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(±)-4-hydroxyproline
proline, (±)-4-hydroxy-

Supplier Sponsors

Name:(±)-4-hydroxypyrrolidine-2-carboxylic acid
CAS Number: 36901-87-8Picture of molecule3D/inchi
FDA UNII: 54EG46W66L
Nikkaji Web:J4.116E
MDL:MFCD00066718
XlogP3-AA:-3.30 (est)
Molecular Weight:131.13133000
Formula:C5 H9 N O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 355.00 to 356.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000001 mmHg @ 25.00 °C. (est)
Flash Point: 336.00 °F. TCC ( 168.60 °C. ) (est)
logP (o/w): -0.350 (est)
Soluble in:
 alcohol
 water, 3.947e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Sigma-Aldrich: Aldrich
For experimental / research use only.
4-Hydroxypyrrolidine-2-carboxylic acid
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
flavoring agents
Recommendation for (±)-4-hydroxyproline usage levels up to:
 not for fragrance use.
 
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :825
National Institute of Allergy and Infectious Diseases:Data
(±)-4-hydroxypyrrolidine-2-carboxylic acid
Chemidplus:0036901878
 
References:
 (±)-4-hydroxypyrrolidine-2-carboxylic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):825
Pubchem (sid):125706174
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
HMDB (The Human Metabolome Database):HMDB00725
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
(±)-4-hydroxy-2-pyrrolidinecarboxylic acid
(±)-4-hydroxypyrrolidine-2-carboxylic acid
 proline, (±)-4-hydroxy-
 

Articles:

PubMed:Determination and stereochemistry of proteinogenic and non-proteinogenic amino acids in Saudi Arabian date fruits.
PubMed:The adhesive skin exudate of Notaden bennetti frogs (Anura: Limnodynastidae) has similarities to the prey capture glue of Euperipatoides sp. velvet worms (Onychophora: Peripatopsidae).
PubMed:Innovative and rapid procedure for 4-hydroxyproline determination in meat-based foods.
PubMed:Analysis of 4-hydroxyproline using 4-chloro-7-nitrobenzo-2-oxa-1,3-diazol derivatization and micellar electrokinetic chromatography combined with laser-induced fluorescence detection.
PubMed:Quantitative separation of 4-hydroxyproline from skeletal muscle collagen by micellar electrokinetic capillary electrophoresis.
PubMed:Determination of myofibrillar and connective tissue protein contents of young and adult avian (Gallus domesticus) skeletal muscles and the N tau-methylhistidine content of avian actins.
PubMed:The determination of hydroxyproline in meat using gas chromatography-mass spectrometry.
PubMed:Nitrosation of sarcosine, proline and 4-hydroxyproline by exposure to nitrogen oxides.
 
Notes:
None found
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