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(-)-cyclocytidine hydrochloride
O-2,2'-cyclocytidine monohydrochloride

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Name:(2R,3R,3aS,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydrofuro[1,2][1,3]oxazolo[3,4-a]pyrimidin-3-ol;hydrochloride
CAS Number: 10212-25-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:233-515-6
FDA UNII: 3T6920M469
MDL:MFCD00012636
Molecular Weight:261.66444000
Formula:C9 H12 Cl N3 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 422.20 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000000 mmHg @ 25.00 °C. (est)
Flash Point: 408.00 °F. TCC ( 209.10 °C. ) (est)
logP (o/w): -2.301 (est)
Soluble in:
 water, 3.943e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Cyclocytidine HCl ≥98% by HPLC
Odor: characteristic
Use: 2,2'-Anhydro-cytidine-HCl is a DNA synthesis inhibitor commonly used as an antineoplastic agent to treat leukemias.
Changzhou Longo Chemical
Cyclocytidine Hydrochloride
George Uhe Company
Ancitabine Hydrochloride
Santa Cruz Biotechnology
For experimental / research use only.
Ancitabine hydrochloride
Sigma-Aldrich: Sigma
For experimental / research use only.
Ancitabine hydrochloride
sds
TCI AMERICA
For experimental / research use only.
2,2'-O-Cyclocytidine Hydrochloride >98.0%(HPLC)(N)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LD50 344 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 353, 1974.

intraperitoneal-mouse LD50 2528 mg/kg
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986

intravenous-mouse LD50 800 mg/kg
Drugs in Japan Vol. 6, Pg. 55, 1982.

oral-mouse LD50 > 7000 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.

intraperitoneal-rat LD50 3800 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.

intravenous-rat LD50 820 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.

oral-rat LD50 > 7000 mg/kg
Drugs in Japan Vol. -, Pg. 86, 1990.

Dermal Toxicity:
subcutaneous-mouse LD50 4050 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.

subcutaneous-rat LD50 > 5500 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for (-)-cyclocytidine hydrochloride usage levels up to:
 not for fragrance use.
 
Recommendation for (-)-cyclocytidine hydrochloride flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :25050
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(2R,3R,3aS,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydrofuro[1,2][1,3]oxazolo[3,4-a]pyrimidin-3-ol;hydrochloride
Chemidplus:0010212256
RTECS:LV2615000 for cas# 10212-25-6
 
References:
 (2R,3R,3aS,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydrofuro[1,2][1,3]oxazolo[3,4-a]pyrimidin-3-ol;hydrochloride
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):25050
Pubchem (sid):134990804
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C13112
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2934.99.4400
ChemSpider:View
Wikipedia:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 ancitabin hydrochlorid
 ancitabin hydrochloride
 ancitabine hydrochloride
2,2'-anhydro-1-beta-dextro-arabinofuranosyl cytosine hydrochloride
2,2'-anhydroarabinosylcytosine hydrochloride
2,2'-anhydroaracytidine hydrochloride
2,2'-anhydrocytarabine hydrochloride
2,2'-anhydrocytidine hydrochloride
 cyclocytidine hydrochloride
2,2'-O-cyclocytidine Hydrochloride
O-2,2'-cyclocytidine monohydrochloride
(2R,3R,3aS,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydrofuro[1,2][1,3]oxazolo[3,4-a]pyrimidin-3-ol;hydrochloride
 OCTD hydrochloride
 
 
Notes:
congener of cytarabine that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action.
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