EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

(+)-pilocarpine hydrochloride
2(3H)-furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)-, hydrochloride (1:1)

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Name:(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one;hydrochloride
CAS Number: 54-71-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-212-5
FDA UNII: 0WW6D218XJ
Beilstein Number:4034491
MDL:MFCD00012722
Molecular Weight:244.72089000
Formula:C11 H17 Cl N2 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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US Patents:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 204.00 °C. @ 760.00 mm Hg
Boiling Point: 431.80 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000000 mmHg @ 25.00 °C. (est)
Flash Point: 419.00 °F. TCC ( 215.00 °C. ) (est)
logP (o/w): -0.095 (est)
Soluble in:
 water, 1.00E+06 mg/L @ 25 °C (exp)
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Pilocarpine Hydrochloride >98%
Odor: characteristic
Use: Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.
Penta International
PILOCARPINE HYDROCHLORIDE
Santa Cruz Biotechnology
For experimental / research use only.
(+)-Pilocarpine hydrochloride ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Pilocarpine hydrochloride ≥98% (titration), powder
sds
TCI AMERICA
For experimental / research use only.
Pilocarpine Hydrochloride >98.0%(HPLC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraarterial-guinea pig LDLo 20 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.

intravenous-guinea pig LDLo 20 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.

intraperitoneal-mouse LD50 155 mg/kg
AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Archiv fuer Toxikologie. Vol. 29, Pg. 39, 1972.

intravenous-mouse LD50 150 mg/kg
Drugs in Japan Vol. -, Pg. 901, 1990.

oral-mouse LD50 200 mg/kg
Drugs in Japan Vol. 6, Pg. 646, 1982.

intraperitoneal-rat LD50 203 mg/kg
Drugs in Japan Vol. -, Pg. 901, 1990.

Dermal Toxicity:
subcutaneous-mouse LD50 200 mg/kg
Drugs in Japan Vol. -, Pg. 901, 1990.

subcutaneous-rat LD50 230 mg/kg
Drugs in Japan Vol. -, Pg. 901, 1990.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for (+)-pilocarpine hydrochloride usage levels up to:
 not for fragrance use.
 
Recommendation for (+)-pilocarpine hydrochloride flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):54-71-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5909
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one;hydrochloride
Chemidplus:0000054717
RTECS:TK1450000 for cas# 54-71-7
 
References:
 (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one;hydrochloride
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5909
Pubchem (sid):134971941
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D02200
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2939.99.0000
ChemSpider:View
Wikipedia:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
Formulations/Preparations:
•adsorbocarpine (burton, parsons)...almocarpine (ayerst)...isopto carpine (alcon)...mi-pilo (barnes-hind)...mistura p (lederle)...pilocar (smp)...pilocel (softcon products)...pilomioton (smp)hcl; pv carpine liquifilm (allergan)...pilofrin liquifilm (allergan)nitrate •ocusert pilo-20, pilo-40 (alza)
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 adsorbocarpine
 akarpine
 almocarpine
 ami-pilo
 amistura P
(3S,4R)-4,5-dihydro-3-ethyl-4-(1-methyl-1H-imidazol-5-ylmethyl)-2(3H)-furanone hydrochloride
 e-pilo
 epicar
3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydro-2(3H)-furanone hydrochloride
(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one hydrochloride
(3S,4R)-3-ethyl-4-[(1-methylimidazol-5-yl)methyl]-3,4,5-trihydrofuran-2-one, chloride
(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one;hydrochloride
(3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone hydrochloride
(3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone monohydrochloride
2(3H)-furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, monohydrochloride, (3S-cis)-
2(3H)-furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, monohydrochloride, (3S,4R)-
2(3H)-furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)-, hydrochloride (1:1)
2(3H)-furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)-, monohydrochloride
 mistura P
 pilocar
 pilocarpine HCl
 pilomiotin
 pilopine HS
 pilostat
 pilovisc
 salagen
 sanpilo
 sno pilo
 spersacarpine hydrochloride
 

Articles:

PubMed:Evaluation of behavioral parameters and mortality in a model of temporal lobe epilepsy induced by intracerebroventricular pilocarpine administration.
PubMed:Status epilepticus during early development disrupts sexual behavior in adult female rats: recovery with sexual experience.
PubMed:[Alkalimetric titrations of salts of organic bases in the Pharmacopoeia].
PubMed:Poly(acrylic acid)-poly(ethylene glycol) nanoparticles designed for ophthalmic drug delivery.
PubMed:Effect of lithium-pilocarpine-induced status epilepticus on ultrasonic vocalizations in the infant rat pup.
PubMed:Impaired skin microcirculation in paediatric patients with type 1 diabetes mellitus.
PubMed:Influence of aspirin on pilocarpine-induced epilepsy in mice.
PubMed:Precise, fast, and flexible determination of protein interactions by affinity capillary electrophoresis: part 1: performance.
PubMed:A ketogenic diet did not prevent effects on the ectonucleotidases pathway promoted by lithium-pilocarpine-induced status epilepticus in rat hippocampus.
PubMed:Eye drops preservative as the cause of corneal band keratopathy in long-term pilocarpine hydrochloride treatment.
PubMed:Amino acid tissue levels and GABAA receptor binding in the developing rat cerebellum following status epilepticus.
PubMed:Simple chemiluminescence determination of pilocarpine in pharmaceuticals and human serum.
PubMed:Area under rheogram as multi-point viscosity characteristic of the sterilized hypromellose hydrogels.
PubMed:Investigations of hippocampal astrocytes in lipopolysaccharide-preconditioned rats in the pilocarpine model of epilepsy.
PubMed:Upregulation of Krüppel-like factor 6 in the mouse hippocampus after pilocarpine-induced status epilepticus.
PubMed:Efficacy and safety of orally administered pilocarpine hydrochloride for patients with juvenile-onset Sjögren's syndrome.
PubMed:Effect of ketogenic diet on nucleotide hydrolysis and hepatic enzymes in blood serum of rats in a lithium-pilocarpine-induced status epilepticus.
PubMed:Pupillary autonomic dysfunction in multiple system atrophy and Parkinson's disease: an assessment by eye-drop tests.
PubMed:Sex-related differences in sweat gland cholinergic sensitivity exist irrespective of differences in aerobic capacity.
PubMed:Neurochemical changes on oxidative stress in rat hippocampus during acute phase of pilocarpine-induced seizures.
PubMed:Behavioural and histological effects of preconditioning with lipopolysaccharide in epileptic rats.
PubMed:Phthriasis palpebrarum mimicking lid eczema and blepharitis.
PubMed:Genetic polymorphisms of CYP2A6 affect the in-vivo pharmacokinetics of pilocarpine.
PubMed:Neuroprotective effects of edaravone, a free radical scavenger, on the rat hippocampus after pilocarpine-induced status epilepticus.
PubMed:Controlled release gelatin hydrogels and lyophilisates with potential application as ocular inserts.
PubMed:Pupillary supersensitivity and visual disturbance in Parkinson's disease.
PubMed:Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy.
PubMed:Sterilized ophthalmic hydrogels with hydroxypropyl methylcellulose: determination and mathematical treatment of flow properties.
PubMed:Effects of the vitamin E in catalase activities in hippocampus after status epilepticus induced by pilocarpine in Wistar rats.
PubMed:Prevention of oral and salivary gland impairment in irradiated adolescent patients with head and neck cancer: a suggested protocol.
PubMed:Effect of pilocarpine hydrochloride on unstimulated whole saliva flow rate and composition in patients with chronic graft-versus-host disease (cGVHD).
PubMed:Efficacy of pilocarpine lozenge for post-radiation xerostomia in patients with head and neck cancer.
PubMed:Pilocarpine treatment in a mixed cohort of xerostomic patients.
PubMed:Involvement of CYP2A6 in the formation of a novel metabolite, 3-hydroxypilocarpine, from pilocarpine in human liver microsomes.
PubMed:Phase transition water-in-oil microemulsions as ocular drug delivery systems: in vitro and in vivo evaluation.
PubMed:Evaluation of monolithic C18 HPLC columns for the fast analysis of pilocarpine hydrochloride in the presence of its degradation products.
PubMed:Pilocarpine hydrochloride for the treatment of xerostomia in patients with Sjögren's syndrome in Taiwan--a double-blind, placebo-controlled trial.
PubMed:Development of a rat pilocarpine model of seizure/status epilepticus that mimics chemical warfare nerve agent exposure.
PubMed:[Pharmacological and clinical profile of pilocarpine hydrochloride (SALAGEN) Tab. 5 mg)].
PubMed:Pilocarpine for the treatment of salivary glands' impairment caused by radioiodine therapy for thyroid cancer.
PubMed:Erythropoietin preconditioning on hippocampus neuronal apoptosis following status epilepticus induced by Li-pilocarpine in rats through anti-caspase-3 expression.
PubMed:Changes in lumen width of nasolacrimal drainage system after adrenergic and cholinergic stimulation.
PubMed:[Analysis of cardiac parameters in animals with epilepsy: possible cause of sudden death?].
PubMed:Vinylpyrrolidone-co-(meth)acrylic acid inserts for ocular drug delivery: synthesis and evaluation.
PubMed:Comparison of sweat rate during graded exercise and the local rate induced by pilocarpine.
PubMed:Disruption of cortical development as a consequence of repetitive pilocarpine-induced status epilepticus in rats.
PubMed:Human cornea construct HCC-an alternative for in vitro permeation studies? A comparison with human donor corneas.
PubMed:Randomized controlled trial of pilocarpine hydrochloride for the moderation of oral mucositis during autologous blood stem cell transplantation.
PubMed:Cultivation and characterization of a bovine in vitro model of the cornea.
PubMed:Changes in the shape of the anterior and posterior corneal surfaces caused by mydriasis and miosis: detailed analysis.
PubMed:The relationship between salivary secretion rate and masticatory efficiency.
PubMed:Effect of pilocarpine hydrochloride on salivary production in previously irradiated head and neck cancer patients.
PubMed:Absorption, distribution and excretion of 14C-pilocarpine following oral administration to rats.
PubMed:Human corneal equivalent as cell culture model for in vitro drug permeation studies.
PubMed:Dual-stimuli-responsive hydrogels based on poly(N-isopropylacrylamide)/chitosan semi-interpenetrating networks.
PubMed:Plasminogen activator activity and inhibition in rabbit tears after photorefractive keratectomy.
PubMed:Efficacy and economic evaluation of pilocarpine in treating radiation-induced xerostomia.
PubMed:Effects of pilocarpine hydrochloride and cevimeline on submandibular/sublingual salivation in rat xerostomia model produced by X-ray irradiation.
PubMed:Influence of process parameters of high-pressure emulsification method on the properties of pilocarpine-loaded nanoparticles.
PubMed:Ultrasonographic biomicroscopy, Scheimpflug photography, and novel provocative tests in contralateral eyes of Chinese patients initially seen with acute angle closure.
PubMed:Pilocarpine hydrochloride.
PubMed:Pilocarpine for radiation-induced xerostomia in head and neck cancer.
PubMed:Ocular drug permeation following experimental excimer laser treatment on the isolated pig eye.
PubMed:N-cholinergic facilitation of glutamate release from an individual retinotectal fiber in frog.
PubMed:In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride.
PubMed:[Development of an organotypic corneal construction as an in vitro model for permeability studies].
PubMed:Pilocarpine treatment of xerostomia in head and neck patients.
PubMed:Prophylactic effects of pilocarpine hydrochloride on xerostomia models induced by X-ray irradiation in rats.
PubMed:Randomized double blind, placebo-controlled study of pilocarpine administered during head and neck irradiation to reduce xerostomia.
PubMed:Reconstruction of an in vitro cornea and its use for drug permeation studies from different formulations containing pilocarpine hydrochloride.
PubMed:Carbopol/pluronic phase change solutions for ophthalmic drug delivery.
PubMed:Physicochemical characterization of a reverse micellar solution after loading with different drugs.
PubMed:Post-radiation severe xerostomia relieved by pilocarpine: a prospective French cooperative study.
PubMed:Reductions with lithium in low molecular weight amines and ethylenediamine
PubMed:Modulation of tear film protein secretion with phosphodiesterase inhibitors.
PubMed:Influence of muscarinic ligands on the amplitudes of the evoked surface potential's late components in the optic tectum of the urodele Plethodon jordani.
PubMed:A case of glaucoma with choroidal hemangioma managed by nonpenetrating trabeculectomy.
PubMed:Comparison of dorzolamide and pilocarpine as adjunctive therapy in patients with open-angle glaucoma and ocular hypertension.
PubMed:s-IgA and cytokine levels in whole saliva of Sjögren's syndrome patients before and after oral pilocarpine hydrochloride administration: a pilot study.
PubMed:Pilocarpine hydrochloride relieves xerostomia in chronic graft-versus-host disease: a sialometrical study.
PubMed:Acute and chronic structural effects of pilocarpine on monkey outflow tissues.
PubMed:Pilocarpine induces an increase in the anterior chamber angular width in eyes with narrow angles.
PubMed:Candida albicans levels in patients with Sjögren's syndrome before and after long-term use of pilocarpine hydrochloride: a pilot study.
PubMed:Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sjögren syndrome: a randomized, placebo-controlled, fixed-dose, multicenter trial. P92-01 Study Group.
PubMed:The use of pilocarpine hydrochloride to prevent xerostomia in a child treated with high dose radiotherapy for nasopharynx carcinoma.
PubMed:Normal variation in, and effect of 2% pilocarpine on, intraocular pressure and pupil size in female horses.
PubMed:Evaluation of pluronic F127-based sustained-release ocular delivery systems for pilocarpine using the albino rabbit eye model.
PubMed:Effects of H-7 on the iris and ciliary muscle in monkeys.
PubMed:Analysis of parotid and mixed saliva in Roe deer (Capreolus capreolus L.).
PubMed:A comparison of artificial saliva and pilocarpine in the management of xerostomia in patients with advanced cancer.
PubMed:In vitro evaluation of pluronic F127-based controlled-release ocular delivery systems for pilocarpine.
PubMed:Long-lasting salivation induced by a novel muscarinic receptor agonist SNI-2011 in rats and dogs.
PubMed:Interictal and ictal activity in the rat cobalt/pilocarpine model of epilepsy decreased by local perfusion of diazepam.
PubMed:[Treatment with pilocarpine hydrochloride for sicca symptoms in Sjögren's syndrome].
PubMed:Influence of alpha-cyclodextrin and hydroxyalkylated beta-cyclodextrin derivatives on the in vitro corneal uptake and permeation of aqueous pilocarpine-HCl solutions.
PubMed:Concomitant pilocarpine during head and neck irradiation is associated with decreased posttreatment xerostomia.
PubMed:Pilocarpine hydrochloride for symptomatic relief of xerostomia due to chronic graft-versus-host disease or total-body irradiation after bone-marrow transplantation for hematologic malignancies.
PubMed:[Preparation and evaluation of solid dispersions of pilocarpine hydrochloride for alleviation of xerostomia].
PubMed:Developmental aspects of the pilocarpine model of epilepsy.
PubMed:Pilot study of controlled-release pilocarpine in normal subjects.
PubMed:Determination of the efficacy of topical oral pilocarpine for postirradiation xerostomia in patients with head and neck carcinoma.
PubMed:A multicenter maintenance study of oral pilocarpine tablets for radiation-induced xerostomia.
PubMed:The effect of topical cholinergic medications on human Tenon's capsule fibroblasts in tissue culture.
PubMed:The incidence of atonic pupil following cataract surgery.
PubMed:Oral pilocarpine hydrochloride for the treatment of refractory xerostomia associated with chronic graft-versus-host disease.
PubMed:Oral pilocarpine for radiation-induced xerostomia: integrated efficacy and safety results from two prospective randomized clinical trials.
PubMed:Effects of postoperative mitomycin C on glaucoma filtration surgery in rabbits treated preoperatively with antiglaucoma medications.
PubMed:The muscarinic receptor agonist L-658,903 modulates the in vivo accumulation of inositol monophosphates in mouse brain.
PubMed:Pilocarpine incorporated into a submicron emulsion vehicle causes an unexpectedly prolonged ocular hypotensive effect in rabbits.
PubMed:Amplitudes of accommodation of primate lenses refilled with two types of inflatable endocapsular balloons.
PubMed:Continuous drug delivery through the use of disposable contact lenses.
PubMed:Effects of antiglaucoma medications on bovine trabecular meshwork cells in vitro.
PubMed:Intraocular pressure reduction with topically administered pilocarpine, timolol and betaxolol in normal tension glaucoma.
PubMed:Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer.
PubMed:Sialadenosis in bulimia. A new treatment.
PubMed:[Studies of releasing rate of pilocarpine hydrochloride from hydrogel eye ointments].
PubMed:A multicenter, randomized, double-blind, placebo-controlled, dose-titration study of oral pilocarpine for treatment of radiation-induced xerostomia in head and neck cancer patients.
PubMed:Analysis of pilocarpine and its trans epimer, isopilocarpine, by capillary electrophoresis.
PubMed:Effects of papaverine pilocarpine and epinephrine on fistulized rabbit conjunctiva.
PubMed:Timolol-pilocarpine fixed-ratio combinations in the treatment of chronic open angle glaucoma. A controlled multicenter study of 48 weeks. Scandinavian Timpilo Study Group.
PubMed:'Black cornea' after long-term epinephrine use.
PubMed:Age-related loss of ciliary muscle mobility in the rhesus monkey. Role of the choroid.
PubMed:Characterization of cholinergic regulation of seizures by the midline thalamus.
PubMed:High-performance liquid chromatographic determination of pilocarpine hydrochloride and its degradation products using a beta-cyclodextrin column.
PubMed:Comparison of the postoperative intraocular pressure with Betagan, Betoptic, Timoptic, Iopidine, Diamox, Pilopine Gel, and Miostat.
PubMed:Outflow facility and its response to pilocarpine decline in aging rhesus monkeys.
PubMed:Pilocarpine treatment of salivary gland hypofunction and dry mouth (xerostomia).
PubMed:Argon laser trabeculoplasty medical therapy to prevent the intraocular pressure rise associated with argon laser trabeculoplasty.
PubMed:Sweating function and retinal vasomotor reactivity in migraine.
PubMed:Occurrence of malignant glaucoma after laser iridotomy.
PubMed:Drug binding of ophthalmic viscoelastic agents.
PubMed:Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy.
PubMed:Consensual pupillary responses to mydriatic and miotic drugs.
PubMed:A technique for accurate application of pilocarpine gel.
PubMed:The susceptibility of rats to pilocarpine-induced seizures is age-dependent.
PubMed:The seizures induced by pilocarpine: behavioral, electroencephalographic and neuropathological studies in rodents.
PubMed:Pilocarpine antagonizes prostaglandin F2 alpha-induced ocular hypotension in monkeys. Evidence for enhancement of Uveoscleral outflow by prostaglandin F2 alpha.
PubMed:Influence of sodium hyaluronate on the meiotic effect of pilocarpine in rabbits.
PubMed:Treatment of elevated intraocular pressure with concurrent levobunolol and pilocarpine.
PubMed:Intraocular pressure effects of multiple doses of drugs applied to glaucomatous monkey eyes.
PubMed:Systemic therapy of salivary gland hypofunction.
PubMed:Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain.
PubMed:The effect of chronic ethanol consumption on salivary gland morphology and function in the rat.
PubMed:Anisocoria and aerosolized anticholinergics.
PubMed:Stirring device for direct microtitration of pilocarpine hydrochloride in individual single-dose containers.
PubMed:In-vitro study of physostigmine salicylate and pilocarpine hydrochloride release from different gel formulations.
PubMed:Stability of pilocarpine hydrochloride and pilocarpine nitrate ophthalmic solutions submitted by U.S. hospitals.
PubMed:The threshold for limbic seizures in rats is decreased by intranigral morphine.
PubMed:The in vivo evaluation of poly(lactic acid) microcapsules of pilocarpine hydrochloride.
PubMed:Effects of the substance P antagonist [D-Arg1,D-Pro2,D-Trp7,9,Leu11]SP on miosis caused by echothiophate iodide or pilocarpine hydrochloride.
PubMed:Controlled release of pilocarpine hydrochloride from ethylene-vinyl alcohol copolymer matrices.
PubMed:Effects of morphine and naloxone on pilocarpine-induced convulsions in rats.
PubMed:[The stability of pilocarpine hydrochloride in eyedrops].
PubMed:[Eye pellets with pilocarpine hydrochloride].
PubMed:The therapy of Adie's syndrome with dilute pilocarpine hydrochloride solutions.
PubMed:[Drug therapy of chronic glaucoma with pilocarpine gel].
PubMed:Alteration of acetylcholine synthesis by pilocarpine. In vivo and in vitro studies.
PubMed:Effect of sterilization by autoclaving on the stability of eye drops of pilocarpine hydrochloride and physostigmine sulphate.
PubMed:Pilocarpine hydrochloride liposomes: characterization in vitro and preliminary evaluation in vivo in rabbit eye.
PubMed:Modification of pancreatic carcinogenesis in the hamster model. XI. Inhibitory effect of pilocarpine hydrochloride.
PubMed:Effect of urea on the activity of certain ophthalmic drugs in man.
PubMed:Monocular polyopia.
PubMed:[The role of the cholinergic system in controlling the nocturnal prolactin surge in pseudopregnant rats].
PubMed:Duration of effect of pilocarpine gel.
PubMed:Ocular hypotensive effects of N-demethylated carbachol on open angle glaucoma.
PubMed:[Investigations of the efficacy and bio-availability of different pilocarpine eye drops].
PubMed:[Permeability of phenylephrine hydrochloride. Its related compounds, and pilocarpine hydrochloride across bovine eye-lens capsule (author's transl)].
PubMed:High-performance liquid chromatographic analysis of pilocarpine hydrochloride, isopilocarpine, pilocarpic acid and isopilocarpic acid in eye-drop preparations.
PubMed:[Effect of methylcellulose and carboxymethylcellulose on the biological availability of eye drops containing pilocarpine hydrochloride].
PubMed:[The effect of pilocarpine hydrochloride on the isolated frog retina (author's transl)].
PubMed:Effects of scopolamine, pilocarpine, and oxotremorine on the exploratory behavior of two psychogenetically selected lines of rats in a complex maze.
PubMed:Dose-response of topical pilocarpine in the normotensive and glaucomatous Beagle.
PubMed:Comparison between pilocarpine and timolol on diurnal pressures in open-angle glaucoma.
PubMed:Topically applied pilocarpine. Human pupillary response as a function of drop size.
PubMed:Efficacy and patient acceptance of pilocarpine gel.
PubMed:[Technology of preparing stable eyedrops of fetanol and its combination with pilocarpine hydrochloride].
PubMed:[Effect of pilocarpine hydrochloride on the aqueous humor production in the rabbit (author's transl)].
PubMed:Paradoxical intraocular pressure response to pilocarpine. A proposed mechanism and treatment.
PubMed:A clinical trial with Piloplex--a new long-acting pilocarpine compound: preliminary report.
PubMed:Direct spectorphotometric assay of quaternary ammonium compounds using bromthymol blue.
PubMed:Piloplex, a new long-acting pilocarpine polymer salt. A: Long-term study.
PubMed:Study of parotid and mixed saliva in the diagnosis of chronic pancreatitis.
PubMed:Piloplex, a new long-acting pilocarpine polymer salt. B: Comparative study of the visual effects of pilocarpine and Piloplex eye drops.
PubMed:Inlfuence of high-viscosity vehicles on miotic effect of pilocarpine.
PubMed:A proposed pilocarpine therapeutic test.
PubMed:[Quantitative semimicro- and microdetermination of pilocarpine hydrochloride via formation of polyiodide complexes].
PubMed:Ciliary muscle dysfunction in Adie's syndrome.
PubMed:Experimental hyphema clearance in rabbits. Drug trials with 1% atropine and 2% and 4% pilocarpine.
PubMed:Clonidine. Effects of a topically administered solution on intraocular pressure and blood pressure in open-angle glaucoma.
PubMed:Development and disappearance of subsensitivity to pilocarpine following a single administration of the irreversible anticholinesterase angent, DFP.
PubMed:Quantitative analysis of degradation products in pilocarpine hydrochloride ophthalmic formulations.
PubMed:Control of the pilocarpine release rate through hydrogels by plasma treatment.
PubMed:[Clinical and experimental examination of the resorption capacity of the tympanic cavity mucosa (author's transl)].
PubMed:Pilocarpine hydrochloride in ophthalmic solutions: modification of a high-pressure liquid chromatographic determination and survey.
PubMed:Pilocarpine therapy in glaucoma: effects on anterior chamber depth and lens thickness in patients receiving long-term therapy.
PubMed:[Use of aminon for the extractive and photometric determination of pilocarpine hydrochloride].
PubMed:Ocular penetration of pilocarpine in rabbits.
PubMed:Inhibition of pancreatic exocrine secretion by vinblastine.
PubMed:[Utilization of dimethyldodecylbenzylammonium chloride for eyedrops made of pilocarpine hydrochloride].
PubMed:[Stability of pilocarpine hydrochloride solutions containing a buffer solvent and preservatives].
PubMed:Formulation of a stable pilocarpine hydrochloride solution.
PubMed:[Influence of gamma-rays on pilocarpine hydrochloride].
PubMed:[Determination of storage conditions of 2 per cent pilocarpine hydrochloride solutions by the method of enhanced disintegration].
PubMed:A comparison of pilocarpine hydrochloride and epinephrine bitartrate.
PubMed:[Study of the stability and storage time of eyedrops--solutions of pilocarpine hydrochloride, atropine sulfate and scopolamine hydrobromide].
PubMed:[Analysis of pharmaceuticals by autoanalyzer. V. Determination of pilocarpine hydrochloride in pharmaceutical preparations].
PubMed:Assay of pilocarpine hydrochloride solutions.
PubMed:[PROPOSALS FOR THE DAB 7. 13. PILOCARPINE HYDROCHLORIDE].
PubMed:[Action of atropine sulfate and pilocarpine hydrochloride on the net water flow at the level of the isolated skin of Rana temporaria temporaria L].
PubMed:Infrared analysis of active ingredients in ointments. II. Pilocarpine hydrochloride and phenacaine hydrochloride.
PubMed:The effects of pilocarpine hydrochloride on hepatic bile secretion.
PubMed:THE PHENOMENON OF LOCAL SKIN REACTIVITY TO BACTERIAL FILTRATES: ELICITATION OF LOCAL REACTIVITY BY WAY OF THE VASCULAR SYSTEM.
 
Notes:
a slowly hydrolyzed muscarinic agonist with no nicotinic effects. pilocarpine is used as a miotic and in the treatment of glaucoma.
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