EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

(-)-sparteine
7,14-methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-, (7S-(7alpha,7aalpha,14alpha,14abeta))-

Supplier Sponsors

CAS Number: 90-39-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:201-988-8
FDA UNII: 298897D62S
Nikkaji Web:J69.077E
MDL:MFCD00069653
XlogP3-AA:2.50 (est)
Molecular Weight:234.38622000
Formula:C15 H26 N2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.02000 @ 25.00 °C.
Refractive Index:1.52600 to 1.53000 @ 20.00 °C.
Melting Point: 30.50 °C. @ 760.00 mm Hg
Boiling Point: 325.00 °C. @ 760.00 mm Hg
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 3.210 (est)
Soluble in:
 water, 3040 mg/L @ 22 °C (exp)
 water, 1374 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
ExtraSynthese
For experimental / research use only.
Sparteine
Sigma-Aldrich: Aldrich
For experimental / research use only.
(-)-Sparteine 99%
sds
TCI AMERICA
For experimental / research use only.
(-)-Sparteine >98.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LD50 15 mg/kg
Veterinary and Human Toxicology. Vol. 41, Pg. 33, 1999.

intramuscular-frog LDLo 1665 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1398, 1935.

intraperitoneal-guinea pig LDLo 23 mg/kg
Journal of Agricultural Research Vol. 32, Pg. 51, 1926.

intravenous-guinea pig LDLo 27 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: TREMOR
Planta Medica. Vol. 50, Pg. 420, 1984.

intraperitoneal-mouse LD50 36 mg/kg
BEHAVIORAL: TREMOR BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Planta Medica. Vol. 50, Pg. 420, 1984.

oral-mouse LD50 220 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: TREMOR
Planta Medica. Vol. 50, Pg. 420, 1984.

intravenous-rabbit LDLo 30 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1398, 1935.

intraperitoneal-rat LD50 42 mg/kg
Compilation of LD50 Values of New Drugs.

oral-rat LD50 960 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 210, Pg. 27, 1974.

Dermal Toxicity:
subcutaneous-frog LDLo 3330 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1398, 1935.

subcutaneous-mouse LD50 105 mg/kg
Pharmacology and Toxicology. English translation of FATOAO. Vol. 21, Pg. 468, 1958.

subcutaneous-rabbit LDLo 100 mg/kg
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 589, 1948.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for (-)-sparteine usage levels up to:
 not for fragrance use.
 
Recommendation for (-)-sparteine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7014
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0000090391
RTECS:WG5950000 for cas# 90-39-1
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):7014
Pubchem (sid):134970944
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2921.30.3000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 esparteina
 genisteine alkaloid
 lupinidine
7,14-methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-
7,14-methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-, (7S-(7alpha,7aalpha,14alpha,14abeta))-
6-beta,7-alpha,9-alpha,11-alpha-pachycarpine
 sparteina
L-sparteine
 sparteinum
 

Articles:

PubMed:Evaluation of total quinolizidine alkaloids content in lupin flours, lupin-based ingredients, and foods.
PubMed:Bacterial removal of quinolizidine alkaloids and other carbon sources from a Lupinus albus aqueous extract.
PubMed:Chemical composition, nutritive value, and toxicology evaluation of Mexican wild lupins.
PubMed:A novel generation of coupling reagents. Enantiodifferentiating coupling reagents prepared in situ from 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and chiral tertiary amines.
PubMed:Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture.
PubMed:A 90-day feeding study of the alkaloids of Lupinus angustifolius in the rat.
PubMed:A new bioassay for testing plant extracts and pure compounds using red flour beetleTribolium castaneum Herbst.
PubMed:Potentially hazardous compound in a herbal slimming remedy.
PubMed:Effects of dietary protein and lupine alkaloids on growth and survivorship ofSpodoptera eridania.
PubMed:Reinvestigation of the alkaloids of Lupinus sericeus Pursh. Identification of a new natural product, 10,17-dioxo-beta-isosparteine.
PubMed:[Lupins - a new source of food for Andean countries. 5. Traditional methods of debittering of lupins by water].
 
Notes:
a quinolizidine alkaloid isolated from several fabaceae including lupinus; spartium; and cytisus. it has been used as an oxytocic and an anti-arrhythmia agent. it has also been of interest as an indicator of cyp2d6 genotype.
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