| PubMed:Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride. |
| PubMed:A novel spectral resolution and simultaneous determination of multicomponent mixture of Vitamins B1, B6, B12, Benfotiamine and Diclofenac in tablets and capsules by derivative and MCR-ALS. |
| PubMed:The effect of benfotiamine on mu-opioid receptor mediated antinociception in experimental diabetes. |
| PubMed:Benfotiamine upregulates antioxidative system in activated BV-2 microglia cells. |
| PubMed:Effect of benfotiamine in podocyte damage induced by peritoneal dialysis fluid. |
| PubMed:Paraptosis cell death induction by the thiamine analog benfotiamine in leukemia cells. |
| PubMed:Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia. |
| PubMed:A randomized, double-blind, crossover, placebo-controlled trial of 6 weeks benfotiamine treatment on postprandial vascular function and variables of autonomic nerve function in Type 2 diabetes. |
| PubMed:Benfotiamine enhances antioxidant defenses and protects against cisplatin-induced DNA damage in nephrotoxic rats. |
| PubMed:Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence. |
| PubMed:Variability of skin autofluorescence measurement over 6 and 12 weeks and the influence of benfotiamine treatment. |
| PubMed:Liver, plasma and erythrocyte levels of thiamine and its phosphate esters in rats with acute ethanol intoxication: a comparison of thiamine and benfotiamine administration. |
| PubMed:Benfotiamine prevents increased β-amyloid production in HEK cells induced by high glucose. |
| PubMed:Change in psychiatric symptomatology after benfotiamine treatment in males is related to lifetime alcoholism severity. |
| PubMed:Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. |
| PubMed:Annexin V imaging detects diabetes-accelerated apoptosis and monitors the efficacy of benfotiamine treatment in ischemic limbs of mice. |
| PubMed:Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations. |
| PubMed:Pharmacokinetics of the transdermal delivery of benfotiamine. |
| PubMed:The effects of long-term oral benfotiamine supplementation on peripheral nerve function and inflammatory markers in patients with type 1 diabetes: a 24-month, double-blind, randomized, placebo-controlled trial. |
| PubMed:Antiglycation activity of thiamin-HCl and benfotiamine in diabetic condition. |
| PubMed:Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy. |
| PubMed:[The effect of long-chain polyunsaturated higher ω-3 fatty acids, benfotiamine and α-lipoic acid on the lipid metabolism in patients with diabetes mellitus type 2 and cardiovascular autonomic neuropathy]. |
| PubMed:Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis. |
| PubMed:Benfotiamine counteracts smoking-induced vascular dysfunction in healthy smokers. |
| PubMed:Solubility enhancement of benfotiamine, a lipid derivative of thiamine by solid dispersion technique. |
| PubMed:Preventive effects of benfotiamine in chronic diabetic complications. |
| PubMed:Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. |
| PubMed:Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. |
| PubMed:The multifaceted therapeutic potential of benfotiamine. |
| PubMed:The defensive effect of benfotiamine in sodium arsenite-induced experimental vascular endothelial dysfunction. |
| PubMed:A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy. |
| PubMed:Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes. |
| PubMed:PP2A contributes to endothelial death in high glucose: inhibition by benfotiamine. |
| PubMed:Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages. |
| PubMed:Comment on: Fraser et al. The effects of long-term oral benfotiamine supplementation on peripheral nerve function and inflammatory markers in patients with type 1 diabetes: a 24-month, double-blind, randomized, placebo-controlled trial. Diabetes Care 2012;35:1095-1097. |
| PubMed:Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response. |
| PubMed:Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1. |
| PubMed:Human pericyte-endothelial cell interactions in co-culture models mimicking the diabetic retinal microvascular environment. |
| PubMed:Thiamine and benfotiamine prevent apoptosis induced by high glucose-conditioned extracellular matrix in human retinal pericytes. |
| PubMed:Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway. |
| PubMed:Pharmacologic Approaches Against Advanced Glycation End Products (AGEs) in Diabetic Cardiovascular Disease. |
| PubMed:Detection of transketolase in bone marrow-derived insulin-producing cells: benfotiamine enhances insulin synthesis and glucose metabolism. |
| PubMed:Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. |
| PubMed:Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro. |
| PubMed:Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis. |
| PubMed:Antinociceptive interaction between benfotiamine and resveratrol in capsaicin-induced licking. |
| PubMed:Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat. |
| PubMed:Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. |
| PubMed:Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study). |
| PubMed:Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy. |
| PubMed:Synergistic antiallodynic interaction between gabapentin or carbamazepine and either benfotiamine or cyanocobalamin in neuropathic rats. |
| PubMed:Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. |
| PubMed:Thiamine and benfotiamine prevent increased apoptosis in endothelial cells and pericytes cultured in high glucose. |
| PubMed:Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose. |
| PubMed:Pharmacokinetics of thiamine derivatives especially of benfotiamine. |
| PubMed:High-dose benfotiamine rescues cardiomyocyte contractile dysfunction in streptozotocin-induced diabetes mellitus. |
| PubMed:Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. |
| PubMed:Benfotiamine reduces genomic damage in peripheral lymphocytes of hemodialysis patients. |
| PubMed:Benfotiamine relieves inflammatory and neuropathic pain in rats. |
| PubMed:Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. |
| PubMed:Benfotiamine in treatment of alcoholic polyneuropathy: an 8-week randomized controlled study (BAP I Study). |
| PubMed:Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. |
| PubMed:Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-alpha. |
| PubMed:Comparative autoradiographic investigations on the tissue distribution of benfotiamine versus thiamine in mice. |
| PubMed:Benfotiamine attenuates nicotine and uric acid-induced vascular endothelial dysfunction in the rat. |
| PubMed:Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. |
| PubMed:Inhibition of macrophage oxidative stress prevents the reduction of ABCA-1 transporter induced by advanced glycated albumin. |
| PubMed:Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes. |
| PubMed:Effects of thiamine and benfotiamine on intracellular glucose metabolism and relevance in the prevention of diabetic complications. |
| PubMed:Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative. |
| PubMed:Current therapeutic interventions in the glycation pathway: evidence from clinical studies. |
| PubMed:Efficacy and tolerability of advanced glycation end-products inhibitor in osteoarthritis: a randomized, double-blind, placebo-controlled study. |
| PubMed:Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes. |
| PubMed:Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling. |
| PubMed:A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy. |
| PubMed:New oral dosage form for elderly patients. II. Release behavior of benfotiamine from silk fibroin gel. |
| PubMed:[The immunometaboic effects of benfotiamine and riboxine on hemolytic anemia]. |
| PubMed:Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes. |
| PubMed:[Oral benfotiamine therapy. Thus you protect the nerves of diabetic patients]. |
| PubMed:[Chronic alcohol abuse. Benfotiamine in alcohol damage is a must]. |
| PubMed:Comparative bioavailability of two vitamin B1 preparations: benfotiamine and thiamine mononitrate. |
| PubMed:Adiponectin decreases postprandially following a heat-processed meal in individuals with type 2 diabetes: an effect prevented by benfotiamine and cooking method. |
| PubMed:Benfotiamine. Monograph. |
| PubMed:Vitamins and their derivatives in the prevention and treatment of metabolic syndrome diseases (diabetes). |
| PubMed:Advanced glycation end-products inhibition improves endothelial dysfunction in rheumatoid arthritis. |
| PubMed:[The effect of benfothiamine in the therapy of diabetic polyneuropathy]. |
| PubMed:High thiamine diphosphate concentrations in erythrocytes can be achieved in dialysis patients by oral administration of benfontiamine. |
| PubMed:Detrimental effects of acute hyperglycaemia on the rat heart. |
| PubMed:[Pathomechanism of diabetic neuropathy: background of the pathogenesis-oriented therapy]. |
| PubMed:[Clinical use of benphothiamine]. |
| PubMed:[A comparative study of blood thiamine levels after injection of thiamine chlorhydrate and per os administration of Benfotiamine]. |
| PubMed:Burning through the pain: treatments for diabetic neuropathy. |
| PubMed:Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation? |
| PubMed:Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine. |
| PubMed:Effects of high glucose and thiamine on the balance between matrix metalloproteinases and their tissue inhibitors in vascular cells. |
| PubMed:High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic rats. |
| PubMed:Vitamin B and its derivatives for diabetic kidney disease. |
| PubMed:Treatment of painful diabetic neuropathy. |
| PubMed:Diabetic neuropathy and oxidative stress: therapeutic perspectives. |
| PubMed:The detrimental effects of acute hyperglycemia on myocardial glucose uptake. |
| PubMed:Thiamine deficiency induces anorexia by inhibiting hypothalamic AMPK. |
| PubMed:Inhibition of AGEs formation by natural products. |
| PubMed:Uncovering the beginning of diabetes: the cellular redox status and oxidative stress as starting players in hyperglycemic damage. |
| PubMed:High-throughput screening of small molecules identifies hepcidin antagonists. |
| PubMed:Current options and perspectives in the treatment of diabetic neuropathy. |
| PubMed:[The immunomodulating action of energizing preparations under physical loading]. |
| PubMed:A case of rheumatoid arthritis presenting with postherpetic neuralgia and abdominal-wall pseudohernia. |
| PubMed:Glucose effects on the peritoneum: what can we learn from rodent models? |
| PubMed:Lipid glycation and protein glycation in diabetes and atherosclerosis. |
| PubMed:[Neuropathy pain: tactic of treatment]. |
| PubMed:[The role of neurotropic therapy in the treatment of acute sensorineural impairment of hearing following a viral infection]. |
| PubMed:[A relationship between analgesic and neurotropic effects by the example of milgamma]. |
| PubMed:[The optimization of the treatment of the vertebrogenic pain syndrome: neurotrophic treatment potentiates the effect of nonsteroidal anti-inflammatory drugs]. |
| PubMed:[The importance of the pharmaceutical form and the routes of administration of B-group vitamins for the efficacious treatment of neurosensorial hearing loss]. |
| PubMed:[Prophylactic and therapeutic application of thiamine (vitamin B1)--a new point of view]. |
| PubMed:[Medicamentous therapy of alcoholic polyneuropathy. Randomized double-blind study comparing 2 vitamin B preparations and a nucleotide preparation]. |
| PubMed:Diabetic neuropathy: new strategies for treatment. |
| PubMed:Vitamin B1 blocks damage caused by hyperglycemia. |
| PubMed:Metabolic correction in the management of diabetic peripheral neuropathy: improving clinical results beyond symptom control. |
| PubMed:[Prevention of complications in diabetes mellitus. Interdisciplinary collaboration to control sequelae]. |
| PubMed:Emerging role of thiamine therapy for prevention and treatment of early-stage diabetic nephropathy. |
| PubMed:Could thiamine pyrophosphate be a regulator of the nitric oxide synthesis in the endothelial cell of diabetic patients? |
| PubMed:Drugs for the treatment of diabetes complications. Zycose: a new player in the field? |
| PubMed:[Cochleovestibular disorders: approaches to diagnostics and treatment]. |
| PubMed:[Sensorineural hearing loss: New prospects for therapy]. |
| PubMed:Oxidative stress in diabetic kidney disease. |
| PubMed:Skin autofluorescence as a measure of advanced glycation endproduct deposition: a novel risk marker in chronic kidney disease. |
| PubMed:[Diabetic neuropathies and angiopathies. Compensating for thiamine deficiency]. |
| PubMed:High-dose thiamine therapy counters dyslipidaemia in streptozotocin-induced diabetic rats. |
| PubMed:[Pharmacologic therapy in peripheral diabetic polyneuropathy]. |
| PubMed:Diabetes mellitus induces bone marrow microangiopathy. |
| PubMed:[The myocardial contractile function and central hemodynamics of patients with insulin-dependent diabetes mellitus during treatment]. |
| PubMed:[Treatment of neuropathies]. |
| PubMed:Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up-regulation contribute to the onset of diabetic cardiomyopathy. |
| PubMed:Effectiveness and retention of thiamine and its analogs administered to steelhead and landlocked Atlantic salmon. |
| PubMed:New approaches for the treatment of genomic damage in end-stage renal disease. |
| PubMed:Vitamin B for treating peripheral neuropathy. |
| PubMed:The potential role of thiamine (vitamin B1) in diabetic complications. |
| PubMed:Inhibitors of advanced glycation end product formation and neurovascular dysfunction in experimental diabetes. |
| PubMed:Schlafen 3, a novel gene, regulates colonic mucosal growth during aging. |
| PubMed:[Vitamin B complex (milgamma) in the treatment of vertebrogenic lumbosacral radiculopathy]. |
| PubMed:[Correction of metabolic disturbances in patients with stable effort angina and metabolic syndrome]. |
| PubMed:[Structural and functional changes of arterial vessels in patients with ischemic heart disease and metabolic syndrome]. |
| PubMed:[Neurometabolic therapy of diabetic neuropathy]. |
| PubMed:[Development of therapeutic agents for diabetic neuropathies]. |
| PubMed:[Progress on the drug therapy for diabetic microangiopathies: AGE inhibitors]. |
| PubMed:[Diabetes mellitus. Retinal lesions should not exist!]. |
| PubMed:Bioavailability of water- and lipid-soluble thiamin compounds in broiler chickens. |
| PubMed:Effect of high-dosed thiamine hydrochloride and S-benzoyl-thiamine-O-monophosphate on thiamine-status after chronic ethanol administration. |
| PubMed:[Diabetic polyneuropathy treatment by milgamma-100 preparation]. |
| PubMed:A 6-month-old girl with cardiomyopathy who nearly died. |
| PubMed:Therapeutic efficacy of "Milgamma" in patients with painful diabetic neuropathy. |
| PubMed:[The effectiveness of the neurotropic agents: benfotiamin combinations]. |
| PubMed:[Physical work capacity in diabetes mellitus under treatment]. |
| PubMed:Crystal structures of the thi-box riboswitch bound to thiamine pyrophosphate analogs reveal adaptive RNA-small molecule recognition. |
| PubMed:The role of AGEs and AGE inhibitors in diabetic cardiovascular disease. |
| PubMed:Advances in biochemical mechanisms of diabetic retinopathy. |
| PubMed:An open-label 52-week clinical extension comparing duloxetine with routine care in patients with diabetic peripheral neuropathic pain. |
| PubMed:Evaluating thiamine deficiency in patients with diabetes. |
| PubMed:[Role of mitochondrial dysfunction in pathogenesis of diabetic microangiopathy]. |
| PubMed:[Milgamma in the treatment of chronic neurosensory hypoacusis]. |
| PubMed:[Treatment of neuropathies]. |
| PubMed:[Bendotiamine efficacy in alcoholic polyneuropathy therapy]. |
| PubMed:[Diabetic neuropathy]. |
| PubMed:Biokinetic parameters and metabolism of S-benzoylthiamine-O-monophosphate. |
| PubMed:Alteration of thiamine pharmacokinetics by end-stage renal disease (ESRD). |
| PubMed:Comparative bioavailability of various thiamine derivatives after oral administration. |
| PubMed:Excretion of intracorporeal cadmium with S-benzoylthiamin monophosphate. |
| PubMed:[Characteristic features of 35S-benzoylthiamine monophosphate in albino mice]. |
| PubMed:Peripheral neuropathy: pathogenic mechanisms and alternative therapies. |
| PubMed:Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer. |
| PubMed:Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats. |
3D/inchi