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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.9872 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-chicken LD50 3300 ug/kg
KIDNEY, URETER, AND BLADDER: OTHER CHANGES
LIVER: OTHER CHANGES
CARDIAC: PERICARDITIS
Applied Microbiology. Vol. 21, Pg. 492, 1971.
oral-duck LD50 500 ug/kg
LIVER: FATTY LIVER DEGERATION
Nature. Vol. 205, Pg. 1112, 1965.
intraperitoneal-mouse LD50 22 mg/kg
Acta Pharmacologica et Toxicologica. Vol. 2, Pg. 109, 1946.
intravenous-mouse LD50 25710 ug/kg
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Annales Recherches Veterinaires. Vol. 5, Pg. 233, 1974.
oral-mouse LD50 46 mg/kg
Toxicology Letters. Vol. 25, Pg. 1, 1985.
oral-quail LD50 16500 ug/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
Poultry Science. Vol. 55, Pg. 786, 1976.
intraperitoneal-rat LD50 12600 ug/kg
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Annales Recherches Veterinaires. Vol. 5, Pg. 233, 1974.
intravenous-rat LD50 12750 ug/kg
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Annales Recherches Veterinaires. Vol. 5, Pg. 233, 1974.
oral-rat LD50 20 mg/kg
LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Food and Cosmetics Toxicology. Vol. 6, Pg. 479, 1968.
unreported-rat LD50 22 mg/kg
Indian Journal of Experimental Biology. Vol. 29, Pg. 813, 1991.
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| Dermal Toxicity: |
subcutaneous-chicken LDLo 11 mg/kg
LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
Applied Microbiology. Vol. 21, Pg. 492, 1971.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for (-)-ochratoxin A usage levels up to: | | | not for fragrance use.
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| Recommendation for (-)-ochratoxin A flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | (2S)-2-[[(3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydroisochromene-7-carbonyl]amino]-3-phenylpropanoic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 442530 |
| Pubchem (cas): | 303-47-9 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | antibiotic 9663 | | (R)-N-((5- | chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo(c)pyran-7-yl)carbonyl)-3-phenyl alanine | | (2S)-2-[[(3R)-5- | chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydroisochromene-7-carbonyl]amino]-3-phenylpropanoic acid | | N-((5- | chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenyl-, (-)- | | (-)-N-((5- | chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenylalanine | | L- | phenylalanine, N-((5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl)-, (R)- |
Articles:
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Mycotoxin. Prod. by Aspergillus melleus, Aspergillus sulphureus and Penicillium viridicatum.Potential contaminant of foodstuffs, especially cereals. Found in stored grain products in UK (1997)
Ochratoxin A, a toxin produced by Aspergillus ochraceus and Penicillium verrucosum, is one of the most abundant food-contaminating mycotoxins in the world. Human exposure occurs mainly through consumption of improperly stored food products, particularly contaminated grain and pork products, as well as coffee, wine grapes and dried grapes. The toxin has been found in the tissues and organs of animals, including human blood and breast milk. Ochratoxin A toxicity has large species- and sex-specific differences.
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3D/inchi