EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

vitamin E
(2R,4'R,8'R)-a-tocopherol

Supplier Sponsors

Name:(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
CAS Number: 1406-18-4Picture of molecule3D/inchi
Other(deleted CASRN):11105-14-9
FDA UNII: H4N855PNZ1
Nikkaji Web:J24.260H
Beilstein Number:94012
XlogP3-AA:10.70 (est)
Molecular Weight:430.71590000
Formula:C29 H50 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:dietary supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
EU SANCO Tocopherol-rich extract View - review
184.1890 alpha-Tocopherols View - review
GRN 307 Palm oil-derived tocols with tocotrienols and a-tocopherol as the principal components View - notice PDF
EU SANCO Alpha-tocopherol View - review
GRN 781 Alpha-tocopherol (fruit and vegetable derived) View - notice PDF
JECFA Food Additive: dl-alpha-Tocopherol

Tocopherol Concentrate, mixed
GSFA Codex: dl-alpha-Tocopherol (307c)

Tocopherol concentrate, mixed (307b)
DG SANTE Food Additives:a-tocopherol
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 485.00 to 486.00 °C. @ 760.00 mm Hg (est)
Flash Point: 410.00 °F. TCC ( 210.20 °C. ) (est)
logP (o/w): 10.962 (est)
Soluble in:
 alcohol
 water, 2.978e-007 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
ADM
NATURAL-SOURCE VITAMIN E 1000 OIL
ADM
NATURAL-SOURCE VITAMIN E 405
ADM
NATURAL-SOURCE VITAMIN E SUPER E 20
American International Chemical, LLC.
Vitamin E
AuNutra® Industries
Natural Vitamin E
Axsyn
For experimental / research use only.
Vitamin E
BOC Sciences
For experimental / research use only.
VitaminE
Camden-Grey Essential Oils
T-50 all natural vitamin E
Odor: characteristic
Use: Sold by weight. T-50 all natural vitamin E. With daily concerns over the safety of synthetic ingredients, why risk the success of your products by using synthetic antioxidants? There are two classes of natural Vitamin E: tocopherols and tocotrienols. We offer you all natural low d-alpha mixed tocopherols or T-50.
DSM Nutritional
Quali®-E (vitamin E)
ECSA Chemicals
VITAMIN E 50 TCF TOCOPHEROL
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
VITAMIN E 70 TCF TOCOPHEROL
Foodchem International
Vitamin E
Graham Chemical
Vitamin E
Kraft Chemical
Tocopherols (Vitamin E)
Maypro Industries
Vitamin E
OQEMA
Vitamin E 50%
OQEMA
Vitamin E Oil 96%
Penta International
VITAMIN E NATURAL
Penta International
VITAMIN E USP / EU GRADE
Penta International
VITAMIN E
Prinova
Vitamin E
Silver Fern Chemical
Vitamin E Oil
WILD Flavors
Vitamin E
Flavor: taste
Through WILD’s agreement with Cognis® Nutrition and Health, natural Vitamin E is now available to customers. Vitamins A, C and E show antioxidant activity. They all reduce oxidative stress in the body by neutralizing free radicals.
Zanos
Vitamin E 50% CWS-S
Zhong Ya Chemical
Vitamin E Powder 50% Min. Feed Grade
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
dietary supplements
Recommendation for vitamin E usage levels up to:
 not for fragrance use.
 
Recommendation for vitamin E flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Opinion on mixed tocopherols, tocotrienol tocopherol and tocotrienols as sources for vitamin E added as a nutritional substance in food supplements[1] - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing aids and Materials in Contact with food (AFC)
View page or View pdf

Scientific Opinion on the substantiation of a health claim related to a combination of flaxseed oil and vitamin E and maintenance of the skin permeability barrier function pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin E as a-tocopherol
View page or View pdf

Scientific Opinion on Dietary Reference Values for vitamin E as a-tocopherol
View page or View pdf

Scientific Opinion on the re-evaluation of tocopherol-rich extract (E 306), a-tocopherol (E 307), ?-tocopherol (E 308) and d-tocopherol (E 309) as food additives
View page or View pdf

Vitamin E and protection of DNA, proteins and lipids from oxidative damage: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):1406-18-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :14985
National Institute of Allergy and Infectious Diseases:Data
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
Chemidplus:0001406184
 
References:
 (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:1406-18-4
Pubchem (cid):14985
Pubchem (sid):134981325
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C02477
HMDB (The Human Metabolome Database):HMDB01893
FooDB:FDB005752
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•aquasol e (armour). capsules (tocopheryl acetate) 100 and 400 iu; drops 50 iuml; e-ferol (forest). capsules (tocopheryl acetate) 200 & 400 iu. •eprolin (lilly). capsules (tocopheryl acetate) 100 iu. •vitamin e: capsules (50, 100, 200, 400, 500, 600, 800, and 1000 iu), solution (200 unitsml in 10 ml containers), drops (10 iudrop in 15 ml containers), tablets (chewable) (100, 200, 400, 500, 800, and 1000 units), wafers (400 iu). tocopherol: capsules (100, 200, 400, and 1000 iu). tocopheryl: capsules (100, 200, and 400 iu), aquasol e (usv) capsules (30, 100, and 400 iu), drops (50 iuml), elixer (33.3 iu5 ml (alcohol 25%)). e prolin: capsules(50 and 100 mg). viterra e: capsules (100, 200, 400, and 600 iu). •oral capsules: 100 units; 200 units e-vitamin succinate (as d-alpha-tocopheryl acid succinate), forest; 400 mg e-vitamin succinate (as d-alpha-tocopheryl acid succinate), forest; vita-plus e (as d-alpha-tocopheryl acetate), scot-tussin; 600, 1000 units •capsules, water miscible: 100 unit aquasol e (as d-alpha-tocopheryl acetate; with parabens), •oil solution water miscible: 50 unitsml aquasol e drops (as d-alpha-tocopheryl acetate; with propylene glycol), astra •tablets 100, 200 units; 400 units pheryl e (as d-alpha- tocopheryl acid succinate) miller; 500, 600, 1000 units •tablets chewable 100, 200, 400 units •vitamin e is also commercially available in combination with other vitamins, minerals, protein supplements, and infant formulas.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 buckthorn sea buckthorn fruit
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 caper seed
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 caper seed oil
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 carrot plant
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 coconut seed
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 lettuce leaf
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 soybean seed
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 soybean seed oil
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 wheat sprout
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Synonyms:
 aquasol E
(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol
[2R-2R*(4R*,8R*)]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol
[2R-[2R*(4R*,8R*)]]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl nicotinate
(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
 emipherol
 etamican
 irganox E 201
 juvela E
 phytogermine
 rocavit E
 spavit E
(R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-ol
(2R,4'R,8'R)-2,5,7,8-tetramethyl-2-(4',8',12'-trimethyltridecyl)-6-chromanol
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-ol
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-6-chromanol
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
(+)-a-tocopherol
(2R,4'R,8'R)-a-tocopherol
(all-R)-a-tocopherol
(R,R,R)-a-tocopherol
a-tocopherol
RRR-a-tocopherol
(2R)-2-((4R,8R)-4,8,12-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-ol
 
 
Notes:
a generic descriptor for all tocopherols and tocotrienols that exhibit alpha-tocopherol activity. by virtue of the phenolic hydrogen on the 2h-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of isoprenoids.
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