| CAS Number: | 38837-70-6 |  3D/inchi
|
| FDA UNII: | Search |
| Nikkaji Web: | J2.942.729A |
| XlogP3-AA: | -3.50 (est) |
| Molecular Weight: | 303.31557000 |
| Formula: | C12 H21 N3 O6 |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
| EFSA/JECFA Comments: |
| The main impurities found using HPLC analysis were L-ã-Glutamyl-L-Valyl-L-Valyl-Glycine (2.0 %) along with L-á-glutamyl-L-valyl-glycine (á-Glu-Val-Gly) plus its cyclisation product 5-oxo-L-prolyl-L-valyl-glycine (PCA-Val-Gly) (the two together amounting to 0.7 %). Other, related small peptides were detected and the sum of all peptide impurities was about 4 %. Residual solvents were tested for by GC and the results were ethyl acetate < 50 mg/kg, methanol < 30 mg/kg, tetrahydrofuran < 10 mg/kg and toluene < 10 mg/kg (Flavour Industry, 2014). |
Category:flavor enhancers, nutrient supplements
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | off white powder (est) |
| Assay: | 99.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 225.00 to 228.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 697.00 to 698.00 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 708.00 °F. TCC ( 375.30 °C. ) (est)
|
| Soluble in: |
| | alcohol | | | water, 3.05e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor Description:mild savory yeasty |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | flavor enhancers, nutrient supplements |
| Recommendation for laevo-gamma-glutamyl-laevo-valyl-glycine usage levels up to: | | | not for fragrance use.
|
| |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 25. Update in publication number(s): 27, 29, 30 |
| Click here to view publication 25 |
| | average usual ppm | average maximum ppm |
| baked goods: | 15.00000 | 30.00000 |
| beverages(nonalcoholic): | 20.00000 | 50.00000 |
| beverages(alcoholic): | 20.00000 | 50.00000 |
| breakfast cereal: | 80.00000 | 160.00000 |
| cheese: | 20.00000 | 50.00000 |
| chewing gum: | 10.00000 | 30.00000 |
| condiments / relishes: | 30.00000 | 60.00000 |
| confectionery froastings: | 15.00000 | 40.00000 |
| egg products: | 15.00000 | 45.00000 |
| fats / oils: | 30.00000 | 60.00000 |
| fish products: | 15.00000 | 45.00000 |
| frozen dairy: | 20.00000 | 50.00000 |
| fruit ices: | 20.00000 | 50.00000 |
| gelatins / puddings: | 15.00000 | 40.00000 |
| granulated sugar: | - | - |
| gravies: | 30.00000 | 60.00000 |
| hard candy: | 20.00000 | 50.00000 |
| imitation dairy: | 20.00000 | 50.00000 |
| instant coffee / tea: | 10.00000 | 30.00000 |
| jams / jellies: | 20.00000 | 50.00000 |
| meat products: | 15.00000 | 45.00000 |
| milk products: | 15.00000 | 45.00000 |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | 15.00000 | 45.00000 |
| processed fruits: | - | - |
| processed vegetables: | 15.00000 | 45.00000 |
| reconstituted vegetables: | 15.00000 | 45.00000 |
| seasonings / flavors: | 80.00000 | 160.00000 |
| snack foods: | 80.00000 | 160.00000 |
| soft candy: | 15.00000 | 40.00000 |
| soups: | 20.00000 | 50.00000 |
| sugar substitutes: | 80.00000 | 160.00000 |
| sweet sauces: | 30.00000 | 60.00000 |
Safety References:
European Food Safety Authority (EFSA) reference(s):
|
Scientific Opinion on Flavouring Group Evaluation 401 (FGE.401): ?-Glutamyl-valyl-glycine from chemical group 34
View page or View pdf
|
| EPI System: View |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :25099093 |
| National Institute of Allergy and Infectious Diseases:Data |
| (2S)-2-amino-5-[[(1R)-1-(carboxymethylcarbamoyl)-2-methyl-propyl]amino]-5-oxo-pentanoic acid |
References:
| | (2S)-2-amino-5-[[(1R)-1-(carboxymethylcarbamoyl)-2-methyl-propyl]amino]-5-oxo-pentanoic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 25099093 |
| Pubchem (sid): | 250183943 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (S)-2- | amino-5-[(R)-1-(carboxymethylamino)-3-methyl-1-oxobutan-2-ylamino]-5-oxopentanoic acid | | (2S)-2- | amino-5-[[(1R)-1-(carboxymethylcarbamoyl)-2-methyl-propyl]amino]-5-oxo-pentanoic acid | | L-gamma- | glutamyl-L-valyl glycine | | L-?- | glutamyl-L-valyl-glycine | | L-gamma- | glutamyl-L-valyl-glycine | | N-(N-L-gamma- | glutamyl-L-valyl)-glycine | | N-(N-laevo-gamma- | glutamyl-laevo-valyl)-glycine | | | glutamyl-valyl-glycine |
Articles:
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