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Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 255.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.008650 mmHg @ 25.00 °C. (est) |
| Flash Point: | 186.00 °F. TCC ( 85.60 °C. ) (est)
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| logP (o/w): | 1.054 (est) |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-man TDLo 1429 ug/kg
BEHAVIORAL: EXCITEMENT
CARDIAC: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 33, Pg. 237, 1928.
intraperitoneal-mouse LD50 254 mg/kg
Pharmazie. Vol. 24, Pg. 776, 1969.
intravenous-mouse LD50 135 mg/kg
Journal of Medicinal Chemistry. Vol. 9, Pg. 966, 1966.
oral-mouse LD50 700 mg/kg
Journal of Medicinal Chemistry. Vol. 9, Pg. 966, 1966.
intravenous-rabbit LDLo 60 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 36, Pg. 363, 1929.
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| Dermal Toxicity: |
subcutaneous-mouse LD50 520 mg/kg
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 55, Pg. 653, 1959.
subcutaneous-rat LD50 350 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 169, Pg. 114, 1933.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for (±)-ephedrine hydrochloride usage levels up to: | | | not for fragrance use.
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| Recommendation for (±)-ephedrine hydrochloride flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzenemethanol, a-(1-(methylamino)ethyl)-, hydrochloride, (R*,R*)-(±)- | | | benzenemethanol, a-[1-(methylamino)ethyl]-, hydrochloride (1:1) | | | benzenemethanol, a-[1-(methylamino)ethyl]-, hydrochloride, S-(R,R)- | | | benzyl alcohol, a-(1-methylaminoethyl)-, hydrochloride | | | ephedrine hydrochloride | | DL- | ephedrine hydrochloride | | | ephedrine, hydrochloride, (±)- | | | ephedrinehydrochloride | | 2-( | methylamino)-1-phenyl-1-propanol hydrochloride (1:1) | | 2-( | methylamino)-1-phenylpropan-1-ol hydrochloride (1:1) | | 2-( | methylamino)-1-phenylpropan-1-ol;hydrochloride | | DL-a-(1-( | methylamino)ethyl) benzyl alcohol hydrochloride | | (R*,S*)-(1)-a-(1-( | methylamino)ethyl)benzyl alcohol hydrochloride | | DL-a(1-( | methylamino)ethyl)benzyl alcohol hydrochloride | | (R*,S*)-a-[1-( | methylamino)ethyl]benzenemethanol hydrochloride | | | racephedrine hydrochloride |
Articles:
| PubMed:Pharmacokinetic comparisons of five ephedrine alkaloids following oral administration of four different Mahuang-Guizhi herb-pair aqueous extracts ratios in rats. |
| PubMed:[Simultaneous determination of scopolamine hydrobromide, atropine sulfate, ephedrine hydrochloride and pseudoephedrine hydrochloride in Zhichuanling oral liquid with HPLC]. |
| PubMed:[Simultaneous determination of ephedrine hydrochloride, D-pseudoephedrine and amygdalin in xiao'er pingchuan qutan granule by HPLC]. |
| PubMed:Extractive determination of ephedrine hydrochloride and bromhexine hydrochloride in pure solutions, pharmaceutical dosage form and urine samples. |
| PubMed:Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production and decreasing proinflammatory cytokine secretion via the PI3K/Akt/GSK3β pathway. |
| PubMed:Ephedrine hydrochloride: novel use in the management of resistant non-neurogenic daytime urinary incontinence in children. |
| PubMed:Clarification of route specific impurities found in methylamphetamine synthesised using the Birch method. |
| PubMed:Precise, fast, and flexible determination of protein interactions by affinity capillary electrophoresis: part 1: performance. |
| PubMed:Ephedrine hydrochloride protects mice from LPS challenge by promoting IL-10 secretion and inhibiting proinflammatory cytokines. |
| PubMed:Simultaneous determination of six active components in traditional herbal medicine 'Oyaksungisan' by HPLC-DAD. |
| PubMed:Pharmacokinetic determination of ephedrine in Herba Ephedrae and Wu Tou Tang decoctions in rats using ultra performance liquid chromatography tandem mass spectrometry. |
| PubMed:[Determination of ephedrine hydrochloride, pseudoephedrine hydrochloride and methylephedrine hydrochloride in maxingshigan decoction by CE]. |
| PubMed:[Simultaneous determination of 5 kinds of alkaloids in Kechuanning tablets by SPE-UPLC under different UV-vis wavelength]. |
| PubMed:Labeling for bronchodilators to treat asthma; cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use. Final rule. |
| PubMed:A novel accelerated oxidative stability screening method for pharmaceutical solids. |
| PubMed:Assessment of acute and chronic pharmacological effects on energy expenditure and macronutrient oxidation in humans: responses to ephedrine. |
| PubMed:[Concentration of biyankang extracts using multi-stage membranes separation]. |
| PubMed:Treatment of hypothalamic obesity with caffeine and ephedrine. |
| PubMed:Use of warm priming solution in open heart surgery: its effects on hemodynamics and acute inflammation. |
| PubMed:Rapid nondestructive on-site screening of methylamphetamine seizures by attenuated total reflection fourier transform infrared spectroscopy. |
| PubMed:Spinal anaesthesia with a micro-catheter in high-risk patients undergoing colorectal cancer and other major abdominal surgery. |
| PubMed:[Direct determination of four components in compound paracetamol and diphenhydramine tablets by wide bore capillary gas chromatography]. |
| PubMed:Flow injection-chemiluminescence determination of sulfadiazine in compound naristillae. |
| PubMed:[Investigate into of effective constituent transference of herba Ephedrae and cortex Magnoliae officinalis in preparation course of Shujin Kechuan capsule]. |
| PubMed:[Study on the preparation and quality standard of Ephedra sinica dispensing granules]. |
| PubMed:Highly sensitive spectrofluorimetric determination of ephedrine hydrochloride in pharmaceutical preparations. |
| PubMed:[Simultaneous determination of ephedrine and chlorpheniramine in human plasma by a highly sensitive liquid chromatography-tandem mass spectrometric method]. |
| PubMed:Liquid chromatography and chemometric-assisted spectrophotometric methods for the analysis of two multicomponent mixtures containing cough suppressant drugs. |
| PubMed:[Case of circulatory depression in an obese patient in prone position during general anesthesia]. |
| PubMed:Single-step recovery of ephedrine hydrochloride from raw materials using expanded bed adsorption. |
| PubMed:[Rheological and biopharmaceutical investigation of polymer drug delivery systems]. |
| PubMed:Structure and drug release of lamellar liquid crystals containing glycerol. |
| PubMed:[HPCE determination of trimebutine maleate in rat plasma and its pharmacokinetics]. |
| PubMed:[Simultaneous determination of chlorpheniramine, paracetamol and pseudo-ephedrine hydrochloride in composite tablets by high performance liquid chromatography]. |
| PubMed:Determination of theophylline and ephedrine HCL in tablets by ratio-spectra derivative spectrophotometry and LC. |
| PubMed:[Propofol anesthesia for a patient with progressive muscular dystrophy]. |
| PubMed:Determination of trimebutine maleate in rat plasma and tissues by using capillary zone electrophoresis. |
| PubMed:A prospective randomised study to assess the efficacy of differenct medications for relief of post-operative nasal obstruction. |
| PubMed:[Sources of error in the European Pharmacopoeia assay of halide salts of organic bases by titration with alkali]. |
| PubMed:[A case of fixed drug eruption due to ephedrine hydrochloride]. |
| PubMed:Effects of crystallization in the presence of the diastereomer on the crystal properties of (SS)-(+)-pseudoephedrine hydrochloride. |
| PubMed:Assay of ephedrine hydrochloride and theophylline in pharmaceutical formulations by differential-derivative spectroscopy. |
| PubMed:Simultaneous assay of ephedrine hydrochloride, theophylline, papaverine hydrochloride and hydroxyzine hydrochloride in tablets using RP-LC. |
| PubMed:Nocturnal enuresis: pathogenesis and treatment. |
| PubMed:Ephedrine pharmacokinetics after the ingestion of nutritional supplements containing Ephedra sinica (ma huang). |
| PubMed:Ophthalmic drug products for over-the-counter human use; proposed amendment of final monograph--FDA. Proposed rule. |
| PubMed:[Determination of paracetmol caffeine and ephedrine hydrochloride in likeshu capsules]. |
| PubMed:[Toxicity of drugs on nasal mucocilia and the method of its evaluation]. |
| PubMed:Do changes in cardiac output affect the inspiratory to end-trial oxygen difference? |
| PubMed:Potentiometric, enantioselective sensors for alkyl and aryl ammonium ions of pharmaceutical significance, based on lipophilic cyclodextrins. |
| PubMed:A prospective randomized study to assess the efficacy of post-operative nasal medication after endonasal surgery. |
| PubMed:Orthostatic hypotension in patients, bed rest subjects, and astronauts. |
| PubMed:[Influence of viscosity on drug release from ointments, creams, gels and emulsions]. |
| PubMed:The effect of some commercially available antihistamine and decongestant intra-nasal formulations on ciliary beat frequency. |
| PubMed:[Crystal morphological and habit investigations of crystalline drugs. II. Amobarbital, barbital and ephedrine hydrochloride]. |
| PubMed:Potentiometric determination of ephedrine hydrochloride using plastic membrane ion-selective electrode. |
| PubMed:Effects of chronic administration of ephedrine during very-low-calorie diets on energy expenditure, protein metabolism and hormone levels in obese subjects. |
| PubMed:Hypertensive crisis from chronic intoxication with nasal decongestant and cough medications. |
| PubMed:[Use of extraction-frequency metric method for the determination of microquantities of ephedrine and its application in pharmaceutical analysis]. |
| PubMed:Release of highly water-soluble medicinal compounds from inert, heterogeneous matrixes. II: Melt. |
| PubMed:Release of highly water-soluble medicinal compounds from inert, heterogeneous matrixes. I: Physical mixture. |
| PubMed:Determination of chlorpheniramine maleate, dihydrocodeine bitartrate and ephedrine hydrochloride in cough mixture by derivative and differential spectrometry. |
| PubMed:[Coronary spasm during laryngoplasty]. |
| PubMed:A simple, effective method of treating vertigo patients. |
| PubMed:Determination of enantiomeric purity of ephedrine and pseudoephedrine by high-performance liquid chromatography with dual optical rotation/UV absorbance detection. |
| PubMed:[Studies on multiwavelength absorbance ratio difference spectrophotometry and its application]. |
| PubMed:Thermal characterization of drug/polymer and excipient/polymer interactions in some film coating formulation. |
| PubMed:A controlled trial of an oral bronchodilator preparation ('Franol') in asthma. |
| PubMed:[Effect of ephedrine on the blood supply and oxygen regimen of the brain during motion sickness]. |
| PubMed:Does ephedrine promote weight loss in low-energy-adapted obese women? |
| PubMed:Use of orthogonal polynomials for unequal intervals to eliminate interference in spectrophotometric analysis. Simultaneous determination of ephedrine hydrochloride and diphenhydramine hydrochloride in two-component mixtures. |
| PubMed:A controlled trial using ephedrine in the treatment of obesity. |
| PubMed:[Arterial hypertension induced by an excess of mineralocorticoids caused by abuse of nasal spray. Report of a case]. |
| PubMed:The effect of d-amphetamine and ephedrine on smoking attitude and behavior. |
| PubMed:[Research concerning the biodisposability of ephedrine hydrochloride tablets]. |
| PubMed:Spectrophotometric determination of ephedrine hydrochloride and phenylephrine hydrochloride. |
| PubMed:A study of the thermic responses to a meal and to a sympathomimetic drug (ephedrine) in relation to energy balance in man. |
| PubMed:High-pressure liquid chromatographic assay of theophylline, ephedrine hydrochloride, and phenobarbital tablets. |
| PubMed:Simultaneous high-performance liquid chromatographic determination of theophylline, ephedrine hydrochloride, and phenobarbital in tablets. |
| PubMed:NMR assay of ephedrine hydrochloride in tablets. |
| PubMed:The effects upon vigilance and reaction speed of the addition of ephedrine hydrochloride to chlorpheniramine maleate. |
| PubMed:Scopolamine alone or combined with ephedrine in seasickness: a double-blind, placebo-controlled study. |
| PubMed:Spectrophotometric method for determination of chlorpheniramine maleate in pharmaceutical preparations in the presence of codeine phosphate and ephedrine hydrochloride. |
| PubMed:[UV spectrophotometric method for the quantitative determination of ephedrine hydrochloride]. |
| PubMed:[Periodatometric method for the quantitative determination of ephedrine hydrochloride in drug mixtures]. |
| PubMed:Simple and specific electron-capture GLC assay for plasma and urine ephedrine concentrations following single doses. |
| PubMed:[Spectrophotometric and photometric determination of ephedrine hydrochloride]. |
| PubMed:Effect of guar gum on the dissolution rate of ephedrine hydrochloride and sulphadimidine tablets. |
| PubMed:[Dansyl chloride as a reagent for sympathomimetic amines, II: Fluorimetric determination of ephedrine hydrochloride as its dansyl derivative in tablets (author's transl)]. |
| PubMed:[Absorption of ephedrine hydrochloride in the presence of auxiliary high-molecular compounds in the intestines of rats]. |
| PubMed:Structure and fragmentation mechanisms of some ions in the mass spectrum of ephedrine. |
| PubMed:UV spectrophotometric determination of aminophylline, amobarbital, and ephedrine hydrochloride in an antiasthma capsule preparation. |
| PubMed:[Changes in bile formation in calves under the influence of ephedrine hydrochloride]. |
| PubMed:Comparison of stability-indicating assay methods: ultraviolet, high pressure liquid chromatography and acid dye. |
| PubMed:The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment. |
| PubMed:Colorimetric determinations of chlorpheniramine maleate, ephedrine hydrochloride, and guaiacolsulfonate potassium in a cough syrup. |
| PubMed:Effects of tonicities and solutes of solutions on the lethality and the survival time after intraduodenal administration of ephedrine hydrochloride in mice. |
| PubMed:[Analysis of a mixture of ephedrine hydrochloride and dimedrol by grid-polybuffer distribution]. |
| PubMed:Quantitative GLC analysis of theophylline, ephedrine hydrochloride, and phenobarbital suspension. |
| PubMed:[Extraction-photometric determination of dimedrol and ephedrine hydrochloride in drug mixtures by means of acid azo dyes]. |
| PubMed:Variations in theophylline, ephedrine hydrochloride and phenobarbital tablets manufactured by thirteen firms. |
| PubMed:[Titration method of determination of ephedrine hydrochloride on the basis of copper complex formation]. |
| PubMed:Determination of aminophylline, ephedrine hydrochloride and sodium caffeinebenzoate in composed prescription drugs. |
| PubMed:[Chromatospectrophotometric method of quantitative determination of theophylline, dimedrol and ephedrine hydrochloride in drug mixtures]. |
| PubMed:[Determination of ephedrine hydrochloride in compound pharmaceutical preparations by means of para-toluenesulfonic acid]. |
| PubMed:Quantitative gas chromatographic determination of methapyrilene fumarate, ephedrine hydrochloride, and codeine phosphate in syrup. |
| PubMed:[Determination of theophylline, caffeine and ephedrine hydrochloride in the preparation Belladrinal tablet]. |
| PubMed:[Reactions for the identification of ephedrine hydrochloride and their use in examination of drug mixtures]. |
| PubMed:USE OF EPHEDRINE HYDROCHLORIDE IN THE PAPYROGRAPHY OF AMINO ACIDS. |
| PubMed:[Action of adrenaline and ephedrine hydrochloride on the activity of Lebistes reticulus (Peociliidae--Cyprinodontiformes)]. |
| PubMed:[EXPERIMENTAL CLINICAL TESTING OF N-HYDROXYETHYLPROMETHAZINE CHLORIDE (APROBIT) COMBINED WITH EPHEDRINE HYDROCHLORIDE IN THE NASAL CAVITY]. |
| PubMed:Spectrophotometric assay of capsules of aminophylline, amobarbital, and ephedrine hydrochloride. |
| PubMed:[Chromatographic purity test for ephedrine hydrochloride. VI. Behavior of the alkaloidal salt solution on aluminum hydroxide column]. |
| PubMed:[Action of alkaline chlorobicarbonated water on the antidiuretic effects of ephedrine hydrochloride]. |
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3D/inchi