EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sodium fluorescein
benzoic acid, 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-, sodium salt (1:2)

Supplier Sponsors

CAS Number: 518-47-8Picture of molecule3D/inchi
Other(deleted CASRN):121511-05-5
ECHA EINECS - REACH Pre-Reg:208-253-0
FDA UNII: 93X55PE38X
Nikkaji Web:J79.264K
Beilstein Number:3833041
MDL:MFCD00167039
Molecular Weight:376.27523856
Formula:C20 H10 Na2 O5
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:coloring agents (for surface only)
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:orange-red to dark red powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 662.60 °C. @ 760.00 mm Hg (est)
Flash Point: 477.00 °F. TCC ( 247.10 °C. ) (est)
logP (o/w): 3.395 (est)
Soluble in:
 water, 1247 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: cosmetic colorants
 
Suppliers:
Abbey Color
Acid Yellow 73
BOC Sciences
For experimental / research use only.
Fluorescein, Disodium Salt (Uranine) 95%
ECSA Chemicals
FLUORESCEIN SODIUM SALT RE-PURE-C.I. 45350,
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
FLUORESCEIN SODIUM SALT RE-PURE-C.I. 45350,
ECSA Chemicals
FLUORESCEIN SODIUM SALT RPE-FOR ANALYSIS-C.I
EMD Millipore
For experimental / research use only.
Fluorescein, Sodium Salt
Glentham Life Sciences
Fluorescein sodium salt, 98% (C.I. 45350)
Kishi Kasei
Yellow No.201
Kishi Kasei
Yellow No.202-(1)
Kishi Kasei
Yellow No.202-(2)
Penta International
FLUORESCEIN SODIUM SALT
Penta International
SODIUM FLUORESCEIN
Santa Cruz Biotechnology
For experimental / research use only.
Fluorescein sodium salt
Sigma-Aldrich
For experimental / research use only.
Fluorescein sodium salt used as fluorescent tracer
TCI AMERICA
For experimental / research use only.
Uranine
Wedor Corporation
URANINE
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LD50 1000 mg/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Toxicology and Applied Pharmacology. Vol. 29, Pg. 97, 1974.

intraperitoneal-guinea pig LDLo 1000 mg/kg
Chemical Warfare Laboratories Technical Memorandum. Vol. #47-6, Pg. 1959

intravenous-man TDLo 7142 ug/kg
SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE GASTROINTESTINAL: NAUSEA OR VOMITING
American Journal of Ophthalmology. Vol. 103, Pg. 111, 1987.

intravenous-man TDLo 14 mg/kg/10M-I
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Anesthesia and Analgesia Vol. 66, Pg. 283, 1987.

intravenous-mouse LD50 1000 mg/kg
Toxicology and Applied Pharmacology. Vol. 29, Pg. 97, 1974.

oral-mouse LD50 4738 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Periodontology. Vol. 48, Pg. 228, 1977.

intravenous-rat LD50 1000 mg/kg
BLOOD: OTHER CHANGES
Toxicology and Applied Pharmacology. Vol. 29, Pg. 97, 1974.

oral-rat LD50 6721 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Periodontology. Vol. 48, Pg. 228, 1977.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
coloring agents (for surface only)
Recommendation for sodium fluorescein usage levels up to:
 not for fragrance use.
 
Recommendation for sodium fluorescein flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):518-47-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10608
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate
Chemidplus:0000518478
EPA/NOAA CAMEO:hazardous materials
RTECS:LM5425000 for cas# 518-47-8
 
References:
 disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:518-47-8
Pubchem (cid):10608
Pubchem (sid):134976488
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D02024
HMDB (The Human Metabolome Database):Search
Export Tariff Code:3204.90.0000
FDA Color Additive Status ListView
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 cosmetic colorants
 hair dyeing agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 acid yellow 73
 acid yellow 73 (c.i. 45350)
 aizen uranine
 basacid yellow 226
 benzoic acid, 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-, sodium salt (1:2)
 c.i. 45350
 calcocid uranine B4315
9-o-carboxyphenyl-6-hydroxy-3-isoxanthone, disodium salt
 certiqual fluoresceine
 ci 45350
 d&c yellow no. 8
 dc yellow no. 8 (c.i. 45350)
 disodium 2-(3-oxo-6-oxidoxanthen-9-yl) benzoate (c.i. 45350)
 disodium 2-(3-oxo-6-oxidoxanthen-9-yl)benzoate
 disodium 2-(6-oxido-3-oxo-3h-xanthen-9-yl)benzoate
 disodium 6-hydroxy-3-oxo-9-xanthene-o-benzoate
 disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate
 floures
 fluor-I-strip A.T.
 fluorescein disodium salt
 fluorescein LT
 fluorescein sodium
 fluorescein sodium salt (c.i. 45350)
 flurenate
 hidacid uranine
 japan yellow 202(1)
 obiturine
 sodium salt of hydroxy-o-carboxy-phenyl-fluorone
 uranin A
 uranin S
 uranine A
 uranine O
 uranine SS
 uranine WSS
 

Articles:

PubMed:Sodium fluorescein use during intraoperative cystoscopy.
PubMed:Determination of alditols by capillary electrophoresis with indirect laser-induced fluorescence detection.
PubMed:Target-to-background enhancement in multispectral endoscopy with background autofluorescence mitigation for quantitative molecular imaging.
PubMed:Do gastrointestinal taste receptors contribute to associative learning and foraging behavior?
PubMed:The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat.
PubMed:The safety of intravenous fluorescein for confocal laser endomicroscopy in the gastrointestinal tract.
PubMed:Influence of carrageenan on the rheology and skin permeation of microemulsion formulations.
PubMed:Phospholipase C-mediated intestinal mucosal damage is ameliorated by quinacrine.
PubMed:The teratogenic potential in rats and rabbits of D & C Yellow No. 8.
PubMed:Influence of surface-active food additives on the integrity and permeability of rat intestinal mucosa.
PubMed:Chemical contamination of animal feeding systems: evaluation of two caging systems and standard cage-washing equipment.
 
Notes:
a phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. it has been approved by fda for use in externally applied drugs and cosmetics. (from merck index, 12th ed; american medical association drug evaluations; 1995, p2275)
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