EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

tocophersolan
vitamin E TPGS

Sponsors

Name:1-O-(2-hydroxyethyl)4-O-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] butanedioate
CAS Number: 9002-96-4Picture of molecule3D/inchi
Other:30999-06-5
FDA UNII:O03S90U1F2
MDL:MFCD00146616
XlogP3-AA:9.90 (est)
Molecular Weight:574.84246000
Formula:C35 H58 O6
NMR Predictor:Predict (works with chrome or firefox)
Category:nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white to pale brown waxy solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 662.00 to 663.00 °C. @ 760.00 mm Hg (est)
Flash Point: 384.00 °F. TCC ( 195.40 °C. ) (est)
logP (o/w): 9.745 (est)
Soluble in:
 water, 1.655e-007 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
 
Suppliers:
BOC Sciences
For experimental / research use only.
Tocofersolan 95%
Odor: characteristic
Use: Tocofersolan is a synthetic water-soluble version of vitamin E unlike its natural counterpart which are fat soluble . It is polyethylene glycol derivative of -tocopherol which enables it water soluble. It is used as a vitamin E supplement or to treat vi Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fat
Santa Cruz Biotechnology
For experimental / research use only.
Tocophersolan
Sigma-Aldrich: Sigma
For experimental / research use only.
D-a-Tocopherol polyethylene glycol 1000 succinate BioXtra, water soluble vitamin E conjugate
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 7000 mg/kg
Journal of Agricultural and Food Chemistry. Vol. 25, Pg. 273, 1977.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: nutrient supplements
Recommendation for tocophersolan usage levels up to:
 not for fragrance use.
 
Recommendation for tocophersolan flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) in use for food for particular nutritional purposes.
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Cancer Citations:Search
Toxicology Citations:Search
NLM Developmental and Reproductive Toxicity:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :71406
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
1-O-(2-hydroxyethyl)4-O-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] butanedioate
Chemidplus:0009002964
 
References:
 1-O-(2-hydroxyethyl)4-O-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] butanedioate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):71406
Pubchem (sid):135076453
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):D06174
HMDB (The Human Metabolome Database):HMDB34354
FooDB:FDB012716
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 butanedioic acid, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl 2-hydroxyethyl ester
2-hydroxyethyl 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl succinate
1-O-(2-hydroxyethyl) 4-O-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] butanedioate
1-O-(2-hydroxyethyl)4-O-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] butanedioate
 poly(oxy-1,2-ethanediyl), a-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2- (4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)-1,4-dioxobutyl)-omega-hydroxy-, (2R-(2R
 poly(oxy-1,2-ethanediyl), a-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)-1,4-dioxobutyl)-omega-hydroxy-
 poly(oxy-1,2-ethanediyl), a-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)-1,4-dioxobutyl)-omega-hydroxy-, (2R-(2R*
mono-(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) succinate polyethylene glycol monoester
 tocofersolan
D-a-tocopherol polyethylene glycol succinate
D-alpha-tocopheryl poly(ethylene glycol) 1000 succinate
dextro-alpha-tocopheryl poly(ethylene glycol) 1000 succinate
(+)-alpha-tocopheryl polyethylene glycol 1000 succinate
 TPGS
 vitamin E TPGS
 
 
Notes:
Vitamin E supplement, antioxidant Tocofersolan (INN) or tocophersolan is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is polyethylene glycol derivative of ?-tocopherol that enables water solubility.
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