EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

vitamin A
retinol

Supplier Sponsors

Name:(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
CAS Number: 68-26-8Picture of molecule3D/inchi
Other(deleted CASRN):13123-33-6
ECHA EINECS - REACH Pre-Reg:200-683-7
FDA UNII: G2SH0XKK91
Nikkaji Web:J1.417F
Beilstein Number:0403040
XlogP3:5.70 (est)
Molecular Weight:286.45830000
Formula:C20 H30 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Name:(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
CAS Number: 11103-57-4Picture of molecule3D/inchi
Other(deleted CASRN):1341-18-0
ECHA EINECS - REACH Pre-Reg:234-328-2
FDA UNII: Search
XlogP3:5.70 (est)
Molecular Weight:286.45830000
Formula:C20 H30 O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1930 Vitamin A View - review
FDA Mainterm (SATF):68-26-8 ; VITAMIN A
FDA Regulation:
FDA PART 101 -- FOOD LABELING
Subpart A--General Provisions
Sec. 101.14 Health claims: general requirements.


FDA PART 101 -- FOOD LABELING
Subpart A--General Provisions
Sec. 101.9 Nutrition labeling of food.


FDA PART 107 -- INFANT FORMULA
Subpart D--Nutrient Requirements
Sec. 107.100 Nutrient specifications.


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.110 Milk.


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.111 Acidified milk.


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.112 Cultured milk.


FDA PART 131 -- MILK AND CREAM


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.127 Nonfat dry milk fortified with vitamins A and D.


FDA PART 131 -- MILK AND CREAM


FDA PART 131 -- MILK AND CREAM


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.147 Dry whole milk.


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.200 Yogurt.


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.203 Lowfat yogurt.


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.206 Nonfat yogurt.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.102 Asiago fresh and asiago soft cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.106 Blue cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.111 Caciocavallo siciliano cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.141 Gorgonzola cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.165 Parmesan and reggiano cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.181 Provolone cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.183 Romano cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.195 Swiss and emmentaler cheese.


FDA PART 135 -- FROZEN DESSERTS
Subpart B--Requirements for Specific Standardized Frozen Desserts
Sec. 135.130 Mellorine.


FDA PART 166 -- MARGARINE
Subpart B--Requirements for Specific Standardized Margarine
Sec. 166.110 Margarine.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE


FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1245 Beta-carotene.


FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1930 Vitamin A.
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 63.00 to 65.00 °C. @ 760.00 mm Hg
logP (o/w): 5.680
Soluble in:
 water, 0.6713 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
American International Chemical, LLC.
Retinol
American International Chemical, LLC.
Vitamin A
Axsyn
For experimental / research use only.
Vitamin A
BASF
Vitamin A Care Grades
BOC Sciences
For experimental / research use only.
Vitamin A >98%
DSM Nutritional
Vitamin A
ECSA Chemicals
RETINOL
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Graham Chemical
Vitamin A
OQEMA
Vitamin A 1000
Penta International
VITAMIN A ALCOHOL USP
Penta International
VITAMIN A ALCOHOL
Prinova
Vitamin A
WILD Flavors
Vitamin A
Flavor: taste
Through WILD’s agreement with Cognis® Nutrition and Health, natural Vitamin E is now available to customers. Vitamins A, C and E show antioxidant activity. They all reduce oxidative stress in the body by neutralizing free radicals.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 2000 mg/kg
Acta Dermato-Venereologica, Supplementum. Vol. 74, Pg. 29, 1975.

oral-mouse LD50 1510 mg/kg
"The Retinoids, Vol.2," Sporn, M.B., et al., eds., New York, Academic Press, Inc., 1984Vol. 2, Pg. 287, 1984.

intraperitoneal-mouse LD50 1510 mg/kg
Journal of the American Academy of Dermatology. Vol. 6, Pg. 652, 1982.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
nutrient supplements
Recommendation for vitamin A usage levels up to:
 not for fragrance use.
 
Recommendation for vitamin A flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the substantiation of a health claim related to vitamin A and contribution to normal development and function of the immune system pursuant to Article 14 of Regulation (EC) No 1924/2006
View page or View pdf

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin A
View page or View pdf

Scientific Opinion on Dietary Reference Values for vitamin A
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):68-26-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :445354
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
Chemidplus:0000068268
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
Chemidplus:0011103574
EPA/NOAA CAMEO:hazardous materials
 
References:
 (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:68-26-8
Pubchem (cid):445354
Pubchem (sid):149148
 (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:11103-57-4
Pubchem (cid):445354
Pubchem (sid):168221
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C00473
HMDB (The Human Metabolome Database):HMDB00305
FooDB:FDB013828
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
Formulations/Preparations:
•aqueous soln (dispersions) of oil-soluble vit are prepared by the use of an emulsifying agent such as polysorbate 80. •there are many types of preparations that contain retinol. these include solutions of pure synthetic retinol and concentrates that contain both retinol and vitamin d in various proportions. vitamin a capsules contain 3 to 15 mg of retinol (10,000 to 50,000 usp vitamin a units) per capsule: tablets are also available. a water-miscible preparation (15 mgml; 50,000 usp unitsml) can be given intramuscularly. tretinoin (all-trans-retinoic acid; retin-a) is available for topical use as a solution (0.05%), a cream (0.05 and 0.1%), and a gel (0.025 and 0.01%). isotretinoin (13-cis-retinoic acid; accutane) is available for oral use as 10, 20, and 40 mg capsules.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 buckthorn sea buckthorn
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 chicory leaf
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 oat leaf
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 parsley shoot
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 poppy opium poppy fruit
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 soybean leaf
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Synonyms:
(all-E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
all-trans-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-1-nona-2,4,6,8-tetraenol
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetr aen-1-ol
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
2,4,6,8-nonatetraen-1-ol, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-
2,6,8-nonatetraen-1-ol, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-
 retinol
all-trans-retinol
all-trans-retinyl alcohol
 vitamin A
all-trans-vitamin A
all-trans-vitamin A alcohol
 
 
Notes:
retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. dietary vitamin a is derived from a variety of carotenoids found in plants. it is enriched in the liver, egg yolks, and the fat component of dairy products. Constit. of many fish-liver oils, milk, egg-yolk, etc. Nutrient, dietary supplement [DFC] Retinol is one of the animal forms of vitamin A. It is a diterpenoid and an alcohol. It is convertible to other forms of vitamin A, and the retinyl ester derivative of the alcohol serves as the storage form of the vitamin in animals. [Wikipedia]
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