EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

cymarin
stropheantin K

Supplier Sponsors

CAS Number: 508-77-0Picture of molecule3D/inchi
Other(deleted CASRN):1367-21-1
ECHA EINECS - REACH Pre-Reg:208-087-9
FDA UNII: UK3LS8435E
Beilstein Number:0101370
MDL:MFCD00003669
XlogP3:0.80 (est)
Molecular Weight:548.67348000
Formula:C30 H44 O9
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 148.00 °C. @ 760.00 mm Hg
Boiling Point: 722.10 °C. @ 760.00 mm Hg (est)
Flash Point: 451.00 °F. TCC ( 232.70 °C. ) (est)
logP (o/w): 0.640
Soluble in:
 water, 98.71 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
CYMARIN
ExtraSynthese
For experimental / research use only.
Cymarin (HPLC) ≥90%
Santa Cruz Biotechnology
For experimental / research use only.
Cymarin
Sigma-Aldrich: Sigma
For experimental / research use only.
Cymarin ≥96% (HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-cat LD50 95 ug/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 223, 1942.

parenteral-cat LD50 110 ug/kg
Bollettino Chimico Farmaceutico. Vol. 98, Pg. 297, 1959.

unreported-cat LDLo 110 ug/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 471, 1964.

intraperitoneal-mouse LD50 12 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 165, 1965.

intravenous-mouse LD50 2800 ug/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 908, 1961.

intravenous-rat LD50 20 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 165, 1965.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for cymarin usage levels up to:
 not for fragrance use.
 
Recommendation for cymarin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :56844123
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0000508770
RTECS:GZ5600000 for cas# 508-77-0
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):56844123
Pubchem (sid):135269993
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2938.90.0000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 cymarine
5-beta-card-20(22)-enolide, 3-beta-(beta-d-cymarosyloxy)-5,14-dihydroxy-19-oxo-
 alvonal MR
K-strophanthin-alpha
 strofantidina cimaroside
 strophanthidin-D-cymarosid
 stropheantin K
 

Articles:

PubMed:Convallatoxin: A new P-glycoprotein substrate.
PubMed:Treatment of human embryonic stem cells with different combinations of priming and inducing factors toward definitive endoderm.
PubMed:Interaction of digitalis-like compounds with p-glycoprotein.
PubMed:Cardiotonic effect of Apocynum venetum L. extracts on isolated guinea pig atrium.
PubMed:LC-ESI-MS/MS characterization of strophanthin-K.
PubMed:Inhibitory effect of Adonis amurensis components on tube-like formation of human umbilical venous cells.
PubMed:Cardenolides as oviposition deterrents to twoPieris species: Structure-activity relationships.
PubMed:Properties of palytoxin-induced whole cell current in single rat ventricular myocytes.
PubMed:Vesicular uptake system for the cation lucigenin in the rat hepatocyte.
PubMed:Chemical constituents ofErysimum cheiranthoides deterring oviposition by the cabbage butterfly,Pieris rapae.
PubMed:Palytoxin-induced K+ efflux from ileal longitudinal smooth muscle of the guinea-pig.
PubMed:Preparation and evaluation of technetium-99m labeled cardiac glycoside derivatives as potential myocardial imaging agent.
PubMed:Palytoxin induces a relatively non-selective cation permeability in frog sciatic nerve which can be inhibited by cardiac glycosides.
PubMed:Human cell mutants affected in the interaction of the 12 beta-OH group of cardiac glycosides with the digitalis receptor.
PubMed:Absorption, metabolism and elimination of strophanthus glycosides in man.
PubMed:Fast atom bombardment and tandem mass spectrometry for structure determination of steroid and flavonoid glycosides.
PubMed:Interaction of palytoxin and cardiac glycosides on erythrocyte membrane and (Na+ + K+) ATPase.
PubMed:Involvement of the sugar moiety in the inhibitory action of the cardiac glycosides on the palytoxin-induced responses in vascular smooth muscles.
PubMed:Photoaffinity labeling of (Na+K+)-ATPase with [125I]iodoazidocymarin.
PubMed:Sugar moiety of cardiac glycosides is essential for the inhibitory action on the palytoxin-induced K+ release from red blood cells.
PubMed:[Effect of plant glycosides on resistance and capacitance vessels].
PubMed:Cytotoxic principles of Parquetina nigrescens (Afzel.) Bullock (Asclepiadaceae).
PubMed:Cardenolides of Trachomitum sarmatiense Woodson.
PubMed:Photoaffinity labeling of the ouabain-binding site on (Na+ plus K+) adenosinetriphosphatase.
PubMed:Isolation of cymarin from Adonis aestivalis.
PubMed:[Our experiences with Cymarin (C 197) in the oral therapy of heart insufficiency].
PubMed:[The inhibitory effect of cardiac glycosides on 86 Rb-uptake of erythrocytes. I. Studies on the determination of cymarin (k-strophantin-a) and digitoxin].
PubMed:[The inhibitory effects of cardiac glycosides on 86 Rb uptake of erythrocytes. 3. The influence of different substances on the inhibitory effect of cymarin on 86 Rb-uptake of erythrocytes].
PubMed:[The inhibitory effect of cardiac glycosides on 86 Rb-uptake of erythrocytes. II. Specificity of the inhibitory effect with special attention to cymarin (k-strophantin-a) and its derivatives].
PubMed:[Clinical quantitative studies on cardio-active glycosides. A review with special reference to the studies on rapid fibrillation using cymarin].
PubMed:Structure-activity relationships of several cardiotonic steroids with respect to inhibition of ion transport in frog muscle.
PubMed:[On the quantitative effectiveness of k-strophanthin-alpha (Cymarin) in intravenous and oral administration].
PubMed:[The effect of strophanthin, corelborin and cymarin on the cardiovascular system in patients with circulatory insufficiency following heart surgery].
PubMed:[Experimental studies of cardiac glycosides corelborin P and cymarin].
PubMed:[Standardization of an Apocynum extract with pure cymarin].
PubMed:[Comparison of the effect of Digitalis lanata standard drug with digoxin and cymarin on guinea pigs].
PubMed:[Oral therapy of cardiac insufficiency with cymarin (Alvonal MR)].
PubMed:[Effect of corelborine P, cymarin and strophanthin K on cardiovascular system of dogs with symptoms of cardiac insufficiency].
PubMed:[The extracardial effect of cymarin on the smooth muscles of the intestine].
PubMed:[Experience with cymarin in the practice].
PubMed:Distribution, excretion and metabolism of cymarin in the rat.
PubMed:[COMPARATIVE STUDIES ON THE EFFECT OF STROPHANTHIN AND CYMARIN IN PATIENTS WITH PREDOMINANTLY LEFT CARDIAC INSUFFICIENCY].
PubMed:[COMPARATIVE BIOLOGICAL EFFECTS OF STROPHANTHIN-K, CORELBORIN-P, CYMARIN AND PERIPLOCIN ON THE CAT HEART IN LESIONS INDUCED WITH ZINC HYDROXIDE].
PubMed:TUMOR INHIBITORS. IV. APOCANNOSIDE AND CYMARIN, THE CYTOTOXIC PRINCIPLES OF APOCYNUM CANNABINUM L.
PubMed:The isolation of cymarin and periplocymarin from the seeds of Castilloa elastica Cerv.
PubMed:[Cymarin, an orally effective k-strophanthin].
PubMed:[On the characteristics of the action of strophanthin and cymarin in experimental myocardial infarct].
PubMed:[Data on comparative studies of the activity of crystalline cymarin and standard liquid Adonis preparation on R. temporaria].
PubMed:[Examination of hexahydroscillaren A & allocymarin as possible antagonists of scillaren A & cymarin on isolated heart].
PubMed:[Comparative therapeutic effects of strophanthin and cymarin in experimental myocarditis].
PubMed:[Some new drugs with cardio-vascular action].
PubMed:[Not Available].
PubMed:[Not Available].
 
Notes:
a cardiotonic cardiac glycoside found in strophanthus. the aglycone is strophanthin.
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