EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

broxuridine
5-bromo-2'-deoxyuridine

Supplier Sponsors

Name:5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
CAS Number: 59-14-3Picture of molecule3D/inchi
Other(deleted CASRN):1236362-78-9
ECHA EINECS - REACH Pre-Reg:200-415-9
FDA UNII: G34N38R2N1
Nikkaji Web:J2.335C
Beilstein Number:0030395
MDL:MFCD00006529
XlogP3:-0.30 (est)
Molecular Weight:307.10067000
Formula:C9 H11 Br N2 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 192.50 °C. @ 760.00 mm Hg
Vapor Pressure:1.700000 mmHg @ 25.00 °C. (est)
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -0.290
Soluble in:
 water, 966.6 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Bromodeoxyuridine (BrdU) > 98% by HPLC
Odor: characteristic
Use: 5-Bromo-2'-deoxyuridine (5-BrdU) is a thymidine analog that can be incorporated into newly synthesized DNA to label it.
Carbosynth
For experimental / research use only.
5-Bromo-2'-deoxyuridine
EMD Millipore
For experimental / research use only.
5-Bromo-2'-deoxyuridine
George Uhe Company
5-Bromo-2'-deoxyuridine
Glentham Life Sciences
5-Bromo-2'-deoxyuridine
Santa Cruz Biotechnology
For experimental / research use only.
5-Bromo-2'-deoxyuridine ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
5-Bromo-2'-deoxyuridine BioUltra, ≥99%
TCI AMERICA
For experimental / research use only.
5-Bromo-2'-deoxyuridine >98.0%(HPLC)(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 3050 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION CARDIAC: PULSE RATE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 530, 1971.

intravenous-mouse LD50 2500 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION CARDIAC: PULSE RATE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 530, 1971.

oral-mouse LD50 9100 mg/kg
BLOOD: CHANGES IN SPLEEN BEHAVIORAL: MUSCLE WEAKNESS
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 530, 1971.

oral-quail LD50 > 100 mg/kg
Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.

intraperitoneal-rat LD50 1500 mg/kg
Advances in Teratology. Vol. 3, Pg. 181, 1968.

intravenous-rat LD50 2320 mg/kg
VASCULAR: OTHER CHANGES
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 735, 1971.

oral-rat LD50 8400 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 467, 1973.

unreported-rat LD50 2300 mg/kg
Drugs in Japan Vol. 6, Pg. 721, 1982.

Dermal Toxicity:
subcutaneous-mouse LD50 3500 mg/kg
CARDIAC: PULSE RATE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 530, 1971.

subcutaneous-rat LD50 3900 mg/kg
CARDIAC: PULSE RATE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 530, 1971.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for broxuridine usage levels up to:
 not for fragrance use.
 
Recommendation for broxuridine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):59-14-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6035
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Chemidplus:0000059143
EPA/NOAA CAMEO:hazardous materials
RTECS:YU7350000 for cas# 59-14-3
 
References:
 5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:59-14-3
Pubchem (cid):6035
Pubchem (sid):134972288
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D01763
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2934.20.8000
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 brdurd
5-bromo-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
5-bromo-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
5-bromo-1-(2-deoxy-b-D-ribofuranosyl)uracil
5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
(+)-5-bromo-2-deoxyuridine
(+)-5-bromo-2'-deoxyuridine
5-bromo-2'-deoxyuridine
 bromodeoxyuridine
5-bromodeoxyuridine
5-bromodesoxyuridine
 bromoouridine
 bromouracil deoxyriboside
5-bromouracil deoxyriboside
5-bromouracil-2-deoxyriboside
1-[(4S,2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-bromo-1,3-dihydropyrimidine-2,4-dione
 radibud
 uridine, 5-bromo-2'-deoxy-
 

Articles:

PubMed:[A combined therapy for maxillary cancer].
PubMed:Effects of orally administered 5-fluorouracil and its derivative 5'-deoxy-5-fluorouridine on 7,12-dimethylbenz[a]anthracene-induced breast carcinomas in rats.
PubMed:[A combined treatment of carcinoma of the maxillary sinus--treatment method for T4 cases].
PubMed:Distinctive eruption characterized by linear supravenous papules and erythroderma following broxuridine (bromodeoxyuridine) therapy and radiotherapy.
PubMed:[Treatment of maxillary cancer].
PubMed:[Effects of oxygen and broxuridine on the cytotoxic effects of D-T neutrons and x-rays].
PubMed:Combined surgery, radiotherapy and regional chemotherapy in carcinoma of the maxillary sinus.
 
Notes:
a nucleoside that substitutes for thymidine in dna and thus acts as an antimetabolite. it causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. it has been given orphan drug status for use in the treatment of primary brain tumors.
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy