(+)-digitoxigenin
3-beta,14-dioxy-digen-(20:22)-olid

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  CODE113324 CODE113324
  Product(s):
  143-62-4 Digitoxigenin ≥95%
  Digitoxigenin is a cardenolide and aglycone constituent of digitoxin, an extract from the foxglove plant, D. purpurea. Digitoxi

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  CODE113324 CODE113324
  Product(s):
  D0541 (+)-Digitoxigenin >97.0%(HPLC)
  SDS

Name: 3-[(3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one CAS Number: 143-62-4 3D/inchi ECHA EINECS - REACH Pre-Reg: 205-603-4 FDA UNII: S63WOD4VOL Nikkaji Web: J5.822J Beilstein Number: 0095448 MDL: MFCD00003687 XlogP3: 2.60 (est) Molecular Weight: 374.52078000 Formula: C23 H34 O4 BioActivity Summary: listing NMR Predictor: Predict (works with chrome, Edge or firefox) Category:pharmaceuticals / chemical synthisis   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Melting Point: 253.00 °C. @ 760.00 mm Hg Boiling Point: 549.30 °C. @ 760.00 mm Hg (est) Flash Point: 371.00 °F. TCC ( 188.20 °C. ) (est) logP (o/w): 2.640 Soluble in:   water, 24.46 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: BOC Sciences For experimental / research use only. Digitoxigenin ≥95% Odor: characteristic Use: Digitoxigenin is a cardenolide and aglycone constituent of digitoxin, an extract from the foxglove plant, D. purpurea. Digitoxi ExtraSynthese For experimental / research use only. Digitoxigenin (HPLC) ≥95% Santa Cruz Biotechnology For experimental / research use only. Digitoxigenin 97% Sigma-Aldrich: Sigma For experimental / research use only. Digitoxigenin sds TCI AMERICA For experimental / research use only. (+)-Digitoxigenin >97.0%(HPLC) sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: intravenous-cat LDLo 254 ug/kg GASTROINTESTINAL: NAUSEA OR VOMITING Journal of the American Pharmaceutical Association. Vol. 27, Pg. 189, 1938. intravenous-guinea pig LDLo 1419 ug/kg BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS CARDIAC: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives Internationales de Pharmacodynamie et de Therapie. Vol. 153, Pg. 436, 1965. intravenous-mouse LD50 1131 ug/kg Life Sciences. Vol. 37, Pg. 775, 1985. oral-mouse LD50 26170 ug/kg BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS CARDIAC: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives Internationales de Pharmacodynamie et de Therapie. Vol. 153, Pg. 436, 1965. intravenous-rat LD50 1600 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 848, 1961. Dermal Toxicity: subcutaneous-mouse LD50 11820 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS CARDIAC: OTHER CHANGES Archives Internationales de Pharmacodynamie et de Therapie. Vol. 153, Pg. 436, 1965. Inhalation Toxicity: Not determined   Safety in Use Information: Category: pharmaceuticals / chemical synthisis Recommendation for (+)-digitoxigenin usage levels up to:   not for fragrance use.   Recommendation for (+)-digitoxigenin flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :4369270 National Institute of Allergy and Infectious Diseases:Data WGK Germany:3 3-[(3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one Chemidplus:0000143624 RTECS:FH4975000 for cas# 143-62-4   References:   3-[(3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one NIST Chemistry WebBook: Search Inchi Pubchem (cid): 4369270 Pubchem (sid): 134973931   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View HMDB (The Human Metabolome Database): Search Export Tariff Code: 2938.90.0000 VCF-Online: VCF Volatile Compounds in Food ChemSpider: View Wikipedia: View EFSA Update of results on the monitoring of furan levels in food: Read Report EFSA Previous report: Results on the monitoring of furan levels in food: Read Report EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   found in nature   Synonyms:   card-20(22)-enolide, 3,14-dihydroxy-, (3-beta,5-beta)-   cardogenen-(20:22)-diol-(3-beta,14)   cerberigenin   digitoxigenin   digitoxigenine 3-[(3S,5R,8R,9S,10S,13R,14S,17R)-3,14- dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one 3-beta,14- dihydroxy-5-beta-card-20(22)-enolide 3-beta,14- dihydroxy-5-beta,14-beta-card-20(22)-enolide 3beta,14- dihydroxy-5beta-card-20(22)-enolide 3-beta,14- dioxy-carden-(20:22)-olid 3-beta,14- dioxy-digen-(20:22)-olid   echujetin   evonogenin   thevetigenin delta-sup(20:22)-3,14,21- trihydroxynorcholenic acid lactone delta20:22-3,14,21- trihydroxynorcholenic acid lactone delta-sup(20:22)-3,14,21- trihydroxynorcholenicacid lactone   Articles:   None found yet. 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Notes: 3 beta,14-dihydroxy-5 beta-card-20(22)enolide. a cardenolide which is the aglycon of digitoxin. synonyms: cerberigenin; echujetin; evonogenin; thevetigenin.