tetrahydroxypropyl ethylenediamine
2-propanol, 1',1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-
 
Notes:
None found
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      Product(s):
      T0781 N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine >98.0%(T)
       
Synonyms   Articles   Notes   Search
1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino]propan-2-ol (Click)
CAS Number: 102-60-3Picture of molecule
Other: 1087406-22-1
ECHA EINECS - REACH Pre-Reg: 203-041-4
FDA UNII: Q4R969U9FR
Nikkaji Web: J5.514J
Beilstein Number: 1781143
MDL: MFCD00004534
XlogP3-AA: -0.70 (est)
Molecular Weight: 292.41984000
Formula: C14 H32 N2 O4
NMR Predictor: Predict (works with chrome or firefox)
Category: chelating agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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NCBI: Search
DG SANTE Food Contact Materials: N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: chelating agents
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Suppliers:
BOC Sciences
For experimental / research use only.
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine N/A
EMD Millipore
For experimental / research use only.
Ethylenediamine-N,N,N',N'-tetra-2-propanol
Santa Cruz Biotechnology
For experimental / research use only.
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
N,N,N',N'-Tetrakis(2-Hydroxypropyl)ethylenediamine 98%
TCI AMERICA
For experimental / research use only.
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine >98.0%(T)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
unreported-mammal (species unspecified) LD50  3900 mg/kg
Farm Chemicals Handbook. Vol. -, Pg. C258, 1991.

intravenous-rat LD  > 500 mg/kg
Dissertation Abstracts International, B: The Sciences and Engineering. Vol. 52, Pg. 762, 1991.

oral-rat LD  > 500 mg/kg
Dissertation Abstracts International, B: The Sciences and Engineering. Vol. 52, Pg. 762, 1991.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: chelating agents
Recommendation for tetrahydroxypropyl ethylenediamine usage levels up to:
 not for fragrance use.
 
Recommendation for tetrahydroxypropyl ethylenediamine flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
EPA Substance Registry Services (TSCA): 102-60-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 7615
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino]propan-2-ol
Chemidplus: 0000102603
RTECS: UB5604000 for cas# 102-60-3
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References:
 1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino]propan-2-ol
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 102-60-3
Pubchem (cid): 7615
Pubchem (sid): 134971616
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
KEGG (GenomeNet): D03948
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2922.19.7000
Haz-Map: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 chelating agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 adeka quadrol
 edetol
 edetol [USAN:INN]
 edetolum
 entprol
 ethylene diamine-N,N,N',N'-tetra-2-propanol
1,1',1'',1'''-ethylene dinitrilotetrapropan-2-ol
1,1',1',1'''-(ethylenedinitrilo)tetra-2-propanol
1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol
1,1',1'',1'''-(ethylenedinitrilo)tetrakis(2-propanol)
1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino]propan-2-ol
 neutrol TE
2-propanol, 1,1',1',1'''-(1,2-ethanediyldinitrilo)tetrakis-
2-propanol, 1,1',1'',1'''-(ethylenedinitrilo)tetra-
2-propanol, 1',1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-
 quadrol L
N,N,N',N'-tetra(2-hydroxypropyl)ethylenediamine
 tetrahydroxypropyl ethylene diamine
 tetrakis-(N-(2-hydroxypropyl)) ethylene diamine
 tetrakis-N-(2-hydroxypropyl) ethane-1,2-diamine
 tetrakis-N-(2-hydroxypropyl) ethylene diamine
N,N,N',N'-tetrakis(2-hydroxypropyl) ethylene diamine
 tetrakis(2-hydroxypropyl)ethylenediamine
N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine
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Articles:
PubMed: Clinical evidence for the activity of tetrahydroxypropyl ethylenediamine (THPE), a new anti-aging active cosmetic.
PubMed: Evaluation of the efficacy of a topical cosmetic slimming product combining tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol, In vitro, ex vivo and in vivo studies.
PubMed: Allergic contact dermatitis caused by tetrahydroxypropyl ethylenediamine in cosmetic products.
PubMed: Contact sensitivity to tetrahydroxypropyl ethylenediamine in a sunscreen, without cross-sensitivity to ethylenediamine.
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