) (est)
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logP (o/w): | 1.054 (est) |
Soluble in: |
| water, 2.50E+05 mg/L @ 25 °C (exp) | | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
intravenous-cat LDLo 60 mg/kg CARDIAC: OTHER CHANGES Medecine Vol. 9, Pg. 59, 1930.
intravenous-dog LDLo 70 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Medecine Vol. 9, Pg. 59, 1930.
parenteral-frog LDLo 440 mg/kg Manshu Igaku Zasshi. Manchuria Medical Journal. Vol. 3, Pg. 1, 1925.
intravenous-guinea pig LD50 98 mg/kg PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
BEHAVIORAL: EXCITEMENT Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963.
intraperitoneal-hamster LDLo 350 mg/kg CARDIAC: OTHER CHANGES Medecine Vol. 9, Pg. 59, 1930.
intraperitoneal-mouse LD50 242 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 158, Pg. 135, 1967.
intravenous-mouse LD50 95 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949.
oral-mouse LD50 400 mg/kg Journal of Medicinal Chemistry. Vol. 9, Pg. 966, 1966.
parenteral-mouse LDLo 500 mg/kg Manshu Igaku Zasshi. Manchuria Medical Journal. Vol. 3, Pg. 1, 1925.
intramuscular-rabbit LD50 175 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.
intravenous-rabbit LD50 65 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949.
intraperitoneal-rat LD50 165 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.
intravenous-rat LD50 69 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 33, Pg. 80, 1944.
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Dermal Toxicity: |
subcutaneous-dog LDLo 220 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Medecine Vol. 9, Pg. 59, 1930.
subcutaneous-frog LDLo 400 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE Medecine Vol. 9, Pg. 59, 1930.
subcutaneous-guinea pig LD50 192 mg/kg PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
BEHAVIORAL: EXCITEMENT Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963.
subcutaneous-mouse LD50 40870 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: EXCITEMENT Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 214, 1946.
subcutaneous-rabbit LD50 165 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.
subcutaneous-rat LD50 1150 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949.
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | pharmaceuticals / chemical synthisis |
Recommendation for (1R,2S)-(-)-ephedrine hydrochloride usage levels up to: | | not for fragrance use.
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Recommendation for (1R,2S)-(-)-ephedrine hydrochloride flavor usage levels up to: |
| not for flavor use.
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Safety References:
References:
| (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride |
NIST Chemistry WebBook: | Search Inchi |
Canada Domestic Sub. List: | 50-98-6 |
Pubchem (cid): | 65326 |
Pubchem (sid): | 135022311 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| altusin | | benzenemethanol, a-[(1S)-1-(methylamino)ethyl]-, (aR)-, hydrochloride (1:1) | | bronkotabs | (-)- | ephedrine hydrochloride | (1R,2S)- | ephedrine hydrochloride | L-erythro- | ephedrine hydrochloride | | ephedroguent | | ephedronguent | L- | erythro-2-(Methylamino)-1-phenylpropan-1-ol hydrochloride | (1R,2S)-(-)-2- | methylamino-1-phenyl-1-propanol hydrochloride | (1R,2S)-2-( | methylamino)-1-phenyl-1-propanol hydrochloride (1:1) | (1R,2S)-2-( | methylamino)-1-phenylpropan-1-ol hydrochloride (1:1) | (1R,2S)-2-( | methylamino)-1-phenylpropan-1-ol;hydrochloride | [R-(R*,S*)]-a-[1-( | methylamino)ethyl]benzenemethanol hydrochloride | (1R,2S)-a-[1-( | methylamino)ethyl]benzyl alcohol hydrochloride | | primatene tablets | | quadrinal | | sanedrine | | tedral |
Articles:
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a phenethylamine found in ephedra sinica. pseudoephedrine is an isomer. it is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. it has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. it has become less extensively used with the advent of more selective agonists. a phenethylamine found in ephedra sinica. pseudoephedrine is an isomer. it is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. it has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. it has become less extensively used with the advent of more selective agonists.
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